CN215385132U - Micro limbal transplant collector for living body - Google Patents
Micro limbal transplant collector for living body Download PDFInfo
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- CN215385132U CN215385132U CN202121731642.0U CN202121731642U CN215385132U CN 215385132 U CN215385132 U CN 215385132U CN 202121731642 U CN202121731642 U CN 202121731642U CN 215385132 U CN215385132 U CN 215385132U
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- 210000004087 cornea Anatomy 0.000 claims abstract description 19
- 239000007787 solid Substances 0.000 claims abstract description 4
- 230000002093 peripheral effect Effects 0.000 claims 1
- 210000001232 limbus corneae Anatomy 0.000 abstract description 19
- 230000008859 change Effects 0.000 abstract description 5
- 231100000241 scar Toxicity 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 4
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- 210000001519 tissue Anatomy 0.000 description 21
- 238000002054 transplantation Methods 0.000 description 12
- 210000000130 stem cell Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 10
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- 210000003128 head Anatomy 0.000 description 5
- 230000002123 temporal effect Effects 0.000 description 5
- 210000001691 amnion Anatomy 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 206010072138 Limbal stem cell deficiency Diseases 0.000 description 3
- 206010071229 Procedural haemorrhage Diseases 0.000 description 3
- 210000000795 conjunctiva Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000011476 stem cell transplantation Methods 0.000 description 3
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 2
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- 230000009471 action Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
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- 210000003786 sclera Anatomy 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
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- 208000032843 Hemorrhage Diseases 0.000 description 1
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- 238000007796 conventional method Methods 0.000 description 1
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Abstract
The utility model relates to a micro limbus transplant collector for a living body, which comprises an upper forceps handle, a lower forceps handle, a knife ring and a knife board, wherein the upper forceps handle is connected with the lower forceps handle through a screw; the front end of the upper forceps handle is provided with a first hollow structure, and the front end of the lower forceps handle is provided with a second hollow structure; the tail end of the cutter ring is provided with a first protrusion embedded with the first hollow structure, and the tail end of the cutter plate is provided with a second protrusion embedded with the second hollow structure; the head end of the cutter ring is of an annular hollow structure, and the head end of the cutter plate is of an annular solid piece. Its advantages are: simple structure, easy and simple to handle, design according to the morphological characteristics of people's cornea, realize the accurate incision of corneal limbus tissue, and art person can select different corneal limbus region to carry out the collection of multiple loci, avoids repairing because of incising the scar that the area is too big to cause in traditional operation, can also change the external member by oneself simultaneously, freely arranges, adjusts the area of required transplant, effectively reduces the operation degree of difficulty and time, easily promotes.
Description
Technical Field
The utility model relates to the technical field of medical instruments, in particular to a micro limbus transplant collector for a living body.
Background
The corneal epithelial stem cells are mainly stored in the limbus, and are key to corneal epithelial turnover metabolism and injury repair. Normal limbal and corneal epithelial stem cells can act as a barrier preventing the conjunctival epithelium from invading the corneal surface. Various acquired or genetic causes, such as: loss or loss of function of corneal epithelial stem cells resulting from chemical and thermal burns, wearing contact lenses, Stevens-Johnson syndrome, congenital aniridia, etc., is called Limbal Stem Cell Deficiency (LSCD). Limbal transplantation is currently the only effective method for treating LSCD.
The limbal transplantation has been carried out so far, and various surgical methods can be selected, and the traditional method comprises the following steps: one to two pieces of 2-3-hour limbal tissue are taken from the limbal region of the eye, the anterior border of which reaches 1mm inside the limbus and the posterior border of which reaches 2mm behind the limbus (conjunctiva) and has a depth of about 100 μm. The cut corneal limbus tissue is placed on the treated ocular graft bed according to the original front and back sides and orientation, 2-4 needles are intermittently sutured at both ends of the donor by 10-0 nylon thread, and the graft is fixed on the corneal limbus part of the ocular graft. The method can obtain more corneal limbus tissues for eyes, and the eyes can heal slowly and have higher risk of corneal limbus stem cell deficiency.
