WO2004037289A2 - Novel injectable depot formulations - Google Patents

Novel injectable depot formulations Download PDF

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Publication number
WO2004037289A2
WO2004037289A2 PCT/IB2003/004576 IB0304576W WO2004037289A2 WO 2004037289 A2 WO2004037289 A2 WO 2004037289A2 IB 0304576 W IB0304576 W IB 0304576W WO 2004037289 A2 WO2004037289 A2 WO 2004037289A2
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WO
WIPO (PCT)
Prior art keywords
ziprasidone
depot formulation
cyclodextrin
sbecd
formulation
Prior art date
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PCT/IB2003/004576
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English (en)
French (fr)
Other versions
WO2004037289A3 (en
Inventor
Jaymin Chandrakant Shah
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Priority to BR0315568-4A priority Critical patent/BR0315568A/pt
Priority to JP2004546264A priority patent/JP2006514923A/ja
Priority to EP03748483A priority patent/EP1575616A2/en
Priority to AU2003267788A priority patent/AU2003267788A1/en
Priority to CA002503076A priority patent/CA2503076A1/en
Priority to MXPA05002561A priority patent/MXPA05002561A/es
Publication of WO2004037289A2 publication Critical patent/WO2004037289A2/en
Priority to NO20052463A priority patent/NO20052463L/no
Publication of WO2004037289A3 publication Critical patent/WO2004037289A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Definitions

  • the invention pertains to injectable depot formulations for aryl-heterocyclic compounds, such as arylpiperazinyl-C 2 and -C 4 alkyleneheterocycle compounds, including ziprasidone; and methods for making same.
  • aryl-heterocyclic compounds such as arylpiperazinyl-C 2 and -C 4 alkyleneheterocycle compounds, including ziprasidone; and methods for making same.
  • the injectable depot formulations of the invention permit controlled release of the active aryl-heterocyclic substances over prolonged periods of time after administration to a patient via intramuscular (IM) injection, for example.
  • IM intramuscular
  • aryl-heterocyclic compounds are known to have psychotropic effects.
  • Ziprasidone in particular is a chlorooxyindole class aryl-heterocyclic that is an atypical anti- psychotic agent often prescribed for the treatment of schizophrenia.
  • Atypical anti-psychotics such as ziprasidone offer distinct advantages over traditional anti-psychotic medications insofar as they are associated with lower incidences of side effects, such as extrapyramidal symptoms (EPS), and confer greater efficacy of treatment to patients who are otherwise not responsive to more traditional drug therapies.
  • Certain illnesses, such as schizophrenia can be particularly difficult to medicate inasmuch as they are considered to be heterogeneous diseases whereby not all patients react similarly to the same treatment regimen.
  • dosage forms where a single administration leads to a sustained release of the medication over an extended period of time. This, in turn, simplifies the dosage regimen that a patient need adhere to, thus reducing the opportunity for non- compliance as occurs with a more rigorous schedule.
  • the depot formulation which can be administered in various ways including intramuscularly by injection.
  • the depot dosage injection is specifically formulated to provide slow absorption of the drug from the site of administration, often keeping therapeutic levels of same in the patient's system for days or weeks at a time. But there are instances where the use of a depot form has not been available.
  • ziprasidone is administered once or twice daily in the form of an immediate release (IR) capsule for acute and long term treatment of schizophrenia; or is administered in intramuscular immediate release injection form for acute control of agitation in schizophrenic patients.
  • IR immediate release
  • Ziprasidone is poorly soluble. Indeed, for the intramuscular immediate release formulation aforesaid, even ziprasidone mesylate, which is generally soluble relative to other known ziprasidone salts, has to be solubilized further, presently with the use of cyclodextrins as described in U.S. Patent No. 6,232,304 incorporated herein by reference, to render it efficacious.
  • aryl-heterocyclic compounds such as ziprasidone
  • aryl-heterocyclic compounds such as ziprasidone
  • the present invention is premised on the finding that the solubilized forms of aryl- heterocyclics typically associated with (or with solubilized levels of active ingredient even greater than) immediate release, can be surprisingly fabricated into depot formulations.
