WO2004024855A1 - Produit d'entretien pour verres de contact contenant des extraits naturels de plantes - Google Patents

Produit d'entretien pour verres de contact contenant des extraits naturels de plantes Download PDF

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Publication number
WO2004024855A1
WO2004024855A1 PCT/EP2003/009971 EP0309971W WO2004024855A1 WO 2004024855 A1 WO2004024855 A1 WO 2004024855A1 EP 0309971 W EP0309971 W EP 0309971W WO 2004024855 A1 WO2004024855 A1 WO 2004024855A1
Authority
WO
WIPO (PCT)
Prior art keywords
contact lens
lens care
extracts
composition according
weight
Prior art date
Application number
PCT/EP2003/009971
Other languages
English (en)
Inventor
Anton Scherer
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh filed Critical Novartis Ag
Priority to AU2003267064A priority Critical patent/AU2003267064A1/en
Publication of WO2004024855A1 publication Critical patent/WO2004024855A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

  • the present invention relates to a contact lens care product, containing water lily extracts or more advantageously water lily extracts in combination with dexpanthenol and sorbitol.
  • the name water lily defines a large variety of plants and herbs belonging to the family of
  • Nymphaeaceae such as Nymphaea odorata or white pond lily.
  • the leaves, the flowers and the roots of Nymphaea odorata have been used for long time for healing wounds for curing inflamed tissues in various parts of the body.
  • the antibacterial properties of the water lily have been attributed to the active ingredients tannins and flavonids, which are found in the extracts of the plant.
  • traces of said composition might still be present on the lens when it is placed in the eye or may have been absorbed by the lens and been release later on demand of the eye.
  • the contact lens care solution containing water lily extracts also benefits from the disinfecting and rinsing properties of water lily extracts coming in direct contact with the eye.
  • compositions containing water lily extracts are not cytotoxic and no negative effects could be associated to the use of such extracts in lens care products.
  • water lily extracts allows substantially diminishing the amounts of preservatives in the contact lens care composition further improving the comfort when wearing the contact lens.
  • the subject of the present invention is therefore a contact lens care composition containing extracts of water lily.
  • the invention similarly relates to the use of extracts of water lily for cleaning and disinfecting contact lenses.
  • Water lily extracts are especially extracts from the leaves, preferably from the root and more preferably from the flowers of a large variety of water nymphs among them the most known being the white pond lily and the blue lotus.
  • Water lily extracts are preferably used in the lens care compositions according to the invention in an amount of ca. 0.005 to 5% by weight, more preferably in an amount of ca. 0.02 to 0.3% by weight, most preferably in an amount of ca. 0.007 to 0.03% by weight, based on the total amount of contact lenses care composition which is advantageously formulated in aqueous solution.
  • Water lily extracts are commercially available in aqueous solution containing an amount for example between 10 and 80% by weight.
  • the contact lens care compositions according to the invention generally contain one or more other constituents, e.g. buffer substances, substances that affect the tonicity, surface-active substances, substances that affect viscosity, complexing agents and/or anti-microbial compounds. Although it is generally unnecessary, an enzymatic cleaning substance may also be present in the contact lens care products according to the invention.
  • buffer substances substances that affect the tonicity, surface-active substances, substances that affect viscosity, complexing agents and/or anti-microbial compounds.
  • an enzymatic cleaning substance may also be present in the contact lens care products according to the invention.
  • the amounts of these or other conventional additives used in the contact lens care compositions according to the invention are variable within the limits known to the person skilled in the art.
  • the contact lens care products according to the invention are preferably formulated in such a way that they are isotonic with the lachrymal fluid.
  • a solution, which is isotonic with the lachrymal fluid is generally understood to be a solution whose concentration corresponds to the concentration of a 0.9% sodium chloride solution. Deviations from this concentration are possible throughout, provided that the contact lenses to be treated are not damaged.
  • the isotonicity with the lachrymal fluid, or even another desired tonicity may be adjusted by adding organic or inorganic substances, which affect the tonicity.
  • the former may be used e.g. in amounts of about 1 to 4.5 percent by weight, and the latter in amounts of about 0.1 to 1.3 percent by weight.
