WO2005016422A1 - Inhalateur utilise pour la distribution de medicaments - Google Patents

Inhalateur utilise pour la distribution de medicaments Download PDF

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Publication number
WO2005016422A1
WO2005016422A1 PCT/FI2004/000478 FI2004000478W WO2005016422A1 WO 2005016422 A1 WO2005016422 A1 WO 2005016422A1 FI 2004000478 W FI2004000478 W FI 2004000478W WO 2005016422 A1 WO2005016422 A1 WO 2005016422A1
Authority
WO
WIPO (PCT)
Prior art keywords
dispenser
inhalator
medicament
dispensing
air duct
Prior art date
Application number
PCT/FI2004/000478
Other languages
English (en)
Inventor
Marko JÄRVIÖ
Marko Puruskainen
Original Assignee
Perlos Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perlos Oyj filed Critical Perlos Oyj
Publication of WO2005016422A1 publication Critical patent/WO2005016422A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • the invention relates to an inhalator for dispensing powdery medicaments, which inhalator has a medicament container for storing the medicament to be dispensed, an air duct, to which the dosages are brought for transfer by means of air flowing in the air duct to the respiratory organs, and a dispenser for dispensing the dosage and transferring it from the medicament container to the air duct, the dispenser having a dispensing part, which has preferably conical dispensing openings leading through it and expanding in the flow direction of air and which is movable to the medicament container and, correspondingly, to the air duct in such a manner that the dispensing openings open toward the medicament container and can, when at the medicament container, be filled with a powdery medicament, and, correspondingly, when at the air duct, open essentially upward in the normal operating position of the inhalator so that air flowing through the dispensing openings transports the powdery medicament onward along the air duct.
  • Inhalators are used for dispensing medicaments in such a manner that during inhalation, a desired amount of medicament is transferred with air flowing through the inhalator to the respiratory organs and in that way to the human body.
  • a suitable amount of powdery medicament is brought to a given dosage space by moving inhalator parts in relation to each other, after which, when air is sucked through the inhalator, the air flowing through the medicament-containing space carries the medicament to the patient's respiratory organs.
  • EP 0 547 429 and EP 0 883 415 disclose some known inhalator solutions.
  • the medicament is dispensed by turning the disc-like dispensing part of the dispenser, comprising several small, conical dispensing openings, to the medicament-containing space, whereby the medicament fills the interior of the openings, after which the dispensing part formed by the conical openings and filled with medicament is turned to the flow duct.
  • the dispensing part when inhaled through the inhalator, air carries the medicament with it when passing through the dispensing openings.
  • the problem with this solution is that when the dispensing part is turned at the air flow duct, part of the powdery medicament always falls through the smaller opening below the conical openings into the interior of the inhalator, which results in loss of medicament, although most of the medicament remains in the openings.
  • the medicament makes the interior of the inhalator dirty, and occasionally, when air flows through the inhalator, an unduly large amount of medicament may be detached from the inhalator interior along with the air flow, whereby the dosage may significantly exceed what is intended.
  • manufacturing such inhalators requires extremely accurate tolerances and, particularly with respect to the mixture of medicament and air, optimal conditions, as well as air ducts that allow as little dirt as possible. It is difficult to realize all these details, particularly in view of the manufacturing technique itself dictating the feasible practical limits to the tolerances.
  • An object of the present invention is to provide an inhalator with which medicament can be dispensed more accurately than before, and in which the interior of the inhalator does not get dirty as easily as before and the loss of medicament is not as great.
  • the inhalator according to the invention is characterized in that when the dispensing openings are at the air duct and when the inhalator is essentially in its operating position, there is below the openings a space, on whose collecting surface, which is formed by the bottom of the space, the medicament dispensed through the dispensing openings falls, and that during inhalation, air flows to the air duct through said space so that the air flowing through the space takes the medicament that has fallen on the collecting surface along through the dispensing openings and on to the respiratory organs.
  • An essential idea of the invention is that a collecting surface is formed in the convergent direction of the convergent dispensing openings of the dispenser, i.e.
  • said collecting surface forms part of the wall of the transverse air duct, i.e. its lower surface in the operating position.