Cultured limbal stem cell transplantation is one of the emerging limbal transplantation surgeries, and although the limbal tissue for the eye is only obtained at about 2x2mm (1 clock point), which overcomes the disadvantages of the conventional limbal transplantation surgeries, it requires in vitro amplification culture, depends on advanced laboratory culture conditions, and simultaneously prolongs the waiting time for patient transplantation.
In 2012, small Limbal stem cell Transplantation (SLET) proposed by Sangwan et al, which has a small amount of tissue for eye to obtain and does not require in vitro Transplantation, has a clinical effectiveness comparable to or even better than that of the conventional methods, and has become one of the most promising therapeutic approaches in Limbal Transplantation. The simple operation steps of the operation formula are as follows: the method comprises the steps of obtaining a corneal limbus graft of about 2x2mm (1 clock point) for an eye, cutting the corneal limbus graft into 8-10 tiny grafts by using scissors, uniformly adhering the tiny grafts to an amniotic membrane by using fibrin glue, and fixing the amniotic membrane on a treated cornea of the eye. However, this type of technique has the following problems, such as: (1) when the corneal limbus implant is obtained, the toughness of the corneal and scleral limbus is high, and the operation difficulty of knife setting is high; (2) when the obtained corneal limbal tissue slice is cut into a tiny transplant, the transplant is small, so that the size of the cut transplant is different, and the healing rate and even the clinical effect of different areas of the cornea can be influenced; (2) although the damage to the donor eye is much smaller than that of the traditional method, the scar repair of the donor eye still occurs according to the current clinical evidence; (3) in addition, the action mechanism of the operation is not clear at present, and the influence of the size, the distribution mode, the glue, the amniotic membrane and the like of the cut transplant on the operation is still a difficult point for research; (4) the operation is complicated in steps, needs the support of amnion, fibrin glue and the like, and limits effective popularization.
Chinese patent documents: CN201821085786.1, application date 2018.07.10, patent names: limbal stem cell transplanters. Discloses a limbal stem cell transplant device, which comprises a negative pressure ring and a tool bit; the negative pressure ring comprises a handle, a suction ring, a track and a sliding column; the sliding column is arranged on the track; the cutter head comprises a blade and a main body; the knife head is connected with a sliding column arranged on the track through a ring column, and the knife head cuts limbal stem cell tissues along the junction area of the cornea and the conjunctiva and the sclera by pushing the sliding column. Its advantages are: through the arrangement of suction rings with different types and different inclination angles, the accurate positioning of the blade in the shell of the tool bit, the distance between the tool bit and the upper end surface of the suction ring, the length of the blade and the like, the extractor can accurately cut a plurality of arc limbus stem cell tissues with adjustable lengths, the thickness of 50 mu m and the width of 3mm in the junction area of the cornea, the conjunctiva and the sclera; the operation is simple and safe, the operation difficulty is greatly reduced, the operation time is saved, the treatment effect of the operation is improved, the treatment benefit is increased, and the learning and culturing period of an operator is shortened.
Chinese patent documents: CN201320103945.7, application date 2013.03.07, patent names: an iris forceps. The iris forceps comprise a forceps handle, two forceps arms and two chucks respectively positioned at the tail ends of the two forceps arms, wherein the two forceps arms are formed at one end of the forceps handle, the chucks are respectively formed at the tail ends of the two forceps arms, and the chucks are designed to be round-head-shaped. When in use, the utility model has large contact area with iris tissues, small damage to the iris tissues and more convenient use.
The utility model discloses a limbal stem cell transplantation device in the patent document CN201821085786.1, which is applied to limbal tissue in ophthalmology, can precisely cut a plurality of arc-shaped limbal tissues with adjustable lengths, the thickness of 50um and the width of 3mm from a cornea, but the limbal tissues produced by the utility model are mainly used for the traditional limbal transplantation operation, and have great damage to the limbal tissue of an eye; in the patent document CN201320103945.7, the iris forceps is applied to pulling iris tissues in ophthalmology, and the iris forceps is composed of a temporal handle, forceps arms and two clamping heads respectively located at the ends of the two temporal arms, wherein the clamping heads are designed to be round-head-shaped, but the iris tissues are pulled instead of the limbus tissues.
