WO2005004953A2 - Systeme de perfusion de solutions pharmacologiques - Google Patents

Systeme de perfusion de solutions pharmacologiques Download PDF

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Publication number
WO2005004953A2
WO2005004953A2 PCT/IB2004/002245 IB2004002245W WO2005004953A2 WO 2005004953 A2 WO2005004953 A2 WO 2005004953A2 IB 2004002245 W IB2004002245 W IB 2004002245W WO 2005004953 A2 WO2005004953 A2 WO 2005004953A2
Authority
WO
WIPO (PCT)
Prior art keywords
infusion
command
pharmacological
solution
flow
Prior art date
Application number
PCT/IB2004/002245
Other languages
English (en)
Italian (it)
Other versions
WO2005004953A3 (fr
Inventor
Marco Pirovano
Stefania Improta
Original Assignee
H.S.-Hospital Service-Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.S.-Hospital Service-Spa filed Critical H.S.-Hospital Service-Spa
Priority to DK04743907.0T priority Critical patent/DK1646413T3/da
Priority to ES04743907T priority patent/ES2425558T3/es
Priority to JP2006518397A priority patent/JP2007526784A/ja
Priority to CN200480019891XA priority patent/CN1822870B/zh
Priority to BRPI0412465-0A priority patent/BRPI0412465A/pt
Priority to EP04743907.0A priority patent/EP1646413B1/fr
Priority to US10/563,909 priority patent/US7744566B2/en
Publication of WO2005004953A2 publication Critical patent/WO2005004953A2/fr
Publication of WO2005004953A3 publication Critical patent/WO2005004953A3/fr
Priority to HK06104821.1A priority patent/HK1083319A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A61M5/16881—Regulating valves

