ZA200304332B - Lens care product containing dexpanthenol. - Google Patents
Lens care product containing dexpanthenol. Download PDFInfo
- Publication number
- ZA200304332B ZA200304332B ZA200304332A ZA200304332A ZA200304332B ZA 200304332 B ZA200304332 B ZA 200304332B ZA 200304332 A ZA200304332 A ZA 200304332A ZA 200304332 A ZA200304332 A ZA 200304332A ZA 200304332 B ZA200304332 B ZA 200304332B
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- ZA
- South Africa
- Prior art keywords
- contact lens
- lens care
- care composition
- dexpanthenol
- composition according
- Prior art date
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- 239000011703 D-panthenol Substances 0.000 title claims description 45
- 235000004866 D-panthenol Nutrition 0.000 title claims description 45
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 title claims description 44
- 229960003949 dexpanthenol Drugs 0.000 title claims description 43
- 239000000203 mixture Substances 0.000 claims description 71
- 239000000126 substance Substances 0.000 claims description 29
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 27
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 26
- 229920002413 Polyhexanide Polymers 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 15
- 239000011780 sodium chloride Substances 0.000 claims description 13
- 239000000872 buffer Substances 0.000 claims description 12
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 10
- 239000000470 constituent Substances 0.000 claims description 10
- 238000004140 cleaning Methods 0.000 claims description 9
- 239000008139 complexing agent Substances 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 230000000249 desinfective effect Effects 0.000 claims description 7
- 230000000845 anti-microbial effect Effects 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 5
- 239000001103 potassium chloride Substances 0.000 claims description 5
- 235000011164 potassium chloride Nutrition 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 2
- 239000000243 solution Substances 0.000 description 14
- 239000007983 Tris buffer Substances 0.000 description 8
- 239000008213 purified water Substances 0.000 description 8
- 238000009472 formulation Methods 0.000 description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 229960002920 sorbitol Drugs 0.000 description 5
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 5
- 239000004599 antimicrobial Substances 0.000 description 4
- 235000010356 sorbitol Nutrition 0.000 description 4
- 229940123208 Biguanide Drugs 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 3
- 235000019799 monosodium phosphate Nutrition 0.000 description 3
- 229920001983 poloxamer Polymers 0.000 description 3
- 229920001992 poloxamer 407 Polymers 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920003091 Methocel™ Polymers 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000004327 boric acid Substances 0.000 description 2
- 150000001642 boronic acid derivatives Chemical class 0.000 description 2
- 150000001860 citric acid derivatives Chemical class 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 229940044476 poloxamer 407 Drugs 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 150000000994 L-ascorbates Chemical class 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- 229920002004 Pluronic® R Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000000882 contact lens solution Substances 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- -1 hexamethylene biguanides Chemical class 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Description
Lens Care Product Containing Dexpanthenol .
The present invention relates to a contact lens care product for hard and soft contact ' lenses, containing dexpanthenol or preferably dexpanthenol in combination with sorbitol.
Dexpanthenol, an alcohol of pantothenic acid, also called Provitamin B5, D-pantothenyl alcohol or D-panthenol, has been used for a long time for healing wounds or in the field of medicinal skin care. It has now surprisingly been found that dexpanthenol can also be used very effectively as a constituent in contact lens care products. The compound has good cleansing action and, in addition, stabilises the lachrymal film when inserting the contact lenses. Vortex motion of the lachrymal liquid can occur through the insertion of contact lenses, namely because of mechanical eruption or through surface-active substances optionally present in the contact lens solution and can lead to severe loss of the aqueous lachrymal layer. It was found that dexpanthenol stabilises the lachrymal film and prevents severe losses of the aqueous layer. This guards against the appearance of dryness, which can lead to a reduced lachrymal film.
The subject of the present invention is therefore a contact lens care composition containing dexpanthenol. The invention similarly relates to the use of dexpanthenol for cleaning and disinfecting contact lenses.
