WO2004052254A1 - Disposable separator for separating the epithelium layer from the cornea of an eye - Google Patents
Disposable separator for separating the epithelium layer from the cornea of an eye Download PDFInfo
- Publication number
- WO2004052254A1 WO2004052254A1 PCT/EP2003/013955 EP0313955W WO2004052254A1 WO 2004052254 A1 WO2004052254 A1 WO 2004052254A1 EP 0313955 W EP0313955 W EP 0313955W WO 2004052254 A1 WO2004052254 A1 WO 2004052254A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- separator
- polymeric material
- cornea
- polymeric
- separating edge
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
- A61F9/0133—Knives or scalpels specially adapted therefor
Definitions
- This invention relates to a blade, in particular to a disposable separator for separating the epithelium layer of a cornea from the underlying Bowman's layer.
- the invention provides a separator to be used with a surgical device that separates the epithelium of a cornea from the underlying Bowman's layer of an eye of a patient, the surgical device including a positioning ring for temporary attachment to the eye and structured to present and expose the cornea to be separated, a separator head assembly structured and disposed to carry said separator, and a drive operably connected to the separator head assembly for causing movement of the separator across the positioning ring and for causing oscillating movement of said separator, said separator comprising a separating edge, said separator having a polymeric separating edge.
- Yet another object of the present invention is to provide a separator that is incapable of being sterilized by autoclaving or steam sterilization after it has already been used one time.
- a separator should, however, be capable of being sterilized by other means, such as, for example, exposure to electromagnetic radiation, or to chemical agents.
- FIG. 1 is a diagram showing a perspective view of a separator according to one embodiment.
- FIG. 2 is a cross-sectional view of the first three layer of tissue of the cornea of an eye.
- Fig. 3 is a diagram showing a partial side view of a separator's flat leading edge according to an embodiment.
- the disclosed separator is ideally suited to the unique requirements for separating the epithelium layer from the underlying Bowman's layer. While microkeratomes developed to sever the stroma for laser in situ keratomileusis were required to be extremely hard and sharp to maintain a radius of curvature as low as 1 micron at the edge, the present separator has no such stringent requirements and can be constructed of cheaper, softer materials. In fact, the edge of the separator cannot be so sharp as to sever Bowman's layer under normal operating conditions, but instead, only has sharpness sufficient to cleave the boundary between the epithelium and Bowman's layer.
- the cornea 200 of the human eye includes five layers, the outer three of which are illustrated in FIG. 2.
- the outer most layer is known is as the epithelium layer 202 and is typically 50 to 90 microns thick.
- the epithelial layer 202 is stratified, possessing 5 to 6 layers of epithelial cells, which are held together by desmosomes (not shown).
- Bowman's membrane 204 separates the epithelium from the stroma layer 206.
- Bowman's membrane 204 is typically about 12 microns thick, while the stroma 206 is from 400 to 450 microns thick and makes up most of the thickness of the cornea.
- Fig. 3 shows a side view of a flat separating edge 302 of a separator 100 according to one embodiment.
- the polymeric separating edge 302 of the separator 100 should not be too wide such that it will reduce the consistency with which the epithelial layer 202 is penetrated.
- the separating edge 302 preferably is about 5 to 25 micrometers thick, and more preferably about 15 micrometers thick.
- Fig. 4 shows a side view of a rounded separating edge 402 according to another embodiment of the separator 100. As shown in FIG. 5, the separating edge can also come to an angled point 502, provided, however, that it is not sufficiently sharp to sever Bowman's layer when used as intended.
- the cornea 200 is forced against the undersurface of the applanator 702. This results in a flattening of the cornea 200 before it comes into contact with the separator 600.
- the separator assembly 600 moves along the cornea 200 of the eye 902
- the separator 600 engages the cornea 200 and removes the epithelium layer 202 located at the surface of the cornea 200 of the eye 902.
