WO2004018633A3 - Abca13 nucleic acids and proteins, and uses thereof - Google Patents

Abca13 nucleic acids and proteins, and uses thereof Download PDF

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Publication number
WO2004018633A3
WO2004018633A3 PCT/US2003/026335 US0326335W WO2004018633A3 WO 2004018633 A3 WO2004018633 A3 WO 2004018633A3 US 0326335 W US0326335 W US 0326335W WO 2004018633 A3 WO2004018633 A3 WO 2004018633A3
Authority
WO
WIPO (PCT)
Prior art keywords
abca13
proteins
nucleic acids
isoforms
methods
Prior art date
Application number
PCT/US2003/026335
Other languages
French (fr)
Other versions
WO2004018633A2 (en
Inventor
Micheal C Dean
Isabelle Arnould-Reguigne
Catherine Prades
Marie-Francoise Rosier-Montus
Patrice Denefle
Sergey Shulenin
Tarmo Annilo
Marcia L Triunfol
Original Assignee
Us Gov Health & Human Serv
Aventis Pharma Sa
Micheal C Dean
Isabelle Arnould-Reguigne
Catherine Prades
Marie-Francoise Rosier-Montus
Patrice Denefle
Sergey Shulenin
Tarmo Annilo
Marcia L Triunfol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Aventis Pharma Sa, Micheal C Dean, Isabelle Arnould-Reguigne, Catherine Prades, Marie-Francoise Rosier-Montus, Patrice Denefle, Sergey Shulenin, Tarmo Annilo, Marcia L Triunfol filed Critical Us Gov Health & Human Serv
Priority to AU2003262789A priority Critical patent/AU2003262789A1/en
Publication of WO2004018633A2 publication Critical patent/WO2004018633A2/en
Publication of WO2004018633A3 publication Critical patent/WO2004018633A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This disclosure provides seven isoforms of a novel transporter protein, referred to as ABCA13, nucleic acid molecules encoding the disclosed isoforms, variants and fragments thereof, and methods of making and using these molecules. Also provided are methods of ameliorating, treating, detecting, prognosing, and diagnosing diseases and conditions believed to be associated with altered expression of ABCA13, such as hypercholesterolemia, drug resistance, retinal degeneration, or neurological disease. Kits are also provided.
PCT/US2003/026335 2002-08-20 2003-08-19 Abca13 nucleic acids and proteins, and uses thereof WO2004018633A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003262789A AU2003262789A1 (en) 2002-08-20 2003-08-19 Abca13 nucleic acids and proteins, and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40500602P 2002-08-20 2002-08-20
US60/405,006 2002-08-20
US45450203P 2003-03-12 2003-03-12
US60/454,502 2003-03-12

Publications (2)

Publication Number Publication Date
WO2004018633A2 WO2004018633A2 (en) 2004-03-04
WO2004018633A3 true WO2004018633A3 (en) 2005-04-21

Family

ID=31949879

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/026335 WO2004018633A2 (en) 2002-08-20 2003-08-19 Abca13 nucleic acids and proteins, and uses thereof

Country Status (2)

Country Link
AU (1) AU2003262789A1 (en)
WO (1) WO2004018633A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
EP2601609B1 (en) 2010-08-02 2017-05-17 Population Bio, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
US10221454B2 (en) 2011-10-10 2019-03-05 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
US11180807B2 (en) 2011-11-04 2021-11-23 Population Bio, Inc. Methods for detecting a genetic variation in attractin-like 1 (ATRNL1) gene in subject with Parkinson's disease
CA2863887C (en) 2012-02-09 2023-01-03 Population Diagnostics, Inc. Methods of screening low frequency gdna variation biomarkers for pervasive developmental disorder (pdd) or pervasive developmental disorder - not otherwise specified (pdd_nos)
EP2895621B1 (en) 2012-09-14 2020-10-21 Population Bio, Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
EP2900835A4 (en) 2012-09-27 2016-05-11 Population Diagnotics Inc Methods and compositions for screening and treating developmental disorders
TWI777197B (en) * 2013-08-05 2022-09-11 德商伊瑪提克斯生物科技有限公司 Novel peptides, cells, and their use against several tumors, methods for production thereof and pharmaceutical composition comprising the same
PL3456339T3 (en) * 2013-08-05 2022-03-21 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumors, such as lung cancer including nsclc
US10724096B2 (en) 2014-09-05 2020-07-28 Population Bio, Inc. Methods and compositions for inhibiting and treating neurological conditions
US11479768B2 (en) * 2015-06-30 2022-10-25 Ethris Gmbh ATP-binding cassette family coding polyribonucleotides and formulations thereof
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
SI3625368T1 (en) 2018-08-08 2023-04-28 Pml Screening, Llc Methods for assessing the risk of developing progressive multifocal leukoencephalopathy caused by john cunningham virus by genetic testing

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074836A1 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel bone marrow nucleic acids and polypeptides
US20020127647A1 (en) * 2000-11-28 2002-09-12 John Shutter ATP-binding cassette transporter-like molecules and uses thereof
US6555323B2 (en) * 2000-02-08 2003-04-29 Pfizer Inc. Assay for ABCA1

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555323B2 (en) * 2000-02-08 2003-04-29 Pfizer Inc. Assay for ABCA1
WO2001074836A1 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel bone marrow nucleic acids and polypeptides
US20020127647A1 (en) * 2000-11-28 2002-09-12 John Shutter ATP-binding cassette transporter-like molecules and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BROCCARDO ET AL: "The ABCA subclass of mammalian transporters", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1461, 1999, pages 395 - 404, XP004273105 *
PRADES ET AL: "The human ATP binding cassette gene ABCA13, located on chromosome 7p12.3, encodes a 5058 amino acid protein with an axtracellular domain encoded i part by a 4.8-kb conserved exon", CYTOGENET. GENOM. RES., vol. 98, 2002, pages 160 - 168, XP002985952 *

Also Published As

Publication number Publication date
AU2003262789A1 (en) 2004-03-11
WO2004018633A2 (en) 2004-03-04
AU2003262789A8 (en) 2004-03-11

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