Dexpanthenol is preferably used in the contact lens care compositions according to the invention in an amount of ca. 0.2 to 10 percent by weight, especially in an amount of ca. 0.5 to § percent by weight, more preferably in an amount of ca. 0.5 to 4 percent by weight, most preferably in an amount of 1 to 3 percent by weight, based on the total amount of contact lens care compositions which is advantageously formulated in aqueous solution.
Apart from dexpanthenol and water, the contact lens care compositions according to the . invention generally contain one or more other constituents, e.g. buffer substances, substances that affect the tonicity, surface-active substances, substances that affect viscosity, complexing agents and/or antimicrobial compounds. Although it is generally unnecessary, an enzymatic cleaning substance may also be present in the contact lens care products according to the invention. The amounts of these or other conventional 8 additives used in the contact lens care compositions according to the invention are variable within the limits known to the person skilled in the art.
The contact lens care products according to the invention are preferably formulated in such a way that they are isotonic with the lachrymal fluid.
A solution which is isotonic with the lachrymal fluid is generally understood to be a solution whose concentration corresponds to the concentration of a 0.9% sodium chloride solution.
Deviations from this concentration are possible throughout, provided that the contact lenses to be treated are not damaged. The isotonicity with the lachrymal fluid, or even another desired tonicity, may be adjusted by adding organic or inorganic substances which affect the tonicity. The former may be used e.g. in amounts of about 1 to 4.5 percent by weight, and the latter in amounts of about 0.1 to 1.3 percent by weight. In general the amount to be added of the substance which affects tonicity, is such that the tonicity of the composition according to the invention is in particular in the range 200 to 450 milliosmol, preferably in the range 270 to 330 milliosmol. Typical organic substances of this kind are, for example, glycerol, urea, propylene glycol or sugar such as mannitol or sorbitol, and typical inorganic substances of this kind are in particular potassium chloride or sodium chloride. Mixtures of these compounds with one another may also be used according to the invention.
Suitable surface-active substances are named for example in EP-A2-180 309. Especially suitable representatives that may be used according to the invention are, for example, the poloxamer types (polyethylene glycol - polypropylene glycol block copolymers, e.g.
Pluronic® or Pluronic® R types) or miranol types. Other representatives are known to the person skilled in the art. These substances may be used, for example, in amounts of up to percent by weight, especially in amounts of 0.4 to 5 percent by weight, based on the : total amount of contact lens care composition. ) Suitable substances which affect viscosity are likewise known to the person skilled in the art. Especially suitable representatives which may be used according to the invention are those named here, for example polyvinyl alcohol, methyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose or polyacrylic acid. Typical amounts of these substances are 0.1 to 2 percent by weight, based on the total amount of contact lens care a composition. ¢ One especially suitable complex former is in particular ethylenediamine tetraacetic acid, abbreviated to EDTA, or salts thereof such as sodium salts. Typical amounts of these substances are 0.01 to 1 percent by weight, based on the total amount of contact lens care composition.
One group of suitable antimicrobial agents is represented by quaternary ammonium salts.
Another example of preferred antimicrobial agents is biguanides, e.g. hexamethylene biguanides or water-soluble polymers, e.g. a polyaminopropy! biguanide, or a suitable salt thereof. One preferred antimicrobial agent is PHMB (polyhexamethylene biguanide).
The antimicrobial agent is preferably used in the contact lens care composition according to the invention in an amount of 0.1 to 100 ppm (0.00001 - 0.01 percent by weight), _ especially in an amount of 0.5 to 50 ppm (0.00005 - 0.005 percent by weight), and most particularly in an amount of 1 to 10 ppm (0.0001 - 0.001 percent by weight), e.g. 1.2 or ppm, based on the total amount of contact lens care composition.
In the context of the present invention, a suitable salt is generally understood to be a water-soluble salt which is advantageously ophthalmologically acceptable. Suitable salts are those with inorganic or organic acids, for example hydrochlorides, hydrobromides, borates, acetates, gluconates, sulfonates, maleates, ascorbates, tartrates or citrates.