- the separator 600 is not sharp enough to excise Bowman's layer 204 during operation of the epithelial separator device.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002508689A CA2508689A1 (en) | 2002-12-10 | 2003-12-09 | Disposable separator for separating the epithelium layer from the cornea of an eye |
EP03789184A EP1569586A1 (en) | 2002-12-10 | 2003-12-09 | Disposable separator for separating the epithelium layer from the cornea of an eye |
AU2003293808A AU2003293808A1 (en) | 2002-12-10 | 2003-12-09 | Disposable separator for separating the epithelium layer from the cornea of an eye |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43230502P | 2002-12-10 | 2002-12-10 | |
US60/432,305 | 2002-12-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004052254A1 true WO2004052254A1 (en) | 2004-06-24 |
Family
ID=32507893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/013955 WO2004052254A1 (en) | 2002-12-10 | 2003-12-09 | Disposable separator for separating the epithelium layer from the cornea of an eye |
Country Status (7)
Country | Link |
---|---|
US (1) | US20040260320A1 (en) |
EP (1) | EP1569586A1 (en) |
KR (1) | KR20060012256A (en) |
CN (1) | CN1761436A (en) |
AU (1) | AU2003293808A1 (en) |
CA (1) | CA2508689A1 (en) |
WO (1) | WO2004052254A1 (en) |
Cited By (4)
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EP1625837A1 (en) * | 2004-08-12 | 2006-02-15 | Gebauer GmbH | Microkeratome as well as surgical blade for it |
WO2006032752A1 (en) * | 2004-09-17 | 2006-03-30 | Moria S.A. | Ophtalmological surgery tool |
US7828844B2 (en) | 2002-09-13 | 2010-11-09 | Forsight Labs, Llc | Inserting lenses into corneal epithelial pockets to improve vision |
US7883520B2 (en) | 2006-04-10 | 2011-02-08 | Forsight Labs, Llc | Corneal epithelial pocket formation systems, components and methods |
Families Citing this family (18)
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US20040127921A1 (en) * | 2002-12-30 | 2004-07-01 | Powell Ian A. | Keyed microkeratome cutting blade assembly |
US20110098790A1 (en) * | 2009-10-26 | 2011-04-28 | Albert Daxer | Methods for treating corneal disease |
DE502004002627D1 (en) * | 2003-05-02 | 2007-02-22 | Albert Daxer | DEVICE FOR CUTTING THE HORN SKIN OF AN EYE |
CN2705138Y (en) * | 2004-05-26 | 2005-06-22 | 无锡市康明医疗器械有限公司 | Automatic eye corneal epithelium separator |
US20060058822A1 (en) * | 2004-09-16 | 2006-03-16 | Sis Ag, Surgical Instrument Systems | Blade and blade carrier suitable therefor |
JP4907183B2 (en) * | 2005-02-01 | 2012-03-28 | 株式会社ニデック | Corneal surgery device and blade for corneal surgery |
BRPI0609858A2 (en) * | 2005-04-27 | 2010-05-11 | Tissue Engineering Refraction Inc | epithelial delamination device (v) and slides useful in this device |
JP4616107B2 (en) * | 2005-07-20 | 2011-01-19 | 株式会社ニデック | Corneal surgery device and head portion used by being attached to main body of corneal surgery device |
US7815657B2 (en) * | 2005-07-20 | 2010-10-19 | Nidek Co., Ltd. | Corneal surgical apparatus |
JP4616106B2 (en) * | 2005-07-20 | 2011-01-19 | 株式会社ニデック | Corneal surgery device and head portion used by being attached to main body of corneal surgery device |
ES2347571T3 (en) * | 2005-08-24 | 2010-11-02 | Wavelight Gmbh | MICROCHIRURGICAL CUTTING INSTRUMENT FOR REFRACTIVE OPHTHALMOLOGICAL TREATMENT. |
MX2008011680A (en) | 2006-03-16 | 2008-12-10 | Daxer Albert | Structural member. |
TW200803820A (en) * | 2006-03-28 | 2008-01-16 | Tissue Engineering Refraction Inc | Partially lubricious epithelial delaminator |
CN101460114B (en) | 2006-05-23 | 2011-07-06 | 阿尔贝特·达克瑟尔 | Corneal implant for correction of impaired vision in the human eye |
ES2644401T3 (en) * | 2007-04-27 | 2017-11-28 | Mani Inc. | Denudation Blade |
KR20180086546A (en) * | 2017-01-22 | 2018-08-01 | 계명대학교 산학협력단 | A ear headset device for stress measurement and stress measurement method using the same |
CN114748241A (en) * | 2021-01-09 | 2022-07-15 | 深圳市眼科医院 | Intraocular forceps with membrane separation mechanism |
US11642246B1 (en) * | 2021-12-06 | 2023-05-09 | Jon Gordon Dishler | Vibrating surgical instrument |
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2003
- 2003-12-09 CA CA002508689A patent/CA2508689A1/en not_active Abandoned
- 2003-12-09 AU AU2003293808A patent/AU2003293808A1/en not_active Abandoned
- 2003-12-09 KR KR1020057010532A patent/KR20060012256A/en not_active Application Discontinuation
- 2003-12-09 WO PCT/EP2003/013955 patent/WO2004052254A1/en not_active Application Discontinuation
- 2003-12-09 EP EP03789184A patent/EP1569586A1/en not_active Withdrawn
- 2003-12-09 CN CNA2003801091347A patent/CN1761436A/en active Pending
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7828844B2 (en) | 2002-09-13 | 2010-11-09 | Forsight Labs, Llc | Inserting lenses into corneal epithelial pockets to improve vision |
EP1625837A1 (en) * | 2004-08-12 | 2006-02-15 | Gebauer GmbH | Microkeratome as well as surgical blade for it |
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US7883520B2 (en) | 2006-04-10 | 2011-02-08 | Forsight Labs, Llc | Corneal epithelial pocket formation systems, components and methods |
Also Published As
Publication number | Publication date |
---|---|
KR20060012256A (en) | 2006-02-07 |
AU2003293808A1 (en) | 2004-06-30 |
CN1761436A (en) | 2006-04-19 |
EP1569586A1 (en) | 2005-09-07 |
CA2508689A1 (en) | 2004-06-24 |
US20040260320A1 (en) | 2004-12-23 |
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