  • the amount to be added of the substance, which affects tonicity is such that the tonicity of the composition according to the invention is in particular in the range 200 to 450 milliosmol, preferably in the range 270 to 330 milliosmol.
  • Typical organic substances of this kind are, for example, glycerol, urea, propylene glycol or sugars such as mannitol or sorbitol, and typical inorganic substances of this kind are in particular potassium chloride or sodium chloride. Mixtures of these compounds with one another may also be used according to the invention.
  • Suitable surface-active substances are named for example in EP-A2-180 309.
  • Especially suitable representatives that may be used according to the invention are, for example, the poloxamer types (polyethylene glycol - polypropylene glycol block copolymers, e.g. Pluronic® or Pluronic® R types) or miranol types.
  • Other representatives are known to the person skilled in the art.
  • These substances may be used, for example, in amounts of up to 20 percent by weight, especially in amounts of 0.4 to 5 percent by weight, based on the total amount of contact lens care composition.
  • Suitable substances which affect viscosity are likewise known to the person skilled in the art.
  • Especially suitable representatives which may be used according to the invention are those named here, for example polyvinyl alcohol, methyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose or polyacrylic acid. Typical amounts of these substances are 0.1 to 2 percent by weight, based on the total amount of contact lens care composition.
  • One especially suitable complex former is in particular ethylenediamine tetraacetic acid, abbreviated to EDTA, or salts thereof such as sodium salts. Typical amounts of these substances are 0.01 to 1 percent by weight, based on the total amount of contact lens care composition.
  • Suitable antimicrobial agents is represented by quaternary ammonium salts.
  • Another example of preferred antimicrobial agents is biguanides, e.g. hexamethylene biguanides or water-soluble polymers, e.g. a polyaminopropyl biguanide, or a suitable salt thereof.
  • One preferred antimicrobial agent is PHMB (polyhexamethylene biguanide).
  • Another example of a suitable antimicrobial agent, which may be used in combination with water lily extracts, is hydrogen peroxide or a source of hydrogen peroxide e.g. sodium perborate, urea perborate or the like.
  • the antimicrobial agent is preferably used in the contact lens care composition according to the invention in an amount of 0.1 to 100 ppm (0.00001 - 0.01 percent by weight), especially in an amount of 0.5 to 50 ppm (0.00005 - 0.005 percent by weight), and most particularly in an amount of 1 to 10 ppm (0.0001 - 0.001 percent by weight), e.g. 1.2 or 5 ppm, based on the total amount of contact lens care composition.
  • a suitable salt is generally understood to be a water- soluble salt, which is advantageously ophthalmologically acceptable.
  • Suitable salts are those with inorganic or organic acids, for example hydrochlorides, hydrobromides, borates, acetates, gluconates, sulfonates, maleates, ascorbates, tartrates or citrates.
  • Suitable buffer substances as a constituent of the contact lens care composition according to the invention are known to the person skilled in the art.
  • examples are borates e.g. boric acid, sodium borate, potassium tetraborate and/or potassium metaborate; citrates e.g. citric acid, potassium citrate; bicarbonates, e.g. sodium bicarbonate; TRIS (trometamol, 2- amino-2-hydroxymethyl-1 ,3-propanediol); phosphate buffers, e.g. Na 2 HPO 4) NaH 2 PO 4 , and KH 2 PO 4 ; or mixtures thereof.
  • borates e.g. boric acid, sodium borate, potassium tetraborate and/or potassium metaborate
  • citrates e.g. citric acid, potassium citrate
  • bicarbonates e.g. sodium bicarbonate
  • TRIS trometamol, 2- amino-2-hydroxymethyl-1 ,3-propanediol
  • the pH value of the care compositions is preferably from e.g. 5 to 8, preferably from 6 to 8, most preferably from 6.6 to 7.4.
  • One preferred embodiment of the present invention relates to a contact lens care composition further comprising dexpanthenol and/or D-sorbit.
  • dexpanthenol and D-sorbit possess a favourable cleansing action and more importantly they stabilize the lachrymal film after inserting the contact lenses, whereupon a heavy loss of the aqueous layer is prevented. This guards against the appearance of dryness, which can lead to a reduced lachrymal film.
  • These favourable properties are further enhanced when the dexpanthenol and D-sorbit are used in combination in a contact lens care solution.
  • Dexpanthenol is used in the preferred contact lens care compositions according to the invention in an amount of, for example, ca. 0.2 to 10 percent by weight, especially in an amount of ca. 0.5 to 5 percent by weight, more preferably in an amount of ca. 0.5 to 4 percent by weight, most preferably in an amount of 1 to 3 percent by weight, based on the total amount of contact lens care compositions which is advantageously formulated in aqueous solution.
