WO2003091431A8 - Methylotrophe produisant une chaine de sucre de type mammifere - Google Patents
Methylotrophe produisant une chaine de sucre de type mammifereInfo
- Publication number
- WO2003091431A8 WO2003091431A8 PCT/JP2003/005464 JP0305464W WO03091431A8 WO 2003091431 A8 WO2003091431 A8 WO 2003091431A8 JP 0305464 W JP0305464 W JP 0305464W WO 03091431 A8 WO03091431 A8 WO 03091431A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sugar chain
- type sugar
- mammalian type
- methylotroph
- mammalian
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/2488—Mannanases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01085—3-Isopropylmalate dehydrogenase (1.1.1.85)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
- C12Y101/03013—Alcohol oxidase (1.1.3.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01012—Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (1.2.1.12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01024—Alpha-mannosidase (3.2.1.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01019—Imidazoleglycerol-phosphate dehydratase (4.2.1.19)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
- C12Y603/02006—Phosphoribosylaminoimidazolesuccinocarboxamide synthase (6.3.2.6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004501993A JP4464269B2 (ja) | 2002-04-26 | 2003-04-28 | 哺乳類型糖鎖生産メチロトロフ酵母 |
US10/511,436 US7972809B2 (en) | 2002-04-26 | 2003-04-28 | Methylotrophic yeast producing mammalian type sugar chain |
DE60325720T DE60325720D1 (de) | 2002-04-26 | 2003-04-28 | Methylotrophe hefe,die eine zuckerkette eines säugers herstellt |
EP03720967A EP1505149B1 (en) | 2002-04-26 | 2003-04-28 | Methylotroph yeast producing mammalian type sugar chain |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002-127677 | 2002-04-26 | ||
JP2002127677 | 2002-04-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003091431A1 WO2003091431A1 (fr) | 2003-11-06 |
WO2003091431A8 true WO2003091431A8 (fr) | 2005-02-17 |
Family
ID=29267659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/005464 WO2003091431A1 (fr) | 2002-04-26 | 2003-04-28 | Methylotrophe produisant une chaine de sucre de type mammifere |
Country Status (6)
Country | Link |
---|---|
US (1) | US7972809B2 (ja) |
EP (1) | EP1505149B1 (ja) |
JP (1) | JP4464269B2 (ja) |
AT (1) | ATE420198T1 (ja) |
DE (1) | DE60325720D1 (ja) |
WO (1) | WO2003091431A1 (ja) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7507573B2 (en) * | 2003-11-14 | 2009-03-24 | Vib, Vzw | Modification of protein glycosylation in methylotrophic yeast |
KR100604994B1 (ko) | 2004-01-30 | 2006-07-26 | 한국생명공학연구원 | 알파1,6-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자 및 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법 |
WO2006014726A2 (en) * | 2004-07-21 | 2006-02-09 | Glycofi, Inc. | Immunoglobulins comprising predominantly a man5glcnac2 glycoform |
US8202523B2 (en) * | 2005-09-22 | 2012-06-19 | ProSci, Inc. | Glycosylated polypeptides produced in yeast mutants and methods of use thereof |
AU2006316838B2 (en) * | 2005-11-15 | 2012-04-12 | Glycofi, Inc | Production of glycoproteins with reduced O-glycosylation |
GB2433260A (en) * | 2005-12-16 | 2007-06-20 | Mologic Ltd | A selectable decarboxylase marker |
AU2007250735A1 (en) | 2006-05-16 | 2007-11-22 | Daiichi Sankyo Company, Limited | Method for high-level secretory production of protein |
EP2505651A3 (en) * | 2006-12-10 | 2013-01-09 | Dyadic International, Inc. | Isolated fungus with reduced protease activity |
EP2134853B1 (en) * | 2007-04-03 | 2018-07-18 | Oxyrane UK Limited | Glycosylation of molecules |
US8409825B2 (en) | 2007-10-31 | 2013-04-02 | National Institute Of Advanced Industrial Science And Technology | Method for high-level secretory production of protein |
US8815580B2 (en) * | 2008-08-08 | 2014-08-26 | Vib Vzw | Cells producing glycoproteins having altered glycosylation patterns and method and use thereof |
JP5652206B2 (ja) | 2008-10-01 | 2015-01-14 | 旭硝子株式会社 | 宿主、形質転換体およびその製造方法、ならびにo−グリコシド型糖鎖含有異種蛋白質の製造方法 |
WO2011039634A2 (en) | 2009-09-29 | 2011-04-07 | Universiteit Gent | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
