WO2003084553A1 - Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis - Google Patents
Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis Download PDFInfo
- Publication number
- WO2003084553A1 WO2003084553A1 PCT/EP2003/003329 EP0303329W WO03084553A1 WO 2003084553 A1 WO2003084553 A1 WO 2003084553A1 EP 0303329 W EP0303329 W EP 0303329W WO 03084553 A1 WO03084553 A1 WO 03084553A1
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- WIPO (PCT)
- Prior art keywords
- proanthocyanidins
- pharmaceutical compositions
- dermatitis
- treatment
- acid
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to pharmaceutical compositions for the topical administration comprising as active ingredients proanthocyanidins, glycyrrhetinic acid and telmesteine, in admixture with a suitable carrier.
- topical pharmaceutical compositions of the present invention are useful for the treatment of inflammatory conditions of the skin, such as atopic dermatitis, allergic contact dermatitis, seborrheic dermatitis, radiation dermatitis, psoriasis, xerosis and atopia as well as of mucosae and eye inflammatory conditions.
- Dermatites are superficial skin inflammations, characterized by vesicles, erythema, edema, oozing, scaling or crusting lesions and intense itching.
- the treatment consists in removing the offending agent, which however cannot in many cases be identified or removed.
- Treatment is therefore based on corticosteroids, which have however well known side-effects: they reduce the immune defenses, which can induce infections, mainly by fungi or Candida; suspension of the treatment should be gradual; they cannot be used during the acute oozing phase; a rebound effect may appear on stopping treatment. Furthermore, corticosteroids should not be used for prolonged treatments, particularly in children, since they can give rise to systemic effects.
- EP 0 694 305 discloses topical compositions of proanthocyanidins combined with coumarins (esculoside and the like) for the treatment of peripheral vasculopathies, such as bedsores, scars, couperose, varices and the like.
- US 5,470,874 describes a combination of proanthocyanidins and vitamin C for the topical use, as sunscreen, for stimulating collagen synthesis and for restoring damaged collagen.
- JP 6,336,421 relates to topical formulations of proanthocyanidins combined with anti-inflammatories, among which glycyrrhetinic acid and derivatives are cited, for the cosmetic use and against sunburns.
- proanthocyanidins in the treatment of pathologies such as chronic dermatitis, seborrheic dermatitis and allergic dermatis has not been described.
- Proanthocyanidins are widely diffused in a number of vegetable species. They are vegetable extracts containing bioflavonoids, with well-defined chemical profile, consisting for about 15% of dimers, about 20% of trimers and tetramers, and of small amounts of catechin and epicatechin. Proanthocyanidins exert both skin protecting action from the aggression by free radicals and restoration action of the damages to the skin structure through stimulation of collagen production. They also contain essential fatty acids similar to those of the skin hydrolipidic barrier, which contribute to keep said barrier intact.
- proanthocyanidins reduce the concentration of enzymes such as elastase, collagenase, hyaluronidase and beta-glucuronidase, which are responsible for the destruction of elastin, collagen and hyaluronic acid proteins. Therefore, proanthocyanidins are widely used in the pharmaceutical and cosmetic industries, thanks to their restoring, regenerating, nutrient and restructurant actions, which restores the skin elasticity and tonicity. According to the present invention, the proanthocyanidins extracted from grape seeds and skin of Vitis vinifera are particularly preferred. Most preferred are the complexes of proanthocyanidins from Vitis vinifera with phospholipids, prepared according to the process disclosed in US 4,963,527.
- 18- ⁇ -Glycyrrhetinic acid extracted from the roots of Glycyrrhiza glabra, is known to have antiinflammatory properties on the skin, in particular in case of burns and redness.
- Telmesteine (N-carbethoxy-4-thiazolidinecarboxylic acid) exerts antiradicalic and protective action against the oxidizing agents responsible for skin damages, as well as inhibiting elastase and collagenase actions.
