WO2004032800A1 - Dispositif de liaison entre un conduit corporel et une prothese - Google Patents
Dispositif de liaison entre un conduit corporel et une prothese Download PDFInfo
- Publication number
- WO2004032800A1 WO2004032800A1 PCT/FR2003/002988 FR0302988W WO2004032800A1 WO 2004032800 A1 WO2004032800 A1 WO 2004032800A1 FR 0302988 W FR0302988 W FR 0302988W WO 2004032800 A1 WO2004032800 A1 WO 2004032800A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sleeve
- prosthesis
- pins
- intubated
- conduits
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/064—Blood vessels with special features to facilitate anastomotic coupling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00535—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
- A61B2017/00557—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated inflatable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B2017/1107—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis for blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2002/065—Y-shaped blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
Definitions
- the present invention relates to the installation of a tubular prosthesis attached either to one end of a body conduit, or between two body conduits to be connected, by intubation of one or both ends of the prosthesis in the body duct (s) and fixation of the intubated parts using a connecting device which is the subject of the invention.
- a first solution consists in directly connecting the conduits together using manual surgical sutures.
- Another solution consists in using a tubular prosthesis, in the form of a sleeve, the two ends of which are intubated respectively in the two conduits to be connected, means being provided for joining together the intubated parts of the prosthesis and the end parts of said conduits. .
- document US 4 21 4 587 also discloses an anastomosis device for two vessels using an elastically radially compressible annular element provided externally with pins. This element must be compressed to reduce its diameter in order to be introduced into the terminal part of the duct to be anastomosed. Once released, it expands to take its nominal diameter.
- annular element ceasing to expand while the intubated part is perhaps not perfectly pressed against the part. end of the conduit to be connected, such an element is necessarily dimensioned for a very reduced range of diameters of conduits to be anastomosed, which means making a range of annular elements of various diameters and choosing precisely the element most suitable for each anastomosis.
- the subject of the invention is a connection device between the previously intubated ends of a body conduit and of a prosthesis of substantially tubular shape, characterized in that it consists of a sleeve with a mesh structure or analog deformable using a balloon catheter and capable of radial expansion between a stable configuration of minimum diameter and a final configuration after expansion also stable, said sleeve comprising, at each end, a series of pins for transfixing the overlapping parts of the sleeve, regularly aligned in a crown and oriented radially, said pins having a hemostatic profile comprising a base part of circular section extended by a terminal part of trihedral shape.
- the expandable sleeve consists of a perforated steel cylinder according to diamond-shaped cuts and the pins are attached and fixed by welding or gluing to the intersections of the sides of said diamonds.
- said sleeve is capable of expanding in a diameter ratio in a transfixion to initial diameter situation greater than 2.
- the out-of-ends part of the sleeve is also provided with transfixion pins.
- the spikes in the crown of the ends of the sleeve are rectilinear and the other spikes are slightly curved with their point oriented towards one or the other of the ends of the sleeve or any other direction, in a random manner.
- the invention applies to the connection between one end of a prosthesis and the terminal part of a body conduit such as an artery with a diameter between 6 mm and 30 mm, but it also applies to the junction between two body conduits via a prosthesis, the two ends of which are intubated in the end portions of the two conduits to be abutted.
- FIG. 1A is a perspective view of an embodiment of the connection device of the invention in its configuration of minimum diameter
- FIG. 1B represents the device of FIG. 1A deployed in its configuration of maximum diameter
- FIG. 2A is an elevation view of a pin
- FIG. 2B illustrates the trihedral profile of the tip of the pin of FIG. 2A
- FIG. 3 is a view illustrating the fixing of a prosthesis on a body conduit using the connection device of the invention
- - Figure 4 is a diagram illustrating the establishment and attachment of a first body conduit to a first end of a prosthesis
- - Figure 5 is a diagram illustrating the establishment and attachment of a second conduit body at the second end of the prosthesis
- FIG. 6 illustrates the application of the method to the establishment of devices according to the invention on a bifurcated prosthesis.
- the device of the invention ensures the connection between a prosthesis 1 0 and a body conduit 1 2, in which one of the ends of the prosthesis 1 0 is intubated.
- This connecting device more particularly intended for vascular conduits can be adapted to any other bodily conduit in which a prosthesis is likely to be intubated.
