WO2004069679A1 - Distributeur goutte a goutte a insert pour optimiser la precision de dosage de liquides - Google Patents

Distributeur goutte a goutte a insert pour optimiser la precision de dosage de liquides Download PDF

Info

Publication number
WO2004069679A1
WO2004069679A1 PCT/IB2003/000473 IB0300473W WO2004069679A1 WO 2004069679 A1 WO2004069679 A1 WO 2004069679A1 IB 0300473 W IB0300473 W IB 0300473W WO 2004069679 A1 WO2004069679 A1 WO 2004069679A1
Authority
WO
WIPO (PCT)
Prior art keywords
drop dispenser
insert element
container
drop
notch
Prior art date
Application number
PCT/IB2003/000473
Other languages
English (en)
Inventor
Peter Fuchs
Original Assignee
Hoffmann Neopac Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann Neopac Ag filed Critical Hoffmann Neopac Ag
Priority to PCT/IB2003/000473 priority Critical patent/WO2004069679A1/fr
Priority to AU2003202768A priority patent/AU2003202768A1/en
Publication of WO2004069679A1 publication Critical patent/WO2004069679A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein

Definitions

  • the invention relates to a drop dispenser according to the preamble of the independent claim.
  • Drop dispensers of this kind are used for dispensing liquids in 0 drops.
  • a typical application are pharmaceutical products, for example eye drops, or cosmetics.
  • the drop dispensers usually comprise a flexible container or are designed as a cap for a flexible container. In contrast to drop dispensers for inflexible containers there is no opening to let air from the outside into the container during dispensing.
  • a problem to be solved by the present invention lies therefore in providing a drop dispenser which avoids the problems described above at least partially.
  • Fig. 1 a vertical cross-sectional view of a preferred embodiment of a drop dispenser according to the invention
  • Fig. 2 the drop dispenser of fig. 1, with a cap
  • Fig. 3 a three dimensional view of the insert element of the drop dispenser shown in fig. 1,
  • Fig. 4 a three dimensional view of a further preferred embodiment of an insert element for a drop dis- chronological according to the invention
  • Fig. 5 a three dimensional partially sectional view of the drop dispenser of fig. 1,
  • Fig. 6 an alternative spout element for the drop dispenser of Fig. 1.
  • Fig. 7 the spout element of Fig. 6 in a cross-sectional view
  • Fig. 8 the spout element of Fig. 6 in a view from below
  • Fig. 9 a vertical cross-sectional view of a further embodiment of a drop dispenser according to the invention.
  • Fig. 10 a three dimensional view of the insert element of the drop dispenser shown in fig. 9,
  • Fig. 11 a schematic view from below of the insert element of the drop dispenser shown in fig. 9, Fig. 12 a schematic side view of the insert element of the drop dispenser shown in fig. 9,
  • Fig. 13 a three dimensional partially sectional view of the drop dispenser of fig. 9,
  • Fig. 14 a vertical cross-sectional view of a further embodiment of a drop dispenser according to the invention with a mounting aid
  • Fig. 15 a side view of the insert element with mounting aid of fig. 14,
  • Fig. 16 a horizontal cross-sectional view of the insert element of fig. 15,
  • Fig. 17 a horizontal cross-sectional view of an alternative embodiment of the insert element
  • Fig. 18 the insert element of fig. 15 in a three dimensional view
  • Fig. 19 the container of fig. 14 in a three dimensional view
  • Fig. 20 the container of fig. 14 mounted on a mandrel as during production process according to the invention
  • Fig. 21 a three dimensional partially sectional view of the arrangement of fig. 20.
  • FIG. 1 A vertical cross-sectional view of a preferred embodiment of a drop dispenser 3 according to the invention is shown in fig. 1.
  • the drop dispenser 3 com- prises an insert element 1, a spout element 2 and part of a container 9.
  • Insert element 1 and spout element 2 are preferably injection molded using thermoplastic synthetic material.
  • the insert element 1 is preferably harder than the spout element 2. This is advantageous because the insert element 1 and in particular its edges slightly push into the wall 15 of the spout element 2 and the insert element 1 stays in its position without additional fixation means.
  • the spout element 2 can be harder than the insert element 1.
  • the insert element 1 can be held by snap-in means, in particular a snap-in rim, or with glue.
  • the container 9 preferably has the shape of a tube or a bottle, in particular a tube or bottle which is at least partially cylindrical or oval and is made at least partially from a plastic material and/or as a laminate. It is designed for holding a liquid, for example eye drops.
  • the container 9 is at least partially flexible and the liquid in the container 9 can be pressurized by squeezing the container 9. For drop dispensing the container 9 is squeezed while being held such that spout element 3 is directed downwards. The liquid passes through throttling passage 11 into delivery passage 12 until there is enough liquid for a drop. The drop is in contact with tear-off edge 10 until it drops away.
  • the throttling passage 11 is formed between the insert element 1 and the spout element 2.
  • the insert element 1 is surrounded and in particular partially enclosed by walls 15 of the spout element 2. These walls 15 or inner surfaces comprise two walls, an annular side wall and a circular or discoidal end wall.
