WO2004018350A1 - 微少流体制御方法および微少流体制御装置 - Google Patents
微少流体制御方法および微少流体制御装置 Download PDFInfo
- Publication number
- WO2004018350A1 WO2004018350A1 PCT/JP2003/010272 JP0310272W WO2004018350A1 WO 2004018350 A1 WO2004018350 A1 WO 2004018350A1 JP 0310272 W JP0310272 W JP 0310272W WO 2004018350 A1 WO2004018350 A1 WO 2004018350A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microfluidic
- fluid
- microchannel
- microfluid
- controlling
- Prior art date
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D7/00—Control of flow
- G05D7/06—Control of flow characterised by the use of electric means
- G05D7/0617—Control of flow characterised by the use of electric means specially adapted for fluid materials
- G05D7/0629—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means
- G05D7/0694—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means by action on throttling means or flow sources of very small size, e.g. microfluidics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
- Y10T137/218—Means to regulate or vary operation of device
- Y10T137/2191—By non-fluid energy field affecting input [e.g., transducer]
Definitions
- the present invention relates to a microfluidic control method and a microfluidic control device, and more particularly to a microfluidic device such as a microfluidic channel or a nanofluidic channel using a microfluidic fluid (driving microfluidic) that responds to an electric field or a magnetic field.
- the present invention relates to a microfluidic control method and a microfluidic control device for controlling a flow rate and a volume control of a microfluidic (sample microfluidic) in a little or nano little order.
- a conventional microfluidic control device the flow rate of microfluidic fluid is controlled using a microvolume control valve or micropump.
- a conventional microfluidic control method a small amount of liquid is moved using cavities in a capillary tube.
- a conventional microfluid control method there is a method in which a microfluid is divided by adding a gas into a microfluidic liquid in a microchannel.
- a micro flow path or a nano flow path is used as a conduit for inflow or outflow of such a minute liquid, and the flow of a liquid or a gas is performed using a minute amount control valve, a microphone port pump, or the like. Therefore, when the micro pump is driven or stopped, an error occurs in the amount of inflow and outflow of the micro fluid. Difficult to control accurately.
- the conventional microfluidic control method has a large flow rate error of the microfluid and cannot be controlled. How to control the flow rate and the amount of flow was the main issue in the conventional micro flow system control method.
- the present invention provides a microfluidic control method capable of sucking a microfluid into a microchannel such as a microchannel or a nanochannel and controlling the flow rate and the amount of the microfluid to solve the above problems. And a microfluidic control device. Disclosure of the invention
- the first microfluid is changed in electric or magnetic field and positioned and moved in the microchannel, and the second microfluid is sucked into the microchannel following the first microfluid
- a microfluidic control method characterized by controlling a second microfluidic fluid in a microchannel in relation to movement of the first microfluidic fluid.
- the present invention provides a first microfluidic moving means for positioning and moving a first microfluidic fluid in a microfluidic channel, and a second microfluidic device following the first microfluidic fluid in the microfluidic channel. And a control means for controlling the second microfluidic device.
- a microfluidic channel such as a microchannel or a nanochannel is filled with a driving microfluid that responds to an electric field or a magnetic field, and the microfluid is moved to move the microfluidic sample into the microchannel and positioned.
- a branch pipe that forms a micro flow path such as a micro flow path or a nano flow path is provided, and the electric field and the gas are introduced by using the liquid or gas contained in the branch pipe.
- the microfluidic fluid that responds to the magnetic field is moved to divide the microfluidic sample, and finer flow and volume control is performed.
- a heating section is provided on the outer periphery of a microchannel such as a microchannel or a nanochannel, and a sample microfluid is moved to the heating section using a driving microfluid that responds to an electric or magnetic field. Heating separates the sample microfluid and controls the flow rate.
- the driving microfluid that responds to an electric or magnetic field is placed in a microchannel such as a microphone channel or a nanochannel, and is applied to the rotating body.
- the drive micro fluid is moved, and the sample micro fluid flows in, out, mixes and separates.
- the inside of and around the micro flow path such as the micro flow path or the nano flow path are subjected to lyophobic, water-repellent and oil-repellent treatments to improve the flow rate control of the sample microfluid.
- FIG. 1 is a basic conceptual cross-sectional view showing an embodiment of a microfluidic control device according to the present invention.
- FIG. 1 is a cross-sectional view of a microfluidic control device that controls a flow rate of an electromagnetic fluid by a magnet arranged on an outer peripheral portion of a microchannel. is there.
- '' Fig. 2 is a basic conceptual cross-sectional view showing an embodiment of a microfluidic control device according to the present invention, in which a plurality of electromagnets are arranged in parallel on the outer peripheral portion of a microchannel to control the flow rate of a magnetic fluid. It is sectional drawing of a control apparatus.
