WO2004089920A3 - Amin-substituierte diphenyldiphosphine und deren verwendung in metallkomplexen für asymmetrische synthesen - Google Patents

Amin-substituierte diphenyldiphosphine und deren verwendung in metallkomplexen für asymmetrische synthesen Download PDF

Info

Publication number
WO2004089920A3
WO2004089920A3 PCT/EP2004/050439 EP2004050439W WO2004089920A3 WO 2004089920 A3 WO2004089920 A3 WO 2004089920A3 EP 2004050439 W EP2004050439 W EP 2004050439W WO 2004089920 A3 WO2004089920 A3 WO 2004089920A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal complexes
amine
diphenyldiphosphines
substituted
asymmetric syntheses
Prior art date
Application number
PCT/EP2004/050439
Other languages
English (en)
French (fr)
Other versions
WO2004089920A8 (de
WO2004089920A2 (de
Inventor
Benoit Pugin
Pierre Martin
Markus Mueller
Frederic Naud
Felix Spindler
Marc Thommen
Gianpietro Melone
Martin Kesselgruber
Original Assignee
Solvias Ag
Benoit Pugin
Pierre Martin
Markus Mueller
Frederic Naud
Felix Spindler
Marc Thommen
Gianpietro Melone
Martin Kesselgruber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvias Ag, Benoit Pugin, Pierre Martin, Markus Mueller, Frederic Naud, Felix Spindler, Marc Thommen, Gianpietro Melone, Martin Kesselgruber filed Critical Solvias Ag
Priority to EP04741445A priority Critical patent/EP1611114A2/de
Priority to JP2006505522A priority patent/JP2006523654A/ja
Priority to US10/552,066 priority patent/US7589196B2/en
Priority to CA002521635A priority patent/CA2521635A1/en
Publication of WO2004089920A2 publication Critical patent/WO2004089920A2/de
Publication of WO2004089920A3 publication Critical patent/WO2004089920A3/de
Publication of WO2004089920A8 publication Critical patent/WO2004089920A8/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1845—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing phosphorus
    • B01J31/1865—Phosphonites (RP(OR)2), their isomeric phosphinates (R2(RO)P=O) and RO-substitution derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1845—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing phosphorus
    • B01J31/1875—Phosphinites (R2P(OR), their isomeric phosphine oxides (R3P=O) and RO-substitution derivatives thereof)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0033—Iridium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0033—Iridium compounds
    • C07F15/004—Iridium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • C07F15/008—Rhodium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5027—Polyphosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65324—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/32—Addition reactions to C=C or C-C triple bonds
    • B01J2231/323—Hydrometalation, e.g. bor-, alumin-, silyl-, zirconation or analoguous reactions like carbometalation, hydrocarbation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/44—Allylic alkylation, amination, alkoxylation or analogues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/827—Iridium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

1,1'-Diphenyl-2,2'-diphosphine mit wenigstens einem Aminsubstituenten in Parastellung zur Phosphingruppe mit den Formeln sind Liganden für Metallkomplexe, die als Katalysatoren für asymmetrische Anlagerungsreaktionen von prochiralen organischen Verbindungen dienen, und deren katalytischen Eigenschaften durch die Substitution der Amingruppe spezifisch auf Substrate eingestellt werden können.
PCT/EP2004/050439 2003-04-07 2004-04-05 Amin-substituierte diphenyldiphosphine und deren verwendung in metallkomplexen für asymmetrische synthesen WO2004089920A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04741445A EP1611114A2 (de) 2003-04-07 2004-04-05 Amin-substituierte diphenyldiphosphine und deren verwendung in metallkomplexen für asymmetrische synthesen
JP2006505522A JP2006523654A (ja) 2003-04-07 2004-04-05 アミン置換ジフェニルホスフィン
US10/552,066 US7589196B2 (en) 2003-04-07 2004-04-05 Amine-substituted biphenyldiphosphines
CA002521635A CA2521635A1 (en) 2003-04-07 2004-04-05 Amine-substituted diphenyldiphosphines and the use thereof in metal complexes for asymmetric syntheses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH6242003 2003-04-07
CH0624/03 2003-04-07

Publications (3)

Publication Number Publication Date
WO2004089920A2 WO2004089920A2 (de) 2004-10-21
WO2004089920A3 true WO2004089920A3 (de) 2005-03-17
WO2004089920A8 WO2004089920A8 (de) 2005-05-26

Family

ID=33136751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/050439 WO2004089920A2 (de) 2003-04-07 2004-04-05 Amin-substituierte diphenyldiphosphine und deren verwendung in metallkomplexen für asymmetrische synthesen

Country Status (6)

Country Link
US (1) US7589196B2 (de)
EP (1) EP1611114A2 (de)
JP (1) JP2006523654A (de)
CN (1) CN1768046A (de)
CA (1) CA2521635A1 (de)
WO (1) WO2004089920A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE102005052588A1 (de) * 2005-11-02 2007-05-10 Grünenthal GmbH Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
TWI496762B (zh) 2006-07-24 2015-08-21 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
FR3035880B1 (fr) * 2015-05-07 2017-06-02 Commissariat Energie Atomique Utilisation de nouveaux composes pour l'extraction selective de terres rares de solutions aqueuses comprenant de l'acide phosphorique et procede d'extraction associe

