Classifications

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  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
  • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
  • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
  • C07C329/12—Dithiocarbonic acids; Derivatives thereof
  • C07C329/14—Esters of dithiocarbonic acids
  • C07C329/16—Esters of dithiocarbonic acids having sulfur atoms of dithiocarbonic groups bound to acyclic carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
  • C07C329/12—Dithiocarbonic acids; Derivatives thereof
  • C07C329/14—Esters of dithiocarbonic acids
  • C07C329/18—Esters of dithiocarbonic acids having sulfur atoms of dithiocarbonic groups bound to carbon atoms of rings other than six-membered aromatic rings
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
  • C07C333/14—Dithiocarbamic acids; Derivatives thereof
  • C07C333/18—Esters of dithiocarbamic acids
  • C07C333/20—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to hydrogen atoms or to acyclic carbon atoms
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  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
  • C07C333/14—Dithiocarbamic acids; Derivatives thereof
  • C07C333/18—Esters of dithiocarbamic acids
  • C07C333/24—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
  • C08F2/00—Processes of polymerisation
  • C08F2/38—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
  • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
  • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
  • C08F20/10—Esters
  • C08F20/12—Esters of monohydric alcohols or phenols
  • C08F20/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
  • C08F20/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G75/00—Macromolecular compounds obtained by reactions forming a linkage containing sulfur with or without nitrogen, oxygen, or carbon in the main chain of the macromolecule
  • C08G75/28—Polythiocarbonates

Definitions

• the present invention relates to s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ "- acetic acid) - trithiocarbonates and derivatives thereof, as well as a process for making the same.
• other functional end groups can be derived from the carboxylic acid end groups.
• the compounds can be utilized as initiators, chain transfer agents, or terminators for controlled free radical polymerizations. Free radical polymerizations utilizing s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " -acetic acid) - trithiocarbonate compounds generally form telechelic polymers.
• an initiator other than the s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " -acetic acid) - trithiocarbonate compound is also utilized, a polymer having a single functional end group is formed in proportion to the amount of the initiator to the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " -acetic acid) - trithiocarbonate compound utilized.
• dithiocarbonate derivatives are disclosed, along with a process for preparing the same.
• the dithiocarbonate compounds can be utilized as initators, chain transfer agents and/or terminators in controlled free radical polymerizations.
• the dithiocarbonates can be used to produce polymers having narrow molecular weight distribution.
• the compounds of the present invention can also introduce functional groups into the resulting polymers.
• the dithiocarbonate compounds have low odor and are substantially colorless.
• Trithiocarbonate compounds have been claimed for various applications, such as pesticides for agriculture, and also as lubricating oil additives.
• the prior art WO 98/01478 reference discloses the use of thiocarbonates to conduct living free radical polymerizations.
• the reference is limited to alkyl and benzyl functional groups, and is unable to make any aryl or carboxylic acid substituted trithiocarbonates with general methods known to the art.
• the WO/01 478 reference states in the background that experiments have shown that dithiocarbamate derivatives have low transfer constants and are substantially ineffective in conferring living characteristics to radical polymerizations.
• U. S. Patent No. 6,1 53,705 relates to a process for polymerizing block polymers of general formula (I):
• the compounds of the present invention are able to confer living characteristics to a free radical polymerization.
• the present invention relates to s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ "- acetic acid) - trithiocarbonates which have the general formula:
• R 2 R 2 where R 1 and R 2 are set forth below, to derivatives thereof, and to a process for making the same.
• the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " -acetic acid) trithiocarbonate compounds can generally be formed from carbon disulfide, a haloform, and a ketone in a strong base, such as sodium hydroxide, followed by acidification.
• the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " -acetic acid) trithiocarbonate compounds can be used as inifertors, i.e. as initiators and chain transfer agents, and/or chain terminators or as a chain-transfer agent during polymerization. The compounds can thus be utilized to control free radical polymerization thermally and chemically to give narrow molecular weight distributions.
• Polymerization of monomers can be in bulk, in emulsion, or in solution.
• Block copolymers can be made if two or more monomers are polymerized in succession.
• the difunctional acid end groups present can further react with other reactive polymers or monomers to form block or random copolymers.
• Free radical polymerizations utilizing the s,s'- bis-( ⁇ , ⁇ '-disubstituted- ⁇ " -acetic acid) - trithiocarbonate compounds generally form telechelic polymers.
• an initiator other than the s,s'-bis- ( ⁇ , ⁇ '-disubstituted - ⁇ " - acetic acid) - trithiocarbonate compound is also utilized, a polymer having a single functional end group is formed in proportion to the amount of said other initiator to the s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " - acetic acid) - trithiocarbonate compound utilized.
• dithiocarbonate compounds of the present invention have the general formulae:
• the dithiocarbonate compounds are xanthate and dithiocarbamate derivatives. A process for preparing the dithiocarbonate compounds is disclosed.
• the dithiocarbonate compounds can be utilized as chain transfer agents in free radical polymerizations, as well as initiators and/or chain terminators. Narrow molecular weight distribution polymers can advantageously be produced with the dithiocarbonates of the present invention.
• the polymers formed in the presence of the dithiocarbonate compounds have at least one terminal carboxyl group which can be further reacted to form block or random copolymers.
• the monomers or polymers polymerized onto the dithiocarbonate compounds are added between the single bonded sulfur atom and the adjacent tertiary carbon atom.
• the polymerizations are conducted under inert atmospheres.
• the compounds and/or the polymers or copolymers of the present invention can be made water soluble or water dispersible through their metal or ammonium salts of the carboxylic acid group.
• T, R , R , R , polymer, a, g, j and f are defined hereinbelow.
• R 1 and R 2 can be the same or different, and can be linear or branched alkyls having from 1 to about 6 carbon atoms, or a C, to about C 6 alkyl having one or more substituents, or one or more aryls or a substituted aryl group having 1 to 6 substituents on the aryl ring, where the one or more substituents, independently, comprise an alkyl having from 1 to 6 carbon atoms; or an aryl; or a halogen such as fluorine or chlorine; or a cyano group; or an ether having a total of from 2 to about 20 carbon atoms such as methoxy, or hexanoxy; or a nitro; or combinations thereof.
• R 1 and R 2 can also form or be a part of a cyclic ring having from 5 to about 1 2 total carbon atoms.
• R 1 and R 2 are preferably, independently, methyl or phenyl groups.
• reaction formula for the s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " -acetic acid) - trithiocarbonates of the present invention can be generally written as follows:
• the process utilized to form the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ "- acetic acid) - trithiocarbonate compounds of the present invention is generally a multi-step process and includes combining the carbon disulfide and a base whereby an intermediate trithio structure is formed, see I, II, III and IV.
• Ketone can serve as solvent for the carbon disulfide/base reaction and thus can be added in the first step of the reaction.
• the haloform, or haloform and ketone, or a ⁇ -trihalomethyl- ⁇ -alkanol are added to the trithio intermediate mixture and reacted in the presence of additional base, see V, VI, and VII .
• reaction product see IX
• the reaction is carried out at a temperature sufficient to complete the interaction of the reactants so as to produce the s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " - acetic acid) - trithiocarbonate compound in a desired time.
• the reaction can be carried out at any temperature within a wide range from about the freezing point of the reaction mass to about the reflux temperature of the solvent.
• the reaction temperature is generally from about minus 1 5° C to about 80° C, desirably from about 0° C to about
• the reaction can be performed at atmospheric pressure.
• the reaction time depends upon several factors, with the temperature being most influential.
• the reaction is generally complete within 20 hours and preferably within 10 hours.
• phase transfer catalyst is preferably utilized if a solvent is used in the reaction.
• solvents are set forth herein below.
• the ketone utilized in the reaction may double as a solvent, and therefore no catalyst usually is needed.