- FIG. 3 is a cross-sectional view illustrating a suction mode of a sample micro-liquid in the micro-fluid control device according to the present invention.
- FIG. 4 is a cross-sectional view showing a movement mode of the sample micro liquid in the micro fluid control device according to the present invention.
- FIG. 5 is a basic conceptual cross-sectional view showing an embodiment of the microfluidic control device of the present invention provided with a liquid separating means or a gas separating means using a branch pipe, and a liquid separating means using a T-shaped branch pipe. Or it is sectional drawing which shows the microfluidic control apparatus provided with the gas separation means.
- FIG. 6 is a basic conceptual cross-sectional view showing one embodiment of the microfluidic control device of the present invention provided with a liquid separating means or a gas separating means using a branch pipe. It is sectional drawing of the microfluidic control apparatus provided with the gas separation means.
- FIG. 7 is a basic conceptual cross-sectional view showing an embodiment of a microfluidic control device according to the present invention in which a heating section is provided on the outer periphery of a microchannel to separate a sample microliquid.
- FIG. 4 is a cross-sectional view of the microfluidic control device, showing a mode in which the microfluid moves.
- FIG. 8 is a basic conceptual cross-sectional view showing an embodiment of a microfluidic control device according to the present invention in which a heating unit is provided on the outer periphery of a microchannel to separate a sample microliquid.
- FIG. 2 is a cross-sectional view of a microfluidic control device showing a form in which a part of the micro fluid is separated by separation.
- FIG. 9 is a basic conceptual cross-sectional view showing one embodiment of a microfluidic control device according to the present invention in which a heating unit is provided on the outer periphery of a microchannel to separate a sample microliquid. It is sectional drawing of the microfluidic control apparatus which shows the form which moves further downstream.
- FIG. 10 is a basic conceptual cross-sectional view showing one embodiment of the microfluidic control device of the present invention using a centrifugal force and a magnetic force by providing a fine channel in a rotating body.
- FIG. 11 is a cross-sectional view showing the movement of a microfluid in the microfluidic control device of the present invention using a centrifugal force and a magnetic force by providing a microchannel in a rotating body.
- FIG. 12 is a basic conceptual cross-sectional view showing an embodiment of a microfluidic control device according to the present invention.
- FIG. 13 is a basic conceptual perspective view showing an embodiment of a microfluidic control device according to the present invention.
- the microfluidic control device for controlling a flow rate of a magnetic fluid by arranging a plurality of electromagnets above a biochip having a channel. It is a perspective view of.
- FIG. 14 is a top view of a biochip having a channel of a specific shape used in the microfluidic control device for controlling the flow rate of the magnetic fluid in the microfluidic control device according to the present invention.
- FIG. 1 shows a configuration example of one embodiment of a microfluidic control device according to the present invention.
- Electric field fluid A which is a fluid A that reacts to an electric field (driving microfluid: first microfluid plug fluid), is injected into microchannel 1 or microchannel, which is a channel through which microfluids move. I do.
- the electromagnetic fluid A is a fluid Floyd such as an oil containing iron powder (kerosene oil, light oil, etc.).
- the magnet 2 is mounted on the outer periphery of the microchannel 1 and the output controls the electromagnetic fluid A.
- FIG. 2 shows another embodiment of the microfluidic control device according to the present invention.
- a fluid A driving microfluid: first microfluid plug fluid
- This magnetic fluid A is a fluid such as oil containing iron powder (kerosene oil, light oil, etc.). It is.
- a plurality of electromagnets 3 are mounted on the outer periphery of the microchannel 1, and the output thereof controls the magnetic magnetic fluid A.
- control of the microfluidic A that responds to an electric field or a magnetic field includes, for example, a side where the microchannel 1 is fixed to generate an electric field or a magnetic field, That is, control is performed by two methods of controlling the electric field generating means or the magnetic field generating means and moving the microchannel 1 while fixing the generating means.
- a plurality of electromagnets 3 are arranged along the microchannel 1, the energization is changed to activate the electromagnets 3, and the microfluidic A that reacts to the magnetic field by the electromagnetic force is controlled.
- Figure 3 shows a microfluidic flow from the end of a microchannel 1 such as a microchannel or nanochannel.
- micro fluid B (micro liquid or micro gas) different from A (driving micro fluid) (sample micro fluid: driven micro fluid: second micro fluid plug fluid) is transferred to micro fluid A from downstream of micro fluid A. At a certain interval, the microfluid A is subsequently injected from the container 4. In this case, a method is shown in which the microfluidic fluid A reacting to the electric field is moved, and the microfluidic fluid B flows into the microfluidic channel 1 by the moving amount.
- Microfluid B is a sample microfluid, such as blood or reagent.
