WO2004039453A3 - 7h-dibenzo[b,g][1,5]dioxocin-5-on-derivate und ihre verwendung - Google Patents

7h-dibenzo[b,g][1,5]dioxocin-5-on-derivate und ihre verwendung Download PDF

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Publication number
WO2004039453A3
WO2004039453A3 PCT/EP2003/011619 EP0311619W WO2004039453A3 WO 2004039453 A3 WO2004039453 A3 WO 2004039453A3 EP 0311619 W EP0311619 W EP 0311619W WO 2004039453 A3 WO2004039453 A3 WO 2004039453A3
Authority
WO
WIPO (PCT)
Prior art keywords
dioxocin
dibenzo
derivatives
hypolipoproteinaemia
hypertriglyceridaemia
Prior art date
Application number
PCT/EP2003/011619
Other languages
English (en)
French (fr)
Other versions
WO2004039453A2 (de
Inventor
Hilmar Bischoff
Frank-Thorsten Hafner
Carsten Schmeck
Joachim Telser
Alexandros Vakalopoulos
Gabriele Wirtz
Marcus Bauser
David Brueckner
Martina Wuttke
Original Assignee
Bayer Healthcare Ag
Hilmar Bischoff
Frank-Thorsten Hafner
Carsten Schmeck
Joachim Telser
Alexandros Vakalopoulos
Gabriele Wirtz
Marcus Bauser
David Brueckner
Martina Wuttke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Hilmar Bischoff, Frank-Thorsten Hafner, Carsten Schmeck, Joachim Telser, Alexandros Vakalopoulos, Gabriele Wirtz, Marcus Bauser, David Brueckner, Martina Wuttke filed Critical Bayer Healthcare Ag
Priority to US10/531,881 priority Critical patent/US20060247303A1/en
Priority to CA002503881A priority patent/CA2503881A1/en
Priority to EP03753564A priority patent/EP1560630A2/de
Priority to AU2003271734A priority patent/AU2003271734A1/en
Priority to JP2004547534A priority patent/JP2006508938A/ja
Publication of WO2004039453A2 publication Critical patent/WO2004039453A2/de
Publication of WO2004039453A3 publication Critical patent/WO2004039453A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/12—Eight-membered rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Die vorliegende Anmeldung betrifft substituierte 7H-Dibenzo[b,g][1,5]dioxocin-5-on-Derivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung in Arzneimitteln, insbesondere als Inhibitoren des Cholesterin-Ester-Transfer-Proteins (CETP) zur Behandlung und/oder Prävention kardiovaskulärer Erkrankungen, insbesondere von Hypolipoproteinämie, Dyslipidämien, Hypertriglyceridämien, Hyperlipidämien und Arteriosklerose.
PCT/EP2003/011619 2002-10-31 2003-10-21 7h-dibenzo[b,g][1,5]dioxocin-5-on-derivate und ihre verwendung WO2004039453A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/531,881 US20060247303A1 (en) 2002-10-31 2003-10-21 7H-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof
CA002503881A CA2503881A1 (en) 2002-10-31 2003-10-21 7h-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof
EP03753564A EP1560630A2 (de) 2002-10-31 2003-10-21 7h-dibenzo[b,g][1,5]dioxocin-5-on-derivate und ihre verwendung
AU2003271734A AU2003271734A1 (en) 2002-10-31 2003-10-21 7h-dibenzo(b,g)(1,5)dioxocin-5-one derivatives and use thereof
JP2004547534A JP2006508938A (ja) 2002-10-31 2003-10-21 ７Ｈ−ジベンゾ［ｂ，ｇ］［１，５］ジオキソシン−５−オン誘導体およびそれらの使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10250687A DE10250687A1 (de) 2002-10-31 2002-10-31 7H-Dibenzo(b,g)(1,5)dioxocin-5-on-Derivate und ihre Verwendung
DE10250687.6 2002-10-31

Publications (2)

Publication Number Publication Date
WO2004039453A2 WO2004039453A2 (de) 2004-05-13
WO2004039453A3 true WO2004039453A3 (de) 2004-08-05

Family

ID=32103199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011619 WO2004039453A2 (de) 2002-10-31 2003-10-21 7h-dibenzo[b,g][1,5]dioxocin-5-on-derivate und ihre verwendung