• the amount of phase transfer catalyst, when utilized in the present invention, is generally from about 0.1 mole percent to about 10 mole percent, desirably from about 0.5 mole percent to about 5 mole percent and preferably from about 2 mole percent to about 4 mole percent per mole of carbon disulfide.
• the phase transfer catalysts can be polyether, and/or an onium salt including a quaternary or tertiary organic compound of a group VA or VIA element of the Periodic Table and salts thereof. Most preferred are quaternary amines, and salts thereof.
• Onium salts more particularly refer to tertiary or quaternary amines and salts such as are generally used in the phase transfer catalysis of heterogeneous reaction in immiscible liquids.
• the general requirement for the onium salt chosen is that it be soluble in both the organic and aqueous phases, when these two liquid phases are present, and usually a little more soluble in the organic phase than the aqueous phase.
• the reaction will also proceed with a phase transfer catalyst when there is only a single organic liquid phase present, but such a reaction is less preferable than one in which both aqueous and organic liquid phases are present.
• a wide variety of onium salts is effective in this ketoform synthesis.
• the onium salts include the well-known salts, tertiary amines and quaternary compounds of group VA elements of the Periodic Table, and some Group VIA elements such as are disclosed in the U .S. Patent No.
• phase transfer catalyst exchanges its original ion for other ions in the aqueous phase, making it possible to carry our chemistry there with the transported anion, including OH-ions.
• the onium salts used in this synthesis include one or more groups having the formula (R n Y) + X " , wherein Y is either a pentavalent ion derived from an element of Group VA, or a tetravalent ion derived from an element of Group VIA; R is an organic moiety of the salt molecule bonded to Y by four covalent linkages when Y is pentavalent, and three covalent linkages when Y is tetravalent; X " is an anion which will dissociate from the cation (R n Y) + in an aqueous environment.
• the group (R n Y) + X " may be repeated as in the case of dibasic quaternary salts having two pentavalent Group VA ions substituted in the manner described.
• the preferred onium salts for use in the invention have the formula (R n Y) + X " , wherein Y is either a pentavalent ion derived from an element
• the onium salts are generally selected to be less preferentially less soluble in the less polar of the two distinct liquid phases. Any of the salts disclosed in the U.S. Patent No.
• R A ,R B ,R C , and R D cumulatively range from about 1 3 to about 57, and preferably range from about 1 6 to about 30.
• R A may also be selected from C 2 H 5 n-C 3 H 7 and n-C 4 H 9 benzyl.
• the tertiary amines or triamines useful as phase transfer catalysts in this synthesis include the alkyl amines and the aryldialkylamines, exemplified by tributylamine and phenyldibutylamine respectively, which are commonly available, wherein each alkyl may have from 1 to about 1 6 carbon atoms.
• polyethers useful as catalysts in this synthesis include cyclic polyethers such as the crown ethers, disclosed in Agenwandte Chemie, supra, and acyclic polyethers having the formula:
• R and R E are, independently, alkyls having from 1 to about 1 6 carbon atoms, or alkyl containing substituted functional groups such as hydroxy, sulfur, amine, ether, etc.
• Most preferred acyclic polyethers have the formula: R - (OCH 2 CH 2 ) r OR " wherein
• R is an alkyl having from 1 to about 1 6 carbon atoms
• R " is an alkyl having from 1 to about 1 6 carbon atoms, or H
• r is an integer in the range from 0 to about 300.
• polyethers such as: tetraethylene glycol dimethyl ether; polyethylene oxide (mol wt. About 5000); poly(ethylene glycol methyl ether); 1 ,2-dimethoxyethane; diethyl ether, and the like.
• Polyether catalysts are especially desirable in this ketoform synthesis because they are directive so as to produce a preponderance of the desired symmetrically substituted isomer, in a reaction which is remarkably free of undesirable byproducts, which reaction proceeds with a relatively mild exotherm so that the reaction is controllable.
• the organic solvent may be any solvent in which the reactants are soluble and include hydrohalomethylenes, particularly hydrochloromethylenes, sulfolane, dibutyl ether, dimethyl sulfone, diisopropyl ether, di-n-propyl ether, 1 ,4-dioxane, tetrahydrofuran, benzene, toluene, hexane, carbon tetrachloride, heptane, mineral spirits and the like.
• hydrohalomethylenes particularly hydrochloromethylenes, sulfolane, dibutyl ether, dimethyl sulfone, diisopropyl ether, di-n-propyl ether, 1 ,4-dioxane, tetrahydrofuran, benzene, toluene, hexane, carbon tetrachloride, heptane, mineral spirits and the like.
• Solvent is generally utilized in an amount generally from about 10 to about 500 percent and preferably from about 50 percent to about 200 percent based on the total weight of the reactants. Insofar as the reactive components are concerned, any of various ke tones having the general formula:
• the ketone is generally used in an amount from about 1 10 mole percent to about 2,000 mole percent per mole of carbon disulfide.
• the ketone is generally utilized in an amount of from about 1 50 mole percent to about 300 mole percent, and preferably from about 1 80 mole percent to about 250 mole percent per mole of carbon disulfide.
• the alkali bases suitable for use in the synthesis of the present invention include, but are not limited to, sodium hydroxide and potassium hydroxide.
• the base is utilized in an amount generally from about 5 times to about 1 5 times the number of moles of carbon disulfide and preferably from about 6 to about 10 times the number of moles of carbon disulfide utilized in the reaction.
• the acids used in the acidification step include, but are not limited to, hydrochloric acid, sulfuric acid, phosphoric acid, etc.
• the acids are utilized in amounts suitable to make the aqueous solution acidic.
• the haloform of the present invention has the general formula CHX 3 wherein X is, independently, chlorine or bromine.
• the amount of haloform used in the present invention is generally from about 1 10 mole percent to about 2000 mole percent, desirably from about 1 50 mole percent to about 300 mole percent, and preferably 1 80 mole percent to about 250 mole percent per mole of carbon disulfide.
• Examples of haloforms include, but are not limited to, chloroform and bromoform, and chloroform is the preferred haloform of the present invention.
• an ⁇ -trihalomethyl- ⁇ -alkanol can be substituted therefore.
• the amount of ⁇ -trihalomethyl- ⁇ -alkanol utilized in the reaction generally is from about 1 10 mole percent to about 2000 mole percent, desirably is from about 1 50 mole percent to about 300 mole percent, and preferably is from about 1 80 mole percent to about 250 mole percent per mole of carbon disulfide.
• the general formula of the ⁇ -trihalomethyl- ⁇ -alkanol is generally represented as follows:
• the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " -acetic acid) -trithiocarbonate compounds produced by the present invention can generally be classified as inifertors, meaning that they act as both a chain transfer agent and an initiator.
• inifertors for block copolymers was discussed by Yagei and Schnabel in Progress in Polymer Science L5, 551 ( 1 990) and is hereby fully incorporated by reference.
• the compounds of the present invention can be utilized as initiators to initiate or start the polymerization of a monomer. They can also act as a chain transfer agent, which interrupts and terminates the growth of a polymer chain by formation of a new radical which can act as a nucleus for forming a new polymer chain.
• the compounds can also be utilized as terminators in that when most of initiating radicals and monomers are consumed, the compounds are incorporated in the polymers as a dormant species.
• another compound such as those listed herein below, is often used as an initiator in the free radical polymerization process as described herein below, and the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " -acetic acid) - trithiocarbonate compounds of the present invention will act as a chain-transfer agent.
• the s,s'-bis-( ⁇ , '-disubstituted - ⁇ " -acetic acid) - trithiocarbonate compounds of the present invention can be used as chain transfer agents in a free radical polymerization process to provide polymerizations which have living characteristics and polymers of controlled molecular weight and low polydispersity, as well as for forming telechelic polymers.