- the topical pharmaceutical compositions of the present invention will contain the active ingredients in admixture with a suitable carrier, preferably a carrier rich in polyunsaturated fatty acids.
- suitable carriers comprise squalene, fatty acids, fatty acids esters, vegetable oils, natural or synthetic triglycerids. More preferably, suitable carriers comprise squalene, karite butter, octyl palmitate and oenothera oil.
- karite butter also known as shea butter
- shea butter is a fat consisting of a mixture of saturated and unsaturated fats, extracted from the seeds of Butirospermum parkii, a tree from northern Africa, which is used in cosmetics thanks to its protective and softening actions, which make it particularly useful for sensitive skins as well as for skins which easily redden.
- Oenothera oil also known as evening primrose oil
- Oenothera biennis is rich in essential polyunsaturated fatty acids, in particular ⁇ -linolenic acid, indispensable for regenerating the skin and all cellular tissues.
- the pharmaceutical compositions of the invention will further contain compounds with antioxidizing activity, such as tocopherols and ascorbic acid or esters thereof, preferably tocopherol acetate and ascorbyl palmitate or tetrapalmitate, to further increase the protective effect on cell membranes and to slow down the oxidation of polyunsaturated fatty acids.
- compounds with antioxidizing activity such as tocopherols and ascorbic acid or esters thereof, preferably tocopherol acetate and ascorbyl palmitate or tetrapalmitate, to further increase the protective effect on cell membranes and to slow down the oxidation of polyunsaturated fatty acids.
- compositions of the present invention may further contain other active ingredients, with complementary or anyway useful actions in the treatment of dermatosis .
- a further preferred embodiment relates to the pharmaceutical compositions of the invention also containing salicylic acid, for the
- a further preferred embodiment relates to the pharmaceutical compositions of the invention also containing hyaluronic acid, for the treatment of radiation dermatitis.
- a further preferred embodiment relates to the pharmaceutical compositions of the invention also containing alpha-bisabolol and allantoin.
- a further preferred embodiment relates to the pharmaceutical compositions of the invention also containing zinc pidolate.
- topical pharmaceutical compositions of the present invention can be in the form of cream, gel, lotion, suspension, spray, ointment, foam.
- the topical pharmaceutical compositions of the present invention will contain the active ingredients in the following concentrations (w/w): a) proanthocyanidins in the form of complexes with phospholipids: 0.01% to 1%; b) glycyrrhetinic acid: 0.1 to 5%, preferably 1 to 2%; c) telmesteine: 0.01% to 1%; and - carriers (squalene, karite butter, octyl palmitate and oenothera oil):
- antioxidants tocopherol acetate 0.5-5%; ascorbyl palmitate 0.01- 0.1%
- the daily dosage will be determined by the physician; by way of example, it will consist of one or more daily applications even for protracted times.
- Example 1 Some examples of formulations according to the present invention are shown hereinafter.
- Example 1 Some examples of formulations according to the present invention are shown hereinafter.
- compositions of the present invention showed very good tolerability. They do not contain allergenic substances, derivatives from animal sources (such as lanolin, beeswax, animal fat), preservatives (such as parabens, isothiazolones, phenol derivatives, and the like) which are often responsible for allergic contact dermatitis.
- animal sources such as lanolin, beeswax, animal fat
- preservatives such as parabens, isothiazolones, phenol derivatives, and the like
- compositions of the present invention are useful for the treatment of already existing skin allergic reactions, for the prevention of recurrent forms, and as adjuvants in the treatment of chronic diseases such as atopic dermatitis, allergic contact dermatitis, seborrheic dermatitis, radiation dermatitis, xerosis and atopia.
- compositions of the present invention are useful in the treatment of conditions such as irritative and eczematous dermatitis, as moisturizers and lenitive agents for sensitive, delicate skin; in allergic irritations due to medicaments, detergents, solvents; in erythema due to excessive exposure to sun radiaitons; in case of insect stings, redness of various origin, post-shaving irritations, slight burns, skin hyper-reactivity; as normalizers after esthetic treatments, such as peeling with acid glycolic or laser-therapy.
