WO2004042386A3 - Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a3 (pde11a3) - Google Patents

Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a3 (pde11a3) Download PDF

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Publication number
WO2004042386A3
WO2004042386A3 PCT/EP2003/011873 EP0311873W WO2004042386A3 WO 2004042386 A3 WO2004042386 A3 WO 2004042386A3 EP 0311873 W EP0311873 W EP 0311873W WO 2004042386 A3 WO2004042386 A3 WO 2004042386A3
Authority
WO
WIPO (PCT)
Prior art keywords
pde11a3
disorders
therapeutics
diagnostics
diseases
Prior art date
Application number
PCT/EP2003/011873
Other languages
French (fr)
Other versions
WO2004042386A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Priority to AU2003279322A priority Critical patent/AU2003279322A1/en
Priority to EP03772261A priority patent/EP1604033A2/en
Publication of WO2004042386A2 publication Critical patent/WO2004042386A2/en
Publication of WO2004042386A3 publication Critical patent/WO2004042386A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

The invention provides a human PDE11A3 which is associated with the disorders of the peripheral and central nervous system (e.g. Alzheimer), cancer (e.g. lung tumor, breast tumor), gastroenterological diseases (e.g. liver cirrhosis), reproduction disorders and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cancer, gastroenterological diseases, reproduction disorders and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE11A3 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2003/011873 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a3 (pde11a3) WO2004042386A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003279322A AU2003279322A1 (en) 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a3 (pde11a3)
EP03772261A EP1604033A2 (en) 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a3 (pde11a3)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02024998 2002-11-08
EP02024998.3 2002-11-08

Publications (2)

Publication Number Publication Date
WO2004042386A2 WO2004042386A2 (en) 2004-05-21
WO2004042386A3 true WO2004042386A3 (en) 2004-07-15

Family

ID=32309322

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011873 WO2004042386A2 (en) 2002-11-08 2003-10-25 Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a3 (pde11a3)

Country Status (3)

Country Link
EP (1) EP1604033A2 (en)
AU (1) AU2003279322A1 (en)
WO (1) WO2004042386A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1085089A2 (en) * 1999-09-17 2001-03-21 Pfizer Limited Human cyclic nucleotide phosphodiesterase
WO2001046436A1 (en) * 1999-12-22 2001-06-28 Tanabe Seiyaku Co., Ltd. Novel phosphodiesterases and genes thereof
WO2001066716A1 (en) * 2000-03-07 2001-09-13 Kyowa Hakko Kogyo Co.,Ltd. Polypeptide having phosphodiesterase activity
WO2002031111A2 (en) * 2000-10-12 2002-04-18 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1085089A2 (en) * 1999-09-17 2001-03-21 Pfizer Limited Human cyclic nucleotide phosphodiesterase
WO2001046436A1 (en) * 1999-12-22 2001-06-28 Tanabe Seiyaku Co., Ltd. Novel phosphodiesterases and genes thereof
US20030190672A1 (en) * 1999-12-22 2003-10-09 Kenji Omori Novel phosphodiesterase and genes thereof
WO2001066716A1 (en) * 2000-03-07 2001-09-13 Kyowa Hakko Kogyo Co.,Ltd. Polypeptide having phosphodiesterase activity
WO2002031111A2 (en) * 2000-10-12 2002-04-18 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MORITA Y ET AL: "Distribution of neurons expressing the PDE10A mRNA in the rat brain", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, 31st Annual Meeting of the Society for Neuroscience;San Diego, California, USA; November 10-15, 2001, pages 105, XP001176686, ISSN: 0190-5295 *
PEREZ-TORRES S ET AL: "Cellular expression of cAMP phosphodiesterase PDE4A, PDE4B and PDE4D mRNAs in Alzheimer's disease brains", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, 31st Annual Meeting of the Society for Neuroscience;San Diego, California, USA; November 10-15, 2001, pages 1134, XP002271232, ISSN: 0190-5295 *

Also Published As

Publication number Publication date
WO2004042386A2 (en) 2004-05-21
EP1604033A2 (en) 2005-12-14
AU2003279322A8 (en) 2004-06-07
AU2003279322A1 (en) 2004-06-07

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