  • D-sorbit is used in the preferred contact lens care compositions according to the invention in an amount of, for example, ca. 0.4 to about 18 percent by weight, especially in an amount of ca. 0.6 to 8 percent by weight, more preferably in an amount of ca. 0.8 to 6 percent by weight, most preferably in an amount of 1 to 3 percent by weight, based on the total amount of contact lens care composition which is advantageously formulated in aqueous solution.
  • the preferred contact lens care compositions according to the invention advantageously contain, in addition to extracts of water lily, dexpanthenol, D-sorbit and water, one or more other constituents, e.g. buffer substances, further substances that affect the tonicity, surface-active substances, substances that affect viscosity, complexing agents and/or antimicrobial compounds, whereby the meanings and preferences given above apply.
  • one or more other constituents e.g. buffer substances, further substances that affect the tonicity, surface-active substances, substances that affect viscosity, complexing agents and/or antimicrobial compounds, whereby the meanings and preferences given above apply.
  • an enzymatic cleaning substance may also be present in the preferred contact lens care compositions according to the invention.
  • the amounts in which these or other conventional additives are contained in the contact lens care compositions according to the invention, which contain dexpanthenol and D-sorbit correspond to the amounts mentioned above, including the preferences given therein.
  • the contact lens care compositions according to the invention are suitable for all kinds of contact lenses. This includes in particular the so-called hard and soft contact lenses, and also the so-called hard-flexible or highly gas-permeable contact lenses.
  • the contact lens care compositions according to the invention have cleaning action and, in addition, optionally have anti-microbial action.
  • the contact lens care compositions according to the invention may be used as cleaning agents, as disinfectants, or e.g. as a solution in which to store, rinse, moisten or soak the contact lenses.
  • extracts of water lily or the combination of extracts of water lily with dexpanthenol and D-sorbit are respectively used in so-called all-in-one solutions, most preferably in those that require no rub and no rinse.
  • the contact lens care compositions according to the invention are produced in known manner, in particular by means of conventional mixing of the constituents with water or dissolving the constituents in water.
  • compositions according to the invention are especially suitable for cleaning and, where appropriate, for disinfecting contact lenses.
  • the contact lens care compositions according to the invention are used in known manner, e.g. by bringing the contact lens into contact with the contact lens care composition for a period of time that is sufficient to clean or disinfect it. In general neither rubbing nor rinsing the lens is necessary before placing it in the eye.
  • a sufficient time span ranges from a few minutes to about 24 hours, preferably up to about 4 to 12 hours; a treatment time of e.g. 1 to 12 hours, preferably 2 to 8 hours and in particular 4 to 6 hours, has proved to be especially practicable.
  • One preferred solution according to the invention contains, for example, flower extracts of white pond lily, one or more buffer substances, sodium chloride and a complexing agent, preferably EDTA.
  • An especially preferred solution according to the invention thus contains e.g.:
  • Poloxamer 407 (Pluronic F127) 0.1- 3 g/l
  • TRIS boric acid and/or sodium borate, and water.
  • a more preferred solution according to the invention contains, for example, flower extracts of white pond lily, one or more buffer substances, sodium chloride, EDTA, water as in the example above and in addition Polyhexanide (PHMB HCI) in an amount between 0.0005 to 0.05 g/l.
  • a further preferred solution according to the invention contains, for example, flower extracts of white pond lily, dexpanthenol, D-sorbit, one or more buffer substances, sodium chloride or potassium chloride and a complexing agent, preferably EDTA.
  • An especially preferred solution according to the invention thus contains e.g. water and:
  • buffer substances which stabilise a pH value of 6 to 8, e.g. Na 2 HPO 4 , NaH 2 PO 4 , TRIS, boric acid and/or sodium borate, and water.
  • a most preferred solution according to the invention contains, for example, flower extracts of white pond lily, dexpanthenol, D-sorbit, one or more buffer substances, sodium chloride, EDTA, water as in the example above and in addition Polyhexanide (PHMB HCI) in an amount between 0.0005 to 0.05 g/l.
  • PHMB HCI Polyhexanide
  • compositions may also contain: a surface-active substance 0.1 to 2 g/l a compound which affects the viscosity 0.1 to 2 g/l
  • a contact lens care composition is produced by mixing together the following components:
  • Poloxamer 407 (Pluronic F127) 1 ,000 g/l