- the microfluidic fluid A (driving microfluidic fluid) in the microchannel 1 to the target position
- the microfluidic fluid A reacts to the electric field in conjunction with the movement of the magnet 2 while moving it. (Driving microfluid) to move another microfluid B (microfluid or microgas sample microfluid).
- the microfluid A responding to the electric field moves and flows out.
- the shape of the microchannel 1 such as a microchannel or a nanochannel is a single channel, and if it has a branch channel, a T-shaped branch tube as shown in Fig. 5, a cross-shaped branch tube as shown in Fig. 6, Alternatively, the fine channel 1 can be formed by other combinations.
- the cross section of the microchannel 1 has a circular, rectangular, or more complex shape, and its typical length is on the order of micrometers to nanometers.
- a microfluidic fluid A that reacts to an electric or magnetic field is driven by a magnet 2 in a microchannel 1 formed in a T-shaped branch pipe.
- liquid or gas 5 third fluid: for example, inert gas, water, salt solution, etc.
- Fig. 6 shows a sample microfluid B that is similarly divided at the intersection of a cross-shaped branch pipe, and is injected with another gas or liquid 6 (third fluid: for example, inert gas, water, or saline). Then, the flow rate of the sample microfluid B is controlled while dividing the sample microfluid B into, for example, two sample microfluids B1 and B2.
- third fluid for example, inert gas, water, or saline
- a heating section 7 such as an electrode is provided on the outer periphery of a microchannel 1 such as a microchannel or a nanochannel, and a driving microfluid A that reacts to an electric or magnetic field is moved to Inject microfluidic B.
- the sample microfluid: B is moved while being positioned in the heating unit 7, and the heating unit 7 is energized and heat is applied. For example, a part of the sample microfluid B is removed.
- the sample microfluid B is divided into two sample microfluids B 1 and B 2. As shown in Fig. 9, the separated sample microfluids B1 and B2 are moved further downstream.
- a microchannel or nanochannel, etc. is attached to the rotating body (reactor) 8, and a minute liquid or gas sample is finely centrifuged from the center by centrifugal force. Flow into channel 1.
- the amount of the sample microfluidic fluid B is controlled by the driving magnetic fluid A and flows into the reactor. It also controls the flow of the sample microfluid B that flows in. That is, the sample microfluids B having different densities sucked into the microchannel 1 are mixed and separated according to the mass and controlled.
- FIG. 12 is a partial cross-sectional perspective view showing an embodiment of a microfluidic control device according to the present invention, in which a plurality of magnets 3 are arranged in parallel on an outer peripheral portion of a microchannel 1 to use a driving magnetic fluid A. To control the flow rate of sample microfluid B 0
- FIG. 13 is a perspective view showing an embodiment of the microfluidic control device according to the present invention, in which a plurality of magnets 3 are arranged in parallel on a biochip (lab-on-chip) 9 provided with a linear channel-like microchannel 9a.
- FIG. 3 is a perspective view of a microfluidic control device that is arranged and controls the flow rate of a sample microfluidic B using a magnetic fluid A;
- a microfluidic control device in which a biochip (lab-on-a-chip) having a specific shape channel (microchannel 10a) used in a microfluidic control device for controlling the flow rate of sample microfluidic B It is 10
- the biochip 10 provided with the fine flow path 10a is arranged, and the flow rate of the sample microfluid B is controlled using the driving magnetic fluid A.
- the lyophobic treatment, water-repellent treatment, and oil-repellent treatment are performed inside or around micro channels such as micro channels or nano channels to control the flow rate with higher accuracy.
- Examples of devices related to the microfluidic control device according to the present invention include micromachines, microelectromechanical systems, small analyzers (TAS) for reacting extremely small amounts of liquid reagents, microchip devices, and lab-on-chip (Lab) such as DNA lab chips.
- TAS small analyzers
- Lab lab-on-chip
- a microfluidic channel such as a microchannel or a nanochannel is filled with a driving microfluid that responds to an electric field or a magnetic field, and the microfluidic sample or microgas is moved into the microfluidic channel by the movement.
- a third fluid such as an inert gas, also flows in from the branch section such as the T-shaped flow path or the cross-shaped flow path to separate and control the flow rate of the sample microfluid.
