WO2003040325A3 - Novel proteins and nucleic acids encoding same - Google Patents

Novel proteins and nucleic acids encoding same Download PDF

Info

Publication number
WO2003040325A3
WO2003040325A3 PCT/US2002/035464 US0235464W WO03040325A3 WO 2003040325 A3 WO2003040325 A3 WO 2003040325A3 US 0235464 W US0235464 W US 0235464W WO 03040325 A3 WO03040325 A3 WO 03040325A3
Authority
WO
WIPO (PCT)
Prior art keywords
small molecule
nucleic acids
molecule target
therapeutic
methods
Prior art date
Application number
PCT/US2002/035464
Other languages
French (fr)
Other versions
WO2003040325A2 (en
Inventor
Michele L Agee
John P Ii Alsobrook
Constance Berghs
Ferenc L Boldog
Catherine E Burgess
John S Chant
Amitabha Chaudhuri
Vincent A Dipippo
Shlomit R Edinger
Andrew Eisen
Original Assignee
Curagen Corp
Michele L Agee
John P Ii Alsobrook
Constance Berghs
Ferenc L Boldog
Catherine E Burgess
John S Chant
Amitabha Chaudhuri
Vincent A Dipippo
Shlomit R Edinger
Andrew Eisen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/287,226 external-priority patent/US20040086875A1/en
Application filed by Curagen Corp, Michele L Agee, John P Ii Alsobrook, Constance Berghs, Ferenc L Boldog, Catherine E Burgess, John S Chant, Amitabha Chaudhuri, Vincent A Dipippo, Shlomit R Edinger, Andrew Eisen filed Critical Curagen Corp
Priority to CA002463325A priority Critical patent/CA2463325A1/en
Priority to JP2003542572A priority patent/JP2006509491A/en
Priority to EP02799178A priority patent/EP1638986A1/en
Publication of WO2003040325A2 publication Critical patent/WO2003040325A2/en
Publication of WO2003040325A3 publication Critical patent/WO2003040325A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
PCT/US2002/035464 2001-02-01 2002-11-05 Novel proteins and nucleic acids encoding same WO2003040325A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002463325A CA2463325A1 (en) 2001-11-05 2002-11-05 Novel proteins and nucleic acids encoding same
JP2003542572A JP2006509491A (en) 2001-11-05 2002-11-05 Novel proteins and nucleic acids encoding them
EP02799178A EP1638986A1 (en) 2001-11-05 2002-11-05 Novel proteins and nucleic acids encoding same

Applications Claiming Priority (102)

Application Number Priority Date Filing Date Title
US35328801P 2001-02-01 2001-02-01
US33862601P 2001-11-05 2001-11-05
US60/338,626 2001-11-05
US33307201P 2001-11-06 2001-11-06
US60/333,072 2001-11-06
US34828301P 2001-11-09 2001-11-09
US60/348,283 2001-11-09
US33561001P 2001-11-15 2001-11-15
US60/335,610 2001-11-15
US33854301P 2001-11-16 2001-11-16
US60/338,543 2001-11-16
US33164101P 2001-11-20 2001-11-20
US33163001P 2001-11-20 2001-11-20
US60/331,641 2001-11-20
US60/331,630 2001-11-20
US33215201P 2001-11-21 2001-11-21
US60/332,152 2001-11-21
US33346101P 2001-11-27 2001-11-27
US60/333,461 2001-11-27
US33402701P 2001-11-28 2001-11-28
US33391201P 2001-11-28 2001-11-28
US60/333,912 2001-11-28
US60/334,027 2001-11-28
US33430001P 2001-11-29 2001-11-29
US60/334,300 2001-11-29
US33442101P 2001-11-30 2001-11-30
US33452601P 2001-11-30 2001-11-30
US60/334,421 2001-11-30
US60/334,526 2001-11-30
US33666401P 2001-12-04 2001-12-04
US33657601P 2001-12-04 2001-12-04
US60/336,664 2001-12-04
US60/336,576 2001-12-04
US33839001P 2001-12-07 2001-12-07
US33831401P 2001-12-07 2001-12-07
US60/338,390 2001-12-07
US60/338,314 2001-12-07
US33900601P 2001-12-10 2001-12-10
US33900801P 2001-12-10 2001-12-10
US60/339,006 2001-12-10
US60/339,008 2001-12-10
US33928601P 2001-12-11 2001-12-11
US60/339,286 2001-12-11
US35328002P 2002-02-01 2002-02-01
US60/353,280 2002-02-01
US60/353,288 2002-02-01
US35439302P 2002-02-04 2002-02-04
US35439202P 2002-02-04 2002-02-04
US35440902P 2002-02-04 2002-02-04
US60/354,409 2002-02-04
US60/354,393 2002-02-04
US60/354,392 2002-02-04
US35994402P 2002-02-27 2002-02-27
US36014802P 2002-02-27 2002-02-27
US60/360,148 2002-02-27
US60/359,944 2002-02-27
US36183302P 2002-03-05 2002-03-05
US36223002P 2002-03-05 2002-03-05
US36179002P 2002-03-05 2002-03-05
US36192502P 2002-03-05 2002-03-05
US36262502P 2002-03-05 2002-03-05
US60/362,230 2002-03-05
US60/361,925 2002-03-05
US60/361,833 2002-03-05
US60/362,625 2002-03-05
US60/361,790 2002-03-05
US36418202P 2002-03-13 2002-03-13
US36418102P 2002-03-13 2002-03-13
US36400002P 2002-03-13 2002-03-13
US36419702P 2002-03-13 2002-03-13
US36422702P 2002-03-13 2002-03-13
US60/364,181 2002-03-13
US60/364,197 2002-03-13
US60/364,227 2002-03-13
US60/364,182 2002-03-13
US60/364,000 2002-03-13
US38162102P 2002-05-17 2002-05-17
US60/381,621 2002-05-17
US38367502P 2002-05-28 2002-05-28
US60/383,675 2002-05-28
US39670302P 2002-07-17 2002-07-17
US60/396,703 2002-07-17
US40155202P 2002-08-06 2002-08-06
US60/401,552 2002-08-06
US40178702P 2002-08-07 2002-08-07
US40159402P 2002-08-07 2002-08-07
US60/401,594 2002-08-07
US60/401,787 2002-08-07
US40361902P 2002-08-15 2002-08-15
US60/403,619 2002-08-15
US40482102P 2002-08-20 2002-08-20
US60/404,821 2002-08-20
US40536802P 2002-08-23 2002-08-23
US40540202P 2002-08-23 2002-08-23
US40563102P 2002-08-23 2002-08-23
US60/405,496 2002-08-23
US60/405,631 2002-08-23
US60/405,402 2002-08-23
US60/405,368 2002-08-23
US60/406,125 2002-08-26
US10/287,226 US20040086875A1 (en) 2001-11-05 2002-11-04 Novel proteins and nucleic acids encoding same
US10/287,226 2002-11-04

