WO2004099124A3 - Neue bioisostere von actinonin - Google Patents

Neue bioisostere von actinonin Download PDF

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Publication number
WO2004099124A3
WO2004099124A3 PCT/EP2004/004902 EP2004004902W WO2004099124A3 WO 2004099124 A3 WO2004099124 A3 WO 2004099124A3 EP 2004004902 W EP2004004902 W EP 2004004902W WO 2004099124 A3 WO2004099124 A3 WO 2004099124A3
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WO
WIPO (PCT)
Prior art keywords
actinonin
novel
bioisosteres
novel bioisosteres
metalloproteinases
Prior art date
Application number
PCT/EP2004/004902
Other languages
English (en)
French (fr)
Other versions
WO2004099124A2 (de
Inventor
Michael Thormann
Michael Almstetter
Original Assignee
Morphochem Ag Komb Chemie
Michael Thormann
Michael Almstetter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ543994A priority Critical patent/NZ543994A/en
Application filed by Morphochem Ag Komb Chemie, Michael Thormann, Michael Almstetter filed Critical Morphochem Ag Komb Chemie
Priority to MXPA05012004A priority patent/MXPA05012004A/es
Priority to US10/556,175 priority patent/US7504436B2/en
Priority to AU2004235958A priority patent/AU2004235958B2/en
Priority to CA2531484A priority patent/CA2531484C/en
Priority to EP04731607A priority patent/EP1622865A2/de
Priority to BRPI0410157-0A priority patent/BRPI0410157A/pt
Priority to JP2006505400A priority patent/JP2006525973A/ja
Publication of WO2004099124A2 publication Critical patent/WO2004099124A2/de
Publication of WO2004099124A3 publication Critical patent/WO2004099124A3/de
Priority to TNP2005000277A priority patent/TNSN05277A1/en
Priority to IS8145A priority patent/IS8145A/is
Priority to NO20055657A priority patent/NO20055657L/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/5545—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having eight-membered rings not containing additional condensed or non-condensed nitrogen-containing 3-7 membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

Die vorliegende Erfindung betrifft neue Bioisostere des Antibiotikums Actinonin der allgemeinen Formel (I). Diese neuen Verbindungen sind insbesondere als Inhibitoren von Metalloproteinasen von Interesse.
PCT/EP2004/004902 2003-05-08 2004-05-07 Neue bioisostere von actinonin WO2004099124A2 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP04731607A EP1622865A2 (de) 2003-05-08 2004-05-07 Neue bioisostere von actinonin
MXPA05012004A MXPA05012004A (es) 2003-05-08 2004-05-07 Nuevos bioisosteros de actinonina.
US10/556,175 US7504436B2 (en) 2003-05-08 2004-05-07 Bioisosteres of actinonin
AU2004235958A AU2004235958B2 (en) 2003-05-08 2004-05-07 Novel bioisosteres of actinonin
CA2531484A CA2531484C (en) 2003-05-08 2004-05-07 Novel bioisosteres of actinonin
NZ543994A NZ543994A (en) 2003-05-08 2004-05-07 Bioisosteres of the antibiotic actinonin as inhibitors of metalloproteinases
BRPI0410157-0A BRPI0410157A (pt) 2003-05-08 2004-05-07 bioisostéreos de actinonina
JP2006505400A JP2006525973A (ja) 2003-05-08 2004-05-07 アクチノニンの新規生体立体異性体
TNP2005000277A TNSN05277A1 (en) 2003-05-08 2005-10-28 Novel bioisosteres of actinonin
IS8145A IS8145A (is) 2003-05-08 2005-11-24 Bý bíóísósterur af aktínóníni
NO20055657A NO20055657L (no) 2003-05-08 2005-11-30 Nye bioisostaererav aktinonin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10320453A DE10320453A1 (de) 2003-05-08 2003-05-08 Neue Bioisostere von Actinonin
DE10320453.9 2003-05-08

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WO2004099124A2 WO2004099124A2 (de) 2004-11-18
WO2004099124A3 true WO2004099124A3 (de) 2005-01-20

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PCT/EP2004/004902 WO2004099124A2 (de) 2003-05-08 2004-05-07 Neue bioisostere von actinonin

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US (1) US7504436B2 (de)
EP (1) EP1622865A2 (de)
JP (1) JP2006525973A (de)
KR (1) KR20060017604A (de)
CN (1) CN1784380A (de)
AU (1) AU2004235958B2 (de)
BR (1) BRPI0410157A (de)
CA (1) CA2531484C (de)
CO (1) CO5640079A2 (de)
DE (1) DE10320453A1 (de)
EC (1) ECSP056205A (de)
IS (1) IS8145A (de)
MA (1) MA27846A1 (de)
MX (1) MXPA05012004A (de)
NO (1) NO20055657L (de)
NZ (1) NZ543994A (de)
RU (1) RU2379284C2 (de)
TN (1) TNSN05277A1 (de)
WO (1) WO2004099124A2 (de)
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FR2912133B1 (fr) * 2007-02-01 2009-04-24 Univ Grenoble 1 Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens
US20100286280A1 (en) * 2007-09-26 2010-11-11 The University Of North Carolina At Chapel Hill Inhibitors of eppin/semenogelin binding as male contraceptives
EP2614051A4 (de) * 2010-09-08 2014-01-29 Univ Pittsburgh P53-mdm2-antagonisten
KR102430183B1 (ko) 2014-09-26 2022-08-08 더 케무어스 컴퍼니 에프씨, 엘엘씨 아이소시아네이트 유도된 유기실란
EP3370518B1 (de) 2015-10-14 2023-08-23 X-Therma, Inc. Zusammensetzungen und verfahren zur verringerung der eiskristallbildung
CN107365302B (zh) * 2016-05-11 2019-12-13 如东瑞恩医药科技有限公司 螺三元环、螺五元环类肽脱甲酰基酶抑制剂
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DE10320453A1 (de) 2004-11-25
MXPA05012004A (es) 2006-02-22
IS8145A (is) 2005-11-24
JP2006525973A (ja) 2006-11-16
ZA200509935B (en) 2007-04-25
CO5640079A2 (es) 2006-05-31
US7504436B2 (en) 2009-03-17
TNSN05277A1 (en) 2007-07-10
MA27846A1 (fr) 2006-04-03
NZ543994A (en) 2008-12-24
EP1622865A2 (de) 2006-02-08
AU2004235958B2 (en) 2009-05-21
US20070060624A1 (en) 2007-03-15
BRPI0410157A (pt) 2006-05-16
NO20055657L (no) 2005-12-14
CA2531484C (en) 2011-07-05
NO20055657D0 (no) 2005-11-30
CA2531484A1 (en) 2004-11-18
RU2005138049A (ru) 2007-07-27
KR20060017604A (ko) 2006-02-24
ECSP056205A (es) 2006-04-19
CN1784380A (zh) 2006-06-07
RU2379284C2 (ru) 2010-01-20
AU2004235958A1 (en) 2004-11-18

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