  • the insert element 1 comprises a lateral notch 6, a transversal notch 7, and preferably a bore 8.
  • the notches, or grooves, are designed to form together with walls 15 of the inside of the spout element 12 the channels of the throttling pas- sage 11.
  • the throttling passage 11 goes first along the lateral notch 6, then along the transversal notch 7 and ends centrally at the bore 8, which is at the inner end of the delivery passage 12.
  • the throttling passage 11 has a sharp bend or more precisely a 90 degree sharp bend.
  • the throttling passage 11 and subsequent turbulences cause a re- duction of pressure and flow rate of the liquid being dispensed.
  • the flow rate substantially stays within a certain range independent of the pressure applied to the container 9 and due to the turbulences even at a high pressure the liquid is not dispensed as a jet or spout which would interfere with the drop formation.
  • the delivery passage 12 is substantially conical, wherein the largest diameter is at the distal end of the spout element 2.
  • the container 9 can be closed with a cap, for which there is a thread 5.
  • Fig. 2 shows the drop dispenser of fig.
  • the cap 16 has an inside thread which matches the outside thread 5 of the container 9.
  • the thread 5 is in particular an M9- thread.
  • the container 9 is tightened by the cap 16 being in full contact with the tear-off rim 10.
  • the cap 16 also protects the spout element 2 against contamination from the outside.
  • the cap 16 has for better handling and for aesthetic reasons an outside surface at a radius which is substantially larger than the radius of the spout element 2.
  • the cap 16 comprises an inner wall and an outer wall with an annular recess in between.
  • Fig. 3 shows a three dimensional view of the insert element 1 of the drop dispenser shown in fig. 1. It is substantially cylindrical. It comprises a lateral notch 6 extending in the direction of the axis of the cylinder from a first circular surface of the cylinder to a second circular surface of the cylinder, a transversal notch 7 extending in radial direction from the end of the lateral notch 6 to the center of said second circular surface and a bore 8 in the center of said second circular surface.
  • the depth of the notches 6, 7 can be varied, in particular to adapt the dispenser to the properties of the liquid to be dispensed and/or a desired speed of drop formation. In particular an adaptation on whether the liquid is high-molecular or not is possible.
  • the throttling passage can also comprise a second path, in particular formed by a second vertical and a second transversal notch.
  • the insert element can as well be plate-shaped, in particular disk-shaped instead of the shown cylindrical shape.
  • Fig. 4 shows a three dimensional view of a further preferred embodiment of an insert element 1 for a drop dispenser 3 according to the invention. It is substantially cylindrical.
  • the lateral notch 6 also starts at the first circular surface of the cylinder, but in contrast to the insert element of fig. 3 ends in the middle of the cylinder at a transversal bore 13 and does not extend all the way to the second circular surface.
  • the transversal bore 13 has a connection to a central bore 14.
  • the throttling passage 11 is only formed partially between the insert element 1 and the wall 15.
  • the central bore 14 and the lateral notch 6 can be designed such that they overlap and that there is no transversal bore 13 necessary.
  • Fig. 5 shows a three dimensional partially sectional view of the drop dispenser of fig. 1.
  • Fig. 6, Fig. 7 and Fig. 8 show different views or sections of a spout element 2 suitable for the drop dispenser of Fig. 1.
  • this spout element 2 has cavities 17. Because of these cavities 17 there is less thermoplastic material needed, and it is less likely that the workpiece gets sink marks while cooling down after injection molding.
  • the spout element 2 shown in fig. 6 to 8 is preferably combined with an insert element 1 as shown in Fig. 4 where the throttling passage has only a central outlet. This has the advantage, that the cavities are not connected to the passages and do not get filled with liquid which might deteriorate therein.
  • Fig. 6 to 8 is preferably combined with an insert element 1 as shown in Fig. 4 where the throttling passage has only a central outlet. This has the advantage, that the cavities are not connected to the passages and do not get filled with liquid which might deteriorate therein.
  • FIG. 9 shows a vertical cross-sectional view of a further embodiment of a drop dispenser according to the invention.
  • the tip or spout element 2 is designed elongated, as a cannula to allow a locally more precise application of the drops.
  • the outside surface of the spout element 2 is conical having the smallest radius at its distal end.
  • the insert element 1 only comprises a lateral notch 6.
  • the throttling passage 11 ends laterally in the delivery passage 12. These turbulences are favorable for drop dis- pensing as already described referring to fig. 1.
  • the delivery passage 12 is also conical as in the embodiment shown in fig. 1, but the smallest radius is at the distal end of the spout element 2.