Publications (2)

Publication Number Publication Date
WO2003040325A2 WO2003040325A2 (en) 2003-05-15
WO2003040325A3 true WO2003040325A3 (en) 2004-02-26

Family

ID=31892463

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/035464 WO2003040325A2 (en) 2001-02-01 2002-11-05 Novel proteins and nucleic acids encoding same

Country Status (1)

Country Link
WO (1) WO2003040325A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004111197A2 (en) * 2003-06-10 2004-12-23 Trustees Of Boston University Gene expression signatures, methods and compositions for diagnosing disorders of the lung
CA2605158A1 (en) 2005-04-14 2006-10-26 The Trustees Of Boston University Diagnostic for lung disorders using class prediction
FR2890859B1 (en) 2005-09-21 2012-12-21 Oreal DOUBLE-STRANDED RNA OLIGONUCLEOTIDE INHIBITING TYROSINASE EXPRESSION
GB0526498D0 (en) * 2005-12-28 2006-02-08 Randox Lab Ltd Method
EP2193211A4 (en) 2007-09-19 2010-12-08 Univ Boston Identification of novel pathways for drug development for lung disease
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
EP3626308A1 (en) 2013-03-14 2020-03-25 Veracyte, Inc. Methods for evaluating copd status
EP3215170A4 (en) 2014-11-05 2018-04-25 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
WO2018009915A1 (en) 2016-07-08 2018-01-11 Trustees Of Boston University Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions
WO2024006973A1 (en) * 2022-06-30 2024-01-04 Board Of Regents, The University Of Texas System Engineered human serine dehydratase enzymes and methods for treating cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] MIYOSHI ET AL., XP002971133, Database accession no. (D14497) *
MOLECULAR AND CELLULAR BIOLOGY, vol. 11, 1991, pages 4088 - 4096 *

Also Published As

Publication number Publication date
WO2003040325A2 (en) 2003-05-15

Similar Documents

Publication Publication Date Title
WO2003000842A3 (en) Novel proteins and nucleic acids encoding same
WO2004000997A3 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2002081498A3 (en) Novel proteins and nucleic acids encoding same
WO2003010327A3 (en) Novel proteins and nucleic acids encoding same
WO2003040325A3 (en) Novel proteins and nucleic acids encoding same
WO2003083046A3 (en) Novel proteins and nucleic acids encoding same
WO2004015060A3 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2003023001A3 (en) Novel proteins and nucleic acids encoding same
WO2003029424A3 (en) Novel proteins and nucleic acids encoding same
WO2003064628A3 (en) Novel proteins and nucleic acids encoding same
WO2002055704A3 (en) Proteins, polynucleotides encoding them and methods of using the same
WO2002072757A3 (en) Novel proteins and nucleic acids encoding same
WO2002000691A3 (en) Polynucleotides and polypeptides encoded thereby
WO2003102159A3 (en) Novel proteins and nucleic acids encoding same
WO2002081510A3 (en) Proteins, polynucleotides encoding them and methods of using the same
WO2002079398A3 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2002099116A8 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2003078572A3 (en) Therapeutic polypeptides, nucleic acids encoding same and methods of use
WO2003022998A3 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2001074851A3 (en) Novel proteins and nucleic acids encoding same
WO2003040329A3 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2001046231A3 (en) Polynucleotides and polypeptides encoded thereby
WO2003057854A3 (en) Novel proteins and nucleic acids encoding same
WO2002083841A3 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2004048512A3 (en) Novel proteins and nucleic acids encoding same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2002363482

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2463325

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003542572

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002799178

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWP Wipo information: published in national office

Ref document number: 2002799178

Country of ref document: EP

WWR Wipo information: refused in national office

Ref document number: 2002799178

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2002799178

Country of ref document: EP