WO2008140565A3 - Use of tumor necrosis factor receptor 14 antagonists for treating psoriasis - Google Patents

Use of tumor necrosis factor receptor 14 antagonists for treating psoriasis Download PDF

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Publication number
WO2008140565A3
WO2008140565A3 PCT/US2007/084140 US2007084140W WO2008140565A3 WO 2008140565 A3 WO2008140565 A3 WO 2008140565A3 US 2007084140 W US2007084140 W US 2007084140W WO 2008140565 A3 WO2008140565 A3 WO 2008140565A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonists
necrosis factor
factor receptor
polypeptides
tumor necrosis
Prior art date
Application number
PCT/US2007/084140
Other languages
French (fr)
Other versions
WO2008140565A2 (en
Inventor
Brian A Fox
James L Holloway
Paul O Sheppard
Stacey R Dillon
Original Assignee
Zymogenetics Inc
Brian A Fox
James L Holloway
Paul O Sheppard
Stacey R Dillon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Brian A Fox, James L Holloway, Paul O Sheppard, Stacey R Dillon filed Critical Zymogenetics Inc
Publication of WO2008140565A2 publication Critical patent/WO2008140565A2/en
Publication of WO2008140565A3 publication Critical patent/WO2008140565A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.
PCT/US2007/084140 2006-11-08 2007-11-08 Use of tumor necrosis factor receptor 14 antagonists for treating psoriasis WO2008140565A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86486406P 2006-11-08 2006-11-08
US60/864,864 2006-11-08

Publications (2)

Publication Number Publication Date
WO2008140565A2 WO2008140565A2 (en) 2008-11-20
WO2008140565A3 true WO2008140565A3 (en) 2009-06-11

Family

ID=40002800

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/084140 WO2008140565A2 (en) 2006-11-08 2007-11-08 Use of tumor necrosis factor receptor 14 antagonists for treating psoriasis

Country Status (1)

Country Link
WO (1) WO2008140565A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9056908B2 (en) 2007-08-03 2015-06-16 Abbvie Biotherapeutics Inc. Therapeutic use of anti-tweak receptor antibodies

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037865A2 (en) * 2003-10-16 2005-04-28 Zymogenetics, Inc. Ztnfr14, A TUMOR NECROSIS FACTOR RECEPTOR

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037865A2 (en) * 2003-10-16 2005-04-28 Zymogenetics, Inc. Ztnfr14, A TUMOR NECROSIS FACTOR RECEPTOR

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AGGARWAL B B ET AL: "TNF blockade: An inflammatory issue", 56TH INTERNATIONAL WORKSHOP ON CYTOKINES AS POTENTIAL THERAPEUTIC TARGETS FOR INFLAMMATORY SKIN DISE; SAN FRANCISCO, CA, USA; NOVEMBER 17 -19, 2004,, 1 January 2006 (2006-01-01), pages 161 - 186, XP009115475, ISBN: 978-3-540-25427-0 *
FIDALGO A ET AL: "Etanercept for psoriasis: Two case reports", INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH, BIOSCIENCE EDIPRINT, GENEVA, CH, vol. 25, no. 4, 1 January 2005 (2005-01-01), pages 159 - 163, XP009115472, ISSN: 0251-1649 *

Also Published As

Publication number Publication date
WO2008140565A2 (en) 2008-11-20

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