  • the present invention is directed to an injectable depot formulation comprising a solubilized aryl-heterocyclic compound, such as ziprasidone, and a viscosity agent.
  • the injectable depot formulation of the invention provides significantly higher solubility of the aryl-heterocyclic drug in the formulation.
  • the invention achieves this improved drug loading and delivery by using solubilizers cooperatively with viscosity agents to obtain the controlled release typifying a depot effect.
  • the invention is useful in treating psychotic illnesses such as schizophrenia in mammals, including humans in need of such treatment.
  • the invention is also useful in treating other disorders and conditions, the treatment of which is facilitated by ziprasidone administration.
  • ziprasidone use is indicated as e.g. in U.S. Patent Nos. 6,245,766; 6,245,765; 6,387,904; 5,312,925; 4,831 ,031; and European EP 0901789 published March 17, 1999, all of which are incorporated herein by reference.
  • aryl- heterocyclics preferably those that have pharmacologic activity, e.g. psychotropic effects.
  • an embodiment of an aryl-heterocyclic compound subject to the practice of the present invention has the structure:
  • Ar is benzoisothiazolyl or an oxide or dioxide thereof, each optionally substituted by one fluoro, chloro, trifluoromethyl, methoxy, cyano, or nitro: n is 1 or 2; and
  • Representative examples of compounds falling within the foregoing definition are found in U.S. Patent No. 4,831 ,031 incorporated herein by reference.
  • the invention preferably applies to the above compounds wherein X and Y together with the phenyl to which they are attached form oxindole; more preferably, the oxindole moiety is 6-chlorooxindole-5-yl.
  • Ar is benzoisothiazoyl; in still another preferred practice, n is 1.
  • a particularly preferred aryl-heterocyclic to which the invention pertains is ziprasidone, which has the structure:
  • aryl heterocyclic compound described herein may be constituted as a free base, it is preferred if aryl-heterocyclic compound is present as a pharmaceutically acceptable salt.
  • salt in this regard intends pharmaceutically acceptable acid addition salts of aryl-heterocyclics, including ziprasidone.
  • the salts can be anhydrous or in the form of one or more solvates, such as hydrates, including mixtures thereof. The salts may also occur in different polymorphic forms.
  • mesylate salts of the aryl heterocyclic ziprasidone may be present in dihydrate or trihydrate forms as disclosed in U.S. Patent Nos.
  • preferred salts are selected from the group consisting of the tosylate, tartrate, napsylate, besylate, aspartate, esylate and mesylate salt.
  • the aryl heterocyclic is ziprasidone mesylate, more preferably in the trihydrate form.
  • the injectable depot formulation of the present invention provides delivery of the aryl heterocyclic active agent at concentrations effective for treatment of illnesses such as schizophrenia over a sustained period of time, i.e. for a period of time beyond that which is obtained by immediate release injection systems.
  • the injectable depot formulation of the present invention provides for example efficacious plasma levels of active agent for at least about 8 hours using typical injection volumes, e.g. about 0.1ml to about 3 ml, about 1 ml to about 2 ml being usual.
  • the sustained period provided by the invention is at least about 24 hours; more preferably up to about 1 week; still more preferably from about 1 week to about 2 weeks or more including up to about 8 weeks using the injection volumes aforesaid.
  • the practice of the invention can deliver at least 0.5 to about 350 mgA per ml injection.
  • the injection volume is from about 1 ml to about 2 ml, thereby providing delivery of from about 0.5 mgA to about 700 mgA ziprasidone over a sustained period of time. More preferably, about 10 mgA to about 560 mgA ziprasidone is provided per injection over a sustained period of time, even more preferably about 280 mgA to about 560 mgA.
  • an injection of the subject depot formulation can result in a sustained delivery of such amounts of ziprasidone over a period of time.
  • the period of time is at least about 8 hours, more preferably at least about 24 hours, even more preferably at least about 1 week.
  • the injection provides a sustained delivery of such amounts of ziprasidone for a period of time of at least about 2 weeks.
  • the injection provides a sustained delivery of such amounts of ziprasidone for a period of time of up to about 8 weeks.
  • the aryl heterocyclic compound is solubilized.
