WO2004080272A3 - Utilisation des genes leprotl1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d'un sujet humain ou animal - Google Patents

Utilisation des genes leprotl1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d'un sujet humain ou animal Download PDF

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Publication number
WO2004080272A3
WO2004080272A3 PCT/FR2004/000572 FR2004000572W WO2004080272A3 WO 2004080272 A3 WO2004080272 A3 WO 2004080272A3 FR 2004000572 W FR2004000572 W FR 2004000572W WO 2004080272 A3 WO2004080272 A3 WO 2004080272A3
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WO
WIPO (PCT)
Prior art keywords
genes
rgrp
leprotl1
diabetes
loss
Prior art date
Application number
PCT/FR2004/000572
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English (en)
Other versions
WO2004080272A2 (fr
Inventor
Bernard Bailleul
Yves Rouille
Karin Seron
Sandrine Belouzard
Original Assignee
Centre Nat Rech Scient
Bernard Bailleul
Yves Rouille
Karin Seron
Sandrine Belouzard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Bernard Bailleul, Yves Rouille, Karin Seron, Sandrine Belouzard filed Critical Centre Nat Rech Scient
Priority to EP04718992A priority Critical patent/EP1601973A2/fr
Priority to CA002518761A priority patent/CA2518761A1/fr
Publication of WO2004080272A2 publication Critical patent/WO2004080272A2/fr
Publication of WO2004080272A3 publication Critical patent/WO2004080272A3/fr
Priority to US11/221,275 priority patent/US20060068429A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une méthode d'identification de composés actifs sur la perte ou la prise de poids ou le diabète chez un sujet humain ou animal, caractérisé en ce que l'on mesure l'effet dudit composé sur (a) l'expression de l'un au moins des gènes LEPROTL1 et OB­ RGRP ou partie de ceux-ci, et/ou (b) le transport intracellulaire jusqu'à la membrane cellulaire, et/ou (c) la présence au niveau de la membrane cellulaire, et/ou (d) l'internalisation depuis la membrane, des protéines codées par l'un au moins desdits gènes ou partie de ceux-ci.
PCT/FR2004/000572 2003-03-10 2004-03-10 Utilisation des genes leprotl1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d'un sujet humain ou animal WO2004080272A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04718992A EP1601973A2 (fr) 2003-03-10 2004-03-10 Utilisation des genes leprotl1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d un sujet humain ou animal
CA002518761A CA2518761A1 (fr) 2003-03-10 2004-03-10 Utilisation des genes leprotl1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d'un sujet humain ou animal
US11/221,275 US20060068429A1 (en) 2003-03-10 2005-09-07 LEPROTL1 and OB-RGRP genes for screening compounds that act on the gain or loss of weight or on diabetes in a human or animal subject

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0302931A FR2852397B1 (fr) 2003-03-10 2003-03-10 Utilisation des genes leprotl 1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d'un sujet humain ou animal.
FR03/02931 2003-03-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/221,275 Continuation US20060068429A1 (en) 2003-03-10 2005-09-07 LEPROTL1 and OB-RGRP genes for screening compounds that act on the gain or loss of weight or on diabetes in a human or animal subject

Publications (2)

Publication Number Publication Date
WO2004080272A2 WO2004080272A2 (fr) 2004-09-23
WO2004080272A3 true WO2004080272A3 (fr) 2004-11-04

Family

ID=32893169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2004/000572 WO2004080272A2 (fr) 2003-03-10 2004-03-10 Utilisation des genes leprotl1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d'un sujet humain ou animal

Country Status (5)

Country Link
US (1) US20060068429A1 (fr)
EP (1) EP1601973A2 (fr)
CA (1) CA2518761A1 (fr)
FR (1) FR2852397B1 (fr)
WO (1) WO2004080272A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070050237A1 (en) * 2005-08-30 2007-03-01 Microsoft Corporation Visual designer for multi-dimensional business logic
MX2019005397A (es) 2016-11-08 2019-10-09 Regeneron Pharma Proteinas de union a antigeno que antagonizan el receptor de leptina.
BR112020012011A2 (pt) 2017-12-18 2020-11-24 Regeneron Pharmaceuticals, Inc. moléculas de ligação a antígeno biespecífica isolada e de ligação a antígeno biespecífica ou cadeia de imunoglobulina, composição farmacêutica, recipiente ou dispositivo de injeção, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, métodos para tratar uma doença ou condição, para tratar uma condição de lipodistrofia em um sujeito, para produzir uma molécula de ligação a antígeno biespecífica, e, para administrar uma molécula de ligação a antígeno biespecífica isolada ou composição farmacêutica.
CN112040980A (zh) 2018-04-06 2020-12-04 瑞泽恩制药公司 用于治疗代谢功能障碍或低瘦蛋白血症的瘦蛋白受体激动剂抗体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAILLEUL B ET AL: "THE LEPTIN RECEPTOR PROMOTER CONTROLS EXPRESSION OF A SECOND DISTINCT PROTEIN", 1997, NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, VOL. 25, NR. 14, PAGE(S) 2752-2758, ISSN: 0305-1048, XP002050420 *
HUANG Y ET AL: "Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1)", 2001, BIOCHIMICA ET BIOPHYSICA ACTA. GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, VOL. 1517, NR. 2, PAGE(S) 327-331, ISSN: 0167-4781, XP004248823 *
SERON K ET AL: "OB-RGRP AND LEPROTL1 DEFINE A NEW FAMILY OF LIPID RAFT-ASSOCIATED TETRASPANNING MEMBRANE PROTEINS LOCALIZED AT THE TGN AND/OR ENDOSOMES", 2001, BIOLOGY OF THE CELL, VOL. 93, PAGE 227, 2001, XP001154434 *

Also Published As

Publication number Publication date
US20060068429A1 (en) 2006-03-30
CA2518761A1 (fr) 2004-09-23
FR2852397B1 (fr) 2005-04-29
EP1601973A2 (fr) 2005-12-07
FR2852397A1 (fr) 2004-09-17
WO2004080272A2 (fr) 2004-09-23

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