  • the spout element 2 and the container 9 are one piece.
  • the container 9 is preferably a laminate tube.
  • Fig. 10 shows a three dimensional view of the insert element 1 of the drop dispenser shown in fig. 9.
  • the insert element 1 is conical and has a lateral notch 6 extending from the first circular surface to the second circular surface, substantially in the direction of the axis of the insert element 1.
  • the actual direction is slightly inclined towards or away from the axis because of the conical shape of the element.
  • the lateral notch 6 can also be inclined sideways and, if a large inclination angle is selected, even have the shape of a spiral .
  • Fig. 11 shows a schematic view from below of the insert element 1 of the drop dispenser shown in fig. 9.
  • the notch 6 has a v-profile, but can also be designed with a u-profile or other profiles, in particular pro- files which are suitable to be formed during injection molding of the insert element 1.
  • the throttling passage can also be formed by leaving out a segment of the circular profile of the insert element 1 or by cutting away such a segment .
  • Fig. 12 shows a schematic side view of the insert element 1 of the drop dispenser 3 shown in fig. 9.
  • Fig. 13 shows a three dimensional partially sectional view of the drop dispenser 3 of fig. 9.
  • Fig. 14 shows a vertical cross-sectional view of a further embodiment of a drop dispenser 3 according to the invention. It comprises a mounting aid 18.
  • the mounting aid 18 is formed by an elongation of the insert element 1.
  • the mounting aid 18 serves as a handle or grip for inserting the insert element 1 into the spout element 2 during the production process.
  • the mounting aid 18 is designed in such a way that it does not interfere with the functioning of the drop dispenser 3. It can therefore remain attached to the drop dispenser 3 and does not have to be removed to finish the production process.
  • Fig. 15 shows a side view of the insert element 1 with mounting aid 18 of fig. 14.
  • the mounting aid 18 comprises a cylindrical shaft 22 and an annulus 23.
  • the shaft 22 is designed to fit into a cylindrical bore of a mandrel or to be held by a gripping device.
  • the annulus 23 functions as a stop edge. It prevents the mounting aid 18 from sinking to far into the bore of the mandrel.
  • the annulus 23 also prevents the insert element 1 from being pushed to far into the delivery passage 12. In this case the annulus 23 contacts the inside of the container 9 along a circular angular surface 20.
  • a recess 21 assures that liquid can still pass from the interior of the container body to the throttling passage 11 no matter how tight the angular surface 20 is pressed to the inte- rior surface of the container 9.
  • annular notch 19 Between the annulus 23 and actual insert portion of the insert element 1 there is an annular notch 19. Due to this annular notch 19 there is an edge, which "hooks" into the interior surface of the spout element 2 and thereby holds the insert element 1 in its place. As already mentioned above this effect can be enforced by making the insert element 1 harder than the spout element 2.
  • the lateral notch 6 gets bigger following it along the fluid path to its distal end. This causes the fluid to slow down and not to enter the delivery passage 12 as a jet or spout.
  • Fig. 16 shows a horizontal cross-sectional view of the insert element with mounting aid of fig. 15.
  • the annular notch 19 goes all around the insert element 1.
  • Fig. 17 shows a horizontal cross-sectional view of an alternative embodiment of the insert element 1.
  • the annular notch 19 is only partial, leaving two sections of the circumference without a notch.
  • Fig. 18 shows the insert element of fig. 15 in a three dimensional view.
  • Fig. 19 shows the container of fig. 14 in a three dimensional, partially sectional view.
  • Fig. 20 shows the container of fig. 14 during the production process.
  • the insert element 1 is first securely placed on the mandrel 24 by inserting its shaft 22 into a central bore in the mandrel .
  • the container 9 with spout element 2 is pushed over the mandrel 24.
  • the insert element 1 is pushed into the delivery passage 12 of the drop dispenser 3.
  • This state is shown in fig. 18.
  • a cap may be screwed or pushed on.
  • the container 9 with drop dispenser 3, now comprising spout element 2 and in- sert element 1, is removed from the mandrel 24 and is passed on to the further production steps for producing a closed and filled container, in particular a tube.
  • the process described above is not limited to a static mandrel 24. Instead, for example, the container 9 may be held static, while the mandrel 24 with insert element 1 is pressed into it.
  • Fig. 21 shows a three dimensional partially sectional view of the arrangement of fig. 20.
  • the drop dispenser according to the invention is well suited to furnish existing lines of containers.
  • a typical container to be combined with the drop dispenser according to the invention is the "NEOPAC POLYFOI ®" laminate tube. Diameters of this tube are 10, 13.5, 16 or 19 mm. The thickness of the wall is 0.3 or 0.5 mm. The length of the tube can be varied, typically in a range between 35 and 80 mm. The volume varies accordingly be- tween 1.5 and 15 ml .