- the excellent tolerability of the compositions of the present invention makes them also suitable in pediatrics.
- the present invention also relates to the use of proanthocyanidins for the preparation of a topical medicament for the treatment of skin inflammations, in particular atopic dermatitis, allergic contact dermatitis, seborrheic dermatitis, radiation dermatitis, xerosis, psoriasis and atopia; and of mucosae inflammatory conditions, in particular of vaginal, rectal, eye gingival and buccal mucosae.
- skin inflammations in particular atopic dermatitis, allergic contact dermatitis, seborrheic dermatitis, radiation dermatitis, xerosis, psoriasis and atopia
- mucosae inflammatory conditions in particular of vaginal, rectal, eye gingival and buccal mucosae.
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Abstract
Description
Claims
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0309061-2A BR0309061A (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising pro-anthocyanidins for treating dermatitis |
AU2003226754A AU2003226754B2 (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
DK03745775T DK1494692T3 (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins, glycyrrhetinic acid and telmestein for the treatment of dermatitis |
GEAP8438A GEP20074176B (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
MXPA04009755A MXPA04009755A (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis. |
KR1020047015962A KR101065645B1 (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
EP03745775A EP1494692B1 (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins, glycyrrhetinic acid and telmesteine for the treatment of dermatitis |
UA20040907928A UA81408C2 (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical composition and use thereof for the preparation of medicament for treatment of dermatitis and mucosae inflammatory conditions |
SI200330829T SI1494692T1 (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins, glycyrrhetinic acid and telmesteine for the treatment of dermatitis |
BRPI0309061-2A BRPI0309061B1 (en) | 2002-04-09 | 2003-03-31 | TOPICAL PHARMACEUTICAL COMPOSITION UNDERSTANDING PRO-ANTOCYANIDINES, GLYCYRETHINIC ACID AND TELMESTEIN FOR TREATMENT OF INFLAMMATORY SKIN AND MUCOSUS CONDITIONS AND USE OF THE SAME |
NZ535813A NZ535813A (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins glycyrrhetinic acid and telmesteine for the treatment of dermatitis |
CA2481770A CA2481770C (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
JP2003581793A JP4861606B2 (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical composition comprising proanthocyanidins for treating dermatitis |
DE60313597T DE60313597T2 (en) | 2002-04-09 | 2003-03-31 | TOPICAL PHARMACEUTICAL COMPOSITIONS WITH PROANTHOCYANIDINES, GLYCYRRHETINIC ACID AND TELEMINE TESTS FOR THE TREATMENT OF DERMATITIS |
CN038078589A CN1646151B (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
HRP20040917AA HRP20040917B1 (en) | 2002-04-09 | 2004-10-05 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
IL164434A IL164434A (en) | 2002-04-09 | 2004-10-05 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
NO20044259A NO332753B1 (en) | 2002-04-09 | 2004-10-07 | Topical pharmaceutical compositions containing proanthocyanidins for the treatment of dermatitis. |