Definitions

  • the present invention relates to a system for the infusion of pharmacological solutions, i.e. a system for performing continuous or intermittent subcutaneous, endovenous, intraarterial or epidural infusions of pharmacological solutions, with a variable and programmed preset flow, for example on the basis of the patient's circadian rhythms, or something else, or constant-flow infusions.
  • the human organism transforms, uses and eliminates drugs according to the levels of activity of the enzymatic and excretory apparatuses.
  • the level of activity of these apparatuses oscillates at a constant rhythm over 24 hours (circadian rhythm) . It is thus possible to determine the optimum infusion profiles according to the circadian rhythm of the patient to obtain greater efficacy from the same treatment with as little toxicity as possible.
  • the infusion of pharmacological solutions is achieved through widespread use of pumps, in particular mechanical pumps such as elastomeric and spring pumps for constant-flow infusions, and electromechanical pumps such as peristaltic or impeller pumps for variable-flow infusions.
  • electromechanical pumps for variable-flow infusions has numerous drawbacks. Firstly, the relevant dimensions and the considerable weight make these pumps very inconvenient to carry, with consequently significant problems of walking for the patient. These pumps furthermore have a high cost and require maintenance that is also costly, which significantly limits their use both in hospital facilities and for treatment at home .
  • the object of the present invention is to provide a system of infusion of pharmacological solutions that has a simple and reliable concept, is of moderate cost and can easily be carried by the patient.
  • a further object of the present invention is to provide a method for programming said system for the purpose of automatically performing one or more infusion protocols.
  • a system for the infusion of pharmacological solutions comprising containing means suitable for containing a pharmacological solution, pumping means for generating a flow of said pharmacological solution from said containing means, characterised in that it furthermore comprises adjusting means, to vary said flow and command and control means operationally associated with said adjusting means.
  • said adjusting means comprises at least one solenoid valve.
  • solenoid valve makes adjustment of the flow of the pharmacological solution extremely simple.
  • said solenoid valve is of the normally closed type.
  • valve of the normally closed type has the advantage of immediately interrupting the delivery of the pharmacological solution if a fault occurs in the command and control means, for example an interruption to the electricity supply.
  • said command and control means commands a pulsed actuation of said solenoid valve, said flow being determined by the number of actuations of the solenoid valve in the time unit.
  • said solenoid valve comprises a solenoid arranged outside the valve part wherein the flow of pharmacological solution transits.
  • said pumping means comprises an elastomeric container wherein said pharmacological solution is inserted.
  • the elastomeric container when it has been filled with the pharmacological solution, exerts a pressure on the solution that has a substantially constant value that pushes the solution into the infusion circuit and through the solenoid valve.
  • the container in elastomeric material is chosen in such a way that the pressure that it exerts on the pharmacological solution is of a value such as to overcome the load losses present in the infusion circuit and in the solenoid valve.
  • said command and control means is operationally associated with a plurality of solenoid valves, each one of which is associated with a different infusion circuit.
  • said command and control means comprises interface means for connecting the command and control means with data processing means .
  • the system according to the invention can be used for a plurality of successive infusions, with different drugs and methods of administration that differ each time .
  • a method for the infusion of a pharmacological solution in a patient comprising generating a flow of said pharmacological solution from a container containing said pharmacological solution, sending said flow to catheter means inserted in the body of said patient, adjusting said flow by adjusting means, characterised in that it furthermore comprises programming said flow and infusion times by means of programming means acting on said adjusting means
  • Figure 1 is a schematic view of the system according to the invention.
  • Figures 2, 3, 4 and 5 are flow diagrams that illustrate the programming of the system according to the invention.
  • Figure 2 is a flow diagram that illustrates in general programming of the system according to the invention;
  • FIG. 3 is a flow diagram that illustrates the so-called
  • Figure 4 illustrates the setting procedure for the dosage curves provided for by the infusion protocol
  • Figure 5 illustrates the setting procedure for infusion cycles provided for by the infusion protocol.
  • the system comprises pumping- means 1, consisting of an elastomeric container 3, fixed to a support 4 provided with fixing and closing means 7, and inserted into a containing and protection element 2 suitable for housing the elastomeric container 3 when the latter dilates through the effect of the introduction of the pharmacological solution and for protecting it from accidental damage.
  • pumping- means consisting of an elastomeric container 3, fixed to a support 4 provided with fixing and closing means 7, and inserted into a containing and protection element 2 suitable for housing the elastomeric container 3 when the latter dilates through the effect of the introduction of the pharmacological solution and for protecting it from accidental damage.
  • the ' containing and protection element 2 is preferably made of transparent material and is provided on its external surface with a graduated scale 5 that enables the monitoring of the quantity of pharmacological solution introduced into the elastomeric container 3 and of the quantity of solution used during the infusion.
  • the protecting element 2 comprises inlet means 9 for introducing a pharmacological solution into the elastomeric container 3.
  • the inlet means 9 is provided with a check valve (not shown) to prevent pharmacological solution introduced into the elastomeric container 3 possibly flowing back through the inlet means 9 through the effect of the pressure exerted thereupon by the walls of the elastomeric container 3.
  • the inlet means 9 is furthermore provided with connecting means 11, for example connecting means of the "luer-lock" type, that can be coupled with delivery means such as for example a syringe to introduce the pharmacological solution to the elastomeric container 3.
  • the inlet means 9 may be equipped with closing means 8, for example a plug, that can be removed only when the pharmacological solution has to be introduced into the elastomeric container 3.
  • the protecting element 2 furthermore comprises outlet means 10 through which the pharmacological solution introduced into the elastomeric container 3 can flow out thereof through the effect of the pressure exerted thereupon by the walls of the container 3.
  • the outlet means 10 can be connected to an end of fitting means 12, for example a joint pipe, the opposite end of which is connected to valve means 13, the function of which is to adjust the flow of pharmacological solution exiting the elastomeric container 3.
  • the valve means 13 may comprise a solenoid valve of the normally closed type.
  • the latter be positioned outside the portion of valve in which the pharmacological solution transits .
  • the valve 13 may be connected to a venous or arterial catheter to be inserted into a vein or into an artery of a patient, for administration of the pharmacological solution.
  • a three-way tap 14 may be interposed between the valve 13 and the catheter to stop the flow of pharmacological solution, enable the transit of the pharmacological solution into the catheter, or deviate said flow elsewhere.
  • the valve 13 is piloted by piloting means 19, connected electrically, by means of an electrical connection 16 to the solenoid of the valve 13.
  • the piloting means 19 comprises a microprocessor to pilot the valve 13, that sends sequences of pulses to the solenoid of the valve that cause corresponding opening and closing of the valve.
  • the flow of pharmacological solution that passes through the valve 13 and is sent to the catheter inserted into the body of the patient is proportional to the number of openings and reclosings of the valve 13 in the time unit, i.e. to the number of pulses in the time unit that the piloting means 19 sends to the valve 13.