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Closures For Containers (AREA)

Abstract

Selon l'invention, le flacon (9) comprend un distributeur goutte à goutte (3) qui a un élément d'insertion (1), lequel possède une encoche latérale (6), une encoche transversale (7) et un orifice central (8). Si on presse le liquide du flacon (9), il traverse les encoches (6, 7) en direction de l'orifice (8) et pénètre dans un conduit d'administration (12). Lesdites encoches (6, 7) forment un conduit à étranglement (11). Le volume du liquide distribué par unité de temps ne dépend pas en grande partie de la pression exercée sur le flacon. Le distributeur goutte à goutte est facile d'emploi, et sa fabrication n'est pas compliquée et peut être de faible coût.
PCT/IB2003/000473 2003-02-07 2003-02-07 Distributeur goutte a goutte a insert pour optimiser la precision de dosage de liquides WO2004069679A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/IB2003/000473 WO2004069679A1 (fr) 2003-02-07 2003-02-07 Distributeur goutte a goutte a insert pour optimiser la precision de dosage de liquides
AU2003202768A AU2003202768A1 (en) 2003-02-07 2003-02-07 Drop dispensing with insert for optimizing the dosing precision of liquids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2003/000473 WO2004069679A1 (fr) 2003-02-07 2003-02-07 Distributeur goutte a goutte a insert pour optimiser la precision de dosage de liquides

