WO2004097358A3 - Diagnostics and therapeutics for diseases associated with human transmembrane serine protease 2 (tmprss2) - Google Patents

Diagnostics and therapeutics for diseases associated with human transmembrane serine protease 2 (tmprss2) Download PDF

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Publication number
WO2004097358A3
WO2004097358A3 PCT/EP2004/004163 EP2004004163W WO2004097358A3 WO 2004097358 A3 WO2004097358 A3 WO 2004097358A3 EP 2004004163 W EP2004004163 W EP 2004004163W WO 2004097358 A3 WO2004097358 A3 WO 2004097358A3
Authority
WO
WIPO (PCT)
Prior art keywords
tmprss2
diseases
therapeutics
diagnostics
serine protease
Prior art date
Application number
PCT/EP2004/004163
Other languages
French (fr)
Other versions
WO2004097358A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Stefanie Polej
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Stefanie Polej
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts, Stefanie Polej filed Critical Bayer Healthcare Ag
Publication of WO2004097358A2 publication Critical patent/WO2004097358A2/en
Publication of WO2004097358A3 publication Critical patent/WO2004097358A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Abstract

The invention provides a human TMPRSS2 which is associated with the cardiovascular disorders, endocrinological diseases, gastroenterological diseqases, metabolic diseases, cancer, respiratory diseases, urological disorders and inflammation. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrinological diseases, gastroenterological diseqases, metabolic diseases, cancer, respiratory diseases, urological disorders and inflammation. The invention also features compounds which bind to and/or activate or inhibit the activity of TMPRSS2 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/004163 2003-05-02 2004-04-20 Diagnostics and therapeutics for diseases associated with human transmembrane serine protease 2 (tmprss2) WO2004097358A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03010005 2003-05-02
EP03010005.1 2003-05-02

Publications (2)

Publication Number Publication Date
WO2004097358A2 WO2004097358A2 (en) 2004-11-11
WO2004097358A3 true WO2004097358A3 (en) 2005-02-10

Family

ID=33395783

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/004163 WO2004097358A2 (en) 2003-05-02 2004-04-20 Diagnostics and therapeutics for diseases associated with human transmembrane serine protease 2 (tmprss2)

Country Status (1)

Country Link
WO (1) WO2004097358A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
US9303291B2 (en) 2007-07-06 2016-04-05 The Regents Of The University Of Michigan MIPOL1-ETV1 gene rearrangements

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9957569B2 (en) 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
CA2622295C (en) 2005-09-12 2019-01-15 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US8106037B2 (en) 2007-08-03 2012-01-31 The Brigham And Women's Hospital, Inc. Identification and treatment of estrogen responsive prostate tumors
AU2010295689B2 (en) 2009-09-17 2014-02-13 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
KR20150008383A (en) 2012-04-16 2015-01-22 리제너론 파아마슈티컬스, 인크. Methods for treating or preventing influenza virus infection by administering a serine protease inhibitor
EP4063856A1 (en) * 2021-03-25 2022-09-28 Universiteit Antwerpen Methods and compositions for in vitro screening of protease inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062942A2 (en) * 1998-06-01 1999-12-09 Urogenesys, Inc. Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
WO2000000605A1 (en) * 1998-06-29 2000-01-06 Myriad Genetics, Inc. Tmprss2 is a tumor suppressor
WO2002004953A2 (en) * 2000-07-12 2002-01-17 Agensys, Inc. Novel tumor antigen useful in diagnosis and therapy of bladder, ovary, lung and kidney cancers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062942A2 (en) * 1998-06-01 1999-12-09 Urogenesys, Inc. Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
WO2000000605A1 (en) * 1998-06-29 2000-01-06 Myriad Genetics, Inc. Tmprss2 is a tumor suppressor
WO2002004953A2 (en) * 2000-07-12 2002-01-17 Agensys, Inc. Novel tumor antigen useful in diagnosis and therapy of bladder, ovary, lung and kidney cancers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AIMES RONALD T ET AL: "Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis.", THROMBOSIS AND HAEMOSTASIS, vol. 89, no. 3, March 2003 (2003-03-01), pages 561 - 572, XP009038637, ISSN: 0340-6245 *
VAARALA MARKKU H ET AL: "The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: Detection of mutated TMPRSS2 form in a case of aggressive disease", INTERNATIONAL JOURNAL OF CANCER, vol. 94, no. 5, 1 December 2001 (2001-12-01), pages 705 - 710, XP002302825, ISSN: 0020-7136 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9303291B2 (en) 2007-07-06 2016-04-05 The Regents Of The University Of Michigan MIPOL1-ETV1 gene rearrangements
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
US9567644B2 (en) 2010-11-19 2017-02-14 The Regents Of The University Of Michigan RAF gene fusions

Also Published As

Publication number Publication date
WO2004097358A2 (en) 2004-11-11

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