- the prosthesis of shape adapted to the body conduit, generally substantially tubular, is not described in more detail since it is within the reach of those skilled in the art.
- the prosthesis is usually in Dacron ®. It may be a straight tubular prosthesis or bifurcated in Y.
- the connecting device 1 4 between the prosthesis 1 0 and the body conduit 1 2 comprises an expandable sleeve 1 6 disposed inside of the prosthesis, an embodiment of which is shown in FIGS. 1 A and 1 B.
- Figure 1 A is shown schematically a tubular sleeve 1 6 in openwork steel in its configuration of minimum diameter, that is to say as it is at the end of manufacture, ready to be used.
- the sleeve 1 6 is for example produced by laser cutting of a suitable steel tube with a wall thickness of a few tenths of a millimeter, with a diameter of 8 mm and a length of 24 mm.
- the cutouts are diamond-shaped so as to produce a regular mesh structure whose branches 1 8 separating the diamonds 20 have, by way of illustration, a length of a few millimeters for example 4 mm for a width of the order of a few tenths of a millimeter.
- Figures 1 A and 1 B simply illustrate the general structure of the sleeve 1 6 and that the dimensional ratios indicated above are not observed in the drawings.
- at the two ends of the sleeve 1 6 of the transfer pins 22 are regularly distributed in a crown radially outward from the external face of the sleeve.
- the pins 22 are made of steel and attached for example by welding or gluing to the end points 24 of the sleeve 1 6.
- the pins 22 have a length of between approximately 0.5 mm and 3 mm and are straight. Their profile is hemostatic and comprises a cylindrical base part 26, with a diameter of the order of a few tenths of a millimeter, extended by an end part 28 of trihedral shape. As with the mesh structure, the pins 22 of FIGS. 1 A and 1 B are not shown in full size.
- all the points 24 of the two ends of the sleeve 1 6 are provided with pins 22.
- the pins 22 of the ends may be of reduced height compared to that of the pins of the intermediate zone. Indeed, when the length of the sleeve 1 6 is greater than the length of the intubated overlapping parts, the end parts of the sleeve are located opposite a single wall to be transfixed so that the pins in these areas can have a reduced height, having less wall thickness to pass through than the other pins of the sleeve.
- a circular crown 30 of spikes 22 ' In the central zone of the sleeve 1 6 is arranged a circular crown 30 of spikes 22 ', at the rate of a spike every two intersections. Between the central crown 30 and each end ring of pins 22 is arranged another ring of pins 22 'identical to the ring 30. The distribution of pins 22' is regular or not.
- the pins 22 ' have the profile shown in FIGS. 2A and 2B, namely a hemostatic profile of the type of the pins 22, with a cylindrical base 32 extended by a terminal tip with a trihedral profile 34 (FIG. 2B).
- the terminal tip 34 is preferably curved in the direction of one or other of the ends of the sleeve 1 6 or in any other direction, the pins 22 'preferably having different orientations, the inclination of said end portions 34 being between 0 and 10 ° and preferably around 5 °.
- Figure 1 B shows the sleeve 1 6 of Figure 1 A in the expanded state, the length of the mesh structure being reduced from 24 mm to 20 mm and the diameter from 8 mm to 20 mm.
- Said structure is not elastic, has no shape memory and is dimensionally stable whatever the amplitude of the expansion which will be given to it, the latter being applied to it using an inflatable balloon of a conventional bloating catheter, when the connection device of the invention is put in place as will now be described with reference to FIGS. 3 to 5.
- connection device in the body conduit
- the connecting device 1 is arranged to the inside of the prosthesis 10 in line with the area of overlap of the body conduit 1 2 and of the prosthesis 1 0.
- the pins 22, 22 ′ perforate both the prosthesis and the body conduit so as to ensure the connection between the two elements.
- the invention also applies to the anastomosis of two bodily conduits via a prosthesis 10 and 1 2.2, the two ends of which are intubated in the terminal parts of said conduits.
- connection device comprises two connection devices 1 4-1 and 1 4-2 constituted for example by a sleeve 1 6 of the type of FIG. 1, arranged respectively at each end at inside the prosthesis 10.
- the invention also relates to a method of setting up the connecting devices.
- the body duct 1 2.1 is intubated a first end of the prosthesis 10.
