WO2004082566A3 - Diagnostics and therapeutics for diseases associated with complement component 3a receptor 1 (c3ar1) - Google Patents

Diagnostics and therapeutics for diseases associated with complement component 3a receptor 1 (c3ar1) Download PDF

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Publication number
WO2004082566A3
WO2004082566A3 PCT/EP2004/002173 EP2004002173W WO2004082566A3 WO 2004082566 A3 WO2004082566 A3 WO 2004082566A3 EP 2004002173 W EP2004002173 W EP 2004002173W WO 2004082566 A3 WO2004082566 A3 WO 2004082566A3
Authority
WO
WIPO (PCT)
Prior art keywords
c3ar1
disorders
diseases
therapeutics
diagnostics
Prior art date
Application number
PCT/EP2004/002173
Other languages
French (fr)
Other versions
WO2004082566A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Holger Summer filed Critical Bayer Healthcare Ag
Publication of WO2004082566A2 publication Critical patent/WO2004082566A2/en
Publication of WO2004082566A3 publication Critical patent/WO2004082566A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9

Abstract

The invention provides a human C3AR1 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases and neurological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases and neurological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of C3AR1 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/002173 2003-03-17 2004-03-04 Diagnostics and therapeutics for diseases associated with complement component 3a receptor 1 (c3ar1) WO2004082566A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03005468 2003-03-17
EP03005468.8 2003-03-17

Publications (2)

Publication Number Publication Date
WO2004082566A2 WO2004082566A2 (en) 2004-09-30
WO2004082566A3 true WO2004082566A3 (en) 2004-12-02

Family

ID=33016822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/002173 WO2004082566A2 (en) 2003-03-17 2004-03-04 Diagnostics and therapeutics for diseases associated with complement component 3a receptor 1 (c3ar1)

Country Status (1)

Country Link
WO (1) WO2004082566A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007065463A1 (en) * 2005-12-09 2007-06-14 Indivumed Gmbh USE OF C3a AND DERIVATIVES THEREOF AS A BIOMARKER FOR BENIGN LUNG TISSUE ALTERATIONS AND MALIGN LUNG TUMORS, METHOD FOR DETECTION AND TEST SYSTEM
US20140329761A1 (en) * 2011-06-20 2014-11-06 The University Of Queensland Prevention and treatment of acute inflammatory conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997028188A1 (en) * 1996-01-30 1997-08-07 The Scripps Research Institute A g protein-coupled receptor with an enlarged extracellular domain
EP0814158A2 (en) * 1996-06-17 1997-12-29 Smithkline Beecham Corporation Human C3a receptor variant; uses in diagnostics and therapeutics
WO2002044737A2 (en) * 2000-11-29 2002-06-06 Lifespan Biosciences, Inc. Diagnostic and therapeutic compositions and methods related to anaphylatoxin c3a receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997028188A1 (en) * 1996-01-30 1997-08-07 The Scripps Research Institute A g protein-coupled receptor with an enlarged extracellular domain
EP0814158A2 (en) * 1996-06-17 1997-12-29 Smithkline Beecham Corporation Human C3a receptor variant; uses in diagnostics and therapeutics
WO2002044737A2 (en) * 2000-11-29 2002-06-06 Lifespan Biosciences, Inc. Diagnostic and therapeutic compositions and methods related to anaphylatoxin c3a receptor

Also Published As

Publication number Publication date
WO2004082566A2 (en) 2004-09-30

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