- the present invention relates to a microfluidic control method and apparatus for handling microfluidic microfluids. It relates to devices with fine structures, such as micro-channel sensors manufactured using integrated circuit micro-machining technology and Actu Yue. For the control of fluids in the micro-mouth area for dispensing, mixing, and separating different fluids in the field of chemical analysis and drug discovery in the field of chemical analysis and drug discovery that handle nano- or micro-little fluid samples. Used.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003255012A AU2003255012A1 (en) | 2002-08-23 | 2003-08-12 | Method and apparatus for controlling minute amount of fluid |
US10/525,367 US20060037657A1 (en) | 2002-08-23 | 2003-08-12 | Method and apparatus for controlling minute amount of fluid |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002-243730 | 2002-08-23 | ||
JP2002243730 | 2002-08-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004018350A1 true WO2004018350A1 (ja) | 2004-03-04 |
Family
ID=31944104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/010272 WO2004018350A1 (ja) | 2002-08-23 | 2003-08-12 | 微少流体制御方法および微少流体制御装置 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20060037657A1 (ja) |
AU (1) | AU2003255012A1 (ja) |
WO (1) | WO2004018350A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8501416B2 (en) | 2005-04-19 | 2013-08-06 | President And Fellows Of Harvard College | Fluidic structures including meandering and wide channels |
CN106140340A (zh) * | 2016-08-19 | 2016-11-23 | 北京工业大学 | 基于流动聚焦型微通道合成微乳液滴的微流控芯片 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070141593A1 (en) | 2005-08-22 | 2007-06-21 | Lee Linda G | Apparatus, system, and method using immiscible-fluid-discrete-volumes |
US9152150B1 (en) | 2007-02-22 | 2015-10-06 | Applied Biosystems, Llc | Compositions, systems, and methods for immiscible fluid discrete volume manipulation |
WO2011124092A1 (en) * | 2010-04-09 | 2011-10-13 | The Hong Kong University Of Science And Technology | Liquid-electronic hybrid divider |
US20120275929A1 (en) * | 2011-04-27 | 2012-11-01 | Aptina Imaging Corporation | Ferrofluid control and sample collection for microfluidic application |
US9068695B2 (en) * | 2012-06-12 | 2015-06-30 | Smrt Delivery Llc | Active guidance of fluid agents using magnetorheological antibubbles |
TWI529402B (zh) | 2013-07-26 | 2016-04-11 | 財團法人工業技術研究院 | 磁性液滴控制裝置及磁性液滴的控制方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0187699A2 (en) * | 1985-01-07 | 1986-07-16 | Btg International Limited | Automatic chemistry machine |
WO1999017093A1 (en) * | 1997-09-26 | 1999-04-08 | The Regents Of The University Of Michigan | Moving microdroplets |
WO2000063704A2 (en) * | 1999-04-16 | 2000-10-26 | Perseptive Biosystems, Inc. | Apparatus and methods for sample analysis |
WO2001044667A1 (en) * | 1999-12-15 | 2001-06-21 | University Of Washington | Magnetically actuated fluid handling devices for microfluidic applications |
JP2002371954A (ja) * | 2001-06-12 | 2002-12-26 | Kawamura Inst Of Chem Res | 流体移送方法、及びマイクロ流体素子の流体移送装置 |
EP1270066A2 (en) * | 2001-06-27 | 2003-01-02 | Tosoh Corporation | Method for transporting liquid, and microreactor |
-
2003
- 2003-08-12 AU AU2003255012A patent/AU2003255012A1/en not_active Abandoned
- 2003-08-12 US US10/525,367 patent/US20060037657A1/en not_active Abandoned
- 2003-08-12 WO PCT/JP2003/010272 patent/WO2004018350A1/ja active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0187699A2 (en) * | 1985-01-07 | 1986-07-16 | Btg International Limited | Automatic chemistry machine |
WO1999017093A1 (en) * | 1997-09-26 | 1999-04-08 | The Regents Of The University Of Michigan | Moving microdroplets |
WO2000063704A2 (en) * | 1999-04-16 | 2000-10-26 | Perseptive Biosystems, Inc. | Apparatus and methods for sample analysis |
WO2001044667A1 (en) * | 1999-12-15 | 2001-06-21 | University Of Washington | Magnetically actuated fluid handling devices for microfluidic applications |
JP2002371954A (ja) * | 2001-06-12 | 2002-12-26 | Kawamura Inst Of Chem Res | 流体移送方法、及びマイクロ流体素子の流体移送装置 |
EP1270066A2 (en) * | 2001-06-27 | 2003-01-02 | Tosoh Corporation | Method for transporting liquid, and microreactor |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8501416B2 (en) | 2005-04-19 | 2013-08-06 | President And Fellows Of Harvard College | Fluidic structures including meandering and wide channels |
US9683993B2 (en) | 2005-04-19 | 2017-06-20 | President And Fellows Of Harvard College | Fluidic structures including meandering and wide channels |
CN106140340A (zh) * | 2016-08-19 | 2016-11-23 | 北京工业大学 | 基于流动聚焦型微通道合成微乳液滴的微流控芯片 |
Also Published As
Publication number | Publication date |
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US20060037657A1 (en) | 2006-02-23 |
AU2003255012A1 (en) | 2004-03-11 |
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