• a living polymerization is a chain polymerization which proceeds in the absence of termination and chain transfer. The following experimental criteria can be utilized to diagnose a living polymerization. 1 . Polymerization proceeds until all monomer has been consumed. Further addition of monomer results in continued polymerization. 2.
• the number average molecular weight, M n (or X n , the number average degree of polymerization) is a linear function of conversion.
• the molecular weight can be controlled by the stoichiometry of the reaction. 5. Narrow molecular weight distribution polymers are produced.
• Chain-end functionalized polymers can be prepared in quantitative yields.
• the number of active end groups should be 2, one for each end.
• radical living polymerization one is the ability of the polymer isolated from the first step of polymerization to be used as a macroinitiator for the second step of a polymerization in which block copolymers or grafted polymers are ultimately formed.
• measurements of molecular weights and a determination of the structure of the blocks are employed.
• structure measurements the examination of NMR or IR signals for the segments where individual blocks are linked together and a determination of the end groups are both very important.
• radical polymerization only some of the criteria for living polymerizations are actually fulfilled.
• the living polymerization processes can be used to produce polymers of narrow molecular weight distribution containing one or more monomers sequences whose length and composition are controlled by the stoichiometery of the reaction and degree of conversion.
• Homopolymers, random copolymers or block polymers can be produced with a high degree of control and with low polydispersity.
• Low polydispersity polymers are those with polydispersities that are significantly less than those produced by conventional free radical polymerization.
• polydispersities polydispersity is defined as the ratio of the weight average to the number average molecular weight M w /M n ) of the polymers formed are typically greater than 2.0.
• Polydispersities obtained by utilizing the s,s'-bis-( ⁇ , '-disubstituted - ⁇ " -acetic acid) - trithiocarbonate compounds and derivatives thereof of the present invention are preferably 1 .75 or 1 .5, or less, often 1 .3 or less, and, with appropriate choice of the chain transfer agent and the reaction conditions, can be 1 .25 or less.
• Free radical polymerizations utilizing the s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " -acetic acid) - trithiocarbonate compounds as both initiators and chain transfer agents generally form telechelic polymers.
• an initiator other than the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " -a cetic acid) - trithiocarbonate compound is also utilized, a polymer having a single functional end group is formed in proportion to the amount of said other initiator to this s,s'-bis- ( ⁇ , ⁇ '-disubstituted - ⁇ " -acetic acid) - trithiocarbonate compound utilized.
• the free radical living polymerization process of the invention can be applied to any monomers or monomer combinations which can be free- radically polymerized. Such monomers include one or more conjugated diene monomers or one or more and vinyl containing monomers, or combinations thereof.
• the diene monomers have a total of from 4 to 1 2 carbon atoms and examples include, but are not limited to, 1 ,3-butadine, isoprene, 1 ,3- pentadiene, 2,3-dimethyl-1-3-butadeine, 2-methyl- 1 ,3-pentadiene, 2,3- dimethyl-1 ,3-pentadiene, 2-phenyl-1 ,3-butadiene, and 4,5-diethyl-1 ,3- octadiene, and combinations thereof.
• the vinyl containing monomers have the following structure:
• R 3 comprises hydrogen, halogen, C, to C 4 alkyl, or substituted C, - C 4 alkyl wherein the substituents, independently, comprise one or more hydroxy, alkoxy, aryloxy(OR 5 ), carboxy, metal carboxylate (COOM) with M being sodium, potassium, calcium, zinc or the like or an ammonium salt, acyloxy, aroyloxy(O 2 CR 5 ), alkoxy-carbonyl(CO 2 R 5 ), or aryloxy-carbonyl; and
• R 4 comprises hydrogen, R 5 , CO 2 H, CO 2 R 5 , COR 5 , CN, CONH 2 , CONHR 5 , O 2 CR 5 , OR 5 , or halogen.
• R 5 comprises C-, to C 18 alkyl, substituted C, - C 18 alkyl, C 2 - C 18 alkenyl, aryl, heterocyclyl, aralkyl, or alkaryl, wherein the substituents independently comprise one or more epoxy, hydroxy, alkoxy, acyl, acyloxy, carboxy (and salts), sulfonic acid (and salts), alkoxy- or aryloxy-carbonyl, dicyanato, cyano, silyl, halo and dialkylamino.
• the monomers comprise maleic anhydride, N-vinyl pyrrolidone, N- alkylmaleimide, N-arylmaleimide, dialkyl fumarate and cyclopolymerizable monomers.
• Specific monomers or comonomers include the following: methyl methacrylate, ethyl methacrylate, propyl methacrylate (all isomers) , butyl methacrylate (all isomers), 2-ethylhexyl methacrylate, isobomyl methacrylate, methacrylic acid, benzyl methacrylate, phenyl methacrylate, methacrylonitrile, alpha-methylstyrene, methyl acrylate, ethyl acrylate, propyl acrylate (all isomers), butyl acrylate (all isomers), 2-ethylhexyl acrylate, isobornyl acrylate, acrylic acid, benzyl acrylate, phenyl acrylate, acrylonitrile, styrene, functional methacrylates, acrylates such as glycidyl methacrylate, 2-hydroxyethyl methacrylate, hydroxypropy
• Preferred monomers are C., - C 18 acrylates; C, - C 8 monoalkyl and dialkyl acrylamides; a combination of C ⁇ - C 8 acrylates and methacrylates; a combination of acrylamides and methacrylamide; C, - C 8 styrene; butadiene; isoprene and acrylonitrile.
• the source of initiating radicals can be any suitable method of generating free radicals such as the thermally induced homolytic scission of a suitable compound(s) (thermal initiators such as peroxides, peroxyesters, or azo compounds), the spontaneous generation from monomer (e.g., styrene), redox initiating systems, photochemical initiating systems or high energy radiation such as electron beam, X- or gamma- radiation.
• the initiating system is chosen such that under the reaction conditions there is no substantial adverse interaction of the initiator or the initiating radicals with the transfer agent under the conditions of the experiment.
• the initiator should also have the requisite solubility in the reaction medium or monomer mixture.
• the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " - acetic acid) - trithiocarbonate compounds of the invention can serve as an initiator, but the reaction must be run at a higher temperature. Therefore, optionally it is desirable to utilize an initiator other than the s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " -acetic acid) - trithiocarbonates compounds of the present invention.
• Thermal initiators are chosen to have an appropriate half-life at the temperature of polymerization. These initiators can include one or more of the following compounds:
• Photochemical initiator systems are chosen to have the requisite solubility in the reaction medium or monomer mixture and have an appropriate quantum yield for radical production under the conditions of the polymerization.
• examples include benzoin derivatives, benzophenone, acyl phosphine oxides, and photo-redox systems production under the conditions of the polymerization; these initiating systems can include combinations of the following oxidants and reductants:
• oxidants potassium peroxydisuffate, hydrogen peroxide, t-butyl hydroperoxide reductants: iron ( 1 1 ), titanium ( 1 1 1 ) , potassium thiosulfite, potassium bisulfite.
• the preferred initiators of the present invention are 2,2'- azobis(isobutyronitrile)(AIBN), or 4,4'-azobis(4-cyanopentanoic acid), or 2,2'- azobis(2-cyano-2-butane), or 1 , 1 '-azobis(cyclohexanecarbanitrile) .
• the amount of initiators utilized in the polymerization process can vary widely as generally from about .001 percent to about 99 percent, and desirably from about 0.01 percent to about 50 or 75 percent based on the total moles of chain transfer agent utilized. Preferably small amounts are utilized from about 0.1 percent to about 5, 10, 1 5, 20, or 25 mole percent based on the total moles of chain transfer agent utilized, i.e. said s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " -acetic acid) - trithiocarbonate compounds.
