WO2003064628A3 - Novel proteins and nucleic acids encoding same - Google Patents

Novel proteins and nucleic acids encoding same Download PDF

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Publication number
WO2003064628A3
WO2003064628A3 PCT/US2003/003401 US0303401W WO03064628A3 WO 2003064628 A3 WO2003064628 A3 WO 2003064628A3 US 0303401 W US0303401 W US 0303401W WO 03064628 A3 WO03064628 A3 WO 03064628A3
Authority
WO
WIPO (PCT)
Prior art keywords
small molecule
nucleic acids
molecule target
therapeutic
methods
Prior art date
Application number
PCT/US2003/003401
Other languages
French (fr)
Other versions
WO2003064628A2 (en
Inventor
John P Ii Alsobrook
Joel S Bader
Constance Berghs
Catherine E Burgess
Stacie J Casman
Elina Catterton
Amitabha Chaudhuri
Shlomit R Edinger
Karen Ellerman
Valerie L Gerlach
Linda Gorman
Xiaojia Guo
John L Herrmann
Weizhen Ji
Nikolai V Khramtsov
Li Li
Charles E Miller
Tatiana Ort
Meera Patturajan
Luca Rastelli
Daniel K Rieger
Suresh G Shenoy
Richard A Shimkets
Kimberly A Spytek
Corine A M Vernet
Haihong Zhong
Mei Zhong
Original Assignee
Curagen Corp
John P Ii Alsobrook
Joel S Bader
Constance Berghs
Catherine E Burgess
Stacie J Casman
Elina Catterton
Amitabha Chaudhuri
Shlomit R Edinger
Karen Ellerman
Valerie L Gerlach
Linda Gorman
Xiaojia Guo
John L Herrmann
Weizhen Ji
Nikolai V Khramtsov
Li Li
Charles E Miller
Tatiana Ort
Meera Patturajan
Luca Rastelli
Daniel K Rieger
Suresh G Shenoy
Richard A Shimkets
Kimberly A Spytek
Corine A M Vernet
Haihong Zhong
Mei Zhong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, John P Ii Alsobrook, Joel S Bader, Constance Berghs, Catherine E Burgess, Stacie J Casman, Elina Catterton, Amitabha Chaudhuri, Shlomit R Edinger, Karen Ellerman, Valerie L Gerlach, Linda Gorman, Xiaojia Guo, John L Herrmann, Weizhen Ji, Nikolai V Khramtsov, Li Li, Charles E Miller, Tatiana Ort, Meera Patturajan, Luca Rastelli, Daniel K Rieger, Suresh G Shenoy, Richard A Shimkets, Kimberly A Spytek, Corine A M Vernet, Haihong Zhong, Mei Zhong filed Critical Curagen Corp
Priority to AU2003212934A priority Critical patent/AU2003212934A1/en
Publication of WO2003064628A2 publication Critical patent/WO2003064628A2/en
Publication of WO2003064628A3 publication Critical patent/WO2003064628A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
PCT/US2003/003401 2002-02-01 2003-02-03 Novel proteins and nucleic acids encoding same WO2003064628A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003212934A AU2003212934A1 (en) 2002-02-01 2003-02-03 Novel proteins and nucleic acids encoding same

Applications Claiming Priority (43)

Application Number Priority Date Filing Date Title
US35328702P 2002-02-01 2002-02-01
US35330102P 2002-02-01 2002-02-01
US60/353,287 2002-02-01
US60/353,301 2002-02-01
US35637102P 2002-02-12 2002-02-12
US35642402P 2002-02-12 2002-02-12
US60/356,424 2002-02-12
US60/356,371 2002-02-12
US35653102P 2002-02-13 2002-02-13
US60/356,531 2002-02-13
US35823902P 2002-02-20 2002-02-20
US60/358,239 2002-02-20
US35960302P 2002-02-26 2002-02-26
US60/359,603 2002-02-26
US35984802P 2002-02-27 2002-02-27
US35986002P 2002-02-27 2002-02-27
US60/359,860 2002-02-27
US60/359,848 2002-02-27
US36504902P 2002-03-01 2002-03-01
US60/365,049 2002-03-15
US36680202P 2002-03-22 2002-03-22
US60/366,802 2002-03-22
US38166602P 2002-05-17 2002-05-17
US60/381,666 2002-05-17
US38953102P 2002-06-18 2002-06-18
US60/389,531 2002-06-18
US38991002P 2002-06-19 2002-06-19
US60/389,910 2002-06-19
US39151602P 2002-06-25 2002-06-25
US60/391,516 2002-06-25
US39326502P 2002-07-02 2002-07-02
US39325602P 2002-07-02 2002-07-02
US60/393,265 2002-07-02
US40182502P 2002-08-07 2002-08-07
US60/401,825 2002-08-07
US40239502P 2002-08-09 2002-08-09
US60/402,395 2002-08-09
US40286702P 2002-08-12 2002-08-12
US60/402,867 2002-08-12
US40582002P 2002-08-23 2002-08-23
US40540102P 2002-08-23 2002-08-23
US60/405,401 2002-08-23
US60/405,820 2002-08-23

Publications (2)

Publication Number Publication Date
WO2003064628A2 WO2003064628A2 (en) 2003-08-07
WO2003064628A3 true WO2003064628A3 (en) 2007-06-21

Family

ID=27671412

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003401 WO2003064628A2 (en) 2002-02-01 2003-02-03 Novel proteins and nucleic acids encoding same

Country Status (1)

Country Link
WO (1) WO2003064628A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485297B2 (en) 2003-08-12 2009-02-03 Dyax Corp. Method of inhibition of vascular development using an antibody
WO2006008008A2 (en) * 2004-07-23 2006-01-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with hepatocyte nuclear factor 4, alpha (hnf4a)
US20090214536A1 (en) * 2005-04-07 2009-08-27 Guoying Yu CACNA1E in Cancer Diagnosis, Detection and Treatment
EP1837404A1 (en) * 2006-03-24 2007-09-26 Universität Zu Köln Mutant lysosomal type 5 P-type ATPase ATP13A2 and its use for diagnosis and therapy of neurodegenerative disorders
RU2559532C2 (en) 2006-11-02 2015-08-10 Акселерон Фарма, Инк. Antagonists of alk1 receptor and ligands and their application
US10059756B2 (en) 2006-11-02 2018-08-28 Acceleron Pharma Inc. Compositions comprising ALK1-ECD protein
US8642031B2 (en) 2006-11-02 2014-02-04 Acceleron Pharma, Inc. Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof
EP3398966A1 (en) 2008-05-02 2018-11-07 Acceleron Pharma, Inc. Methods and compositions for modulating angiogenesis and pericyte composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011003A (en) * 1994-05-26 2000-01-04 Metris Therapeutics Limited FLT-4(FMS-like tyrosine kinase), FLT-15, variants thereof used as growth factor inhibitors
US6773895B2 (en) * 2000-09-01 2004-08-10 Boehringer Ingelheim Pharma Kg Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011003A (en) * 1994-05-26 2000-01-04 Metris Therapeutics Limited FLT-4(FMS-like tyrosine kinase), FLT-15, variants thereof used as growth factor inhibitors
US6773895B2 (en) * 2000-09-01 2004-08-10 Boehringer Ingelheim Pharma Kg Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE SWISSPROT [online] HAMPE ET AL.: "Nucleotide sequence and structural organization of the human FMS proto-oncogene", XP003014066, Database accession no. (P07333) *
ONCOGENE RES., vol. 4, no. 1, 1989, pages 9 - 17 *

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Publication number Publication date
WO2003064628A2 (en) 2003-08-07

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