  • the piloting means 19 can be set for piloting a single valve 13, or a plurality of valves 13, if an infusion of a plurality of pharmacological solutions has to be given according to preset times and methods .
  • the piloting means 19 will be programmed to actuate the respective valves 13 according to the times and methods required for the infusion cycle that is to be run.
  • the system according to the invention may be of the disposable type, i.e. be usable for a sole infusion cycle, " with one or more pharmacological solutions.
  • the piloting means 19 is preferably supplied by battery means 18, inserted into the piloting means 19.
  • the duration of the battery means 18 will preferably be chosen according to the duration of the infusion cycle to be run.
  • the system according to the invention may be of the multiple use type, i.e. usable for several infusion cycles for the same patient or for several patients.
  • the piloting means 19 may be supplied by a rechargeable or replaceable source of supply and may also be connected by means of suitable connecting means 17 to data processing means, by means of which it is possible to modify programming of the microprocessor, to run different infusion cycles for the same patient of for different patients, monitoring the trend of the infusion cycles, testing new infusion cycles for the purpose of adapting them to the specific physiology of the patient for whom they are intended, etc.
  • the piloting means 19 can be associated with reading means suitable for receiving a data recording support, for example a smart-card, on which are stored data for programming the microprocessor. In this way programming of the microprocessor may occur both from a remote station and by means of said data recording support. In the case of a multiple use system it is furthermore advantageous to provide washing means to eliminate from the fitting means 12 and from the valve means 13 residue of pharmacological solution, before using the system for the infusion of a new pharmacological solution.
  • FIGS. 2 to 5 illustrate the manner in which the system according to the invention is programmed to run one or more infusion cycles of a pharmacological solution.
  • Programming can be fixed, for the disposable systems, i.e. intended to run a single cycle or group of infusion cycles on a single ' patient.
  • ' programming ' may be modifiable, if the piloting means of the system according to the invention is associated with reading means for a datastorage support or is connectable to a personal computer.
  • To program the system according to the invention for an infusion protocol proceed as follows.
  • a container 3 containing a preset quantity of pharmacological solution is inserted into the support 4 by connecting the container 3 to the . inlet of the valve 13 by means of the fitting means 12 and the outlet of the valve 13 to a conduit that emerges in a container placed on an electronic balance. At this point one proceeds to set and test a new infusion protocol.
  • the system according to the invention checks that the new protocol to be stored has not already been stored in the microprocessor of the piloting means 19, and if it has not an identifier is stored in the microprocessor such as a name of the new infusion protocol, an identifier of the type of pharmacological solution to be used and the maximum quantity in volume of pharmacological solution to be delivered on the basis of the new infusion protocol.
  • the solenoid valve is calibrated by conducting a series of openings and reclosings of the valve 13 with preset duration and at preset intervals of time, then comparing the quantity of solution delivered by the valve 13 with a theoretical preset value. If the quantity of solution delivered by the valve 13 differs from the theoretical preset value by a quantity greater than a preset quantity the aforementioned durations and intervals are varied until the quantity of delivered solution is not different from the theoretical amount by a quantity less than said preset quantity. If, however, it is not possible to reach this result within a preset time, an error signal is activated that indicates a solenoid valve fault. ' "
  • the so-called self-learning procedure is run, over the course of which it is checked that at each opening of the solenoid valve 13 a preset quantity in weight of pharmacological solution is delivered, storing for each of said openings also the temperature of the solution. This procedure is used to ascertain that there are no irregularities in the delivery of the pharmacological solution that are not detectable in the calibrating procedure.
  • the weight of delivered solution is compared with a reference value, from which it must not deviate by a quantity greater than a set quantity. If the deviation is greater than said preset quantity for a preset number of opening cycles of the valve 13, the self-learning procedure is stopped by a solenoid valve fault message.
  • the procedure is continued until the complete emptying of the container 3, then ascertaining that the system is able to correctly deliver the maximum quantity of pharmacological solution provided for by the infusion protocol .
  • the dosage curve of the pharmacological solution provided for by the infusion cycle and the parameters of the infusion cycle are set.
  • the profile of the curve is set by fixing the duration of the infusion curve, the volume of pharmacological solution that has to be injected on the basis of the infusion curve and the number of days, i.e. the number of repetitions at daily intervals of the infusion curve, provided for by the infusion protocol.
  • the type of infusion curve to be plotted for example sinusoid or square wave, or other, is then selected from a preset group of curve types. " The system then calculates the theoretical number, duration and distribution of the opening cycles of the solenoid valve 13 required to plot the infusion curve of which the profile has been set. Subsequently, the quantity of pharmacological solution is calculated that is delivered by the dosage curve and it is ascertained that this quantity is not greater than what is available in the container 3. In the latter case, the curve parameters are modified to determine an adjustment factor of the curve in such a way as to make the quantity delivered fall within the quantity available in the container.
  • the dosage curve may be customized on the basis of the particular requirements of the patient.
  • the last procedure to be conducted concerns the setting of the parameters of the infusion cycle that has to be run on the basis of the chosen protocol.
  • the type of dosage curve for the selected infusion cycle is selected, then one selects whether the infusion cycle should start as soon as the startup of the system or at a preset time, indicating in the latter case whether the infusion cycle has to start on the day on which the system is started up or the day after.
  • the actual quantity of pharmacological solution delivered by the system may be checked by comparing it with the theoretical quantity that should have been delivered according to the infusion cycle. To that end, the infusion cycle is started and checking at preset time intervals whether or not the cycled has terminated. At the end of the cycle the system ascertains whether the quantity of pharmacological solution provided for by the protocol has been delivered. If the quantity of pharmacological solution (A.U.C) delivered differs from the theoretical quantity to be delivered by a quantity that is greater than a preset value, for example by more than 10%, an error signal is activated, otherwise the next infusion cycle is started up, if provided for by the protocol. After all the infusion cycles provided for by the protocol have terminated and for each cycle the quantity of pharmacological solution actually delivered has been ascertained, the infusion protocol is stored.
  • A.U.C pharmacological solution
  • the stored protocol is not modifiable; if modifications have to be made, a new protocol containing the aforementioned modifications must be stored.
  • the protocol can be stored on a personal computer connectable to the system according to the invention, or, if the system according to the invention is provided with reading means of a data-storage support, the protocol can be stored on said datastorage support. If the infusion protocol is stored on a personal computer, the latter will transmit to the microprocessor of the command and control means the data on the infusion cycle, when the system has to run the aforementioned cycle. If, on the other hand, the protocol has been stored on a data-storage support, the transmission to said microprocessor of the data on said protocol is achieved by inserting the data-storage support into the aforementioned reading means, in such a way that the data can be read by the microprocessor . Lastly, if the system is of the disposable type, the protocol is stored directly in the microprocessor of the piloting means .

