WO2004032855A2 - Methode d'inhibition de l'angiogenese faisant appel a des inhibiteurs du facteur de croissance transformateur beta 3 - Google Patents

Methode d'inhibition de l'angiogenese faisant appel a des inhibiteurs du facteur de croissance transformateur beta 3 Download PDF

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Publication number
WO2004032855A2
WO2004032855A2 PCT/US2003/031778 US0331778W WO2004032855A2 WO 2004032855 A2 WO2004032855 A2 WO 2004032855A2 US 0331778 W US0331778 W US 0331778W WO 2004032855 A2 WO2004032855 A2 WO 2004032855A2
Authority
WO
WIPO (PCT)
Prior art keywords
beta
growth factor
transforming growth
angiogenesis
inhibitors
Prior art date
Application number
PCT/US2003/031778
Other languages
English (en)
Other versions
WO2004032855A3 (fr
Inventor
Eric G. Marcusson
Nicholas M. Dean
Original Assignee
Isis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals, Inc. filed Critical Isis Pharmaceuticals, Inc.
Priority to AU2003275474A priority Critical patent/AU2003275474A1/en
Publication of WO2004032855A2 publication Critical patent/WO2004032855A2/fr
Publication of WO2004032855A3 publication Critical patent/WO2004032855A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense

Definitions

  • transforming growth factor-beta 3 upregulation of transforming growth factor-beta 3 expression has been demonstrated in hepatocellular carcinoma cells and perineoplastic stroma of the liver, suggesting a role in tumor progression (Abou-Shady et al . , Am. J. Surg . , 1999, 177, 209- 215) . Furthermore, increased expression of transforming growth factor-beta 3 in breast cancer patients is a prognostic indicator inversely correlated with survival (Ghellal et al . , Anticancer Res . , 2000, 20 , 4413-4418).
  • Aqueous suspensions may further contain substances that increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran.
  • the suspension may also contain stabilizers.
  • Pharmaceutical compositions include, but are not limited to, solutions, emulsions, foams and liposome-containing formulations.
  • the pharmaceutical compositions and formulations used may comprise one or more penetration enhancers, carriers, excipients or other active or inactive ingredients.

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des méthodes d'inhibition de l'angiogénèse faisant appel à des inhibiteurs du facteur de croissance transformateur bêta 3. Ces méthodes permettent de prévenir, de réduire ou de traiter l'angiogénèse. L'invention concerne des méthodes de traitement de maladies et de troubles associés à l'angiogénèse, et d'états associés à une croissance de vaisseaux sanguins aberrante ou excessive. L'invention concerne des inhibiteurs du facteur de croissance transformateur bêta 3 comprenant des petites molécules, des anticorps, des peptides (notamment des peptides négatifs dominants) et des composés antisens, notamment des ribozymes, des molécules d'ARN inhibitrices, notamment des molécules d'ARNsi et des oligonucléotides antisens.
PCT/US2003/031778 2002-10-07 2003-10-07 Methode d'inhibition de l'angiogenese faisant appel a des inhibiteurs du facteur de croissance transformateur beta 3 WO2004032855A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003275474A AU2003275474A1 (en) 2002-10-07 2003-10-07 Method for inhibiting angiogenesis with transforming growth factor-beta 3 inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41707402P 2002-10-07 2002-10-07
US60/417,074 2002-10-07

Publications (2)

Publication Number Publication Date
WO2004032855A2 true WO2004032855A2 (fr) 2004-04-22
WO2004032855A3 WO2004032855A3 (fr) 2005-06-02

Family

ID=32093960

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/031778 WO2004032855A2 (fr) 2002-10-07 2003-10-07 Methode d'inhibition de l'angiogenese faisant appel a des inhibiteurs du facteur de croissance transformateur beta 3

Country Status (2)

Country Link
AU (1) AU2003275474A1 (fr)
WO (1) WO2004032855A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109548A2 (fr) * 2007-03-02 2008-09-12 Mdrna, Inc. Composés d'acides nucléiques conçus pour inhiber l'expression du gène tgfb et utilisations de ceux-ci

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673341B2 (en) * 1998-07-06 2004-01-06 Beth Israel Deaconness Medical Center Methods of inhibiting proliferative diseases by inhibiting TGF-β-mediated angiogenesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673341B2 (en) * 1998-07-06 2004-01-06 Beth Israel Deaconness Medical Center Methods of inhibiting proliferative diseases by inhibiting TGF-β-mediated angiogenesis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAO Y. ET AL: 'Antiangiogenic Cancer Therapy' SEMINARS IN CANCER BIOLOGY vol. 14, April 2004, pages 139 - 145 *
HOLIFIELD ET AL: 'TGF-B1, -B2 and -B3 Cooperate to Facilitate Tubulogenesis in the Explanted Quail Heart' JOURNAL OF VASCULAR RESEARCH vol. 41, March 2004, pages 491 - 498 *
KIM ET AL: 'Transforming Growth Factor-B: Biology and Clinical Relevance' JOURNAL OF BIOCHEMISTRY vol. 38, no. 1, January 2005, pages 1 - 8 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109548A2 (fr) * 2007-03-02 2008-09-12 Mdrna, Inc. Composés d'acides nucléiques conçus pour inhiber l'expression du gène tgfb et utilisations de ceux-ci
WO2008109548A3 (fr) * 2007-03-02 2009-02-26 Mdrna Inc Composés d'acides nucléiques conçus pour inhiber l'expression du gène tgfb et utilisations de ceux-ci

Also Published As

Publication number Publication date
WO2004032855A3 (fr) 2005-06-02
AU2003275474A8 (en) 2004-05-04
AU2003275474A1 (en) 2004-05-04

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