  • the term "solubilized” and related variations of same as used herein means that the heterocyclic has a solubility in water that is in excess of its free or salt forms to a degree sufficient to provide the prolonged (depot) duration of systemic exposure of active agent at the therapeutic levels contemplated by the invention.
  • the heterocyclic can be "solubilized” using a cyclodextrin or other solubilizer to achieve the increased solubility contemplated herein.
  • the heterocyclic may be partly or fully solubilized.
  • ziprasidone as the aryl heterocyclic compound.
  • mgA/ml relates to the weight (in mg) of aryl-heterocyclic compound, e.g. ziprasidone, per ml of composition to which the term is being applied.
  • molecular weight 412.9.
  • ziprasidone concentration is at least about 0.5 to about 350 mgA/ml, for example about 60mgA/ml, in the depot formulation of the present invention which can include amounts in solution and amounts in suspension as appertain. More preferably for ziprasidone, concentration is between about 70 mgA/ml to about 280 mgA/ml depot formulation, including between about 140 mgA/ml and about 210 mgA/ml, of depot formulation; higher concentrations are also within the scope of the invention.
  • Various techniques to solubilize ziprasidone to obtain these levels of concentration involve, without limitation, the use of cyclodextrins and other solubilizers.
  • the preferred solubilizer (to form the solubilized aryl-heterocyclic compound of the invention) is a cyclodextrin.
  • Cyclodextrins are cyclic oligosaccharides with hydroxyl groups on the outer surface and a void cavity in the center.
  • the outer surface is usually hydrophilic hence cyclodextrins are soluble in water.
  • the void on the other hand is typically hydrophobic. Cyclodextrins have the ability to form complexes with guest molecules, such as ziprasidone.
  • Cyclodextrins contemplated by the invention include without limitation: ⁇ , ⁇ , ⁇ -cyclodextrins, methylated cyclodextrins, hydroxypropyl- ⁇ -cyclodextrin (HPBCD), hydroxyethyl- ⁇ -cyclodextrin (HEBCD), branched cyclodextrins in which one or two glucoses or maltoses are enzymatically attached to the cyclodextrin ring, ethyl- and ethyl-carboxymethyl cyclodextrins, dihydropropyl cyclodextrins, and sulfoalkyl ether cylcodextrins, such as sulfobutyl ether- ⁇ -cyclodextrin (SBECD).
  • HPBCD hydroxypropyl- ⁇ -cyclodextrin
  • HEBCD hydroxyethyl- ⁇ -cyclodextrin
  • the cyclodextrins can be unsubstituted or substituted in whole or in part as known in the art; mixtures of cyclodextrins are also useable.
  • the preferred cyclodextrins for the depot formulation of the invention include ⁇ -cyclodextrin, HPBCD, SBECD or mixtures thereof; SBECD being most preferred.
  • Cyclodextrin complexes with ziprasidone can be rendered soluble in water as described in U.S. Patent No. 6,232,304 incorporated by reference above.
  • a pre-formed (solid) complex of cyclodextrin and ziprasidone can be employed, or the cyclodextrin can be presented separately into the depot formulation to solubilize the ziprasidone, such as by adding the cyclodextrin conjointly or in admixture with the viscosity agent or other components.
  • Viscosity agents include those known in the art such as viscosified water, pharmaceutically acceptable oils and oil-based agents, polymeric agents and other non- aqueous viscous vehicles.
  • Preferred viscosity agents include without limitation: cellulose derivatives, polyvinylpyrrolidone, alginates, chitosan, dextrans, gelatin, polyethylene glycols, polyoxyethylene ethers, polyoxypropylene ethers, polylactides, polyglycolides, polycaprolactones, polyanhydrides, polyamines, polyurethanes, polyesteramides, polyorthoesters, polydioxanones, polyacetals, polycarbonates, polyorthocarbonates, polyphosphazenes, succinates, polycarbonates, poly(maleic acid), poly(amino acids), polyhydroxycellulose, chitin, copolymers and terpolymers of the foregoing, and mixtures thereof.
  • Preferred cellulose derivatives include methyl cellulose, sodium carboxymethyl cellulose (NaCMC) and hydroxypropyl methyl cellulose.