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Système de perfusion de solutions pharmacologiques comportant un contenant (3) pour une solution pharmacologique et des moyens de pompage (1) pour générer un flux d'une solution pharmacologique à partir dudit contenant (3), caractérisé en ce que le système comporte en outre des moyens de réglage (13) du flux et des moyens de commande et de pilotage (19) associés de manière opérationnelle aux moyens de réglage (13). Procédé de perfusion d'une solution pharmacologique chez un patient, consistant à générer un flux de ladite solution à partir d'un contenant, à diriger le flux vers un cathéter pouvant être introduit dans le corps du patient, et à régler le flux à l'aide de moyens de réglage (13) actionnés par des moyens de commande et de pilotage (19), ledit procédé consistant en outre à programmer le flux et les temps de perfusion à l'aide de moyens de programmation reliés de manière opérationnelle auxdits moyens de commande et de pilotage (19).
PCT/IB2004/002245 2003-07-11 2004-07-09 Systeme de perfusion de solutions pharmacologiques WO2005004953A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DK04743907.0T DK1646413T3 (da) 2003-07-11 2004-07-09 System til infusion af farmakologiske opløsninger
ES04743907T ES2425558T3 (es) 2003-07-11 2004-07-09 Sistema de perfusión de soluciones farmacológicas
JP2006518397A JP2007526784A (ja) 2003-07-11 2004-07-09 薬理学的溶液の注入のシステム
CN200480019891XA CN1822870B (zh) 2003-07-11 2004-07-09 药剂溶液注射系统
BRPI0412465-0A BRPI0412465A (pt) 2003-07-11 2004-07-09 sistema de infusão de soluções farmacológicas
EP04743907.0A EP1646413B1 (fr) 2003-07-11 2004-07-09 Systeme de perfusion de solutions pharmacologiques
US10/563,909 US7744566B2 (en) 2003-07-11 2004-07-09 System of infusion of pharmacological solutions
HK06104821.1A HK1083319A1 (en) 2003-07-11 2006-04-24 System of infusion of pharmacological solutions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMO2003A000201 2003-07-11
IT000201A ITMO20030201A1 (it) 2003-07-11 2003-07-11 Sistema di infusione di soluzioni farmacologiche