Country Status (11)

Country Link
US (1) US20060247303A1 (de)
EP (1) EP1560630A2 (de)
JP (1) JP2006508938A (de)
AR (1) AR041723A1 (de)
AU (1) AU2003271734A1 (de)
CA (1) CA2503881A1 (de)
DE (1) DE10250687A1 (de)
PE (1) PE20040786A1 (de)
TW (1) TW200420555A (de)
UY (1) UY28047A1 (de)
WO (1) WO2004039453A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070087197A (ko) 2003-09-26 2007-08-27 니뽄 다바코 산교 가부시키가이샤 잔여 리포프로테인 생산 저해 방법
ATE555097T1 (de) * 2004-12-18 2012-05-15 Bayer Pharma AG 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente
US7972954B2 (en) * 2006-01-24 2011-07-05 Infineon Technologies Ag Porous silicon dielectric
DE102006012548A1 (de) * 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
CN101298447B (zh) * 2008-06-27 2011-05-25 扬州慧清医药科技开发有限公司 2-苄氧基-3-乙基-4-甲基-5-氯-6-［(四氢-2h-吡咯-2-氧基)甲基］苯酚的一种合成方法
CN101298448B (zh) * 2008-06-27 2011-01-05 扬州慧清医药科技开发有限公司 2-苄氧基-3-乙基-4-甲基-5-氯-6-[(四氢-2h-吡喃-2-氧基)甲基]苯酚的合成方法
CN103044383B (zh) * 2011-10-17 2015-01-07 复旦大学 一种制备天然产物Penicillide消旋体的方法
CN103087040B (zh) * 2011-11-01 2015-10-28 复旦大学 Penicillide衍生物、其制备方法及其在药用用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0352884A (ja) * 1989-07-20 1991-03-07 Kitasato Inst:The Ｆｏ―６０８ａ物質およびその製造法
US5089487A (en) * 1989-06-13 1992-02-18 Bayer Aktiengesellschaft Circulation-active dibenzo[1,5]dioxocin-5-ones
US5198463A (en) * 1992-03-30 1993-03-30 Merck & Co., Inc. Oxytocin antagonists
WO1994012175A1 (en) * 1992-11-25 1994-06-09 Taisho Pharmaceutical Co., Ltd. Lipid level depressant containing penicillide compound as active ingredient
WO1994018190A1 (en) * 1993-02-08 1994-08-18 Taisho Pharmaceutical Co., Ltd. Depsidone compound

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089487A (en) * 1989-06-13 1992-02-18 Bayer Aktiengesellschaft Circulation-active dibenzo[1,5]dioxocin-5-ones
JPH0352884A (ja) * 1989-07-20 1991-03-07 Kitasato Inst:The Ｆｏ―６０８ａ物質およびその製造法
US5198463A (en) * 1992-03-30 1993-03-30 Merck & Co., Inc. Oxytocin antagonists
WO1994012175A1 (en) * 1992-11-25 1994-06-09 Taisho Pharmaceutical Co., Ltd. Lipid level depressant containing penicillide compound as active ingredient
WO1994018190A1 (en) * 1993-02-08 1994-08-18 Taisho Pharmaceutical Co., Ltd. Depsidone compound

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199116, Derwent World Patents Index; Class B02, AN 1991-112659, XP002267674 *
DATABASE WPI Section Ch Week 199424, Derwent World Patents Index; Class B02, AN 1994-199937, XP002267673 *
DATABASE WPI Section Ch Week 199434, Derwent World Patents Index; Class B02, AN 1994-279649, XP002267672 *

Also Published As

Publication number Publication date
AU2003271734A1 (en) 2004-05-25
EP1560630A2 (de) 2005-08-10
TW200420555A (en) 2004-10-16
AR041723A1 (es) 2005-05-26
UY28047A1 (es) 2004-05-31
DE10250687A1 (de) 2004-05-13
JP2006508938A (ja) 2006-03-16
US20060247303A1 (en) 2006-11-02
PE20040786A1 (es) 2004-12-03
WO2004039453A2 (de) 2004-05-13
CA2503881A1 (en) 2004-05-13

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