US10/963,848 US7262180B2 (en) | 2002-04-09 | 2004-10-12 | Compositions and methods for the treatment of inflammatory conditions of mucosae, skin and the eye |
HK05107779.7A HK1075617A1 (en) | 2002-04-09 | 2005-09-05 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
US11/358,747 US20060247183A1 (en) | 2002-04-09 | 2006-02-21 | Compositions and methods for the treatment of inflammatory conditions of mucosae, skin and the eye |
CY20071100718T CY1106628T1 (en) | 2002-04-09 | 2007-05-29 | TOPICAL PHARMACEUTICAL COMPOSITIONS INCLUDING PROANTHOCYANIDINS, GLYCYRACHITINIC ACID AND TELMESTEIN FOR THE TREATMENT OF DERMATITIS |
US11/841,564 US20080015155A1 (en) | 2002-04-09 | 2007-08-20 | Compositions and Methods for the Treatment of Inflammatory Conditions of the Mucosae, Skin and the Eye |
US12/013,244 US20080114057A1 (en) | 2002-04-09 | 2008-01-11 | Compositions and methods for the treatment of inflammatory conditions of the mucosae, skin and the eye |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002MI000756A ITMI20020756A1 (en) | 2002-04-09 | 2002-04-09 | TOPICAL PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DERMATITIS |
ITMI2002A000756 | 2002-04-09 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/963,848 Continuation-In-Part US7262180B2 (en) | 2002-04-09 | 2004-10-12 | Compositions and methods for the treatment of inflammatory conditions of mucosae, skin and the eye |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003084553A1 true WO2003084553A1 (en) | 2003-10-16 |
Family
ID=11449673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/003329 WO2003084553A1 (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
Country Status (31)
Country | Link |
---|---|
US (4) | US7262180B2 (en) |
EP (1) | EP1494692B1 (en) |
JP (1) | JP4861606B2 (en) |
KR (1) | KR101065645B1 (en) |
CN (1) | CN1646151B (en) |
AR (1) | AR039269A1 (en) |
AT (1) | ATE361084T1 (en) |
AU (1) | AU2003226754B2 (en) |
BR (2) | BRPI0309061B1 (en) |
CA (1) | CA2481770C (en) |
CY (1) | CY1106628T1 (en) |
DE (1) | DE60313597T2 (en) |
DK (1) | DK1494692T3 (en) |
ES (1) | ES2285158T3 (en) |
GE (1) | GEP20074176B (en) |
HK (1) | HK1075617A1 (en) |
HR (1) | HRP20040917B1 (en) |
IL (1) | IL164434A (en) |
IT (1) | ITMI20020756A1 (en) |
JO (1) | JO2448B1 (en) |
MX (1) | MXPA04009755A (en) |
MY (1) | MY137060A (en) |
NO (1) | NO332753B1 (en) |
NZ (1) | NZ535813A (en) |
PL (1) | PL204953B1 (en) |
PT (1) | PT1494692E (en) |
RU (1) | RU2320362C2 (en) |
TW (1) | TWI345979B (en) |
UA (1) | UA81408C2 (en) |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4698360A (en) * | 1985-04-09 | 1987-10-06 | Societe Civile D'investigations Pharmacologiques D'aquitaine | Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof |
JPH06336421A (en) * | 1993-05-28 | 1994-12-06 | Kose Corp | External agent for skin |
EP0694305A1 (en) * | 1994-07-26 | 1996-01-31 | INDENA S.p.A. | Pharmaceutical or cosmetic formulations containing coumarins and proanthocyanidinis |
DE10131641A1 (en) * | 2000-12-22 | 2002-06-27 | Schwabe Willmar Gmbh & Co | St. John's wort extracts having reduced chlorophyll and proanthocyanidin contents, useful as topical medicaments, e.g. for treating stomatitis, acne, viral infections or psoriasis |
EP1256335A1 (en) * | 2001-05-10 | 2002-11-13 | Cognis France S.A. | Use of procyanidine oligomers |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US487774A (en) * | 1892-12-13 | Sectional steam-boiler | ||