Publications (2)

Publication Number Publication Date
WO2005004953A2 true WO2005004953A2 (fr) 2005-01-20
WO2005004953A3 WO2005004953A3 (fr) 2005-03-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/002245 WO2005004953A2 (fr) 2003-07-11 2004-07-09 Systeme de perfusion de solutions pharmacologiques

Country Status (10)

Country Link
US (1) US7744566B2 (fr)
EP (1) EP1646413B1 (fr)
JP (1) JP2007526784A (fr)
CN (1) CN1822870B (fr)
BR (1) BRPI0412465A (fr)
DK (1) DK1646413T3 (fr)
ES (1) ES2425558T3 (fr)
HK (1) HK1083319A1 (fr)
IT (1) ITMO20030201A1 (fr)
WO (1) WO2005004953A2 (fr)

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CN114259620B (zh) * 2020-09-16 2024-03-08 深圳迈瑞科技有限公司 输液管路状态的判定方法及相关设备

Also Published As

Publication number Publication date
ITMO20030201A0 (it) 2003-07-11
US20060167404A1 (en) 2006-07-27
EP1646413A2 (fr) 2006-04-19
CN1822870B (zh) 2010-04-28
ITMO20030201A1 (it) 2005-01-12
US7744566B2 (en) 2010-06-29
DK1646413T3 (da) 2013-08-26
WO2005004953A3 (fr) 2005-03-10
ES2425558T3 (es) 2013-10-16
EP1646413B1 (fr) 2013-05-22
BRPI0412465A (pt) 2006-09-19
JP2007526784A (ja) 2007-09-20
HK1083319A1 (en) 2006-06-30
CN1822870A (zh) 2006-08-23

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