Publications (1)

Publication Number Publication Date
WO2004069679A1 true WO2004069679A1 (fr) 2004-08-19

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AU (1) AU2003202768A1 (fr)
WO (1) WO2004069679A1 (fr)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006058011A1 (fr) * 2004-11-23 2006-06-01 Allergan, Inc. Flacon compte-gouttes a faible volume autoclavable
EP1858533A2 (fr) * 2005-02-22 2007-11-28 The Johns Hopkins University School Of Medicine Utilisation du fluide amniotique en traitement d'affections et de lesions oculaires
WO2008131323A1 (fr) * 2007-04-23 2008-10-30 3M Innovative Properties Company Ensemble filtre pour embout distributeur
FR2934572A1 (fr) * 2008-07-31 2010-02-05 Thea Lab Embout pour flacon de conditionnement de liquide a distribuer goutte a goutte.
WO2011030063A1 (fr) * 2009-09-11 2011-03-17 Rexam Healthcare La Verpilliere Dispositif de distribution de liquide
JP2011143971A (ja) * 2009-12-14 2011-07-28 Kao Corp スクイズ容器用キャップ
CN102725074A (zh) * 2009-09-28 2012-10-10 瓦卢瓦有限合伙公司 流体制品分配装置
FR2974350A1 (fr) * 2011-04-21 2012-10-26 Rexam Healthcare La Verpillier Dispositif de distribution de produit liquide muni d'un organe de reduction de debit
EP2597044A1 (fr) 2011-11-25 2013-05-29 Hoffmann Neopac AG Insert compte-gouttes et récipient avec insert compte-gouttes
WO2013075256A1 (fr) 2011-11-25 2013-05-30 Hoffmann Neopac Ag Insert pour un orifice de tube de distribution de gouttes
JP2013154923A (ja) * 2012-01-31 2013-08-15 Yoshino Kogyosho Co Ltd 滴下容器
WO2014089015A1 (fr) * 2012-12-03 2014-06-12 RLM Group Ltd. Techniques de distribution et de dosage améliorées pour contenant de fluide
FR3009781A1 (fr) * 2013-08-26 2015-02-27 Oreal Distribution controlee d'une composition cosmetique de maquillage
US9096352B2 (en) 2012-12-03 2015-08-04 RLM Group Ltd. Enhanced dispensing and dosaging techniques for fluid containers
US9296525B2 (en) 2012-12-03 2016-03-29 RLM Group Ltd. Enhanced dispensing and dosaging techniques for fluid containers
EP2344216A4 (fr) * 2008-09-23 2016-04-06 Noble House Group Pty Ltd Dispositif de transfert de fluides corporels
EP3081111A1 (fr) * 2013-12-10 2016-10-19 Yonwoo Co., Ltd. Réceptacle pour produit cosmétique de type tube conçu pour distribuer un contenu liquide sous forme de gouttes
EP3241781A1 (fr) * 2016-05-03 2017-11-08 Hoffmann Neopac AG Tube doté d'un insert d'étranglement
US10220988B2 (en) 2008-03-27 2019-03-05 Nemera La Verpillière Device for dispensing a liquid in the form of drops
EP3650368A4 (fr) * 2018-03-28 2020-09-09 Shenzhen Beauty Star Co., Ltd Tuyau goutte-à-goutte
CN112693734A (zh) * 2020-12-22 2021-04-23 爱索尔（广州）包装有限公司 水状膏体定量出液组件及包装容器