• initiators other than the s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " -acetic acid) - trithiocarbonate compounds are utilized in lesser amounts, such as from about 0.001 percent to about 5 percent, desirably from about 0.01 percent to about 4.5 percent, and preferably from about 0.1 percent to about 3 percent based on the molar equivalent to the total moles of chain transfer agent utilized.
• solvents may be utilized in the free radical polymerization process.
• solvents include, but are not limited to, C 6 - C 12 alkanes, toluene, chlorobenzene, acetone, t-butyl alcohol, and dimethylformamide.
• the solvents are chosen so that they do not chain transfer themselves.
• the amount of solvent utilized in the present invention polymerization process is generally from about 10 percent to about 500 percent the weight of the monomer, and preferably from about 50 percent to about 200 percent the weight of the monomer utilized in the polymerization.
• chain transfer agent (CTA) utilized depends on the desired molecular weight of the polymer to be formed and can be calculated as known by one skilled in the art.
• a formula for calculating the amount of chain transfer agent is as follows:
• polymers having two different structures see XIX and XXII, can be formed.
• the resulting polymers are either telechelic polymers (formed by the trithiocarbonate compounds of the present invention) with identical functional groups at the ends of the chain, or a polymer having a single functional end group and also an initiator terminated chain (formed by using a conventional initiator such as AIBN) .
• AIBN a conventional initiator such as AIBN
• the ratios between the resulting polymers can be controlled to give desired results and generally depends on the amount of initiator utilized.
• the resulting polymers are always telechelic.
• the amount of the repeat group m, m', m ", n, n', or n " is generally from about 1 to about 1 0,000, desirably from about 5 to about 500, and preferably from about 1 0 to about 200.
• repeat groups of the polymers of the present invention are generally indicated by formulas XIX and XXII and can be the same or different. That is, random copolymers, terpolymers, etc., can be formed within either of the two repeat groups noted, as well as block copolymers which can be formed by initially adding one monomer and then subsequently adding a different monomer (e.g. an internal block copolymer) .
• the polymers formed by the present invention can be generally represented by the following formula: repeat groups repeat groups R derived from vinyl derived from vinyl containing
• the above formula can contain an initiator end group thereon as in XXII.
• the reaction conditions are chosen as known to one skilled in the art so that the temperature utilized will generate a radical in a controlled fashion, wherein the temperature is generally from about room temperature to about 200°C. The reaction can be run at temperatures lower than room temperature, but it is impractical to do so.
• the temperature often depends on the initiator chosen for the reaction, for example, when AIBN is utilized, the temperature generally is from about 40°C to about 80°C, when azo dicyanodivaleric acid is utilized, the temperature generally is from about 50°C to about 90°C, when di-t-butylperoxide is utilized, the temperature generally is from about 1 10°C to about 1 60°C, when s,s'-bis-( ⁇ , ⁇ ' - disubstituted - ⁇ " - acetic acid) is utilized, the temperature is generally from about 80°C to about 200°C .
• the low polydispersity polymers prepared as stated above by the free radical polymerization can contain reactive end groups from the monomers which are able to undergo further chemical transformation or reaction such as being joined with another polymer chain, such as to form block copolymers for example. Therefore, any of the above listed monomers, i.e. conjugated dienes or vinyl containing monomers, can be utilized to form block copolymers utilizing the s,s'-bis-( ⁇ , ⁇ '-distributed - ⁇ " -acetic acid) - trithiocarbonate compounds as chain transfer agent.
• the substituents may be non-reactive such as alkoxy, alkyl, or aryl. Reactive groups should be chosen such that there is no adverse reaction with the chain transfer agents under the conditions of the experiment.
• the process of this invention can be carried out in emulsion, solution or suspension in either a batch, semi-batch, continuous, or feed mode. Otherwise-conventional procedures can be used to produce narrow polydispersity polymers.
• the chain transfer agent is added before polymerization is commenced.
• the reactor is typically charged with chain transfer agent and monomer or medium plus monomer.
• the desired amount of initiator is then added to the mixture and the mixture is heated for a time which is dictated by the desired conversion and molecular weight.
• Polymers with broad, yet controlled, polydispersity or with multimodal molecular weight distribution can be produced by controlled addition of the chain transfer agent over the course of the polymerization process.
• the medium will often be predominately water and the conventional stabilizers, dispersants and other additives can be present.
• the reaction medium can be chosen from a wide range of media to suit the monomer(s) being used.
• the use of feed polymerization conditions allows the use of chain transfer agents with lower transfer constants and allows the synthesis of block polymers that are not readily achieved using batch polymerization processes. If the polymerization is carried out as a feed system the reaction can be carried out as follows. The reactor is charged with the chosen medium, the chain transfer agent and optionally a portion of the monomer(s) . The remaining monomer(s) is placed into a separate vessel.
• Initiator is dissolved or suspended in the reaction medium in another separate vessel.
• the medium in the reactor is heated and stirred while the monomer + medium and initiator + medium are introduced over time, for example by a syringe pump or other pumping device.
• the rate and duration of feed is determined largely by the quantity of solution the desired monomer/chain transfer agent/initiator ratio and the rate of the polymerization.
• heating can be continued for an additional period.
• the polymer can be isolated by stripping off the medium and unreacted monomer(s) or by precipitation with a non-solvent. Alternatively, the polymer solution/emulsion can be used as such, if appropriate to its application.
• the invention has wide applicability in the field of free radical polymerization and can be used to produce polymers and compositions for coatings, including clear coats and base coat finishes for paints for automobiles and other vehicles or industrial, architectural or maintenance finishes for a wide variety of substrates.
• coatings can further include pigments, durability agents, corrosion and oxidation inhibitors, rheology control agents, metallic flakes and other additives.
• Block and star, and branched polymers can be used as compatibilizers, thermoplastic elastomers, dispersing agents or rheology control agents.
• polymers of the invention are in the fields of imaging, electronics (e.g., photoresists), engineering plastics, adhesives, sealants, paper coatings and treatments, textile coatings and treatments, inks and overprint varnishes, and polymers in general.
• the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " -acetic acid) - trithiocarbonate compound can be utilized to create telechelic polymers having two functional groups at both chain ends.
• the term "telechelic polymer” was proposed in 1 960 by Uraneck et al. to designate relatively low molecular weight macromolecules possessing one or more, and preferably two reactive functional groups, situated at the chain ends, thereof.
• the functional end groups of both the s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " -acetic acid) - trithiocarbonate compound and the polymers formed therefrom, have the capacity for selective reaction to form bonds with another molecule.
• the functionality of a telechelic polymer or prepolymer is equal to the number of such end groups.
• Telechelic polymers containing a functional group, such as COOH, at each end are useful for synthesizing further chain extended copolymers and block copolymers.
• reaction conditions for the reactive functional acid end groups of the telechelic polymers or s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " - acetic acid) - trithiocarbonate compounds of the present invention are generally the same as those for forming the above noted free radical polymers.
• the acid in the monomeric or in the polymeric form can be transformed to its derivatives in the conventional manner.
• the ester can be made by refluxing the acid in alcohol with an acid catalyst with removal of water.
• Amides can be formed by heating the acid with an amine with the removal of water.
• 2- hydroxy-ethyl ester can be formed by directly reacting the acid with an epoxide with or without a catalyst such as triphenylphosphine or an acid like toluene-sulfonic acid.
• a catalyst such as triphenylphosphine or an acid like toluene-sulfonic acid.
• any of the above noted monomers such as the one or more diene monomers or one or more vinyl containing monomers, can be utilized to form the telechelic monomers from the bis-( ⁇ , ⁇ '-distributed - ⁇ " -acetic acid) - trithiocarbonate compounds of the present invention.
• Any of the above noted components, such as solvent, etc. can be utilized in the herein above stated amounts.