Suitable buffer substances as a constituent of the contact lens care compasition according to the invention are known to the person skilled in the art. Examples are boric acid, borates, e.g. sodium borate, citric acid, citrates, e.g. potassium citrate, bicarbonates, e.g. sodium bicarbonate, TRIS (trometamol, 2-amino-2-hydroxymethyl-1,3-propanediol), ‘ phosphate buffers, e.g. Na;,HPO,4, NaH,PQO,, and KH.PO, or mixtures thereof.
Co The pH value of the care compositions is preferably from e.g. 5 to 8, preferably from 6 to 8, most preferably from 7 to 7.6.
One preferred embodiment of the present invention relates to a contact lens care compositions containing dexpanthenol and D-sorbit.
D-sorbit, a hexavalent sugar alcohol, also called sorbitol, D-sorbitol or D-glucitol, is used in . gels as a moisture-retaining agent and plasticiser.
The addition of D-sorbit to adjust the tonicity of contact lens care products is known. GB 2,205,175 and US 3,888,782 describe sorbit as a carrier material for the preparation of powder mixtures for contact lens care products. It has now surprisingly been found that the combination dexpanthenol and D-sorbit can be used effectively as a constituent in contact lens care compositions. The combination dexpanthenol and D-sorbit possesses a favourable cleansing action and also stabilises the lachrymal film after inserting the contact lenses, whereupon a heavy loss of the aqueous layer is prevented. This guards against the appearance of dryness, which can lead to a reduced lachrymal film. The usage of the active ingredient combination dexpanthenol and D-sorbit also substantially improves comfort when wearing contact lenses. Negative effects caused by surface-active substances and preservatives are reduced and the contact lenses are prevented from drying out.
Furthermore, it has been shown in studies that the addition of dexpanthenol and D-sorbit is not cytotoxic and does not have negative effects on the antimicrobial efficacy of the solutions. It has surprisingly been found that the addition of sorbit substantially increases the microbiological efficacy of antimicrobial compounds present in the contact lens care compositions according to the invention, e.g. of PHMB, without resulting in negative effects as regards toxicity.
Dexpanthenol is preferably used in the preferred sorbit-containing contact lens care compositions according to the invention in the amount indicated above, whereby the said preferences apply. ’ D-sorbit is used in the preferred contact lens care compositions according to the invention in an amount of about 0.4 to about 18 percent by weight, especially in an amount of 0.6 to ’ 8 percent by weight, more preferably in an amount of 0.8 to 6 percent by weight, most preferably in an amount of 1 to 3 percent by weight, based on the total amount of contact lens care composition which is advantageously formulated in aqueous solution.
The preferred contact lens care compositions according to the invention advantageously . contain, in addition to dexpanthenol, D-sorbit and water, one or more other constituents, e.g. buffer substances, further substances that affect the tonicity, surface-active . substances, substances that affect viscosity, complexing agents and/or antimicrobial compounds, whereby the meanings and preferences given above apply. Although it is generally unnecessary, an enzymatic cleaning substance may also be present in the preferred contact lens care compositions according to the invention. The amounts in which these or other conventional additives are contained in the contact lens care compositions according to the invention, which contain dexpanthenol and D-sorbit, correspond to the . amounts mentioned above, including the preferences given therein.
The contact lens care compositions according to the invention are suitable for all kinds of contact lenses. This includes in particular the so-called hard and soft contact lenses, and also the so-called hard-flexible or highly gas-permeable contact lenses. The contact lens care compositions according to the invention have cleaning action and, in addition, optionally have antimicrobial action. Depending on the intended purpose of use, the contact lens care compositions according to the invention may be used as cleaning agents, as disinfectants, or e.g. as a solution in which to store, rinse, moisten or soak the contact lenses. Preferably, dexpanthenol or the combination of dexpanthenol and D-sorbit are respectively used in so-called all-in-one solutions, but may also be advantageously added to other contact lens care products, for example neutralisation solutions, hard lens care compositions, storing and disinfecting solutions. All these solutions are notable for their good tolerance.
The contact lens care compositions according to the invention are produced in known manner, in particular by means of conventional mixing of the constituents with water or dissolving the constituents in water.