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2310777A (en) * 1939-03-24 1943-02-09 Giavotto Pietro Drop-counting bottle
US3102651A (en) * 1960-10-03 1963-09-03 Arthur H Boese Flow control neck or head
US4936498A (en) * 1987-03-24 1990-06-26 Oy Star Ab Tip part of a dosage vessel
US5105993A (en) * 1989-12-29 1992-04-21 La Haye Laboratories, Inc. Disposable medical dispenser with a filtering dispenser nozzle
US6076709A (en) * 1998-05-04 2000-06-20 Dentsply Detrey G.M.B.H. Dental adhesive container dropping system
US6371340B1 (en) * 1998-11-17 2002-04-16 Crown Cork & Seal Technologies Corporation Dispensing closures
WO2002072444A1 (fr) * 2001-03-13 2002-09-19 Stella Kunststofftechnik Gmbh Bouchon de dosage au goutte par goutte destine au dosage de liquides sous forme de gouttes et contenant comportant un tel bouchon
WO2003016163A1 (fr) * 2001-08-09 2003-02-27 Tadashi Hagihara Recipient a mecanisme a vitesse d'ecoulement de decharge

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2310777A (en) * 1939-03-24 1943-02-09 Giavotto Pietro Drop-counting bottle
US3102651A (en) * 1960-10-03 1963-09-03 Arthur H Boese Flow control neck or head
US4936498A (en) * 1987-03-24 1990-06-26 Oy Star Ab Tip part of a dosage vessel
US5105993A (en) * 1989-12-29 1992-04-21 La Haye Laboratories, Inc. Disposable medical dispenser with a filtering dispenser nozzle
US6076709A (en) * 1998-05-04 2000-06-20 Dentsply Detrey G.M.B.H. Dental adhesive container dropping system
US6371340B1 (en) * 1998-11-17 2002-04-16 Crown Cork & Seal Technologies Corporation Dispensing closures
WO2002072444A1 (fr) * 2001-03-13 2002-09-19 Stella Kunststofftechnik Gmbh Bouchon de dosage au goutte par goutte destine au dosage de liquides sous forme de gouttes et contenant comportant un tel bouchon
WO2003016163A1 (fr) * 2001-08-09 2003-02-27 Tadashi Hagihara Recipient a mecanisme a vitesse d'ecoulement de decharge