• the acid groups of the s,s'-bis-( ⁇ , '-disubstituted - ⁇ " -acetic acid) - trithiocarbonate compound can be converted to other functional groups either before or after polymerization. Even if the s,s'-bis-( ⁇ , ⁇ '- disubstituted - ⁇ " -a cetic acid) - trithiocarbonate compounds have functional end groups which have been converted from the acid end groups before polymerization, the monomers added during polymerization still add to the chain between the sulfur-tertiary carbon as shown in the mechanisms above as well as below at XXIII and XXIV.
• the carboxylic end groups of the s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " -acetic acid) - trithiocarbonate compounds or the polymerized s,s'-bis-( ⁇ , ⁇ '-disubstituted - ⁇ " - acetic acid) - trithiocarbonate compounds can be converted or changed into other functional end groups such as esters, thioesters, amides, beta mercapto esters, beta hydroxy esters, or beta amino esters. Examples of these functional end groups are shown below.
• repeat units m and n can be derived either from conjugated diene monomers, or the indicated vinyl monomers, or combinations thereof, as generally set forth in formula W.
• E is XR', that is R', independently, comprises H, C-, - C 18 alkyls which can be optionally substituted with one or more halogen, hydroxyl, or alkoxy, C ⁇ - C 18 hydroxyalkyls, and C, - C 18 aminoalkyls and X comprises oxygen, sulfur, NH, or NR'.
• R 6 through R 9 independently comprise H, C 1 - C 18 alkyls, aryl groups or substituted aryl groups having from 1 to 6 substituents on the ring, such as halogen, hydroxyl, or alkoxy, C., - C 18 hydroxyalkys, C, - C 18 aminoalkyls, C, - C 18 mercapto alkyls, and the like.
• Y can comprise oxygen, sulfur, NH, or NR 6 to R 9 .
• R 2 R 2 wherein E is OR 10 , that is where Z can comprise a leaving group, such as a halide or alkylsulfonate or aryl sulfonate.
• R 10 can comprise C, - C 18 , a alkyl or substituted alkyl wherein said substituent is halogen, hydroxyl, or alkoxy,
• An example of an already formed telechelic polymer, made from a vinyl monomer, undergoing conversion of the acid end group is as follows: HOOC COOH XXXI 11
• Another aspect of present invention further relates to forming the following compounds:
• R 11 comprises a benzyl group, C, - C 18 alkyl, or substituted alkyl such as halogen, hydroxyl, or alkoxy, C 1 - C 18 hydroxyalkyl, carboxylalkyl, or carboalkoxyalkyl.
• Q + X is a phase transfer catalyst such as tetrabutylammoniumhydrogensulfate, or octadecyltrimethylammoniumchloride (Aliquot 336) .
• the resulting compound is an s - substituted alkyl - s '- ( ⁇ , ⁇ ' ⁇ disubstituted- ⁇ " -a cetic acid) - trithiocarbonate .
• R 11 is an alkyl having from 1 - 1 8 carbon atoms, aralkyl, hydroxyalkyl, cyanoalkyl, aminoalkyl, carboxylalkyl, or carboalkoxyalkyl, mercaptoalkyl, etc.
• R 1 and R 2 are as stated herein above.
• any of the carboxyl terminated polymers such as W, or the E terminated polymers, and the like, can be reacted with one or more monomers and/or one or more polymers know to the art and to the literature to yield various resulting block polymers which are derived from the same monomer or from two or more different monomers.
• each acid end group can be reacted with an excess of an epoxy compound such as a glycidyl bisphenol A and then subsequently polymerized with additional glycidyl bisphenol A to form an epoxy polymer.
• an epoxy compound such as a glycidyl bisphenol A
• other block polymers or copolymers can be reacted with the carboxylic end group or the other end groups generally denoted by E hereinabove.
• Dithiocarbonates I. Dithiocarbamates
• a further embodiment of the present invention relates to dithiocarbonate compounds which have the general formula:
• T is a divalent radical having a nitrogen atom directly connected to each carbon atom of the two thiocarbonyl groups present; wherein R 12 and R 13 , independently, is the same or different, is optionally substituted, and is a linear or branched alkyl having from 1 to about 6 or about 1 2 carbon atoms; or an aryl group having from 6 to about 1 8 carbon atoms, optionally containing heteroatoms; wherein the R 12 and/or R 13 substituents, independently, comprise an alkyl having from 1 to 6 carbon atoms; an aryl group; a halogen; a cyano group; an ether having a total of from 2 to about 20 carbon atoms; a nitro; or combinations thereof.
• R 12 and R 13 can also form or be a part of a substituted or unsubstituted cyclic ring having from 3 to about 1 2 total carbon atoms wherein the substituents are described above.
• R 12 and R 13 are preferably, independently, methyl or phenyl groups; wherein R 15 and R 16 , independently, is the same or different, optionally is substituted, optionally contains heteroatoms; and is hydrogen; a linear or branched alkyl having from 1 to about 1 8 carbon atoms, an aryl group having from about 6 to about 18 carbon atoms optionally saturated or unsaturated; an arylalkyl having from about 7 to about 1 8 carbon atoms; an alkenealkyl having from 3 to about 1 8 carbon atoms; or derived from a polyalkylene glycol ether having from 3 to about 200 carbon atoms.
• R 15 and R 16 can also be derived from amines such as, but not limited to, piperazine, morpholine, pyrrolidine, piperidine, 4-alkyl amino-2,2,6,6-tetramethyl piperidine, 1 -alkylamioalkyl-3,3,5,5-tetramethyl-2-piperazinone, hexamethyleneimine, phenothiazine, iminodibenzyl, phenoxazine, N,N'- diphenyl-1 ,4-phenylenediamine, dicyclohexylamine and derivatives thereof.
• amines such as, but not limited to, piperazine, morpholine, pyrrolidine, piperidine, 4-alkyl amino-2,2,6,6-tetramethyl piperidine, 1 -alkylamioalkyl-3,3,5,5-tetramethyl-2-piperazinone, hexamethyleneimine, phenothiazine, iminodibenz
• R 15 and R 16 can also form a substituted or unsubstituted cyclic ring, optionally containing heteroatoms, along with the nitrogen having a total of from 4 to about 1 2 carbon atoms, such as benzotriazole, tolyltriazole, imidazole, 2-oxazolidone, 4,4-dimethyloxazolidone and the like.
• the R 15 and R 16 substituents, independently, can be the same as described herein with respect to R 14 .
• R 15 and R 16 are preferably, independently, a phenyl group or an alkyl or substituted alkyl having from 1 to about 1 8 carbon atoms such as a methyl group, or R 15 and R 16 , independently, are hexamethylene.
• metals such as sodium or bases such as sodium hydroxide are referred to and the application of the present invention is not meant to be solely limited thereto.
• Other metals or bases such as, but not limited to, potassium and potassium hydroxide, respectively, are contemplated by the disclosure of the present invention.
• T of above formula is ( NR 15 R 16 - ⁇ -and the dithiocarbamate compound is a S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamate generally having the following formula: wherein R 12 , R 13 , R 15 , and R 16 are as defined hereinabove.
• the dithiocarbarbamate compound is a bis-S-( ⁇ , ⁇ '- disubstituted- ⁇ "-acetic acid) dithiocarbamate having the following formula:
• R 12 and R 13 are defined hereinabove; and wherein T is a divalent bridging radical having a nitrogen atom directly connected to each of the thiocarbonyl groups present.