In summary, there is a need for a small limbal transplant collector for living body, which has a simple structure and easy operation, is designed according to the morphological characteristics of human cornea, realizes the precise incision of limbal tissue, allows operators to select different limbal regions for multi-site collection, avoids scar repair caused by an excessively large incision area in the conventional surgery, can replace kits by themselves, is freely matched, adjusts the area of the transplant, effectively reduces the difficulty and time of the surgery, and is easy to popularize. There is no report on the micro limbal transplant collector for living body.
Disclosure of Invention
It is an object of the present invention to overcome the disadvantages of the prior art and to provide a micro limbal implant for living beings that conforms to the curvature of the limbusA body collector which can directly collect a plurality of micro limbal transplants with the same size from different areas of the living supply eye, and the area specification of each transplant is 0.4mm2/0.6mm2/0.8mm2Etc., the obtained transplant can be used directly for limbal transplantation. The application of the present invention can improve the SLET technique from the following aspects: (1) manual cutting is not needed; (2) the size of the obtained micro transplant is controllable; (3) the cornea limbus tissue collection with smaller area can be carried out from different areas of the eye, the injury to the eye is smaller than before, and the scar-free repair is hopeful to be realized; (4) and standardized operation conditions are provided for further researching the action mechanism of the SLET operation, such as the curative effect of the size, the distribution distance and the like of the transplant on the operation.
In order to achieve the purpose, the utility model adopts the technical scheme that:
a micro limbus transplant collector for a living body comprises an upper forceps handle, a lower forceps handle, a knife ring and a knife plate; the front end of the upper forceps handle is provided with a first hollow structure, and the front end of the lower forceps handle is provided with a second hollow structure; the tail end of the cutter ring is provided with a first protrusion embedded with the first hollow structure, and the tail end of the cutter plate is provided with a second protrusion embedded with the second hollow structure; the head end of the cutter ring is of an annular hollow structure, and sharp blades are arranged around the lower part of the cutter ring; the head end of the knife board is an annular solid piece, and sharp blades are arranged around the upper part of the knife board; the cutter ring is matched with the cutter plate, and the head end of the cutter ring and the head end of the cutter plate can be designed into different areas.
As a preferable technical proposal, the ends of the upper forceps handle and the lower forceps handle are connected together and elastically.
As a preferable technical proposal, the knife plate has the thickness of 0.3mm, and the curvature radius of the upper periphery of the knife plate which is a sharp blade plane is equal to the average value of the front curvature radius of the human cornea of 7.8 mm.
As a preferable technical scheme, the curvature radius of the plane of the cutter ring is equal to the mean value of 7.8mm of the curvature radius of the front cornea.
As a preferable technical scheme, the specifications of the cutter ring and the cutter plate, the diameter of the cutter plate/the outer diameter of the cutter ring/the inner diameter of the cutter ring comprise 1.6mm/1.6mm/1.28 mm; 1.8mm/1.8mm/1.56 mm; 1.0mm/1.0mm/0.9 mm.
The utility model has the advantages that:
1. the collector is designed according to the morphological characteristics of human cornea, can realize the accurate incision of corneal limbus tissue in practical application, and the operator can select different corneal limbus regions to collect multiple sites, thereby avoiding scar repair caused by overlarge incision area in the traditional operation.
2. Can accurately draw materials in practical application, obtain a plurality of limbus transplants of the same specification, the transplant that obtains can directly carry out the transplantation of small limbus stem cell, accords with the curvature of cornea when this apparatus uses simultaneously, can effectively reduce intraoperative hemorrhage, reduce limbus scar formation, still can provide the help for the experimental study of the influence of study limbus transplant size to the operation effect.
3. Simple structure, easy and simple to handle, can change the external member by oneself, the area of the required transplant body of adjustment, the collocation is free, effectively reduces the operation degree of difficulty and time, and can repeat the disinfection and use, easily promotes in the reality.
Drawings
FIG. 1 is a schematic perspective view of a micro limbal transplant collector for a living body according to the present invention.
FIG. 2 is a structural schematic diagram of an upper forceps handle and a lower forceps handle of the micro limbal transplant collector for a living body.
FIG. 3 is a schematic structural diagram of a cutter ring and a cutter plate of a micro limbal transplant collector for a living body according to the present invention.
