WO2004042388A3 - Diagnostics and therapeutics for diseases associated with human phosphodiesterase 8a (pde8a) - Google Patents

Diagnostics and therapeutics for diseases associated with human phosphodiesterase 8a (pde8a) Download PDF

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Publication number
WO2004042388A3
WO2004042388A3 PCT/EP2003/011876 EP0311876W WO2004042388A3 WO 2004042388 A3 WO2004042388 A3 WO 2004042388A3 EP 0311876 W EP0311876 W EP 0311876W WO 2004042388 A3 WO2004042388 A3 WO 2004042388A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
pde8a
therapeutics
diagnostics
diseases associated
Prior art date
Application number
PCT/EP2003/011876
Other languages
French (fr)
Other versions
WO2004042388A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Priority to EP03810408A priority Critical patent/EP1604035A2/en
Priority to AU2003276187A priority patent/AU2003276187A1/en
Publication of WO2004042388A2 publication Critical patent/WO2004042388A2/en
Publication of WO2004042388A3 publication Critical patent/WO2004042388A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides a human PDE8A which is associated with the disorders of the peripheral and central nervous system (eg. Alzheimer), cardiovascular diseases (eg. arteriosclerosis), gastroenterological disease (eg. esophagus tumor), urological disorders (eg.prostate BPH), reproduction disorders (eg. uterus tumor) and respiratory diseases (eg. lung tumor). The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases, gastroenterological disease, urological disorders, reproduction disorders and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE8A as well as pharmaceutical compositions comprising such compounds.
PCT/EP2003/011876 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 8a (pde8a) WO2004042388A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03810408A EP1604035A2 (en) 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 8a (pde8a)
AU2003276187A AU2003276187A1 (en) 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 8a (pde8a)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02025000.7 2002-11-08
EP02025000 2002-11-08

Publications (2)

Publication Number Publication Date
WO2004042388A2 WO2004042388A2 (en) 2004-05-21
WO2004042388A3 true WO2004042388A3 (en) 2004-09-23

Family

ID=32309324

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011876 WO2004042388A2 (en) 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 8a (pde8a)

Country Status (3)

Country Link
EP (1) EP1604035A2 (en)
AU (1) AU2003276187A1 (en)
WO (1) WO2004042388A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798246A (en) * 1996-03-25 1998-08-25 Incyte Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterase
US6080548A (en) * 1997-11-19 2000-06-27 Incyte Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterases
US6133007A (en) * 1997-10-16 2000-10-17 Icos Corporation Phosphodiesterase 8A

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798246A (en) * 1996-03-25 1998-08-25 Incyte Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterase
US6133007A (en) * 1997-10-16 2000-10-17 Icos Corporation Phosphodiesterase 8A
US6080548A (en) * 1997-11-19 2000-06-27 Incyte Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FISHER D A ET AL: "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 246, no. 3, 29 May 1998 (1998-05-29), pages 570 - 577, XP002091360, ISSN: 0006-291X *
PEREZ-TORRES S ET AL: "Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization.", EXPERIMENTAL NEUROLOGY, vol. 182, no. 2, August 2003 (2003-08-01), pages 322 - 334, XP002270743, ISSN: 0014-4886 *
PEREZ-TORRES S ET AL: "Cellular expression of cAMP phosphodiesterase PDE4A, PDE4B and PDE4D mRNAs in Alzheimer's disease brains", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, 31st Annual Meeting of the Society for Neuroscience;San Diego, California, USA; November 10-15, 2001, pages 1134, XP002270742, ISSN: 0190-5295 *
SODERLING S H ET AL: "REGULATION OF CAMP AND CGMP SIGNALING: NEW PHOSPHODIESTERASES AND NEW FUNCTIONS", CURRENT OPINION IN CELL BIOLOGY, CURRENT SCIENCE, LONDON, GB, vol. 12, no. 2, April 2000 (2000-04-01), pages 174 - 179, XP001003042, ISSN: 0955-0674 *

Also Published As

Publication number Publication date
EP1604035A2 (en) 2005-12-14
AU2003276187A8 (en) 2004-06-07
AU2003276187A1 (en) 2004-06-07
WO2004042388A2 (en) 2004-05-21

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