The compositions according to the invention are especially suitable for cleaning and, where appropriate, for disinfecting contact lenses. The contact lens care compositions according to the invention are used in known manner, e.g. by bringing the contact lens into contact with the contact lens care composition for a period of time that is sufficient to clean or disinfect it. Depending on the lens type and the degree of soiling, a sufficient time span ranges from a few minutes to about 24 hours, preferably up to about 4 to 12 hours; a treatment time of e.g. 1 to 12 hours, preferably 2 to 8 hours and in particular 4 to 6 hours, : has proved to be especially practicable. - One preferred solution according to the invention contains, for example, dexpanthenol, one or more buffer substances, PHMB, sodium chloride or potassium chloride and a complexing agent, preferably EDTA.
An especially preferred solution according to the invention thus contains e.g.: dexpanthenol 5 to 20 g/l
NaCl or KCI 3to9 g/l
PHMB 0.0005 to 0.05 g/l
EDTA O1to2g/l as well as buffer substances which stabilise a pH value of 6 to 8, e.g. Na;HPO,,
NaH,PO,, TRIS, and water.
A further preferred solution according to the invention contains, for example, dexpanthenol, D-sorbit, one or more buffer substances, PHMB, sodium chloride or potassium chloride and a complexing agent, preferably EDTA.
An especially preferred solution according to the invention thus contains e.g. dexpanthenol 510 20 g/l
D-sorbit 10 to 30 g/l
NaCl or KCI Oto5g/l,e.q.0g/lor1to5g/l
PHMB 0.0005 to 0.05 g/l
EDTA 0.1t029g/ as well as buffer substances which stabilise a pH value of 6 to 8, e.g. Na;HPO,,
NaH,PO,, TRIS, and water.
The above-mentioned preferred solutions may also contain: a surface-active substance 0.1to2 g/l a compound which affects the viscosity 0.1to2g/
The following examples serve to illustrate the invention. They are in no way intended to limit the subject matter of the invention, especially the subject matter of the examples.
. Example 1: Formulation for a contact lens care composition
A contact lens care composition is produced by mixing together the following components: - dexpanthenol 10.0 g/l
EDTA 1.0 g/l sodium chloride 7.0 g/l
TRIS buffer 25 g/l
Methocel E5 (cellulose ether product) 0.5 g/l
PHMB 0.001 g/l aqua purificata ad 1000 ml.
Example 2: Formulation for a contact lens care composition
A contact lens care composition is produced by mixing together the following components: dexpanthenol 10.0 g/l
EDTA 1.0 g/l sodium chloride 7.0all ”
TRIS buffer 254g/
PHMB 0.001 g/l aqua purificata ad 1000 ml
Example 3: Formulation for a contact lens care composition
A contact lens care composition is produced by mixing together the following components: dexpanthenol 10.0 g/l
EDTA 0.25 g/l sodium chloride 8.6 g/l disodium hydrogen phosphate 0.072 ¢/I sodium dihydrogen phosphate ~~ 0.622 g/l
PHMB 0.001 g/l
Poloxamer 407 1.0g/ aqua purificata ad 1000 ml
A contact lens care composition is produced by mixing together the following components: dexpanthenol 10.0 g/t
D-sorbit 18.0 g/l : EDTA 1.0 g/l
TRIS buffer 2.5 gfl . Methocel E5 0.5 g/l
PHMB 0.001 g/l aqua purificata ad 1000 mi.