FIG. 4 is a schematic view of the knife plate inserted into the shallow layer of the limbus in the practice of the utility model.
Figure 5 is a schematic view of the upper and lower forceps handles kneaded by the surgeon in the practical application of the utility model.
FIG. 6 is a schematic view showing the engagement between the cutter ring and the cutter plate in the practical application of the present invention.
FIG. 7 is a schematic diagram of a corneal limbal graft after dissection in accordance with the practice of the utility model.
Detailed Description
The utility model is further described with reference to the following examples and with reference to the accompanying drawings.
The reference numerals and components referred to in the drawings are as follows:
1. the upper forceps handle 11 is a first hollow structure
2. The second hollow structure of the lower forceps handle 21
3. Knife ring 31. knife ring
4. Knife plate 41, second projection
5. Limbal implant
Example 1
Referring to fig. 1, fig. 1 is a schematic perspective view of a micro limbal transplant collector for a living body according to the present invention. A micro limbus transplant collector for a living body comprises an upper forceps handle 1, a lower forceps handle 2, a knife ring 3 and a knife board 4; the tail ends of the upper forceps handle 1 and the lower forceps handle 2 are integrally and elastically connected, a first hollow structure 11 is arranged at the front end of the upper forceps handle 1, and a second hollow structure 21 is arranged at the front end of the lower forceps handle 2; the tail end of the cutter ring 3 is provided with a first protrusion 31 embedded with the first hollow structure 11, and the tail end of the cutter plate 4 is provided with a second protrusion 41 embedded with the lower groove 21; the head end of the cutter ring 3 is of an annular hollow structure, and sharp blades are arranged around the lower part of the cutter ring; the head end of the knife board 4 is an annular solid piece, and sharp blades are arranged around the upper part of the knife board; the cutter ring 3 is matched with the cutter plate 4, and the head end of the cutter ring 3 and the head end of the cutter plate 4 can be designed into different areas.
It should be noted that: the utility model is designed according to the shape of human corneal limbus, when the transplant is collected, the lower knife plate 4 can be directly inserted into the superficial corneal limbus, after the knife plate 4 is completely inserted, the upper forceps handle and the lower forceps handle are clamped (the knife plate 4 is fixed at the top end of the lower forceps handle 2, the knife ring 3 is fixed at the top end of the upper forceps handle 2), the knife ring 3 is matched with the knife plate 4 for biting and cutting, a round-like limbus transplant with corresponding specification can be successfully taken down, the cutting plane is smoother, the separation is more thorough, and the bleeding is less, which is specifically embodied as follows: the top end of the lower forceps handle 2 is connected with a knife plate 4, the knife plate 4 is a circular-like blade (the diameter is divided into different specifications), the thickness is 0.3mm, the sharp end is arranged at the top, the mean value of the curvature radius of the blade plane is about 7.8mm close to the front curvature radius of the cornea, the upper forceps handle 2 is connected with a knife ring 3, the knife ring 3 is a circular-like hollowed-out blade (the outer diameter is divided into different specifications, the inner diameter is divided into different specifications), the sharp end corresponds to the knife plate 4, and the mean value of the curvature radius of the knife ring 3 plane is about 7.8mm close to the front curvature radius of the cornea; the utility model can change the external member, change the specification of the front end cutter ring 3 and cutting board 4, thus adjust the size of the living body transplant body that needs to be gathered, the concrete embodiment is: the specifications of the cutter ring 3 and the cutter plate 4 (the diameter of the cutter plate 3/the outer diameter of the cutter ring 4/the inner diameter of the cutter ring 4) comprise 1.6mm/1.6mm/1.28 mm; 1.8mm/1.8mm/1.56 mm; 1.0mm/1.0mm/0.9mm …; the collector can accurately obtain materials in practical application, and obtain a plurality of limbal transplants with the same specification, the obtained transplants can be directly transplanted with the micro limbal stem cells, and the instrument conforms to the curvature of the cornea when in use, can effectively reduce intraoperative hemorrhage and limbal scar formation, and also can provide help for experimental research on the influence of the size of the limbal transplant on the operation effect;
