WO2007047504A3 - Natriuretic peptide modified transferrin fusion proteins - Google Patents

Natriuretic peptide modified transferrin fusion proteins Download PDF

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Publication number
WO2007047504A3
WO2007047504A3 PCT/US2006/040207 US2006040207W WO2007047504A3 WO 2007047504 A3 WO2007047504 A3 WO 2007047504A3 US 2006040207 W US2006040207 W US 2006040207W WO 2007047504 A3 WO2007047504 A3 WO 2007047504A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
natriuretic peptide
peptide modified
transferrin fusion
modified transferrin
Prior art date
Application number
PCT/US2006/040207
Other languages
French (fr)
Other versions
WO2007047504A2 (en
Inventor
Homayoun Sadeghi
Andrew J Turner
Christopher P Prior
David J Ballance
Original Assignee
Biorexis Pharmaceutical Corp
Homayoun Sadeghi
Andrew J Turner
Christopher P Prior
David J Ballance
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorexis Pharmaceutical Corp, Homayoun Sadeghi, Andrew J Turner, Christopher P Prior, David J Ballance filed Critical Biorexis Pharmaceutical Corp
Priority to CA002625600A priority Critical patent/CA2625600A1/en
Priority to EP06825957A priority patent/EP1951277A2/en
Priority to JP2008535740A priority patent/JP2009511060A/en
Publication of WO2007047504A2 publication Critical patent/WO2007047504A2/en
Publication of WO2007047504A3 publication Critical patent/WO2007047504A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Abstract

Fusion proteins of transferrin and natriuretic peptides with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor.
PCT/US2006/040207 2005-10-14 2006-10-16 Natriuretic peptide modified transferrin fusion proteins WO2007047504A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002625600A CA2625600A1 (en) 2005-10-14 2006-10-16 Natriuretic peptide modified transferrin fusion proteins
EP06825957A EP1951277A2 (en) 2005-10-14 2006-10-16 Natriuretic peptide modified transferrin fusion proteins
JP2008535740A JP2009511060A (en) 2005-10-14 2006-10-16 Natriuretic peptide modified transferrin fusion protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72619805P 2005-10-14 2005-10-14
US60/726,198 2005-10-14

Publications (2)

Publication Number Publication Date
WO2007047504A2 WO2007047504A2 (en) 2007-04-26
WO2007047504A3 true WO2007047504A3 (en) 2007-06-14

Family

ID=37963135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/040207 WO2007047504A2 (en) 2005-10-14 2006-10-16 Natriuretic peptide modified transferrin fusion proteins

Country Status (4)

Country Link
EP (1) EP1951277A2 (en)
JP (1) JP2009511060A (en)
CA (1) CA2625600A1 (en)
WO (1) WO2007047504A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2162464A1 (en) * 2007-06-06 2010-03-17 Boehringer Ingelheim International GmbH Natriuretic fusion proteins
CA2699916A1 (en) 2007-09-18 2009-08-06 The Jackson Laboratory Antibodies and fc fusion protein modifications with enhanced persistence or pharmacokinetic stability in vivo and methods of use thereof
US8551938B2 (en) 2009-09-25 2013-10-08 Alcon Research, Ltd. NPR-B agonists
WO2011038061A2 (en) 2009-09-25 2011-03-31 Alcon Research, Ltd. Novel npr-b agonists
TW201121995A (en) 2009-12-18 2011-07-01 Alcon Res Ltd Novel NPR-B agonists
US9018168B2 (en) 2010-08-12 2015-04-28 Madeleine Pharmaceuticals Pty Ltd Therapeutic method for treating congestive heart failure
NZ724348A (en) 2010-11-30 2019-12-20 Genentech Inc Low affinity blood brain barrier receptor antibodies and uses therefor
EP2678002A2 (en) 2011-02-25 2014-01-01 Medtronic, Inc. Therapy for kidney disease and/or heart failure
WO2013033675A1 (en) 2011-09-02 2013-03-07 Medtronic, Inc. Chimeric natriuretic peptide compositions and methods of preparation
TW201442721A (en) * 2013-01-23 2014-11-16 Daiichi Sankyo Co Ltd Glycosilated atrial natriuretic peptide
WO2014164981A1 (en) 2013-03-12 2014-10-09 The General Hospital Corporation Modified mullerian inhibiting substance (mis) proteins and uses thereof for the treatment of diseases
ES2945994T3 (en) 2013-03-15 2023-07-11 Gladiator Biosciences Inc Gla domains as addressing agents
CA2933335A1 (en) 2013-12-11 2015-06-18 The General Hospital Corporation Use of mullerian inhibiting substance (mis) proteins for contraception and ovarian reserve preservation
AU2015243961A1 (en) 2014-04-10 2016-10-27 Bayer Healthcare Llc Compounded media powder formulation and method of preparation of liquid medium for cell culture

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403336B1 (en) * 1985-06-20 2002-06-11 Fujisawa Pharmaceutical Co., Ltd. Process for the production of α-human atrial natriuretic polypeptide
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
US6987088B2 (en) * 1999-07-02 2006-01-17 Genentech, Inc. Compounds that bind HER2

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403336B1 (en) * 1985-06-20 2002-06-11 Fujisawa Pharmaceutical Co., Ltd. Process for the production of α-human atrial natriuretic polypeptide
US6987088B2 (en) * 1999-07-02 2006-01-17 Genentech, Inc. Compounds that bind HER2
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LI H. ET AL.: "Transferrin/Transferrin Receptor-Mediated Drug Delivery", MEDICINAL RESEARCH REVIEWS, vol. 22, no. 3, pages 225 - 250, XP003014317 *
WANG W. ET AL.: "AlbuBNP, a Recombinant B-Type Natriuretic Peptide and Human Serum Albumin Fusion Hormone, as a Long-Term Therapy of Congestive Heart Failure", PHARM. RES., vol. 21, no. 11, 2004, pages 2105 - 2110, XP003014318 *

Also Published As

Publication number Publication date
JP2009511060A (en) 2009-03-19
CA2625600A1 (en) 2007-04-26
WO2007047504A2 (en) 2007-04-26
EP1951277A2 (en) 2008-08-06

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