• R 17 and R 18 independently, is the same or different, is optionally substituted, and is hydrogen, a linear or branched alkyl having from 1 to about 18 carbon atoms, an aryl group having from about 6 to about 18 carbon atoms, an arylalkyl having from 7 to about 18 carbon atoms, an alkenealkyl having from 3 to about 18 carbon atoms, wherein the substitutents can be the same as described herein for R 1 and R 2 ; wherein R 19 is optionally substituted, and is non-existent, or an alkylene group having from 1 to about 18 carbon atoms with about 1 to about 6 carbon atoms preferred, or derived from a polyalkylene glycol ether having from 3 to about 200 carbon atoms, wherein the substituents can be the same as described herein for R 1 and R 2 or are heteroatoms such as oxygen, nitrogen, sulfur or phosphorous; and wherein R 20 and R 21 independently, is the same or different, and is optionally substituted as described for
• T is:
• n is 0 to about 18, with 0 to about 6 preferred;
• n 0 to about 18, with to about 6 preferred;
• T bridging radicals are:
• the S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamates are generally a reaction product of a metal salt of a dithiocarbamate, a haloform, and a ketone.
• a phase transfer catalyst, solvent, and a base such as sodium hydroxide or potassium hydroxide can also be utilized to form the S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamates.
• the metal salt of a dithiocarbamate is either prepared or purchased from a supplier such as Aldrich of Milwaukee, WI or Acros of Sommerville, NJ. Metal salts of dithiocarbamates are made in situ from amine, carbon disulfide, and a metal hydroxide as disclosed in the literature. Examples of metal salts of dithiocarbamates include sodium N,N-dimethyl dithiocarbamate and sodium N,N-diethyl-dithiocarbamate.
• the S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamate is formed by combining a metal salt of the dithiocarbamate with a haloform, a ketone, a base, optionally a solvent and a catalyst, in a reaction vessel preferably under an inert atmosphere.
• the base is preferably added to the other components over a period of time to maintain a preferred temperature range and avoid by-products.
• the reaction product is subsequently acidified, completing the reaction.
• the reaction product is isolated as a solid or liquid and is optionally purified.
• the limiting agents of the reaction are usually the amine and carbon disulfide, or the metal salt of the dithiocarbamate when utilized.
• the haloform is utilized in the reaction in an amount from about 0 percent to about 500 percent molar excess, with about 50 percent to about 200 percent molar excess preferred.
• the ketone is utilized in the reaction in an amount from 0 percent to about 3000 percent molar excess, with about 100 percent to about 1000 percent molar excess preferred.
• the metal hydroxide when utilized, is present in an amount from 1 0 percent to 500 percent molar excess, with about 60 percent to 1 50 percent molar excess preferred.
• reaction formula for the S-( ⁇ , ⁇ '-disubstituted- ⁇ "- acetic acid) dithiocarbamate of the present invention is generally as follows: R , 15
• the reaction is carried out at a temperature sufficient to initiate and complete reaction of the reactants in order to produce the S-( ⁇ , ⁇ '- disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamate compound in a desired time.
• the reaction can be carried out at any temperature within a wide range of from about the freezing point of the reaction mass to about the reflux temperature of the solvent.
• the reaction temperature is generally from about minus 1 5° C to about 80° C, desirably from about 0° C to about 50° C, and preferably from about 1 5° C to about 35° C, with about 1 5° C to about 25° C being preferred.
• the reaction can be performed at atmospheric pressure.
• the reaction time depends on several factors, with the temperature being most influential.
• the reaction is generally complete within 20 hours and preferably within about 10 hours.
• a catalyst preferably a phase transfer catalyst, is generally utilized when the optional solvent is used in the reaction. Examples of preferable catalysts and solvents are listed hereinabove and incorporated by reference.
• Preferred phase transfer catalysts include tricaprylmethylammonium chloride (Aliquot 336), benzyltriethylammonium chloride, and tetrabutylammonium hydrogen sulfate.
• the amount of catalyst and solvents utilized in the reaction to form the S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '- disubstituted- ⁇ "-acetic acid) dithiocarbamate compound are generally the same as set forth above and herein incorporated by reference.
• the catalyst is optionally eliminated from the process.
• ketones, haloforms, bases, and acids utilized in the dithiocarbamate reaction can be the same as those listed above for the trithiocarbonate synthesis and amounts thereof are herein incorporated by reference.
• an ⁇ -trihalomethyl- ⁇ -alkanol can be utilized in place of the haloform and ketone in the amounts noted hereinabove for the trithiocarbonate synthesis.
• R 15 and R 16 are defined hereinabove.
• the reaction scheme for the formation of the bis S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbonate is similar to the above reaction scheme and obvious to one of ordinary skill in the art.
• a phase transfer catalyst such as tetrabutylammoniumhydrogensulfate or octadecyltrimethylammoniumchloride (Aliquot 336) as mentioned above is utilized in a preferred embodiment.
• S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamate compounds are utilized in essentially the same manner as the trithiocarbonate compounds mentioned hereinabove.
• the S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamate compounds in various embodiments are utilized as initiators to initiate or start the polymerization of a monomer, as a chain transfer agent which interrupts and terminates the growth of a polymer chain by formation of a new radical which can act as the nucleus for forming a new polymer chain, and/or as a terminator which are incorporated into a polymer as a dormant species.
• the S-( ⁇ , ⁇ '- disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamate compounds are utilized as chain transfer agents in free radical polymerizations having living characteristics to provide polymers of controlled molecular weight and low polydispersity.
• the present invention also relates to both a process for forming polymers or copolymer derived from the dithiocarbamate compounds having the following general formulae:
• R 12 , R 13 , R 15 , R 16 and T are defined hereinabove, wherein the polymer is derived from a monomer as described herein, such as but not limited to, a conjugated diene monomer, or a vinyl containing monomer, or combinations thereof, wherein each polymer repeat unit is the same or different, and wherein f is generally from 1 to about 10,000, and preferably from about 3 to about 5,000.
• Preferred polymers are derived from alkyl acrylate, vinyl acetate, acrylic acid, and styrene. Of course, it is to be understood that when f is 1 , the polymer is a single reacted monomer unit.
• dithiocarbamate polymers or copolymers can be prepared by bringing into contact with each other the monomer(s) which form(s) the (polymer) repeat units and the S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) or bis S-
• the monomers are polymerized into the dithiocarbamate compounds adjacent to the thiocarbonylthio linkage, between the single bonded sulfur atom and the tertiary carbon atom of the compound.
• the dithiocarbamate compounds of the present invention are used to produce polymers which are substantially colorless.
• the polymers or copolymers of the dithiocarbamate compounds are hydrolytically stable because the electro-donating amino groups render the thiocarbonyl group less electrophilic.
• the polymers are also stable toward nucleophiles such as amines.
• the reaction conditions are chosen as known to one ordinarily skilled in the art so that the temperature utilized will generate a radical in a controlled fashion with the temperature being generally from about room temperature to about 200°C.
• the reaction can be performed at temperatures lower than room temperature, but it is impractical to do so.
• the temperature often depends on the initiator chosen for the reaction, for example, when AIBN is utilized, the temperature generally is from about
• the temperature when azodicyanodivaleric acid is utilized, the temperature generally is from about 50°C to about 90°C, when di-t- butylperoxide is utilized, the temperature generally is from about 1 10°C to about 1 60°C, and when S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '- disubstituted- ⁇ "-acetic acid) dithiocarbamate is utilized, the temperature is generally from about 1 20°C to about 200°C.
• the low polydispersity polymers prepared as stated above by the free radical polymerization can contain reactive end groups from the monomers which are able to undergo further chemical transformation or reaction such as being joined with another polymer chain, such as to form copolymers for example. Therefore, any of the above listed monomers, i.e. conjugated dienes or vinyl containing monomers, are utilized to form copolymers utilizing the S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) or bis S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamate compounds as chain transfer agent. Moreover, in one embodiment the polymers are crosslinked using a crosslinker during polymerization.
• Suitable crosslinkers include, but are not limited to, polyallyl pentaerythritol, polyallyl sucrose, trimethylol propane diacrylate, trimethylol propane triacrylate, glycerol triacrylate, methylene bis- acrylamide and ethylene-glycol diacrylate.