  • An advantage of the invention is that the medicament falling through the convergent, such as conical, dispensing openings of the dispensing part cannot fall into the inside of the inhalator but stays in the air flow duct, being thus forced along the air flow.
  • the interior of the inhalator getting dirty may be significantly reduced at the same time ass the loss of medicament can be made significantly smaller than before.
  • the dosage received at a time is much more accurately of the desired amount than known dosages.
  • FIG. 1a and 1 b show schematically an inhalator according to the invention, partly cut out in the dispensing and inhalation positions, respectively; and Figure 2 shows a second inhalator according to the invention, partly cut out in the inhalation position.
  • FIGs 1a and 1b show schematically an inhalator according to the invention, partly cut out in the dispensing and inhalation positions, respectively.
  • the inhalator comprises an upper frame 1 and a lower frame 2, which are connected to each other rotatably around the longitudinal axis of the inhalator, i.e. around axis A according to Figure 1 , which is substantially vertical in the operating position. This rotatability is needed for dispensing medicament to the dispenser, and correspondingly for transferring the medicament in the dispenser to the air duct.
  • the upper frame 1 and the lower frame 2 may consist of one or more parts connected to each other, depending on the manufacturing technique.
  • the frames are connected to each other immovably in the direction of axis A but rotatably around it.
  • a medicament container 3 in which the powdery medicament to be inhaled is stored and which is closed by its upper end, for example with a plug 4.
  • a dispenser 5 which comprises a disc-like dispensing part 5a and a solid shutoff part 5b, shown by way of example.
  • the dispenser 5 is connected unrotatably by means of a stud 2a, for example, or by some other means in relation to the lower frame 2 in such a manner that it rotates around axis A in relation to the upper frame when the frames are turned relative to each other.
  • the dispensing part can be turned to the medicament container 3 by turning the frames 1 and 2 in relation to each other for dispending medicament, and correspondingly it can be turned away from the medicament container and to the air duct 6 when filled with medicament.
  • the shutoff part 5b is turned simultaneously to the air duct and to the medicament container. This will be explained in detail later.
  • a support member 7 is mounted unrotatably relative to the upper frame, the dispenser 5 moving against the surface of the support member between the support member and the medicament container. The support member 7 is pressed toward the medicament container with a spring 8 between the lower frame 2 and the support member 7.
  • FIG. 1a shows a case where the dispenser 5 is turned to the dispensing position by turning the frames 1 and 2 in relation to each other around the vertical axis A of the inhalator.
  • the dispensing openings 5c of the dispenser 5 are located below the medicament container 3 and in connection with the interior of the medicament container 3.
  • the medicament in the interior of the medicament container 3 can flow to the dispensing openings 5c of the dispenser 5 and fill them at the same time as the solid surface of the support member 7 against the dispenser 5 prevents the powdery medicament from falling through the dispensing openings 5c.
  • the dispensing openings 5c are shaped away from the medicament container 3, i.e. in the operating position to be downwardly convergent, such as conical. This is necessary in order for the powdery medicament to stay in the dispensing opening and not to fall through it when the dispenser 5 is turned to the air duct for inhalation.
  • the surface at the lower end of the medicament container 3 is, on the other hand, firmly against the surface of the dispenser 5. Thus, when the dispenser 5 is turned away from the dispensing position, the lower edge of the medicament container 3 wipes off the excessive medicament from the top of the dispensing openings of the dispenser 5.
  • the dispenser 5 can thus carry with it only such an amount of medicament that fits in its several dispensing openings 5c, and thus the dosage transferred from the medicament container 3 is always of the same size.
  • the dispenser 5 turns to the air duct at the same time as the continuous, solid shutoff part 5b connected to the dispenser turns to the medicament container 3, closing the lower surface of the medicament container 3 and preventing the medicament from discharging from the container.
  • the dispensing openings 5c turn to the air duct 6, as indicated by Figure 1 b.
  • the air duct 6 continues to the upper end of the inhalator, from where the air is sucked through the inhalator.
  • some medicament falls out of them, ending up, in this case, at the bottom of the space 9 below the dispensing openings 5c, i.e. on the collecting surface 9a. In this way, no medicament can fall to the inside of the rest of the inhalator structure to make it dirty.
  • the dispenser 5 may be, with respect to its dispensing part, a disc-like part intended to be rotated continuously in the same direction around the vertical axis in the operating position of the inhalator.