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556740A (en) * 1982-08-27 1985-12-03 Hoffmann-La Roche Inc. Phosphorus compounds
EP0850945A1 (de) * 1996-12-26 1998-07-01 Takasago International Corporation Chirale Diphosphin-Verbindung, Zwischenprodukte zu ihrer Herstellung, Übergangsmetall-Komplexe davon und asymmetrischer Hydrierungskatalysator
EP1002801A1 (de) * 1998-11-19 2000-05-24 Solvias AG Chirale Diphenyldiphosphine und d-8 Metall-Komplexe davon

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556740A (en) * 1982-08-27 1985-12-03 Hoffmann-La Roche Inc. Phosphorus compounds
EP0850945A1 (de) * 1996-12-26 1998-07-01 Takasago International Corporation Chirale Diphosphin-Verbindung, Zwischenprodukte zu ihrer Herstellung, Übergangsmetall-Komplexe davon und asymmetrischer Hydrierungskatalysator
EP1002801A1 (de) * 1998-11-19 2000-05-24 Solvias AG Chirale Diphenyldiphosphine und d-8 Metall-Komplexe davon

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHMID R ET AL: "NEW DEVELOPMENTS IN ENANTIOSELECTIVE HYDROGENATION", PURE & APPLIED CHEMISTRY, PERGAMON PRESS, OXFORD, GB, vol. 68, no. 1, 1996, pages 131 - 138, XP000884387, ISSN: 0033-4545 *

Also Published As

Publication number Publication date
EP1611114A2 (de) 2006-01-04
CA2521635A1 (en) 2004-10-21
CN1768046A (zh) 2006-05-03
US7589196B2 (en) 2009-09-15
WO2004089920A8 (de) 2005-05-26
US20060276643A1 (en) 2006-12-07
WO2004089920A2 (de) 2004-10-21
JP2006523654A (ja) 2006-10-19

Similar Documents

Publication Publication Date Title
MY139377A (en) Ligands for pnicogen chelate complexes with a metal of subgroup viii and use of the complexes as catalysts for hydroformylation, carbonylation, hydrocyanation or hydrogenation
MXPA04001348A (es) NUEVOS COMPUESTOS DE FOSFITOS Y SUS COMPLEJOS METaLICOS.
AU2003288125A1 (en) Bidentate c,p chiral phosphine ligands
WO2007109365A3 (en) Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
WO2003016321A3 (de) Neue phosphitverbindungen und neue phosphitmetallkomplexe
CA2413190A1 (en) Methods for treating rheumatic diseases using a soluble ctla4 molecule
PL377656A1 (pl) Ligandy Ó2Ű do różnych zastosowań farmaceutycznych
NO20050092L (no) Gruppe 4 metallkomplekser inneholdende 4-aryl-substituerte trisykliske indenyl derivater
WO2005016266A3 (en) Methods for treating cardiovascular disease using a soluble ctla4 molecule
UA96449C2 (en) Stable laquinimod preparations
TW200716605A (en) 2,6-quinolinyl derivatives, processes for preparing them and their uses
TW200732337A (en) Organic compounds
IL187006A0 (en) Ferrocenyl ligands, production and use thereof
WO2006100169A3 (en) Unsymmetrically substituted phospholane catalysts
PL1561754T3 (pl) Sposób wytwarzania związków kompleksowych 1,2-diaminocykloheksan-platyna(II)
TW200724547A (en) Bidentate C, P chiral phosphine ligands
WO2005121155A8 (en) A process for the synthesis of terbinafine and derivatives thereof
WO2000064841A3 (en) Phosphine ligands, metal complexes and compositions thereof for cross-coupling reactions
WO2006136695A3 (fr) Nouvelles arylphosphines p-chirales ortho-fonctionnalisees et derives: leur preparation et utilisation en catalyse asymetrique
HK1077827A1 (en) Diazabicyclononane and-decane derivatives their use as opioid receptor ligands
WO2004089920A3 (de) Amin-substituierte diphenyldiphosphine und deren verwendung in metallkomplexen für asymmetrische synthesen
IL177220A0 (en) Linker compound, ligand conjugate, and production methods thereof
EP1966223A4 (de) Katalysatorzusammensetzung mit gruppe-4-übergangsmetallkomplexen und verfahren zur herstellung von polyolefinen unter anwendung davon
DE50214495D1 (de) Neue übergangsmetall-komplexe und deren einsatz in übergangsmetall-katalysierten reaktionen
SI1888537T1 (sl) Postopek priprave 4-((1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
CFP Corrected version of a pamphlet front page

Free format text: REVISED ABSTRACT RECEIVED BY THE INTERNATIONAL BUREAU AFTER COMPLETION OF THE TECHNICAL PREPARATIONS FOR INTERNATIONAL PUBLICATION

WWE Wipo information: entry into national phase

Ref document number: 4135/DELNP/2005

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 20048090252

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2006276643

Country of ref document: US

Ref document number: 2521635

Country of ref document: CA

Ref document number: 10552066

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2004741445

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006505522

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2004741445

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 10552066

Country of ref document: US