WO2004042387A3 - Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a1 (pde11a1) - Google Patents

Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a1 (pde11a1) Download PDF

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Publication number
WO2004042387A3
WO2004042387A3 PCT/EP2003/011875 EP0311875W WO2004042387A3 WO 2004042387 A3 WO2004042387 A3 WO 2004042387A3 EP 0311875 W EP0311875 W EP 0311875W WO 2004042387 A3 WO2004042387 A3 WO 2004042387A3
Authority
WO
WIPO (PCT)
Prior art keywords
pde11a1
therapeutics
diagnostics
diseases associated
compounds
Prior art date
Application number
PCT/EP2003/011875
Other languages
French (fr)
Other versions
WO2004042387A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Priority to EP03775231A priority Critical patent/EP1604034A2/en
Priority to AU2003283302A priority patent/AU2003283302A1/en
Publication of WO2004042387A2 publication Critical patent/WO2004042387A2/en
Publication of WO2004042387A3 publication Critical patent/WO2004042387A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

The invention provides a human PDE11A1 which is associated with the disorders of the peripheral and central nervous system (e.g. Alzheimer), cardiovascular diseases, cancer (e.g. colon tumor, lung tumor) and gastroenterological diseases (e.g. liver cirrhosis). The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases, cancer and gastroenterological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE11A1 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2003/011875 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a1 (pde11a1) WO2004042387A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03775231A EP1604034A2 (en) 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a1 (pde11a1)
AU2003283302A AU2003283302A1 (en) 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a1 (pde11a1)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02024997.5 2002-11-08
EP02024997 2002-11-08

Publications (2)

Publication Number Publication Date
WO2004042387A2 WO2004042387A2 (en) 2004-05-21
WO2004042387A3 true WO2004042387A3 (en) 2004-07-15

Family

ID=32309321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011875 WO2004042387A2 (en) 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a1 (pde11a1)

Country Status (3)

Country Link
EP (1) EP1604034A2 (en)
AU (1) AU2003283302A1 (en)
WO (1) WO2004042387A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0967284A1 (en) * 1998-05-28 1999-12-29 Pfizer Limited Phosphodiesterases
WO2001066716A1 (en) * 2000-03-07 2001-09-13 Kyowa Hakko Kogyo Co.,Ltd. Polypeptide having phosphodiesterase activity
US6416991B1 (en) * 1999-01-07 2002-07-09 Incyte Genomics, Inc. Human cyclic nucleotide PDES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0967284A1 (en) * 1998-05-28 1999-12-29 Pfizer Limited Phosphodiesterases
US6416991B1 (en) * 1999-01-07 2002-07-09 Incyte Genomics, Inc. Human cyclic nucleotide PDES
WO2001066716A1 (en) * 2000-03-07 2001-09-13 Kyowa Hakko Kogyo Co.,Ltd. Polypeptide having phosphodiesterase activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MORITA Y ET AL: "Distribution of neurons expressing the PDE10A mRNA in the rat brain", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, 31st Annual Meeting of the Society for Neuroscience;San Diego, California, USA; November 10-15, 2001, pages 105, XP001176686, ISSN: 0190-5295 *
PEREZ-TORRES S ET AL: "Cellular expression of cAMP phosphodiesterase PDE4A, PDE4B and PDE4D mRNAs in Alzheimer's disease brains", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, 31st Annual Meeting of the Society for Neuroscience;San Diego, California, USA; November 10-15, 2001, pages 1134, XP002271232, ISSN: 0190-5295 *
YUASA KEIZO ET AL: "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A). Comparison of rat and human PDE11A splicing variants", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 268, no. 16, August 2001 (2001-08-01), pages 4440 - 4448, XP002196953, ISSN: 0014-2956 *

Also Published As

Publication number Publication date
WO2004042387A2 (en) 2004-05-21
AU2003283302A8 (en) 2004-06-07
AU2003283302A1 (en) 2004-06-07
EP1604034A2 (en) 2005-12-14

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