  • the dispenser 5 comprises several groups of dispensing openings 5c, and correspondingly between them, a solid area of an appropriate size forming the shutoff part 5b.
  • the dispenser 5 is always turned in the same direction one step at a time in such a way that at the medicament container 3 and correspondingly at the air duct there are dispensing openings 5c and correspondingly a solid shutoff part 5b of the dispenser 5 alternately in one group, the shutoff part 5b closing the opening(s) of the medicament container 3.
  • the dispenser 5 may also be designed to operate in such a manner that it is moved with a reciprocating turning movement alternately to the medicament container 3 and to the air duct 6. In the latter case, the dispenser 5 has correspondingly a solid shutoff part which turns below the medicament container 3, closing the medicament into the medicament container 3.
  • the dispenser 5 may be only a reciprocatingly turning disc-like component of a disc-like structure.
  • the dispenser can be designed to operate with a reciprocating straight movement.
  • the dispenser 5 comprises a shutoff part 5b and a dispensing part 5a having dispensing openings 5c, positioned successively in the direction of movement. Between the dispenser and the inhalator frame, there is most preferably a spring which attempts to push the dispenser 5 to the inhalation position. The dispenser thus tends to be in the inhalation position, whereby the dispensing openings 5c are at the air duct 6.
  • the dispenser When medicament is to be dispensed, the dispenser is pushed to another position, whereby the dispensing openings 5c move to the medicament container 3 and are filled with medicament.
  • the dispenser 5 When the dispenser 5 is allowed to return to the original position, the dispensing openings 5c move to the air duct 6, whereby the medicament falling from them falls onto the collecting surface 9a and is transferred, in the above-described manner, along with flowing air during inhalation through the dispensing openings to the respiratory organs. It is preferable to implement the dispenser 5 in such a manner that it is pushed in to the dispensing position when a protective cover known as such and not shown is mounted on the inhalator.
  • FIG. 1 shows another inhalator according to the invention in the inhalation position and partly cut out.
  • air to the space 9 flows not directly from an opening from the outside on the side but from the interior of the inhalator through an opening 10'.
  • the medicament falling from the dispensing openings ends up at the bottom of the space 9, from where an air flow takes it with it.
  • the air may come from the interior of the inhalator through openings 10" which are at the edges of the space 9 and connected to the interior of the inhalator, as far as the air flow causes the medicament fallen to the bottom of the space 9 to be carried along, as described earlier.
  • air inlet openings from the inside and outside of the inhalator are feasible.
  • the medicament container 3 may be closed by the end opposite to the dispenser with a separate plug, but it may also be originally made closed at that end, in which case the medicament container is filled with medicament from the opposite end.
  • Different embodiments of either a continuously rotating or a reciprocatingly moving dispenser are feasible, but what is essential is that there is below the dispensing openings of the dispenser a space connected to the air duct, on the collecting surface of which medicament falls and which is dimensioned in relation to the air flow in such a way that during inhalation, the air flow carries with it the medicament that has fallen.
  • the inhalator may also be provided with a mechanism indicating the used dosages, implemented for instance with a wheel or the like which is turned to a given extent per each loading time, for example.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un inhalateur utilisé pour distribuer des médicaments en poudre, ledit inhalateur comportant un contenant (3) à médicament qui conserve le médicament devant être distribué, un passage (6) pour l'air où arrivent les doses devant être transférées aux organes respiratoires, au moyen d'air s'écoulant dans le passage (6) pour l'air et un distributeur (5) qui distribue la dose et qui la transfère du contenant (3) à médicament jusqu'au passage (6) pour l'air. Le distributeur (5) comprend de préférence des ouvertures coniques (5c) de distribution qui le traversent et qui s'étendent dans le sens d'écoulement de l'air, qui, au niveau du contenant (3) à médicament peuvent être remplies avec le médicament en poudre et qui, de manière correspondante, au niveau du passage (6) pour l'air, s'ouvrent sensiblement vers le haut en position de fonctionnement normal de l'inhalateur de sorte que l'air s'écoulant dans les ouvertures (5c) de distribution transporte le médicament en poudre vers l'avant le long du passage (6) pour l'air.
PCT/FI2004/000478 2003-08-15 2004-08-13 Inhalateur utilise pour la distribution de medicaments WO2005016422A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20031158A FI20031158A (fi) 2003-08-15 2003-08-15 Inhalaattori
FI20031158 2003-08-15

