WO2005003780A3 - Diagnostics and therapeutics for diseases associated with sensory neuron-specific g protein-coupled receptor 4 (snsr4) - Google Patents

Diagnostics and therapeutics for diseases associated with sensory neuron-specific g protein-coupled receptor 4 (snsr4) Download PDF

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Publication number
WO2005003780A3
WO2005003780A3 PCT/EP2004/006061 EP2004006061W WO2005003780A3 WO 2005003780 A3 WO2005003780 A3 WO 2005003780A3 EP 2004006061 W EP2004006061 W EP 2004006061W WO 2005003780 A3 WO2005003780 A3 WO 2005003780A3
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WO
WIPO (PCT)
Prior art keywords
disorders
snsr4
therapeutics
diagnostics
protein
Prior art date
Application number
PCT/EP2004/006061
Other languages
French (fr)
Other versions
WO2005003780A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2005003780A2 publication Critical patent/WO2005003780A2/en
Publication of WO2005003780A3 publication Critical patent/WO2005003780A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human SNSR4 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders, cancer disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders, cancer disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of SNSR4 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/006061 2003-06-17 2004-06-04 Diagnostics and therapeutics for diseases associated with sensory neuron-specific g protein-coupled receptor 4 (snsr4) WO2005003780A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03013714 2003-06-17
EP03013714.5 2003-06-17

Publications (2)

Publication Number Publication Date
WO2005003780A2 WO2005003780A2 (en) 2005-01-13
WO2005003780A3 true WO2005003780A3 (en) 2005-07-07

Family

ID=33560742

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/006061 WO2005003780A2 (en) 2003-06-17 2004-06-04 Diagnostics and therapeutics for diseases associated with sensory neuron-specific g protein-coupled receptor 4 (snsr4)

Country Status (1)

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WO (1) WO2005003780A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032519A1 (en) * 1997-12-22 1999-07-01 Astrazeneca Canada Inc. Novel g protein-coupled receptor
WO2004042402A2 (en) * 2002-11-04 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human mas-related gene x1 (mrgx1)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032519A1 (en) * 1997-12-22 1999-07-01 Astrazeneca Canada Inc. Novel g protein-coupled receptor
WO2004042402A2 (en) * 2002-11-04 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human mas-related gene x1 (mrgx1)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE Geneseq [online] 26 November 1999 (1999-11-26), "Human dorsal root receptor 4 hDRR4.", XP002306690, retrieved from EBI accession no. GSN:AAY30162 Database accession no. AAY30162 *
DATABASE UniProt [online] 25 October 2004 (2004-10-25), "Mas-related G-protein coupled receptor member X1 (Sensory neuron- specific G-protein coupled receptor 4).", XP002306692, retrieved from EBI accession no. UNIPROT:MRG1_HUMAN Database accession no. MRG1_HUMAN *
HONG YANGUO ET AL: "Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain-potential function of a novel receptor.", BRITISH JOURNAL OF PHARMACOLOGY, vol. 141, no. 3, February 2004 (2004-02-01), pages 423 - 430, XP002306359, ISSN: 0007-1188 *
LEMBO P M C ET AL: "Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs", NATURE NEUROSCIENCE, NATURE AMERICA, INC, US, vol. 5, no. 3, March 2002 (2002-03-01), pages 201 - 209, XP002264104, ISSN: 1097-6256 *

Also Published As

Publication number Publication date
WO2005003780A2 (en) 2005-01-13

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