the utility model relates to an operation method of a micro limbal transplant collector for a living body, which comprises the following steps: during the micro corneal limbus transplantation, the area of the corneal limbus transplant body which needs to be collected by the eye is designed according to the range of the corneal pathological changes of the eye, and a cutting board 4 and a cutting ring 3 with proper specifications are installed. The micro limbal graft collector is then used to quantitatively collect the limbus for different areas of the eye. During collection, an operator holds the temporal handle with hands, the knife plate 4 connected with the lower forceps handle 2 is inserted into the superficial corneal limbus (see the attached drawing 4), after the knife plate 4 completely enters, the upper temporal handle 1 and the lower forceps handle 2 are folded (see the attached drawing 5), so that the knife ring 3 connected with the upper temporal handle 2 is close to the knife plate 4, in the process that the knife ring 3 is in contact with the knife plate 4, the blade below the knife ring 3 directly cuts the corneal limbus into a similar circular pattern (see the attached drawing 6) shown in the knife ring 3 by acting force, a tiny corneal limbus transplant for transplantation (see the attached drawing 7) is obtained, then other parts are replaced for repeated operation, and the average obtaining time of one transplant is about 10 s. If the corneal limbus transplant with other areas needs to be obtained, only the corresponding matched knife ring 3 and knife plate 4 need to be replaced.
The micro limbal transplant collector for the living body is designed according to the morphological characteristics of human cornea, can realize the accurate cutting of the limbal tissue in practical application, and can be used for collecting multiple sites by an operator by selecting different limbal regions, thereby avoiding the scar repair caused by overlarge cutting area in the traditional operation; the instrument can accurately obtain materials in practical application, a plurality of limbal transplants with the same specification can be obtained, the obtained transplants can be directly transplanted to the micro limbal stem cells, and simultaneously the instrument conforms to the curvature of the cornea when in use, can effectively reduce intraoperative hemorrhage and limbal scarring, and also can provide help for experimental research on the influence of the size of the limbal transplant on the operation effect; simple structure, easy and simple to handle, can change the external member by oneself, the area of the required transplant body of adjustment, the collocation is free, effectively reduces the operation degree of difficulty and time, and can repeat the disinfection and use, easily promotes in the reality.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.
Claims (5)
1. A micro limbus transplant collector for a living body is characterized by comprising an upper forceps handle, a lower forceps handle, a knife ring and a knife plate; the front end of the upper forceps handle is provided with a first hollow structure, and the front end of the lower forceps handle is provided with a second hollow structure; the tail end of the cutter ring is provided with a first protrusion embedded with the first hollow structure, and the tail end of the cutter plate is provided with a second protrusion embedded with the second hollow structure; the head end of the cutter ring is of an annular hollow structure, and sharp blades are arranged around the lower part of the cutter ring; the head end of the knife board is an annular solid piece, and sharp blades are arranged around the upper part of the knife board; the cutter ring is matched with the cutter plate, and the head end of the cutter ring and the head end of the cutter plate can be designed into different areas.
2. The collector for a tiny limbal transplant for a living body according to claim 1, wherein the ends of the upper forceps handle and the lower forceps handle are integrally and elastically connected.
3. The collector of a micro limbal transplant for a living body according to claim 1 wherein the blade plate is 0.3mm thick and the radius of curvature of the upper peripheral sharp blade plane is equal to the mean 7.8mm of the radius of curvature of the anterior human cornea.
4. The collector of a micro limbal transplant for a living body according to claim 1 wherein the radius of curvature of the plane of the blade ring is equal to the mean radius of curvature of 7.8mm before human cornea.
5. The micro limbal graft collector for a living body according to claim 1, wherein the knife ring and knife plate are arranged in a format comprising knife plate diameter/knife ring outer diameter/knife ring inner diameter, which comprises 1.6mm/1.6mm/1.28 mm; 1.8mm/1.8mm/1.56 mm; 1.0mm/1.0mm/0.9 mm.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113456341A (en) * | 2021-07-28 | 2021-10-01 | 上海市同济医院 | Micro limbus transplant collector for living body |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113456341A (en) * | 2021-07-28 | 2021-10-01 | 上海市同济医院 | Micro limbus transplant collector for living body |
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