WO2003095967A3 - Diagnostics and therapeutics for diseases associated with chemokine receptor 9(ccr9) - Google Patents

Diagnostics and therapeutics for diseases associated with chemokine receptor 9(ccr9) Download PDF

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Publication number
WO2003095967A3
WO2003095967A3 PCT/EP2003/004597 EP0304597W WO03095967A3 WO 2003095967 A3 WO2003095967 A3 WO 2003095967A3 EP 0304597 W EP0304597 W EP 0304597W WO 03095967 A3 WO03095967 A3 WO 03095967A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
ccr9
therapeutics
diagnostics
diseases associated
Prior art date
Application number
PCT/EP2003/004597
Other languages
French (fr)
Other versions
WO2003095967A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Priority to AU2003229767A priority Critical patent/AU2003229767A1/en
Publication of WO2003095967A2 publication Critical patent/WO2003095967A2/en
Publication of WO2003095967A3 publication Critical patent/WO2003095967A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a human CCR9 which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, gastrointestinal diseases, genitourinary diseases and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases, gastrointestinal diseases, genitourinary diseases and hematological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CCR9 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2003/004597 2002-05-14 2003-05-02 Diagnostics and therapeutics for diseases associated with chemokine receptor 9(ccr9) WO2003095967A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003229767A AU2003229767A1 (en) 2002-05-14 2003-05-02 Diagnostics and therapeutics for diseases associated with chemokine receptor 9(ccr9)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02010163.0 2002-05-14
EP02010163 2002-05-14

Publications (2)

Publication Number Publication Date
WO2003095967A2 WO2003095967A2 (en) 2003-11-20
WO2003095967A3 true WO2003095967A3 (en) 2004-04-01

Family

ID=29414671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/004597 WO2003095967A2 (en) 2002-05-14 2003-05-02 Diagnostics and therapeutics for diseases associated with chemokine receptor 9(ccr9)

Country Status (2)

Country Link
AU (1) AU2003229767A1 (en)
WO (1) WO2003095967A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0227989D0 (en) * 2002-12-02 2003-01-08 Imp College Innovations Ltd Chimaeric molecules
EP3416641A1 (en) 2016-02-16 2018-12-26 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Modulators of ccr9 for treating tumor resistance to immune responses
EP3416640A1 (en) 2016-02-16 2018-12-26 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Modulators of tumor immune resistance for the treatment of cancer
CN113502271B (en) * 2021-07-20 2023-08-11 广州赛隽生物科技有限公司 Mesenchymal stem cells for treating inflammatory bowel disease and application thereof
CN115006423B (en) * 2022-06-28 2023-07-18 四川大学 Application of tetrahedral framework nucleic acid in preparation of medicine for preventing and/or treating brain trauma sequelae

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053635A1 (en) * 1999-03-11 2000-09-14 Millennium Pharmaceuticals, Inc. Anti-gpr-9-6 and anti-teck antibodies and methods of identifying modulators of gpr-9-6 and teck functions
JP2002345487A (en) * 2000-09-05 2002-12-03 Teijin Ltd New protein, dna and use thereof
WO2003099773A1 (en) * 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053635A1 (en) * 1999-03-11 2000-09-14 Millennium Pharmaceuticals, Inc. Anti-gpr-9-6 and anti-teck antibodies and methods of identifying modulators of gpr-9-6 and teck functions
JP2002345487A (en) * 2000-09-05 2002-12-03 Teijin Ltd New protein, dna and use thereof
WO2003099773A1 (en) * 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Derwent World Patents Index; AN 2003-460883, XP002267588 *
KUNKEL ERIC J ET AL: "Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 192, no. 5, 4 September 2000 (2000-09-04), pages 761 - 767, XP002267587, ISSN: 0022-1007 *
PAPADAKIS K A ET AL: "The role of thymus-expressed chemokine and its receptore CCR9 on lymphocytes in the regional specialization of the mucosal immune system 1", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 165, 2000, pages 5069 - 5076, XP002956582, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2003095967A2 (en) 2003-11-20
AU2003229767A1 (en) 2003-11-11
AU2003229767A8 (en) 2003-11-11

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