Abstract

L'invention concerne une composition d'entretien pour verres de contact contenant des extraits de nénuphar blanc. L'invention porte également sur l'utilisation d'une composition du type décrit pour le nettoyage et éventuellement la désinfection des verres de contact.
PCT/EP2003/009971 2002-09-09 2003-09-08 Produit d'entretien pour verres de contact contenant des extraits naturels de plantes WO2004024855A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003267064A AU2003267064A1 (en) 2002-09-09 2003-09-08 Contact lens care product containing natural plant extracts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02020167 2002-09-09
EP02020167.9 2002-09-09

Publications (1)

Publication Number Publication Date
WO2004024855A1 true WO2004024855A1 (fr) 2004-03-25

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Application Number Title Priority Date Filing Date
PCT/EP2003/009971 WO2004024855A1 (fr) 2002-09-09 2003-09-08 Produit d'entretien pour verres de contact contenant des extraits naturels de plantes

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AU (1) AU2003267064A1 (fr)
WO (1) WO2004024855A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007057157A1 (fr) * 2005-11-16 2007-05-24 Novartis Ag Solutions d'entretien pour lentilles de contact
US9308264B2 (en) 2000-11-08 2016-04-12 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6357696A (ja) * 1986-08-28 1988-03-12 株式会社資生堂 洗浄料
JPS6447708A (en) * 1987-08-18 1989-02-22 Shiseido Co Ltd Cosmetic
US6162393A (en) * 1998-08-06 2000-12-19 Ndt, Inc. Contact lens and ophthalmic solutions
US6296859B1 (en) * 1998-03-09 2001-10-02 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Synergistic composition comprising a compound of lipoamino acid structure and a water lily extract
WO2002055118A1 (fr) * 2001-01-12 2002-07-18 Novartis Ag Produit de nettoyage de lentilles contenant du dexpanthenol

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6357696A (ja) * 1986-08-28 1988-03-12 株式会社資生堂 洗浄料
JPS6447708A (en) * 1987-08-18 1989-02-22 Shiseido Co Ltd Cosmetic
US6296859B1 (en) * 1998-03-09 2001-10-02 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Synergistic composition comprising a compound of lipoamino acid structure and a water lily extract
US6162393A (en) * 1998-08-06 2000-12-19 Ndt, Inc. Contact lens and ophthalmic solutions
WO2002055118A1 (fr) * 2001-01-12 2002-07-18 Novartis Ag Produit de nettoyage de lentilles contenant du dexpanthenol

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198816, Derwent World Patents Index; Class D21, AN 1988-108909, XP002230597 *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 238 (C - 603) 5 June 1989 (1989-06-05) *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9308264B2 (en) 2000-11-08 2016-04-12 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
US9585394B2 (en) 2000-11-08 2017-03-07 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
US10064410B2 (en) 2000-11-08 2018-09-04 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
US10595532B2 (en) 2000-11-08 2020-03-24 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
WO2007057157A1 (fr) * 2005-11-16 2007-05-24 Novartis Ag Solutions d'entretien pour lentilles de contact
US7666823B2 (en) 2005-11-16 2010-02-23 Novartis Ag Lens care solutions

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Publication number Publication date
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