- the first connecting device 1 4.1 is introduced inside the prosthesis 10 by the second end, and put in place, as illustrated by Figure 4 using an inflatable balloon 36 attached to the delivery catheter 38 in the known manner.
- the second connecting device 14.2 ( Figure 5) is introduced via an orifice 40 formed at the level of the prosthesis 1 0, closed after placement, with manual stitches.
- FIG. 6 there is shown a bifurcated prosthesis in Y 10 'whose first end is intubated in a first body conduit 1 2'-1 and fixed with a first sleeve 1 4'-1 according to invention using the catheter 38 inserted into the prosthesis 10 'by one of the bifurcated ends.
- the two bifurcated ends of the prosthesis 10 ' are intubated in two other body conduits 1 2'-2 and 1 2'-3 and fixed using two others sleeves 14'-2 and 14'-3 which are successively put in place as in the case illustrated in FIG. 5 by introduction of the catheter 38 provided with the balloon 36 on which the transfixing sleeve is threaded (1 4'-2, 1 4'-3), through an orifice 40 'which will then be closed.
- the sleeve 1 6 can expand over a large diameter range, the ratio between the final diameter, in situ, of the sleeve and the initial diameter being advantageously greater than 2, and because the final state is stable since there is no retraction of the sleeve once the deployment balloon is deflated, an effective plating of the sleeve 1 6 is carried out against the intubated facing parts, both tight and firm thanks to the pins 22, 22 'of transfixing said intubated parts.
- the ability of the sleeve 1 6 to an expansion of variable amplitude allows using a single size sleeve to be used for anastomoses for example of vessels whose diameters can vary within a wide range, for example arteries with a diameter between 6 and 30 mm.
- sleeves 1 6 of different sizes and having pins 22, 22 'of different shapes and dimensions and distributed on the sleeve in different ways.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- External Artificial Organs (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03780211A EP1549252B1 (fr) | 2002-10-10 | 2003-10-10 | Dispositif de liaison entre un conduit corporel et une prothese |
DE60318597T DE60318597T2 (de) | 2002-10-10 | 2003-10-10 | Verbindungsvorrichtung zwischen einem körperkanal und einer prothese |
AU2003288310A AU2003288310A1 (en) | 2002-10-10 | 2003-10-10 | Device for connection between a corporeal duct and a prosthesis |
US10/530,801 US7828834B2 (en) | 2002-10-10 | 2003-10-10 | Device for connection between a corporeal duct and a prosthesis |
DK03780211T DK1549252T3 (da) | 2002-10-10 | 2003-10-10 | Forbindelsesindretning mellem en legemskanal og en protese |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR02/12601 | 2002-10-10 | ||
FR0212601A FR2845590B1 (fr) | 2002-10-10 | 2002-10-10 | Dispositif de liaison entre une prothese et un conduit corporel et dispositif de connexion de deux conduits corporels disposes bout a bout |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004032800A1 true WO2004032800A1 (fr) | 2004-04-22 |
Family
ID=32039611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2003/002988 WO2004032800A1 (fr) | 2002-10-10 | 2003-10-10 | Dispositif de liaison entre un conduit corporel et une prothese |
Country Status (10)
Country | Link |
---|---|
US (1) | US7828834B2 (fr) |
EP (1) | EP1549252B1 (fr) |
AT (1) | ATE383127T1 (fr) |
AU (1) | AU2003288310A1 (fr) |
DE (1) | DE60318597T2 (fr) |
DK (1) | DK1549252T3 (fr) |
ES (1) | ES2299740T3 (fr) |
FR (1) | FR2845590B1 (fr) |
PT (1) | PT1549252E (fr) |
WO (1) | WO2004032800A1 (fr) |
Cited By (3)
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EP2416733B1 (fr) * | 2009-04-07 | 2014-12-17 | Cook Medical Technologies LLC | Ensemble introducteur et dispositif médical implantable |
CN107530160A (zh) * | 2015-02-20 | 2018-01-02 | 波士顿科学国际有限公司 | 具有可回缩锚定件的支架 |
EP3362006A4 (fr) * | 2015-10-12 | 2019-05-15 | Reflow Medical, Inc. | Stents pourvus d'éléments saillants d'administration de médicament et systèmes et procédés associés |
