WO2003087141A3 - Adenine phosphoryltransferase from escherichia coli - Google Patents

Adenine phosphoryltransferase from escherichia coli Download PDF

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Publication number
WO2003087141A3
WO2003087141A3 PCT/CA2003/000494 CA0300494W WO03087141A3 WO 2003087141 A3 WO2003087141 A3 WO 2003087141A3 CA 0300494 W CA0300494 W CA 0300494W WO 03087141 A3 WO03087141 A3 WO 03087141A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphoryltransferase
adenine
escherichia coli
provides
polypeptides
Prior art date
Application number
PCT/CA2003/000494
Other languages
French (fr)
Other versions
WO2003087141A2 (en
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Megan Domagala
Ivy Ng
Simon Houston
Francois Vallee
Teresa Clarke
Donald Awrey
Bryan Beattie
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Megan Domagala
Ivy Ng
Simon Houston
Francois Vallee
Teresa Clarke
Donald Awrey
Bryan Beattie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Megan Domagala, Ivy Ng, Simon Houston, Francois Vallee, Teresa Clarke, Donald Awrey, Bryan Beattie filed Critical Affinium Pharm Inc
Priority to AU2003213959A priority Critical patent/AU2003213959A1/en
Publication of WO2003087141A2 publication Critical patent/WO2003087141A2/en
Publication of WO2003087141A3 publication Critical patent/WO2003087141A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02007—Adenine phosphoribosyltransferase (2.4.2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
PCT/CA2003/000494 2002-04-09 2003-04-09 Adenine phosphoryltransferase from escherichia coli WO2003087141A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003213959A AU2003213959A1 (en) 2002-04-09 2003-04-09 Adenine phosphoryltransferase from escherichia coli

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37097902P 2002-04-09 2002-04-09
US60/370,979 2002-04-09

Publications (2)

Publication Number Publication Date
WO2003087141A2 WO2003087141A2 (en) 2003-10-23
WO2003087141A3 true WO2003087141A3 (en) 2003-12-04

Family

ID=29250614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2003/000494 WO2003087141A2 (en) 2002-04-09 2003-04-09 Adenine phosphoryltransferase from escherichia coli

Country Status (2)

Country Link
AU (1) AU2003213959A1 (en)
WO (1) WO2003087141A2 (en)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ARONOV ALEX M ET AL: "Virtual screening of combinatorial libraries across a gene family: In search of inhibitors of Giardia lamblia guanine phosphoribosyltransferase.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 45, no. 9, September 2001 (2001-09-01), pages 2571 - 2576, XP002256402, ISSN: 0066-4804 *
BOEHM H-J: "LUDI: RULE-BASED AUTOMATIC DESIGN OF NEW SUBSTITUENTS FOR ENZYME INHIBITOR LEADS", JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, ESCOM SCIENCE PUBLISHERS BV, XX, vol. 6, no. 6, December 1992 (1992-12-01), pages 593 - 606, XP001008405, ISSN: 0920-654X *
GSCHWEND D A ET AL: "MOLECULAR DOCKING TOWARDS DRUG DISCOVERY", JOURNAL OF MOLECULAR RECOGNITION, HEYDEN & SON LTD., LONDON, GB, vol. 9, 1996, pages 175 - 186, XP000882526, ISSN: 0952-3499 *
HERSHEY H V ET AL: "NUCLEOTIDE SEQUENCE AND DEDUCED AMINO-ACID SEQUENCE OF ESCHERICHIA-COLI ADENINE PHOSPHORIBOSYLTRANSFERASE AND COMPARISON WITH OTHER ANALOGOUS ENZYMES", GENE (AMSTERDAM), vol. 43, no. 3, 1986, pages 287 - 294, XP009018388, ISSN: 0378-1119 *
SCHMID M B: "MICROBIAL GENOMICS - NEW TARGETS, NEW DRUGS", EXPERT OPINION ON THERAPEUTIC TARGETS, ASHLEY PUBLICATIONS, LONDON, GB, vol. 5, no. 4, August 2001 (2001-08-01), pages 465 - 475, XP009015173, ISSN: 1472-8222 *
SHI WUXIAN ET AL: "Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae.", BIOCHEMISTRY, vol. 40, no. 36, 11 September 2001 (2001-09-11), pages 10800 - 10809, XP002256401, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
AU2003213959A8 (en) 2003-10-27
AU2003213959A1 (en) 2003-10-27
WO2003087141A2 (en) 2003-10-23

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