WO2003065044A8 - Diagnostics and therapeutics for diseases associated with gpr72 - Google Patents

Diagnostics and therapeutics for diseases associated with gpr72

Info

Publication number
WO2003065044A8
WO2003065044A8 PCT/EP2003/000476 EP0300476W WO03065044A8 WO 2003065044 A8 WO2003065044 A8 WO 2003065044A8 EP 0300476 W EP0300476 W EP 0300476W WO 03065044 A8 WO03065044 A8 WO 03065044A8
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
diseases
gpr72
nervous system
therapeutics
Prior art date
Application number
PCT/EP2003/000476
Other languages
French (fr)
Other versions
WO2003065044A3 (en
WO2003065044A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Ag
Priority to AU2003205627A priority Critical patent/AU2003205627A1/en
Publication of WO2003065044A2 publication Critical patent/WO2003065044A2/en
Publication of WO2003065044A8 publication Critical patent/WO2003065044A8/en
Publication of WO2003065044A3 publication Critical patent/WO2003065044A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

Diagnostics and therapeutics for diseases associated with GPR72Abstract of DisclosureThe invention also provides a human GPR72 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral nervous system, disorders of the central nervous system, COPD, asthma, genito-urological disorders, or inflammation diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral nervous system, disorders of the central nervous system, COPD, asthma, genito-urological disorders, or inflammation diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR72 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2003/000476 2002-02-01 2003-01-20 Diagnostics and therapeutics for diseases associated with gpr72 WO2003065044A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003205627A AU2003205627A1 (en) 2002-02-01 2003-01-20 Diagnostics and therapeutics for diseases associated with gpr72

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02001941.0 2002-02-01
EP02001941 2002-02-01

Publications (3)

Publication Number Publication Date
WO2003065044A2 WO2003065044A2 (en) 2003-08-07
WO2003065044A8 true WO2003065044A8 (en) 2003-12-24
WO2003065044A3 WO2003065044A3 (en) 2004-03-04

Family

ID=27635779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000476 WO2003065044A2 (en) 2002-02-01 2003-01-20 Diagnostics and therapeutics for diseases associated with gpr72

Country Status (2)

Country Link
AU (1) AU2003205627A1 (en)
WO (1) WO2003065044A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1941282A1 (en) * 2005-09-19 2008-07-09 Eisai R&D Management Co., Ltd. Methods for identifying gpr83 agonists and antagonists capable of modulating regulatory t cell function
CA2589393C (en) 2006-06-13 2016-04-12 Euroscreen S.A. Ligand for g-protein coupled receptor gpr72 and uses thereof
EP1867994B1 (en) * 2006-06-13 2012-09-26 Euroscreen S.A. Ligand for G-protein coupled receptor GPR72 and uses thereof
US20090280092A1 (en) * 2007-01-22 2009-11-12 Wiebke Hansen G-Protein Coupled Receptor 83 As a Molecular Switch for the Induction of Regulatory (immunosuppressive) T-cells
US8557533B2 (en) 2007-02-01 2013-10-15 Helmut Jonuleit Screening method for the identification of agents capable of activating CD4+CD25+ regulatory T-cells through interactions with the HIV-1 GP120 binding site on CD4

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1165147A (en) * 1996-02-07 1997-11-19 武田药品工业株式会社 Guanine nudeotide combined protein coupled receptor proteins, their production and use
CA2231754A1 (en) * 1997-05-07 1998-11-07 Smithkline Beecham Corporation A novel human g-protein coupled receptor hcept09
SE9904660D0 (en) * 1999-12-17 1999-12-17 Astra Pharma Inc Novel assays

Also Published As

Publication number Publication date
AU2003205627A1 (en) 2003-09-02
WO2003065044A3 (en) 2004-03-04
WO2003065044A2 (en) 2003-08-07

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