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7178703B2 (en) 2004-11-23 2007-02-20 Allergan, Inc. Autoclaveable small-volume dropper bottle
WO2006058011A1 (fr) * 2004-11-23 2006-06-01 Allergan, Inc. Flacon compte-gouttes a faible volume autoclavable
EP1858533A2 (fr) * 2005-02-22 2007-11-28 The Johns Hopkins University School Of Medicine Utilisation du fluide amniotique en traitement d'affections et de lesions oculaires
EP1858533A4 (fr) * 2005-02-22 2009-09-09 Univ Johns Hopkins Med Utilisation du fluide amniotique en traitement d'affections et de lesions oculaires
JP2010524641A (ja) * 2007-04-23 2010-07-22 スリーエム イノベイティブ プロパティズ カンパニー ディスペンサー先端部フィルターアセンブリ
WO2008131323A1 (fr) * 2007-04-23 2008-10-30 3M Innovative Properties Company Ensemble filtre pour embout distributeur
US11524822B2 (en) 2008-03-27 2022-12-13 Nemera La Verpillière Device for dispensing a liquid in the form of drops
US11155391B2 (en) 2008-03-27 2021-10-26 Nemera La Verpillière Device for dispensing a liquid in the form of drops
US10640268B2 (en) 2008-03-27 2020-05-05 Nemera La Verpillière Device for dispensing a liquid in the form of drops
US10220988B2 (en) 2008-03-27 2019-03-05 Nemera La Verpillière Device for dispensing a liquid in the form of drops
FR2934572A1 (fr) * 2008-07-31 2010-02-05 Thea Lab Embout pour flacon de conditionnement de liquide a distribuer goutte a goutte.
EP2344216A4 (fr) * 2008-09-23 2016-04-06 Noble House Group Pty Ltd Dispositif de transfert de fluides corporels
WO2011030063A1 (fr) * 2009-09-11 2011-03-17 Rexam Healthcare La Verpilliere Dispositif de distribution de liquide
FR2950037A1 (fr) * 2009-09-11 2011-03-18 Rexam Pharma La Verpilliere Dispositif de distribution de liquide
CN102725073A (zh) * 2009-09-11 2012-10-10 雷盛医疗拉韦尔皮列尔公司 液体分配装置
RU2529526C2 (ru) * 2009-09-11 2014-09-27 Рексам Хелткэа Ля Верпийер Устройство для подачи жидкости
JP2018011973A (ja) * 2009-09-11 2018-01-25 レグザム・エルスカール・ラ・ベルピリエール 液体ディスペンサ装置
US8827124B2 (en) 2009-09-11 2014-09-09 Rexam Healthcare La Verpilliere Liquid dispensing device
CN102725074A (zh) * 2009-09-28 2012-10-10 瓦卢瓦有限合伙公司 流体制品分配装置
JP2011143971A (ja) * 2009-12-14 2011-07-28 Kao Corp スクイズ容器用キャップ
FR2974350A1 (fr) * 2011-04-21 2012-10-26 Rexam Healthcare La Verpillier Dispositif de distribution de produit liquide muni d'un organe de reduction de debit
WO2012143664A1 (fr) 2011-04-21 2012-10-26 Rexam Healthcare La Verpilliere Dispositif de distribution de produit liquide muni d'un organe de réduction de débit
US9090384B2 (en) * 2011-11-25 2015-07-28 Hoffmann Neopac Ag Insert for a tube for dispensing liquid content and tube with such an insert
EP2597044A1 (fr) 2011-11-25 2013-05-29 Hoffmann Neopac AG Insert compte-gouttes et récipient avec insert compte-gouttes
WO2013075256A1 (fr) 2011-11-25 2013-05-30 Hoffmann Neopac Ag Insert pour un orifice de tube de distribution de gouttes
JP2013154923A (ja) * 2012-01-31 2013-08-15 Yoshino Kogyosho Co Ltd 滴下容器
US9096352B2 (en) 2012-12-03 2015-08-04 RLM Group Ltd. Enhanced dispensing and dosaging techniques for fluid containers
US9296525B2 (en) 2012-12-03 2016-03-29 RLM Group Ltd. Enhanced dispensing and dosaging techniques for fluid containers
WO2014089015A1 (fr) * 2012-12-03 2014-06-12 RLM Group Ltd. Techniques de distribution et de dosage améliorées pour contenant de fluide
WO2015028733A1 (fr) * 2013-08-26 2015-03-05 Oreal Distribution contrôlée d'une composition cosmétique de maquillage
FR3009781A1 (fr) * 2013-08-26 2015-02-27 Oreal Distribution controlee d'une composition cosmetique de maquillage
EP3081111A4 (fr) * 2013-12-10 2017-05-03 Yonwoo Co., Ltd. Réceptacle pour produit cosmétique de type tube conçu pour distribuer un contenu liquide sous forme de gouttes
JP2017504379A (ja) * 2013-12-10 2017-02-09 ヨンウー カンパニー，リミテッド 液状内容物を滴状に吐出するチューブ型化粧品容器
EP3081111A1 (fr) * 2013-12-10 2016-10-19 Yonwoo Co., Ltd. Réceptacle pour produit cosmétique de type tube conçu pour distribuer un contenu liquide sous forme de gouttes
US10093461B2 (en) 2016-05-03 2018-10-09 Hoffmann Neopac Ag Tube with throttle insert
CH712432A1 (de) * 2016-05-03 2017-11-15 Hoffmann Neopac Ag Tube mit Drosseleinsatz.
EP3241781A1 (fr) * 2016-05-03 2017-11-08 Hoffmann Neopac AG Tube doté d'un insert d'étranglement
EP3650368A4 (fr) * 2018-03-28 2020-09-09 Shenzhen Beauty Star Co., Ltd Tuyau goutte-à-goutte
CN112693734A (zh) * 2020-12-22 2021-04-23 爱索尔（广州）包装有限公司 水状膏体定量出液组件及包装容器

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