WO2004085672A2 - Moniteur d'alarme pour agents chimiques - Google Patents

Moniteur d'alarme pour agents chimiques Download PDF

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Publication number
WO2004085672A2
WO2004085672A2 PCT/US2004/008611 US2004008611W WO2004085672A2 WO 2004085672 A2 WO2004085672 A2 WO 2004085672A2 US 2004008611 W US2004008611 W US 2004008611W WO 2004085672 A2 WO2004085672 A2 WO 2004085672A2
Authority
WO
WIPO (PCT)
Prior art keywords
alarm monitor
reagent
alarm
monitor
membrane
Prior art date
Application number
PCT/US2004/008611
Other languages
English (en)
Other versions
WO2004085672A3 (fr
Inventor
Ronald J. Forni
Kevin Beltis
Lisa Conerly Suneus
Daniel J. Ehntholt
Robert Etheredge
Robert Fricke
Jeffrey Jasperse
Alan S. Louie
Wade Luongo
Ingrid G. Marenchic
Deirdre Mckeown
Ratcharit Ponoum
Michael Reed
Emily Reichert
Craig Rusin
George Selecman
Original Assignee
Tiax Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tiax Llc filed Critical Tiax Llc
Publication of WO2004085672A2 publication Critical patent/WO2004085672A2/fr
Publication of WO2004085672A3 publication Critical patent/WO2004085672A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

La présente invention concerne un dispositif portatif peu coûteux capable de détecter des niveaux peu élevés d'agents chimiques toxiques en temps quasi-réel. Ce dispositif est capable de détecter des composés organophosphorés tels que le sarin et le soman à des niveaux de méiose, respectivement de 0,1mg/m3 et 2ug/m3, après environ deux minutes d'exposition. Ce dispositif est une application d'une plate-forme de chimie, d'alimentation en fluide et d'électronique comprenant une utilisation spécifique d'enzymes stabilisées et immobilisées ou autres entités chimiques pour conférer spécificité et sensibilité.
PCT/US2004/008611 2003-03-21 2004-03-22 Moniteur d'alarme pour agents chimiques WO2004085672A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45684003P 2003-03-21 2003-03-21
US60/456,840 2003-03-21

Publications (2)

Publication Number Publication Date
WO2004085672A2 true WO2004085672A2 (fr) 2004-10-07
WO2004085672A3 WO2004085672A3 (fr) 2005-05-19

Family

ID=33098162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/008611 WO2004085672A2 (fr) 2003-03-21 2004-03-22 Moniteur d'alarme pour agents chimiques

Country Status (1)

Country Link
WO (1) WO2004085672A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008029174A1 (de) * 2008-06-19 2009-12-24 Siemens Aktiengesellschaft Biosensor und Verfahren zum Bestimmen eines Gifts sowie Verwendungen des Biosensors
CN114270170A (zh) * 2019-06-27 2022-04-01 费森尤斯医疗保健控股公司 透析系统中的氨检测

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272484A (en) * 1978-12-27 1981-06-09 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Filling for optodes
DE4323277A1 (de) * 1992-07-15 1994-01-20 Seiko Instr Inc Quantitativer Analysator
USH1297H (en) * 1990-04-04 1994-04-05 The United States Of America As Represented By The Department Of Energy Detection device for hazardous materials

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272484A (en) * 1978-12-27 1981-06-09 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Filling for optodes
USH1297H (en) * 1990-04-04 1994-04-05 The United States Of America As Represented By The Department Of Energy Detection device for hazardous materials
DE4323277A1 (de) * 1992-07-15 1994-01-20 Seiko Instr Inc Quantitativer Analysator

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ANDRISANO V ET AL: "Determination of inhibitors' potency (IC50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column" JOURNAL OF CHROMATOGRAPHY. BIOMEDICAL APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 753, no. 2, 5 April 2001 (2001-04-05), pages 375-383, XP004230300 ISSN: 0378-4347 *
BACHMANN T T ET AL: "Improved multianalyte detection of organophosphates and carbamates with disposable multielectrode biosensors using recombinant mutants of Drosophila acetylcholinesterase and artificial neural networks." BIOSENSORS & BIOELECTRONICS. JUN 2000, vol. 15, no. 3-4, June 2000 (2000-06), pages 193-201, XP001010317 ISSN: 0956-5663 *
CHRIS TILLERY: "Personal Alarm Monitor" JUSTNET, 18 October 2002 (2002-10-18), pages 1-2, XP002290610 Retrieved from the Internet: URL:http://web.archive.org/web/20021018163 729/http://www.nlectc.org/virlib/InfoDetai l.asp?intInfoID=329> *
DATABASE MEDLINE [Online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; May 1992 (1992-05), ZHUANG P ET AL: "Spin labeling and kinetic studies of a membrane-immobilized proteolytic enzyme." XP002290614 Database accession no. NLM1369378 & BIOTECHNOLOGY PROGRESS. 1992 MAY-JUN, vol. 8, no. 3, May 1992 (1992-05), pages 204-210, ISSN: 8756-7938 *
DEVIC ERIC ET AL: "Detection of anatoxin-a(s) in environmental samples of cyanobacteria by using a biosensor with engineered acetylcholinesterases" APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 68, no. 8, August 2002 (2002-08), pages 4102-4106, XP002290612 ISSN: 0099-2240 *
R. K. GORDON ET AL.: "OP nerve agent decontamination, detoxification, and detection using polyurethane immobilized enzymes" PROCEEDINGS OF CBMTS III, SPIEZ, SWITZERLAND, 7 - 12 MAY 2000, [Online] 2000, pages 1-5, XP002290611 Retrieved from the Internet: URL:http://www.jmedchemdef.org/archives/CB MTSIII/cbmts3-13.pdf> -& INDEX OF THE CONFERENCE PROCEEDINGS CBMTSIII, [Online] page 1, XP002306192 Retrieved from the Internet: URL:http://www.jmedchemdef.org/archives/CB MTSiii/cbmtsiii.html> -& ASA NEWSLETTER, [Online] page 1, XP002306193 Retrieved from the Internet: URL:http://www.asanltr.com/cbmts/cbmts/III /default.htm> *
SINGH A K ET AL: "Development of sensors for direct detection of organophosphates. Part I: Immobilization, characterization and stabilization of acetylcholinesterase and organophosphate hydrolase on silica supports" BIOSENSORS & BIOELECTRONICS, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 14, no. 8-9, December 1999 (1999-12), pages 703-713, XP002243724 ISSN: 0956-5663 *
WORSFOLD P J ET AL: "IMMOBILIZED BIOLUMINESCENT REAGENTS IN CONTINUOUS FLOW SYSTEMS" TRAC TRENDS ANAL CHEM (PERS ED) AUG 1986, vol. 5, no. 7, August 1986 (1986-08), pages 183-185, XP002291298 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008029174A1 (de) * 2008-06-19 2009-12-24 Siemens Aktiengesellschaft Biosensor und Verfahren zum Bestimmen eines Gifts sowie Verwendungen des Biosensors
CN114270170A (zh) * 2019-06-27 2022-04-01 费森尤斯医疗保健控股公司 透析系统中的氨检测

Also Published As

Publication number Publication date
WO2004085672A3 (fr) 2005-05-19

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