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DE10154163A1 (de) * | 2001-11-03 | 2003-05-22 | Advanced Med Tech | Vorrichtung zum Aufrichten und Stabilisieren der Wirbelsäule |
WO2006034436A2 (fr) | 2004-09-21 | 2006-03-30 | Stout Medical Group, L.P. | Dispositif de support expansible et procede d'utilisation |
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US20090125096A1 (en) * | 2007-11-12 | 2009-05-14 | Medtronic Vascular, Inc. | Stent Graft With Pins |
US9375327B2 (en) | 2007-12-12 | 2016-06-28 | Intact Vascular, Inc. | Endovascular implant |
US20110230954A1 (en) * | 2009-06-11 | 2011-09-22 | Peter Schneider | Stent device having focal elevating elements for minimal surface area contact with lumen walls |
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US8128677B2 (en) | 2007-12-12 | 2012-03-06 | Intact Vascular LLC | Device and method for tacking plaque to a blood vessel wall |
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US9180005B1 (en) | 2014-07-17 | 2015-11-10 | Millipede, Inc. | Adjustable endolumenal mitral valve ring |
US9980840B2 (en) | 2014-12-08 | 2018-05-29 | Cook Medical Technologies Llc | Delivery device with an expandable positioner for positioning a prosthesis |
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ITUB20160782A1 (it) * | 2016-01-27 | 2017-07-27 | Alessandro Luci | metodo e dispositivo riassorbibile per preservare il flusso sanguigno e per il confezionamento di anastomosi cardiovascolari o di qualsiasi altro organo cavo in corso di interventi chirurgici |
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US11666464B2 (en) | 2019-01-28 | 2023-06-06 | Tensor Flow Ventures Llc | Magnetic stent and stent delivery |
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- 2002-10-10 FR FR0212601A patent/FR2845590B1/fr not_active Expired - Fee Related
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- 2003-10-10 US US10/530,801 patent/US7828834B2/en not_active Expired - Fee Related
- 2003-10-10 AU AU2003288310A patent/AU2003288310A1/en not_active Abandoned
- 2003-10-10 ES ES03780211T patent/ES2299740T3/es not_active Expired - Lifetime
- 2003-10-10 PT PT03780211T patent/PT1549252E/pt unknown
- 2003-10-10 DK DK03780211T patent/DK1549252T3/da active
- 2003-10-10 AT AT03780211T patent/ATE383127T1/de not_active IP Right Cessation
- 2003-10-10 DE DE60318597T patent/DE60318597T2/de not_active Expired - Lifetime
- 2003-10-10 EP EP03780211A patent/EP1549252B1/fr not_active Expired - Lifetime
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EP2416733B1 (fr) * | 2009-04-07 | 2014-12-17 | Cook Medical Technologies LLC | Ensemble introducteur et dispositif médical implantable |
US9724220B2 (en) | 2009-04-07 | 2017-08-08 | Cook Medical Technologies Llc | Introducer assembly and implantable medical device |
CN107530160A (zh) * | 2015-02-20 | 2018-01-02 | 波士顿科学国际有限公司 | 具有可回缩锚定件的支架 |
EP3362006A4 (fr) * | 2015-10-12 | 2019-05-15 | Reflow Medical, Inc. | Stents pourvus d'éléments saillants d'administration de médicament et systèmes et procédés associés |
AU2016339033B2 (en) * | 2015-10-12 | 2021-04-08 | Reflow Medical, Inc. | Stents having protruding drug-delivery features and associated systems and methods |
US11253379B2 (en) | 2015-10-12 | 2022-02-22 | Reflow Medical, Inc. | Stents having protruding drug-delivery features and associated systems and methods |
Also Published As
Publication number | Publication date |
---|---|
DE60318597T2 (de) | 2008-12-24 |
AU2003288310A1 (en) | 2004-05-04 |
DE60318597D1 (de) | 2008-02-21 |
US20060149349A1 (en) | 2006-07-06 |
ATE383127T1 (de) | 2008-01-15 |
US7828834B2 (en) | 2010-11-09 |
DK1549252T3 (da) | 2008-05-19 |
FR2845590A1 (fr) | 2004-04-16 |
FR2845590B1 (fr) | 2005-10-21 |
PT1549252E (pt) | 2008-04-17 |
ES2299740T3 (es) | 2008-06-01 |
EP1549252A1 (fr) | 2005-07-06 |
EP1549252B1 (fr) | 2008-01-09 |
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