• the substituents may be non-reactive such as alkoxy, alkyl, or aryl. Reactive groups should be chosen such that there is no adverse reaction with the chain transfer agents under the conditions of the experiment.
• the process of this invention is carried out in emulsion, solution or suspension in either a batch, semi-batch, continuous, or feed mode. Bulk polymerization (no solvent) is also achieved because propagation is slower.
• the chain transfer agent is added before polymerization is commenced.
• the polydispersity of polymers or copolymers produced from the dithiocarbamates is generally less than about 3.0.
• the reactor is typically charged with chain transfer agent and monomer or medium plus monomer.
• the desired amount of initiator is then added to the mixture and the mixture is heated for a time which is dictated by the desired conversion and molecular weight.
• Polymers with broad, yet controlled, polydispersity or with multimodal molecular weight distribution can be produced by controlled addition of the chain transfer agent over the course of the polymerization process.
• the medium will often be predominately water and the conventional stabilizers, dispersants and other additives can be present.
• the reaction medium can be chosen from a wide range of media to suit the monomer(s) being used.
• the use of feed polymerization conditions allows the use of chain transfer agents with lower transfer constants and allows the synthesis of block polymers that are not readily achieved using batch polymerization processes.
• the reaction can be carried out as follows.
• the reactor is charged with the chosen medium, the chain transfer agent and optionally a portion of the monomer(s).
• the remaining monomer(s) is placed into a separate vessel.
• Initiator is dissolved or suspended in the reaction medium in still another separate vessel.
• the medium in the reactor is heated and stirred while the monomer + medium and initiator + medium are introduced over time, for example by a syringe pump or other pumping device.
• the rate and duration of feed is determined largely by the quantity of solution the desired monomer/chain transfer agent/initiator ratio and the rate of the polymerization. When the feed is complete, heating can be continued for an additional period.
• the polymer can be isolated by stripping off the medium and unreacted monomer(s) or by precipitation with a non-solvent. Alternatively, the polymer solution/emulsion can be used as such, if appropriate to its application.
• the applications for the S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) dithiocarbamate compounds include any of those listed hereinabove with regard to the trithiocarbonate compounds.
• Derivatives of the dithiocarbamate polymers or copolymers can also be formed including esterification products from the alcohol and/or diol end groups present. Thioesters can be formed utilizing mercaptan, and amides can be formed from amines, etc.
• Ammonium salts can be formed from primary, secondary, and tertiary amines.
• Metal salts can be formed from alkaline or alkaline earth hydroxides, oxides and the like.
• the invention has wide applicability in the field of free radical polymerization and can be used to produce polymers and compositions for coatings, including clear coats and base coat finishes for paints for automobiles and other vehicles or industrial, architectural or maintenance finishes for a wide variety of substrates.
• Such coatings can further include conventional additives such as pigments, durability agents, corrosion and oxidation inhibitors, rheology control agents, metallic flakes and other additives.
• Block, star, and branched polymers can be used as compatibilizers, thermoplastic elastomers, dispersing agents or rheology control agents.
• polymers of the invention are in the fields of imaging, electronics (e.g., photoresists), engineering plastics, adhesives, sealants, paper coatings and treatments, textile coatings and treatments, inks and overprint varnishes, and polymers in general.
• Alkyl and alkylene groups from 1 to 6 carbon atoms are preferred; wherein the R 1 substituents comprise an alkyl having from 1 to 6 carbon atoms; an aryl; a halogen such as fluorine or chlorine; a cyano group; an amino group; an alkene group; an alkoxycarbonyl group; an aryloxycarbonyl group; a carboxy group; an acyloxy group; a carbamoyl group; an alkylcarbonyl group; an alkylarylcarbonyl group; an arylcarbonyl group; an arylalkylcarbonyl group; a phthalimido group; a maleimido group; a succinimido group; amidino group; guanidimo group; allyl group; epoxy group; alkoxy group; an alkali metal salt; a cationic substitutent such as a quaternary ammonium salt; a hydroxyl group; an ether having a total of from 2
• the compounds of the above formula are generally identified as O- alkyI-S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) xanthates.
• the O-alkyl-S-( ⁇ , ⁇ '- disubstituted- ⁇ "-acetic acid) xanthates are generated as the reaction product of an alkoxylate salt, carbon disulfide, a haloform, and a ketone.
• a metal salt of xanthate can be utilized in place of the alkoxylate salt and carbon disulfide.
• the alkoxylate salt or carbon disulfide, or alternatively the metal salt of xanthate are typically the limiting agents for the reaction.
• the haloform is utilized in the reaction in an amount generally from 0 percent to about 500 percent molar excess, and preferably from about 50 to about 200 percent molar excess.
• the ketone is utilized in the reaction in an amount generally from 0 percent to about 3000 percent molar excess, and preferably from about 1 00 percent to about 1 000 percent molar excess.
• the metal hydroxide when utilized, is present in an amount from 1 0 percent to 500 percent molar excess, with about 60 percent to 150 percent molar excess preferred.
• the preparation of the O-alkyl-S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) xanthates begins with the addition of a xanthate, i.e., a salt of xanthic acid to a reaction vessel, preferably equipped with an agitating device, thermometer, addition funnel, and a condenser.
• a xanthate i.e., a salt of xanthic acid
• the xanthate can be prepared from an alkoxylate salt and carbon disulfide as known in the art.
• the sodium salt of O-ethyl xanthate, CH 3 CH 2 OC(S)S " Na + can be prepared from sodium ethoxide and carbon disulfide in the presence of a solvent such as an acetone, and optionally a catalyst, such as Aliquot 336 or other catalyst stated herein or known in the art, in a reaction vessel, preferably at about 0° to about 25°C.
• a solvent such as an acetone
• a catalyst such as Aliquot 336 or other catalyst stated herein or known in the art
• the metal salt of O-ethyl xanthate is also commercially available from sources such as Aldrich Chemical of Milwaukee, WI. ln a further step, a ketone, a haloform, optionally a solvent, and a catalyst, all as described hereinabove, are added to the reaction vessel containing the xanthate metal salt.
• a ketone is used as the solvent, the catalyst is optionally eliminated from the process.
• a strong base as noted hereinabove is added to the mixture, preferably over an extended period of time.
• the reaction components are preferably mixed throughout the reaction.
• the reaction product is subsequently acidified with an acid as noted hereinabove, completing the reaction and forming the O-alkyl-S-( ⁇ , ⁇ '- disubstituted- ⁇ "-acetic acid) xanthate.
• the reaction is conducted at a temperature generally from about 0° C to about 80° C, and preferably from about 1 5° C to about 50° C, with room temperature being preferred.
• the reaction can be performed at atmospheric pressure under an inert atmosphere.
• the reaction time generally depends on temperature, and generally is complete within 20 hours, and preferably within 10 hours.
• An ⁇ -trihalomethyl- ⁇ -alkanol can be utilized in place of a haloform and ketone, as noted hereinabove with regard to the trithiocarbonate compounds.
• the O-alkyl-S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) xanthates can be utilized as an initiator to initiate or start the polymerization of a monomer, as a chain transfer agent which interrupts and terminates the growth of a polymer chain by formation of a new radical which can act as the nucleus for forming a new polymer chain, and/or as a terminator which are incorporated into a polymer as a dormant species.
• the O-alkyl-S- ( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) xanthates are utilized as chain transfer agents in free radical polymerizations having living characteristics to provide polymers of controlled molecular weight and low polydispersity.
• Xanthate (Co)Polymers are utilized as chain transfer agents in free radical polymerizations having living characteristics to provide polymers of controlled molecular weight and low polydispersity.
