WO2004000997A3 - Therapeutic polypeptides, nucleic acids encoding same, and methods of use - Google Patents

Therapeutic polypeptides, nucleic acids encoding same, and methods of use Download PDF

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Publication number
WO2004000997A3
WO2004000997A3 PCT/US2003/017512 US0317512W WO2004000997A3 WO 2004000997 A3 WO2004000997 A3 WO 2004000997A3 US 0317512 W US0317512 W US 0317512W WO 2004000997 A3 WO2004000997 A3 WO 2004000997A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
methods
polypeptide
acids encoding
encoding same
Prior art date
Application number
PCT/US2003/017512
Other languages
French (fr)
Other versions
WO2004000997A2 (en
Inventor
David W Anderson
Ferenc L Boldog
Catherine E Burgess
Stacie J Casman
Shlomit R Edinger
Andrew Eisen
Karen Ellerman
Valerie L Gerlach
Linda Gorman
Xiaojia Guo
Vladimir Y Gusev
Weizhen Ji
Li Li
John R Macdougall
Uriel M Malyankar
Isabelle Millet
Tatiana Ort
Muralidhara Padigaru
Sudhirdas K Prayaga
Meera Patturajan
Carol E A Pena
John A Peyman
Daniel K Rieger
Mark E Rothenberg
Paul Sciore
Suresh G Shenoy
Glennda Smithson
Kimberly A Spytek
David J Stone
Raymond J Taupier Jr
Velizar T Tchernev
Corine A M Vernet
Edward Z Voss
Bryan D Zerhusen
Mei Zhong
Original Assignee
Curagen Corp
David W Anderson
Ferenc L Boldog
Catherine E Burgess
Stacie J Casman
Shlomit R Edinger
Andrew Eisen
Karen Ellerman
Valerie L Gerlach
Linda Gorman
Xiaojia Guo
Vladimir Y Gusev
Weizhen Ji
Li Li
John R Macdougall
Uriel M Malyankar
Isabelle Millet
Tatiana Ort
Muralidhara Padigaru
Sudhirdas K Prayaga
Meera Patturajan
Carol E A Pena
John A Peyman
Daniel K Rieger
Mark E Rothenberg
Paul Sciore
Suresh G Shenoy
Glennda Smithson
Kimberly A Spytek
David J Stone
Raymond J Taupier Jr
Velizar T Tchernev
Corine A M Vernet
Edward Z Voss
Bryan D Zerhusen
Mei Zhong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/454,246 external-priority patent/US20050053930A1/en
Application filed by Curagen Corp, David W Anderson, Ferenc L Boldog, Catherine E Burgess, Stacie J Casman, Shlomit R Edinger, Andrew Eisen, Karen Ellerman, Valerie L Gerlach, Linda Gorman, Xiaojia Guo, Vladimir Y Gusev, Weizhen Ji, Li Li, John R Macdougall, Uriel M Malyankar, Isabelle Millet, Tatiana Ort, Muralidhara Padigaru, Sudhirdas K Prayaga, Meera Patturajan, Carol E A Pena, John A Peyman, Daniel K Rieger, Mark E Rothenberg, Paul Sciore, Suresh G Shenoy, Glennda Smithson, Kimberly A Spytek, David J Stone, Raymond J Taupier Jr, Velizar T Tchernev, Corine A M Vernet, Edward Z Voss, Bryan D Zerhusen, Mei Zhong filed Critical Curagen Corp
Priority to CA002486490A priority Critical patent/CA2486490A1/en
Priority to EP03754372A priority patent/EP1572948A2/en
Priority to AU2003272200A priority patent/AU2003272200A1/en
Publication of WO2004000997A2 publication Critical patent/WO2004000997A2/en
Publication of WO2004000997A3 publication Critical patent/WO2004000997A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
PCT/US2003/017512 2002-03-19 2003-06-04 Therapeutic polypeptides, nucleic acids encoding same, and methods of use WO2004000997A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002486490A CA2486490A1 (en) 2002-03-19 2003-06-04 Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP03754372A EP1572948A2 (en) 2002-06-04 2003-06-04 Therapeutic polypeptides, nucleic acids encoding same, and methods of use
AU2003272200A AU2003272200A1 (en) 2002-06-04 2003-06-04 Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Applications Claiming Priority (42)