  • Preferred polylactides, polyglycolides, copolymers and terploymers thereof include poly-lactic-co-glycolic acid (PLGA).
  • PLGA poly-lactic-co-glycolic acid
  • in situ gelling systems e.g. stearic acid (SA) and N-methyl pyrrolidone (NMP) combinations, sucrose acetate isobutyrate, PLGA.
  • the viscosity agent is present in an amount effective to provide the depot effect contemplated herein.
  • an effective amount of viscosity agent is that amount necessary to provide the depot formulation of the invention with a viscosity of greater than about 3.2 centipoise (cps); more preferably between about 20 and about 200 cps; still more preferably between about 30 and about 165 cps.
  • ziprasidone is solubilized with a cyclodextrin such as SBECD, wherein the cyclodextrin is present in a concentration of up to about 60% w/v, more preferably, a concentration of about 40% w/v, still more preferably a concentration of about 30%.
  • the depot formulation comprises a concentration of cyclodextrin, e.g. SBECD, of from about 5% to about 35%, especially from about 10% to about 20%.
  • the depot formulation comprising a cyclodextrin in this regard takes the form of an aqueous suspension, wherein the viscosity agent, e.g.
  • NaCMC or the like is present in water, e.g. sterilized water for injection, in an amount sufficient to render the viscosity of the depot formulation greater than 3.2 cps, preferably between about 20 cps to about 200 cps, more preferably, between about 30 cps to about 165 cps.
  • NaCMC can be present in an amount of about 0.1 % w/v to about 3% w/v, preferably from about 0.5% w/v to about 2%.
  • the aqueous suspension depot formulation further comprises a pharmaceutically acceptable surfactant, for example a polyoxyethylene sorbitan ester such as Polysorbate 80 (Tween 80).
  • the pharmaceutically acceptable surfactant can be present in an amount e.g. of up to about 1 % w/v; preferably about 0.01 to about 0.1 %.
  • the depot formulation can be in kit form as described in commonly-owned U.S. Provisional Application 60/421 ,295 filed October 25, 2002, and as described in patent applications claiming priority of U.S. 60/421 ,295, the entire contents of which are incorporated herein by reference.
  • the kit includes a first component of e.g. dry ziprasidone mesylate trihydrate in an amount sufficient to provide a dosage within the ranges described above, i.e.
  • a second component comprised of viscous aqueous vehicle, such as NaCMC and a sufficient amount of water to render a total volume for injection of about 1 to about 3 ml, preferably 1 to about 2 ml; and SBECD or another cyclodextrin in an amount of about 5 to about 35% w/v to solubilize the ziprasidone.
  • a pharmaceutically acceptable surfactant such as, without limitation, a polyoxyethylene sorbitan ester such as Polysorbate 80 (Tween 80) can be included with the viscosified NaCMC-water to improve wetting of the dry ziprasidone when the contents of the two elements are admixed together to form the injectable depot formulation of the invention.
  • a depot formulation formulated as such can, in one embodiment, deliver at least about 10 to about 30 mg per day of ziprasidone for at least about 8 hours, preferably at least about 24 hours, more preferably at least about 1 week, even more preferably at least about 2 weeks.
  • a high concentration of cyclodextrin e.g. SBECD
  • the cyclodextrin serves as both solubilizer and viscosity agent. That is, at high concentrations of cyclodextrin, the complex with ziprasidone forms an aqueous solution having a viscosity sufficiently high to provide a depot formulation.
  • Ziprasidone in this regard is solubilized with a cyclodextrin concentration of greater than about 50% w/v, preferably from about 50% w/v to about 60% w/v; more preferably, the cyclodexdrin concentration is between about 55% to about 60% w/v, e.g.
  • aqueous solution suitable for an injectable depot formulation with a viscosity of about 22.6 cps and higher.
  • a crystallization inhibitor such as polyvinyl pyrrolidone (e.g. PVP 30) and the like may be added to delay crystallization and enhance the physical stability of the depot formulation.
  • a complex of ziprasidone and a cyclodextrin is formed and isolated as a solid.
  • This solubilized solid complex can then be suspended in a suitable viscosity vehicle, including non-aqueous viscous agents in which the ziprasidone- cyclodextrin complex is not soluble.