• Polymers or copolymers of the following formulas can be prepared from the O-alkyl-S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) xanthates:
• R 12 , R 13 , and R 14 are as defined hereinabove, wherein the polymer is derived from a conjugated diene monomer, or a vinyl containing monomer, or combinations thereof, as defined hereinabove and incorporated by reference, and wherein each g repeat unit, independently, is the same or different and is generally from 1 to about 10,000, and preferably from about
• Preferred monomers are alkyl acrylates, acrylic acid, and styrene.
• g is 1
• the polymer is a single reacted monomer unit.
• the above polymers or copolymers can be prepared by bringing into contact with each other the monomer(s) which form O-alkyl-S-( ⁇ , ⁇ '- disubstituted- ⁇ "-acetic acid) xanthate compound, and optionally a) solvent, and b) a radical polymerization initiator; in suitable amounts, as described hereinabove.
• the monomers are polymerized into the xanthate compounds adjacent to the thiocarbonylthio linkage, between the single bonded sulfur atom and the tertiary carbon atom of the compound.
• the O-alkyl dithiocarbonate compounds of the present invention can be used to produce polymers which are substantially colorless.
• the polymers or copolymers of the O-alkyl dithiocarbanate compounds are more hydrolytically stable because the electro-donating amino groups render the thiocarbonyl group less electrophilic and the polymers are stable toward nucleophiles such as amines.
• reaction conditions are chosen as known to one skilled in the art so that the temperature utilized will generate a radical in a controlled fashion, wherein the temperature is generally from about room temperature to about 200°C.
• the reaction can be performed at temperatures lower than room temperature, but it is impractical to do so.
• the temperature often depends on the initiator chosen for the reaction, for example, when AIBN is utilized, the temperature generally is from about 40°C to about 80°C, when azodicyanodivaleric acid is utilized, the temperature generally is from about 50°C to about 90°C, when di-t-butylperoxide is utilized, the temperature generally is from about 1 1 0°C to about 1 60°C, and when O-aIkyl-S-( ⁇ , ⁇ '- disubstituted- ⁇ "-acetic acid) xanthate is utilized, the temperature is generally from about 80°C to about 200°C .
• the polymers or copolymers prepared from the O-alkyl-S-( ⁇ , ⁇ '-disubstituted- ⁇ "- acetic acid) xanthate contain reactive end groups which are able to further undergo chemical transformation or reaction in order to be joined with another polymer chain, in order to form extended copolymers for example.
• the process of the invention can be carried out, for example, in emulsion solution or suspension in either a batch, semi-batch, continuous, bulk or feed mode. Conventional procedures can be used to produce narrow polydispersity polymers. For lowest polydispersity polymers, the chain transfer agent is added before polymerization is commenced.
• the polydispersity of the xanthate polymers or copolymers is generally less than about 3.0.
• the reactor when carried out in batch mode in solution, the reactor is typically charged with chain transfer agent and monomer or medium plus monomer. The desired amount of initiator is then added to the mixture and the mixture is heated for a time which is dictated by the desired conversion and molecular weight. Polymers with broad, yet controlled, polydispersity or with multimodal molecular weight distribution can be produced by controlled addition of the chain transfer agent over the course of the polymerization process.
• the medium will often be predominately water and the conventional stabilizers, dispersants and other additives can be present.
• the reaction medium can be chosen from a wide range of media to suit the monomer(s) being used.
• the use of feed polymerization conditions allows the use of chain transfer agents with lower transfer constants and allows the synthesis of block polymers that are not readily achieved using batch polymerization processes.
• the reaction can be carried out as follows. The reactor is charged with the chosen medium, the chain transfer agent and optionally a portion of the monomer(s). The remaining monomer(s) is placed into a separate vessel. Initiator is dissolved or suspended in the reaction medium in another separate vessel. The medium in the reactor is heated and stirred while the monomer + medium and initiator + medium are introduced over time, for example by a syringe pump or other pumping device. The rate and duration of feed is determined largely by the quantity of solution the desired monomer/chain transfer agent/initiator ratio and the rate of the polymerization. When the feed is complete, heating can be continued for an additional period.
• the polymer can be isolated by stripping off the medium and unreacted monomer(s) or by precipitation with a non-solvent. Alternatively, the polymer solution/emulsion can be used as such, if appropriate to its application.
• the applications for the O-alkyl-S-( ⁇ , ⁇ '-disubstituted- ⁇ "-acetic acid) xanthate dithiocarbonate compounds include any of those listed hereinabove with regard to the trithiocarbonate and dithiocarbamate compounds.
• the dithiocarbonate compounds of the invention have wide applicability in the field of free radical polymerization and can be used as thickeners and to produce polymers and compositions for coatings, including clear coats and base coat finishes for paints for automobiles and other vehicles or industrial, architectural or maintenance finishes for a wide variety of substrates.
• Such coatings can further include pigments, durability agents, corrosion and oxidation inhibitors, rheology control agents, metallic flakes and other additives.
• Block and star, and branched polymers can be used as compatibilizers, thermoplastic elastomers, dispersing agents or rheology control agents.
• polymers of the invention are composites, potting resins, foams, laminate, in the fields of imaging, electronics (e.g., photoresists), engineering plastics, adhesives, sealants, paper coatings and treatments, textile coatings and treatments, inks and overprint varnishes, and polymers in general, and the like.
• Trithiocarbonate ( 1 .0g
• n-butylacrylate (20g, 1 56.1 mmole) with 1 ml decane as internal standard were purged with nitrogen for 1 5 min., then polymerized at
• PhCH CH 2 + H00C polystyrene
• the trithiocarbonate was used as inifertor to make polystyrene.
• the trithiocarbonate (2.0g, 7.1 mmole) and styrene (25g, 240.4mmole) with 1 ml decane as internal standard were polymerized at 1 40°C under nitrogen for 6 hours.
• the following table showed the progress of the polymerization.
• the trithiocarbonate was used as chain-transfer agent to make block copolymers of 2-ethylhexylacrylate and styrene.
• the trithiocarbonate ( 1 .5g,
• sodium O-ethylxanthate was formed in situ. 7.6 grams carbon disulfide, 1 gram tetrabutylammonium hydrogen sulfate and
• the sodium dithiocarbamate utilized in this example was sodium morpholinodithiocarbamate.
• the reaction was conducted as explained in Example 14.
• the product was afforded in good yield as white powders.
• the sodium dithiocarbamate utilized in this example was sodium N,N- diethyl dithiocarbamate .
• the reaction was conducted as explained in Example 14 and acetone was replaced by cyclohexanone.
• the product was afforded in good yield as white powders.
• Example 21 The procedure of Example 21 was utilized and the disodium salts of piperizine bis-(dithiocarbamic acid) was replaced by sodium dimethyldithiocarbamate, and BTEAC was replaced by tetrabutylammonium hydrogensulfate, the desired product was obtained as white powders.
• Example 21 The reaction was performed as in Example 21 , but the dithiocarbamate salt was sodium N-phenyl-N- 1-naphthyl dithiocarbamate, and the ketone was acetone.
• the product was obtained as beige-colored powders after recrystallization from a mixture of toluene and heptane.
• Example 26 The diethylamine of the procedure of Example 26 was replaced by dimethyl-amine (40% in water) .
• the product was white crystals after recrystallization from toluene.
• (Mn)e ⁇ is the Mn measured by GPC from polymerization products. In bulk polymerization, 20-25 grams of monomer, 0.01-0.05 grams of an initiator such as AIBN and the amount of the dithiocarbonate as needed to give desired Mn (calculated using formula Xll(a)) are purged with nitrogen gas, then heated to temperature gradually. Sometimes air or water-cooling is necessary to keep the temperature under 83°C. The resulting polymers were subjected to MALDI mass spectrum measurement. The spectrum clearly showed the carboxyl-terminating group in every polymer chain.
• Block copolymerization was performed by making the first polymer in bulk, then add the second monomer and same amount of initiator, then polymerizing in the same manner. Random copolymerization could have been performed if both monomers were added at the same time.

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