FR2509988B1 (en) * | 1981-07-23 | 1986-05-30 | Oreal | MIXTURE OF VEGETABLE OILS BASED ON JOJOBA OIL AS AN OXIDATION STABILIZING AGENT AND COSMETIC COMPOSITIONS CONTAINING THE SAME |
IL64700A0 (en) * | 1982-01-01 | 1982-03-31 | Binderman Itzhak | Dental care compositions |
JPS60109519A (en) | 1983-11-17 | 1985-06-15 | Nippon Shinyaku Co Ltd | "nifedipine(r)" composition and production thereof |
US5422118A (en) * | 1986-11-07 | 1995-06-06 | Pure Pac, Inc. | Transdermal administration of amines with minimal irritation and high transdermal flux rate |
IT1201151B (en) * | 1987-01-14 | 1989-01-27 | Indena Spa | PHOSPHOLIPID COMPLEXES WITH EXTRACTS FROM VITIS VINIFERA, PROCEDURE FOR THEIR PREPARATION AND COMPOSITIONS THAT CONTAIN THEM |
IT1215469B (en) | 1987-05-08 | 1990-02-14 | Yason Srl | Muco-regulating and elastase inhibiting compsn. |
JPH0725660B2 (en) * | 1990-05-29 | 1995-03-22 | サンスター株式会社 | Cosmetics with anti-inflammatory properties against sunburn |
IT1254321B (en) * | 1992-04-10 | 1995-09-14 | Kemiprogress S R L | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PREVENTION OF CUTANEOUS INFLAMMATIONS AND ORAL MUCOSA. |
US5650432A (en) * | 1995-03-24 | 1997-07-22 | Jlb, Inc. | Method of treating or preventing non-viral microbial infection |
US5470874A (en) | 1994-10-14 | 1995-11-28 | Lerner; Sheldon | Ascorbic acid and proanthocyanidine composition for topical application to human skin |
US5945409A (en) * | 1995-03-10 | 1999-08-31 | Wilson T. Crandall | Topical moisturizing composition and method |
JPH1059846A (en) * | 1996-06-10 | 1998-03-03 | Kikkoman Corp | Preventive or remedy for cararacta |
US6471972B1 (en) * | 1996-11-07 | 2002-10-29 | Lvmh Recherche | Cosmetic treatment method for fighting against skin ageing effects |
US5811446A (en) * | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
DE19880535T1 (en) * | 1997-07-02 | 1999-04-29 | Neutrogena Corp N D Ges D Staa | Methods of using compositions containing dichlorophenylimidazole dioxolane to treat seborrheic dermatitis, dandruff, psoriasis and acne, and compositions thereof |
EP0958833A1 (en) * | 1998-05-20 | 1999-11-24 | Erasmus Universiteit Rotterdam | Methods and means for preventing or treating inflammation |
IT1304183B1 (en) * | 1998-12-18 | 2001-03-08 | Indena Spa | PROANTOCYANIDINE A2 COMPLEXES WITH PHOSPHOLIPIDES AS AGENTIANTIATEROSCLEROTICI. |
JP2000212057A (en) * | 1999-01-26 | 2000-08-02 | Kansai Koso Kk | Cosmetic composition |
JP2001039844A (en) * | 1999-07-29 | 2001-02-13 | Kikkoman Corp | Gargle for throat |
US6274124B1 (en) * | 1999-08-20 | 2001-08-14 | Dragoco Gerberding & Co. Ag | Additive for improving the water resistance of cosmetic or dermatological formulations |
JP2001081021A (en) * | 1999-09-09 | 2001-03-27 | Ichimaru Pharcos Co Ltd | Cosmetic composition |
US6685970B1 (en) * | 1999-09-21 | 2004-02-03 | Kyowa Hakko Kogyo Co., Ltd. | Compositions containing proanthocyanidin and a vitamin B6 derivative or a salt thereof |
EP1226809B1 (en) * | 1999-10-29 | 2007-05-30 | Kyowa Hakko Kogyo Co., Ltd. | Skin texture-improving agents |
ITMI20020756A1 (en) * | 2002-04-09 | 2003-10-09 | Sinclair Pharma S R L | TOPICAL PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DERMATITIS |
-
2002
- 2002-04-09 IT IT2002MI000756A patent/ITMI20020756A1/en unknown
-
2003
- 2003-03-31 CN CN038078589A patent/CN1646151B/en not_active Expired - Fee Related