  • a solid preformed complex can be obtained by lyophilizing the high concentration solution of the second embodiment described above.
  • the lyophilized complex can be suspended in non-aqueous viscosity agents including without limitation: sesame seed oil, including aluminum monostearate (ALMS) gelled sesame seed oil; and in situ gelling systems such as e.g. stearic acid (SA) and NMP combinations.
  • ALMS aluminum monostearate
  • SA stearic acid
  • ziprasidone is solubilized using a combination of cyclodextrin and one or more co-solvents in which said ziprasidone is soluble.
  • a mixture of cyclodextrin such as SBECD and a co-solvent or co-solvents, such as a pyrrolidone or mixture of pyrrolidones, for example 2-pyrrolidone and/or NMP, in water, can be used to form the solubilized ziprasidone of the invention.
  • Suitable viscosity agents such as polyethylene glycol (PEG), can be employed to form the injectable depot formulation of the invention.
  • solutions of up to about 140 mgA/ml ziprasidone mesylate salt can be prepared using 60% NMP/water with 40% SBECD with 10% PEG (e.g. PEG 3350); in another practice of this embodiment, a 140 mgA/ml solution of ziprasidone can be prepared using 60% 2-pyrrolidone/water with 40% SBECD and 30% PEG 3350 as viscosity agent.
  • a crystallization inhibitor such as PVP 30, at e.g. up to about 70 mg/ml, can be added.
  • a non-aqueous depot formulation can be prepared in accordance with the invention by utilizing the co-solvents above with non-aqueous but polar solvents such as benzyl benzoate (BB) and the like.
  • non-aqueous but polar solvents such as benzyl benzoate (BB) and the like.
  • BB benzyl benzoate
  • a 140 mgA/ml ziprasidone formulation can be prepared using 30%BB, 70% 2-pyrrolidone with 40% SBECD, the formulation having a viscous gel-like consistency suitable for a depot effect.
  • pH modifiers known in the art to be acidic in nature may be employed in any of the foregoing formulations.
  • the following examples are illustrative only; they are not to be construed as limiting of the scope or spirit of the invention.
  • EXAMPLE 1 This example demonstrates an embodiment of the invention wherein the depot formulation comprises ziprasidone solubilized with cyclodextrin and having a cellulose derivative as a viscosity agent forming an aqueous suspension.
  • ziprasidone powder in the form of ziprasidone mesylate trihydrate was provided.
  • the ziprasidone powder was admixed with a vehicle constituted as follows: SBECD at 30% w/v
  • Total fill of the vehicle was 3 ml.
  • the ziprasidone powder was admixed with 2.3 ml of the vehicle to produce a 2.5 ml aqueous suspension at 70 mgA/ml ziprasidone.
  • the resultant admixture was agitated for 1 minute followed by a 15 minute period of waiting to wet the ziprasidone powder whereafter the admixture was again agitated for an additional minute.
  • a 21 gauge syringe was loaded with 2 ml of the final admixture to provide a dose of 140mg ziprasidone. Viscosity was about 31 to about 80 cps.
  • PK pharmacokinetic
  • Comparative Sample (1) an immediate release formulation comprised of solubilized ziprasidone, but no viscosity agent
  • Comparative Sample (2) an aqueous suspension comprised of a viscosity agent (SBECD) and unsolubilized ziprasidone.
  • SBECD viscosity agent
  • the 2 ml volumes in all cases were injected intramuscularly and plasma levels measured over time.
  • Comparative Sample (1) showed no depot effect, i.e. the serum concentration of ziprasidone was not quantifiable after 48 hrs; there was no sustained serum concentration.
  • Comparative Sample (2) showed a ziprasidone serum concentration of 4.6 ⁇ 2.4 ng/ml (mean of 12-336 hrs).
  • the present invention on the other hand showed a ziprasidone serum concentration of 12.9 ⁇ 3.7 ng/ml, which represented an increase in depot effect of approximately 280% over that of the next closest sample, Comparative Sample (2).
  • Table 1 Various combinations of the two vials and dosing instructions to prepare 140 and 210 mgA/ml aqueous suspensions with vehicle containing 10 and 20% SBECD.