Application Number Priority Date Filing Date Title
US36549102P 2002-03-19 2002-03-19
US60/365,491 2002-03-19
US38550402P 2002-06-04 2002-06-04
US60/385,504 2002-06-04
US38604102P 2002-06-05 2002-06-05
US60/386,041 2002-06-05
US38697402P 2002-06-06 2002-06-06
US38645302P 2002-06-06 2002-06-06
US60/386,453 2002-06-06
US60/386,974 2002-06-06
US38700202P 2002-06-07 2002-06-07
US38681602P 2002-06-07 2002-06-07
US60/387,002 2002-06-07
US60/386,816 2002-06-07
US38754002P 2002-06-10 2002-06-10
US60/387,540 2002-06-10
US38765902P 2002-06-11 2002-06-11
US60/387,659 2002-06-11
US38793402P 2002-06-12 2002-06-12
US60/387,934 2002-06-12
US38912302P 2002-06-13 2002-06-13
US60/389,123 2002-06-13
US38972902P 2002-06-17 2002-06-17
US38974202P 2002-06-17 2002-06-17
US60/389,742 2002-06-17
US60/389,729 2002-06-17
US39000602P 2002-06-19 2002-06-19
US60/390,006 2002-06-19
US39670602P 2002-07-17 2002-07-17
US60/396,706 2002-07-17
US40283202P 2002-08-12 2002-08-12
US60/402,832 2002-08-12
US40348602P 2002-08-13 2002-08-13
US60/403,486 2002-08-13
US40352202P 2002-08-14 2002-08-14
US60/403,522 2002-08-14
US40374802P 2002-08-15 2002-08-15
US60/403,748 2002-08-15
US38703702P 2002-11-06 2002-11-06
US60/387,037 2002-11-06
US10/454,246 2003-06-03
US10/454,246 US20050053930A1 (en) 2000-07-18 2003-06-03 Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Publications (2)

Publication Number Publication Date
WO2004000997A2 WO2004000997A2 (en) 2003-12-31
WO2004000997A3 true WO2004000997A3 (en) 2007-08-16

Family

ID=34140035

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017512 WO2004000997A2 (en) 2002-03-19 2003-06-04 Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Country Status (2)

Country Link
CA (1) CA2486490A1 (en)
WO (1) WO2004000997A2 (en)

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US9182405B2 (en) 2006-04-04 2015-11-10 Singulex, Inc. Highly sensitive system and method for analysis of troponin
US9494598B2 (en) 2006-04-04 2016-11-15 Singulex, Inc. Highly sensitive system and method for analysis of troponin
US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

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US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
KR101270829B1 (en) 2004-09-23 2013-06-07 제넨테크, 인크. Cystein engineered antibodies and conjugates
EP1907580A2 (en) * 2005-07-28 2008-04-09 Oncotherapy Science, Inc. Method for diagnosing and treating renal cell carcinoma
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US9315581B2 (en) 2009-12-23 2016-04-19 A Vipep Pty Limited Immuno-conjugates and methods for producing them
US20130028917A1 (en) 2010-04-15 2013-01-31 Spirogen Developments Sàrl Pyrrolobenzodiazepines and conjugates thereof
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CA2833404A1 (en) 2011-04-21 2012-10-26 Garvan Institute Of Medical Research Modified variable domain molecules and methods for producing and using them b
JP5987053B2 (en) 2011-05-12 2016-09-06 ジェネンテック， インコーポレイテッド Multiple reaction monitoring LC-MS / MS method for detecting therapeutic antibodies in animal samples using framework signature peptides
AU2012322607B2 (en) 2011-10-14 2017-02-16 Genentech, Inc. Pyrrolobenzodiazepines and conjugates thereof
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
LT2906253T (en) 2012-10-12 2018-10-10 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-psma antibody conjugates
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PT2906296T (en) 2012-10-12 2018-06-01 Medimmune Ltd Pyrrolobenzodiazepine-antibody conjugates
CA2887899C (en) 2012-10-12 2020-03-31 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
CN105209077B (en) 2013-03-13 2019-06-11 麦迪穆有限责任公司 Pyrrolobenzodiazepines Zhuo and its conjugate
AR096287A1 (en) 2013-03-13 2015-12-23 Spirogen Sàrl PIRROLOBENZODIACEPINS AND CONJUGATES
CA2904044C (en) 2013-03-13 2020-03-31 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US10442836B2 (en) 2013-08-12 2019-10-15 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3054986B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
MX2016007578A (en) 2013-12-16 2016-10-03 Genentech Inc 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
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US10188746B2 (en) 2014-09-10 2019-01-29 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
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CN107108724A (en) 2014-09-12 2017-08-29 豪夫迈·罗氏有限公司 Cysteine engineered antibody and conjugate
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9182405B2 (en) 2006-04-04 2015-11-10 Singulex, Inc. Highly sensitive system and method for analysis of troponin
US9494598B2 (en) 2006-04-04 2016-11-15 Singulex, Inc. Highly sensitive system and method for analysis of troponin
US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

Also Published As

Publication number Publication date
WO2004000997A2 (en) 2003-12-31
CA2486490A1 (en) 2003-12-31

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