- 2003-03-31 JP JP2003581793A patent/JP4861606B2/en not_active Expired - Fee Related
- 2003-03-31 CA CA2481770A patent/CA2481770C/en not_active Expired - Lifetime
- 2003-03-31 KR KR1020047015962A patent/KR101065645B1/en active IP Right Grant
- 2003-03-31 AU AU2003226754A patent/AU2003226754B2/en not_active Ceased
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- 2003-03-31 DE DE60313597T patent/DE60313597T2/en not_active Expired - Lifetime
- 2003-03-31 BR BRPI0309061-2A patent/BRPI0309061B1/en unknown
- 2003-03-31 BR BR0309061-2A patent/BR0309061A/en not_active IP Right Cessation
- 2003-03-31 GE GEAP8438A patent/GEP20074176B/en unknown
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- 2003-03-31 PL PL371853A patent/PL204953B1/en unknown
- 2003-03-31 EP EP03745775A patent/EP1494692B1/en not_active Expired - Lifetime
- 2003-03-31 WO PCT/EP2003/003329 patent/WO2003084553A1/en active IP Right Grant
- 2003-04-08 TW TW092107980A patent/TWI345979B/en not_active IP Right Cessation
- 2003-04-08 AR ARP030101233A patent/AR039269A1/en not_active Application Discontinuation
- 2003-04-08 MY MYPI20031288A patent/MY137060A/en unknown
- 2003-04-08 JO JO200338A patent/JO2448B1/en active
-
2004
- 2004-10-05 IL IL164434A patent/IL164434A/en not_active IP Right Cessation
- 2004-10-05 HR HRP20040917AA patent/HRP20040917B1/en not_active IP Right Cessation
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- 2004-10-07 NO NO20044259A patent/NO332753B1/en not_active IP Right Cessation
- 2004-10-12 US US10/963,848 patent/US7262180B2/en not_active Expired - Lifetime
-
2005
- 2005-09-05 HK HK05107779.7A patent/HK1075617A1/en not_active IP Right Cessation
-
2006
- 2006-02-21 US US11/358,747 patent/US20060247183A1/en not_active Abandoned
-
2007
- 2007-05-29 CY CY20071100718T patent/CY1106628T1/en unknown
- 2007-08-20 US US11/841,564 patent/US20080015155A1/en not_active Abandoned
-
2008
- 2008-01-11 US US12/013,244 patent/US20080114057A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4698360A (en) * | 1985-04-09 | 1987-10-06 | Societe Civile D'investigations Pharmacologiques D'aquitaine | Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof |
US4698360B1 (en) * | 1985-04-09 | 1997-11-04 | D Investigations Pharmacologiq | Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof |
JPH06336421A (en) * | 1993-05-28 | 1994-12-06 | Kose Corp | External agent for skin |
EP0694305A1 (en) * | 1994-07-26 | 1996-01-31 | INDENA S.p.A. | Pharmaceutical or cosmetic formulations containing coumarins and proanthocyanidinis |
DE10131641A1 (en) * | 2000-12-22 | 2002-06-27 | Schwabe Willmar Gmbh & Co | St. John's wort extracts having reduced chlorophyll and proanthocyanidin contents, useful as topical medicaments, e.g. for treating stomatitis, acne, viral infections or psoriasis |
EP1256335A1 (en) * | 2001-05-10 | 2002-11-13 | Cognis France S.A. | Use of procyanidine oligomers |
Non-Patent Citations (2)
Title |
---|
EGGENSPERGER H: "ACTIVE COMPLEXES FOR SMOOTH SKIN NATURE COMBATS OXIDATIVE STRESS WIRKSTOFFKOMPLEXE FUER GLATTE HAUT NATUR GEGEN OXIDATIVEN STRESS", COSSMA: COSMETICS, SPRAY TECHNOLOGY, MARKETING, BRAUN FACHVERLAGE, KARLSRUHE, DE, vol. 2, no. 8, August 2001 (2001-08-01), pages 38 - 39, XP008016527, ISSN: 1439-7676 * |
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 03 28 April 1995 (1995-04-28) * |
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