WO2007006591A3 - Dihalogenation d'hydroxipyridones n,o-disubstituees et leurs utilisations - Google Patents

Dihalogenation d'hydroxipyridones n,o-disubstituees et leurs utilisations Download PDF

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Publication number
WO2007006591A3
WO2007006591A3 PCT/EP2006/009181 EP2006009181W WO2007006591A3 WO 2007006591 A3 WO2007006591 A3 WO 2007006591A3 EP 2006009181 W EP2006009181 W EP 2006009181W WO 2007006591 A3 WO2007006591 A3 WO 2007006591A3
Authority
WO
WIPO (PCT)
Prior art keywords
disubstituted
hydroxipyridones
dihalogenation
compounds
dihalogeno
Prior art date
Application number
PCT/EP2006/009181
Other languages
English (en)
Other versions
WO2007006591A2 (fr
Inventor
Genevieve Balme
David Conreaux
Nuno Monteiro
Emmanuel Bossharth
Philippe Desbordes
Original Assignee
Bayer Cropscience Sa
Centre Nat Rech Scient
Genevieve Balme
David Conreaux
Nuno Monteiro
Emmanuel Bossharth
Philippe Desbordes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Sa, Centre Nat Rech Scient, Genevieve Balme, David Conreaux, Nuno Monteiro, Emmanuel Bossharth, Philippe Desbordes filed Critical Bayer Cropscience Sa
Publication of WO2007006591A2 publication Critical patent/WO2007006591A2/fr
Publication of WO2007006591A3 publication Critical patent/WO2007006591A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procédé pour la préparation de 3,5-dihalogéno-4-hydroxypyridin-2(1H)-one N,O-disubstituées. Ces composés peuvent être symétriques ou non symétriques et sont notamment utiles pour la synthèse de composés à activité agrochimique ou pharmaceutique.
PCT/EP2006/009181 2005-07-13 2006-07-12 Dihalogenation d'hydroxipyridones n,o-disubstituees et leurs utilisations WO2007006591A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05356121.3 2005-07-13
EP05356121 2005-07-13

Publications (2)

Publication Number Publication Date
WO2007006591A2 WO2007006591A2 (fr) 2007-01-18
WO2007006591A3 true WO2007006591A3 (fr) 2007-05-10

Family

ID=36603510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/009181 WO2007006591A2 (fr) 2005-07-13 2006-07-12 Dihalogenation d'hydroxipyridones n,o-disubstituees et leurs utilisations

Country Status (2)

Country Link
TW (1) TW200740755A (fr)
WO (1) WO2007006591A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8969347B2 (en) 2008-06-03 2015-03-03 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9359379B2 (en) 2012-10-02 2016-06-07 Intermune, Inc. Anti-fibrotic pyridinones

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0723354D0 (en) 2007-11-29 2008-01-09 Freeform Design & Innovation L Clamp for use with a workbench
US9359300B2 (en) 2010-12-06 2016-06-07 Confluence Life Sciences, Inc. Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
CA2819889C (fr) 2010-12-06 2020-12-15 Confluence Life Sciences, Inc. Composes pyridinone-pyridinyle substitues
EP3372580B1 (fr) * 2011-01-25 2020-07-22 Bayer CropScience Aktiengesellschaft Procédé de production de dérivés de la 1-h-pyrrolidine-2,4-dione
HUE054178T2 (hu) 2013-06-07 2021-08-30 Aclaris Therapeutics Inc Metil/fluor-piridinil-metoxi-szubsztituált piridinon-piridinil-vegyületek és fluor-pirimidinil-metoxi-szubsztituált piridinon-piridinil-vegyületek
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
JP2023519890A (ja) 2020-03-27 2023-05-15 アクラリス セラピューティクス，インコーポレイテッド 免疫状態の処置のためのｍｋ２経路阻害剤の経口組成物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0316185A2 (fr) * 1987-11-10 1989-05-17 The Dow Chemical Company N-cyanométhyl-pyridine-2-ones insecticides
WO1992014714A1 (fr) * 1991-02-16 1992-09-03 Fisons Plc Pyridinones et pyrimidinones substitues utilises comme antagonistes d'angiotensine ii
WO2003068230A1 (fr) * 2002-02-14 2003-08-21 Pharmacia Corporation Pyridinones substituees servant de modulateurs de la map kinase p38
WO2005018557A2 (fr) * 2003-08-13 2005-03-03 Pharmacia Corporation Pyridinones substitues

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0316185A2 (fr) * 1987-11-10 1989-05-17 The Dow Chemical Company N-cyanométhyl-pyridine-2-ones insecticides
WO1992014714A1 (fr) * 1991-02-16 1992-09-03 Fisons Plc Pyridinones et pyrimidinones substitues utilises comme antagonistes d'angiotensine ii
WO2003068230A1 (fr) * 2002-02-14 2003-08-21 Pharmacia Corporation Pyridinones substituees servant de modulateurs de la map kinase p38
WO2005018557A2 (fr) * 2003-08-13 2005-03-03 Pharmacia Corporation Pyridinones substitues

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CANADIAN JOURNAL OF CHEMISTRY , 58(5), 501-26 CODEN: CJCHAG; ISSN: 0008-4042, 1980 *
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002388789 *
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002388790 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MAEHR, HUBERT ET AL: "The chemistry of aurodox and related antibiotics", XP002388788, retrieved from STN Database accession no. 1980:445839 *
FAIDALLAH, HASSAN M., ACTA CHIM. HUNG, vol. 125, no. 2, 1988, pages 281 - 288 *
STUMM, G.; NICLAS, H.J., PHARMAZIE, vol. 43, no. 4, 1988, pages 286 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8969347B2 (en) 2008-06-03 2015-03-03 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9290450B2 (en) 2008-06-03 2016-03-22 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9359379B2 (en) 2012-10-02 2016-06-07 Intermune, Inc. Anti-fibrotic pyridinones

Also Published As

Publication number Publication date
WO2007006591A2 (fr) 2007-01-18
TW200740755A (en) 2007-11-01

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