  • the depot formulation is a non-aqueous suspension comprising a pre-formed ziprasidone/cyclodextrin complex and having a viscosity agent.
  • a 1095.3 gm batch of solution was prepared in an 80° C water bath. After SBECD was dissolved in sterilized water for injection (SWFI) ziprasidone mesylate trihydrate was added to the resulting solution. During the entire process, the solution was stirred magnetically. The drug solution (82 mgA/ml) was filtered through a 0.45 ⁇ m filter and 2 ml aliquots were pipetted into 20 ml vials.
  • SWFI sterilized water for injection
  • the vials of solution prepared above were lyophilized to obtain the ziprasidone- SBECD complex as a freeze dried solid.
  • a lyophilization cycle was used with the following conditions: 1) Freezing step: temperature was -55° C at 1 ° C/minute; 2) Primary drying: from -55° C to -32° C at 0.05° C/minute, held at -32° C for 7 days, vacuum 100 mTorr; 3) Secondary drying: from -32° C to 8° C at 0.1° C/minute, held at 8° C for 20 hours, vacuum 70 mTorr, then from 8° C to 30° C at 0.1° C/minute, held at 30° C for 20 hours, vacuum 70 mTorr.
  • the complex was comprised of ziprasidone at approximately 80 mgA/ml with about 56% SBECD.
  • the depot formulation comprises ziprasidone solubilized with cyclodextrin where the cyclodextrin also serves as the viscosity agent.
  • This particular example employs a high concentration of SBECD to form an aqueous solution of ziprasidone at about 80 mgA/ml with about 56% SBECD.
  • SBECD standard average molecular weight
  • Ziprasidone mesylate was added in about 50 mg increments while heat was supplied to maintain the system at 50-60°C.
  • the stock solution was prepared using the same method as described above, however due to the higher solution volume (20 ml), the dissolution time was much longer (over 4 hours) even though micronized ziprasidone mesylate was used. During compounding, significant volume expansion was noted. To correct for the volume expansion, the specific gravity of the solution was determined to be 1.188 gm/ml. The volume of water used to prepare this solution was 20 ml, however, the final volume of the solution was 36.6 ml, and the weight of the solution was 43.5 gm. Therefore, taking into consideration 83% volume expansion, the corrected concentrations of drug and SBECD in this solution are 77 mgA/ml and 55% w/v, respectively. HPLC analysis of this solution by the potency method showed a potency of 75 mgA/ml (102.3 mg/ml), and no degradation products were detected.

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PCT/IB2003/004576 2002-10-25 2003-10-13 Novel injectable depot formulations WO2004037289A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BR0315568-4A BR0315568A (pt) 2002-10-25 2003-10-13 Formulações de depósito injetáveis
JP2004546264A JP2006514923A (ja) 2002-10-25 2003-10-13 注射可能な新規なデポ製剤
EP03748483A EP1575616A2 (en) 2002-10-25 2003-10-13 Novel injectable depot formulations
AU2003267788A AU2003267788A1 (en) 2002-10-25 2003-10-13 Novel injectable depot formulations
CA002503076A CA2503076A1 (en) 2002-10-25 2003-10-13 Novel injectable depot formulations
MXPA05002561A MXPA05002561A (es) 2002-10-25 2003-10-13 Nuevas formulaciones de liberacion prolongada inyectables.
NO20052463A NO20052463L (no) 2002-10-25 2005-05-23 Nye injiserbare depotpreparater

Applications Claiming Priority (2)

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US42147302P 2002-10-25 2002-10-25
US60/421,473 2002-10-25

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WO2004037289A2 true WO2004037289A2 (en) 2004-05-06
WO2004037289A3 WO2004037289A3 (en) 2005-12-01

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US (1) US20040138237A1 (ko)
EP (1) EP1575616A2 (ko)
JP (1) JP2006514923A (ko)
KR (1) KR20050055781A (ko)
CN (1) CN1849110A (ko)
AR (1) AR041722A1 (ko)
AU (1) AU2003267788A1 (ko)
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US11083796B2 (en) 2005-07-26 2021-08-10 Durect Corporation Peroxide removal from drug delivery vehicle
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PA8586201A1 (es) 2004-09-16
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