Publications (1)

Publication Number Publication Date
WO2005016422A1 true WO2005016422A1 (fr) 2005-02-24

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PCT/FI2004/000478 WO2005016422A1 (fr) 2003-08-15 2004-08-13 Inhalateur utilise pour la distribution de medicaments

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FI (1) FI20031158A (fr)
WO (1) WO2005016422A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014161901A1 (fr) * 2013-04-03 2014-10-09 Sanofi Sa Élément de dosage pour un dispositif d'inhalation et ensemble destiné à un dispositif d'inhalation comprenant un élément de dosage
WO2016180753A1 (fr) * 2015-05-08 2016-11-17 Iconovo Ab Inhalateur à poudre sèche

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524769A (en) * 1981-07-08 1985-06-25 Aktiebolaget Draco Dosage inhalator
EP0424790A2 (fr) * 1989-10-27 1991-05-02 Miat S.P.A. Inhalateur à dosages multiples pour des médicamments sous forme de poudre
EP0518087A1 (fr) * 1991-06-14 1992-12-16 Miat S.P.A. Insufflateur à doses multiples pour l'administration de médicaments pulvérulents
EP0520440A1 (fr) * 1991-06-26 1992-12-30 Schering Corporation Dispositif d'inhalation pour médicaments en poudre
EP0652022A1 (fr) * 1993-05-12 1995-05-10 Teijin Limited Dispositif et procede de distribution de medicaments en poudre en doses multiples
EP1066849A1 (fr) * 1999-01-14 2001-01-10 Teijin Limited Dispositif et procede servant a administrer une quantite constante de poudre
WO2002011800A2 (fr) * 2000-08-10 2002-02-14 Meridica Limited Dispositif pour administrer un agent physiologiquement actif sous forme de poudre

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524769A (en) * 1981-07-08 1985-06-25 Aktiebolaget Draco Dosage inhalator
EP0424790A2 (fr) * 1989-10-27 1991-05-02 Miat S.P.A. Inhalateur à dosages multiples pour des médicamments sous forme de poudre
EP0518087A1 (fr) * 1991-06-14 1992-12-16 Miat S.P.A. Insufflateur à doses multiples pour l'administration de médicaments pulvérulents
EP0520440A1 (fr) * 1991-06-26 1992-12-30 Schering Corporation Dispositif d'inhalation pour médicaments en poudre
EP0652022A1 (fr) * 1993-05-12 1995-05-10 Teijin Limited Dispositif et procede de distribution de medicaments en poudre en doses multiples
EP1066849A1 (fr) * 1999-01-14 2001-01-10 Teijin Limited Dispositif et procede servant a administrer une quantite constante de poudre
WO2002011800A2 (fr) * 2000-08-10 2002-02-14 Meridica Limited Dispositif pour administrer un agent physiologiquement actif sous forme de poudre

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014161901A1 (fr) * 2013-04-03 2014-10-09 Sanofi Sa Élément de dosage pour un dispositif d'inhalation et ensemble destiné à un dispositif d'inhalation comprenant un élément de dosage
WO2016180753A1 (fr) * 2015-05-08 2016-11-17 Iconovo Ab Inhalateur à poudre sèche
US11000652B2 (en) 2015-05-08 2021-05-11 Iconovo Ab Dry powder inhaler

Also Published As

Publication number Publication date
FI20031158A (fi) 2005-02-16
FI20031158A0 (fi) 2003-08-15

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