Example 5: Formulation for a contact lens care composition
A contact lens care composition is produced by mixing together the following components: dexpanthenol 10.0 g/i
D-sorbit 18 g/l
EDTA 1.0 g/l
TRIS butter 25 g/l
PHMB 0.001 g/l aqua purificata ad 1000 mi
Example 6: Formulation for a contact lens care composition
A contact lens care composition is produced by mixing together the following components: dexpanthenol 10.0 g/l
D-sorbit 18 g/l
EDTA 0.25 g/l disodium hydrogen phosphate 0.072 g/l sodium dihydrogen phosphate ~~ 0.622 g/l
PHMB 0.001 g/l
Poloxamer 407 1.0 g/l aqua purificata ad 1000 mi
Example 7: Formulation for a contact lens care composition ‘ A contact lens care composition is produced by mixing together the following components: dexpanthenol 20.0 g/l ’ D-sorbit 18.8 g/l
EDTA 0.25 g/l sodium dihydrogen phosphate 4.6 g/l
TRIS 3.3g/
PHMB 0.001 g/l . Pluronic F127 1.04g/ aqua purificata ad 1000 ml
Example 8: Formulation for a hard lens care composition
A contact lens care composition is produced by mixing together the following components: dexpanthenol 20.0 g/l
D-sorbit 18.8 g/l sodium borate 0.05 g/l boric acid 5.09 hydroxyethyl cellulose 3.4 g/l
Pluronic 17R4 1.09/ sodium perborate 0.28 g/l stabiliser (Dequest 2060 S) 0.12 g/l aqua purificata ad 1000 ml
Claims (16)
1. Contact lens care composition comprising dexpanthenol.
2. Contact lens care composition according to claim 1, comprising dexpanthenol and D- sorbit.
3. Contact lens care composition according to claim 1 or 2, comprising an aqueous solution comprising 0.5 to 4 percent by weight, preferably 1 to 3 percent by weight, of dexpanthenol, based on the total weight of the contact lens care composition.
4. Contact lens care composition according to claim 2 or 3, comprising 0.8 to 6 percent by weight, preferably 1 to 3 percent by weight, of D-sorbit, based on the total weight of the contact lens care composition.
5. Contact lens care composition according to one of claims 1 to 4, which comprises one or more further constituents selected from the group consisting of buffer substances, substances that affect the tonicity, surface-active substances, substances that affect viscosity, complexing agents and/or antimicrobial compounds.
6. Contact lens care composition according to claim 1, which comprises dexpanthenol, one or more buffer substances, PHMB, sodium chloride or potassium chloride and a complexing agent.
7. Contact lens care compasition according to claim 6, which contains dexpanthenol 5to20 g/l NaCl or KCI 3to9 g/l PHMB 0.0005 to 0.05 g/I ‘ EDTA | 0.1t02gl as well as buffer substances and water, and it has a pH value of 6 to 8.
8. Contact lens care composition according to one of claims 2 to 5, which comprises dexpanthenol, D-sorbit, one or more buffer substances, PHMB, sodium chloride or potassium chloride and a complexing agent.
. 9. Contact lens care composition according to claim 8, which comprises dexpanthenol 5to 20 g/l * D-sorbit 10 to 30 g/l NaCl or KCI Oto 5 g/l PHMB 0.0005 to 0.05 g/l EDTA 0.1to2g/ as well as buffer substances and water, and it has a pH value of 6 to 8.
10. Contact lens care composition according to claim 7 or 9, which comprises, in addition, a surface-active substance.
11. Use of a contact lens care composition according to one of claims 1, 6 or 7, for cleaning and optionally disinfecting a contact lens.
12. Use of a contact lens care composition according to one of claims 2 to 5 or 8 to 10, for cleaning and optionally disinfecting a contact lens.
13. Use of dexpanthenol as a constituent of a contact lens care composition.
14. Use of a combination of dexpanthenol and D-sorbit as constituents of a contact lens care composition.
15. Method for cleaning and optionally disinfecting a contact lens, wherein a contact lens care composition according to one of claims 1, 6 or 7 is brought into contact with a contact lens for a period of time that is sufficient to clean and optionally disinfect it. +
16. Method for cleaning and optionally disinfecting a contact lens, wherein a contact lens ’ care composition according to one of claims 2 to 5 or 8 to 10 is brought into contact with a contact lens for a period of time that is sufficient to clean and optionally disinfect it.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP01100764 | 2001-01-12 |
Publications (1)
Publication Number | Publication Date |
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ZA200304332B true ZA200304332B (en) | 2004-04-28 |
Family
ID=33442668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200304332A ZA200304332B (en) | 2001-01-12 | 2003-06-03 | Lens care product containing dexpanthenol. |
Country Status (1)
Country | Link |
---|---|
ZA (1) | ZA200304332B (en) |
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2003
- 2003-06-03 ZA ZA200304332A patent/ZA200304332B/en unknown
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