WO2011053545A1 (en) * | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Granulocyte-colony stimulating factor produced in glycoengineered pichia pastoris |
WO2011061629A2 (en) | 2009-11-19 | 2011-05-26 | Oxyrane Uk Limited | Yeast strains producing mammalian-like complex n-glycans |
US9689015B2 (en) | 2010-09-29 | 2017-06-27 | Oxyrane Uk Limited | De-mannosylation of phosphorylated N-glycans |
US9347050B2 (en) | 2010-09-29 | 2016-05-24 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
JP5885191B2 (ja) * | 2011-01-04 | 2016-03-15 | 国立研究開発法人産業技術総合研究所 | 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法 |
JP5975577B2 (ja) | 2011-03-04 | 2016-08-23 | 株式会社糖鎖工学研究所 | シアル酸含有糖鎖の製造方法 |
JP5932766B2 (ja) * | 2011-03-11 | 2016-06-08 | 株式会社カネカ | Vps遺伝子が破壊されている酵母を用いる異種タンパク質の製造方法 |
US9371519B2 (en) | 2011-10-03 | 2016-06-21 | National Institute Of Advanced Industrial Science And Technology | Complex type sugar chain hydrolase |
EP3628326B1 (en) | 2012-03-15 | 2024-02-28 | Oxyrane UK Limited | Methods and materials for treatment of pompe's disease |
ES2897639T3 (es) * | 2014-07-30 | 2022-03-02 | Daiichi Sankyo Co Ltd | Método para la producción secretora de alto nivel mejorada de proteínas |
JP2018501814A (ja) | 2014-11-11 | 2018-01-25 | クララ フーズ カンパニー | 卵白タンパク質産生のための方法および組成物 |
CN108026558B (zh) | 2015-07-09 | 2021-08-17 | 非营利性组织佛兰芒综合大学生物技术研究所 | 产生具有改变的n-和o-糖基化模式的糖蛋白的细胞及其方法和用途 |
MX2020003362A (es) * | 2017-10-03 | 2020-07-29 | Bolt Threads Inc | Cepas modificadas para la produccion de seda recombinante. |
EP3997118A4 (en) | 2019-07-11 | 2023-07-19 | Clara Foods Co. | PROTEIN COMPOSITIONS AND CONSUMABLE PRODUCTS THEREOF |
US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
CN113549560B (zh) * | 2020-04-24 | 2024-02-13 | 中国人民解放军军事科学院军事医学研究院 | 一种用于糖蛋白制备的工程化酵母构建方法及其菌株 |
CN115466318B (zh) * | 2022-06-24 | 2023-06-02 | 西南大学 | 盔形毕赤酵母分泌蛋白PgAsp1及其应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1341130C (en) * | 1984-07-27 | 2000-10-31 | Adrianus Marinus Ledeboer | Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology |
AU625392B2 (en) | 1987-10-29 | 1992-07-09 | Zymogenetics Inc. | Methods of regulating protein glycosylation |
EP0578746B1 (en) * | 1991-04-01 | 2002-07-03 | Merck & Co., Inc. | GENES WHICH INFLUENCE $i(PICHIA) PROTEOLYTIC ACTIVITY, AND USES THEREFOR |
GB9404270D0 (en) * | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
JPH093097A (ja) * | 1995-06-16 | 1997-01-07 | Green Cross Corp:The | ピキア属酵母由来の糖鎖伸長タンパク、該蛋白質をコードするdna、修飾該dnaおよび形質転換体 |
CU22722A1 (es) * | 1996-10-03 | 2002-02-28 | Ct Ingenieria Genetica Biotech | Sistema de transformación para la expresión de genes heterólogos en la levadura candida utilis |
JP2000078978A (ja) * | 1998-09-04 | 2000-03-21 | Kirin Brewery Co Ltd | プロテアーゼ活性の低下したカンジダ・ボイジニ株及び異種タンパク質製造用宿主としてのその使用 |
ES2231217T3 (es) | 1999-06-24 | 2005-05-16 | Zymogenetics, Inc. | Promotor y finalizador de la gliceraldehido-3-fosfato deshidrogenasa-1 de pichia methanolica. |
DE60139720D1 (de) | 2000-06-28 | 2009-10-08 | Glycofi Inc | Verfahren für die Herstellung modifizierter Glykoproteine |
DK1294910T3 (da) | 2000-06-30 | 2009-03-02 | Vib Vzw | Protein glykosyleringsmodifikation i Pichia Pastoris |
JP2006511220A (ja) * | 2002-12-23 | 2006-04-06 | グライコフィ, インコーポレイテッド | 遺伝子発現のステロイド受容体調節 |
-
2003
- 2003-04-28 US US10/511,436 patent/US7972809B2/en active Active
- 2003-04-28 AT AT03720967T patent/ATE420198T1/de not_active IP Right Cessation
- 2003-04-28 DE DE60325720T patent/DE60325720D1/de not_active Expired - Lifetime
- 2003-04-28 EP EP03720967A patent/EP1505149B1/en not_active Expired - Lifetime
- 2003-04-28 JP JP2004501993A patent/JP4464269B2/ja not_active Expired - Fee Related
- 2003-04-28 WO PCT/JP2003/005464 patent/WO2003091431A1/ja active Application Filing
Also Published As
Publication number | Publication date |
---|---|
DE60325720D1 (de) | 2009-02-26 |
US20060148039A1 (en) | 2006-07-06 |
EP1505149A4 (en) | 2005-11-16 |
WO2003091431A1 (fr) | 2003-11-06 |
EP1505149A1 (en) | 2005-02-09 |
ATE420198T1 (de) | 2009-01-15 |
EP1505149B1 (en) | 2009-01-07 |
US7972809B2 (en) | 2011-07-05 |
JPWO2003091431A1 (ja) | 2005-09-02 |
JP4464269B2 (ja) | 2010-05-19 |
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