WO2003082911A3 - Utilisation de la proteine maba (fabg1) de mycobacterium tuberculosis pour la conception et le criblage d'antibiotiques - Google Patents
Utilisation de la proteine maba (fabg1) de mycobacterium tuberculosis pour la conception et le criblage d'antibiotiques Download PDFInfo
- Publication number
- WO2003082911A3 WO2003082911A3 PCT/FR2003/000990 FR0300990W WO03082911A3 WO 2003082911 A3 WO2003082911 A3 WO 2003082911A3 FR 0300990 W FR0300990 W FR 0300990W WO 03082911 A3 WO03082911 A3 WO 03082911A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fabg1
- designing
- proteins
- mycobacterium tuberculosis
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03740540A EP1490491B1 (fr) | 2002-03-29 | 2003-03-28 | Utilisation de la proteine maba (fabg1) de mycobacterium tuberculosis pour la conception et le criblage d'antibiotiques |
DE60312497T DE60312497T2 (de) | 2002-03-29 | 2003-03-28 | Verwendung von protein maba (fabg1) aus mycobacterium tuberculosis zur herstellung und nachweis von antibiotika |
AU2003258723A AU2003258723A1 (en) | 2002-03-29 | 2003-03-28 | Use of the protein maba (fabg1) of less thanigreater thanmycobacterium tuberculosisless than/igreater than for designing and screening antibiotics |
US10/503,939 US20060035294A1 (en) | 2002-03-29 | 2003-03-28 | Use of the protein maba (fabg1) of mycobacterium tuberculosis for designing and screening antibiotics |
US12/423,586 US20100240084A1 (en) | 2002-03-29 | 2009-04-14 | Use of the protien maba (fabg1) of mycobacterium tuberculosis for designing and screening antibiotics |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0204018A FR2837836B1 (fr) | 2002-03-29 | 2002-03-29 | UTILISATION DE LA PROTEINE Maba (FABG1) DE MYCOBACTERIUM TUBERCULOSIS POUR LA CONCEPTION ET LE CRIBLAGE D'ANTIBIOTIQUES |
FR02/04018 | 2002-03-29 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/423,586 Division US20100240084A1 (en) | 2002-03-29 | 2009-04-14 | Use of the protien maba (fabg1) of mycobacterium tuberculosis for designing and screening antibiotics |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003082911A2 WO2003082911A2 (fr) | 2003-10-09 |
WO2003082911A3 true WO2003082911A3 (fr) | 2004-04-01 |
Family
ID=27839347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2003/000990 WO2003082911A2 (fr) | 2002-03-29 | 2003-03-28 | Utilisation de la proteine maba (fabg1) de mycobacterium tuberculosis pour la conception et le criblage d'antibiotiques |
Country Status (8)
Country | Link |
---|---|
US (2) | US20060035294A1 (fr) |
EP (1) | EP1490491B1 (fr) |
AT (1) | ATE356872T1 (fr) |
AU (1) | AU2003258723A1 (fr) |
DE (1) | DE60312497T2 (fr) |
ES (1) | ES2283790T3 (fr) |
FR (1) | FR2837836B1 (fr) |
WO (1) | WO2003082911A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1996611A1 (fr) * | 2006-03-23 | 2008-12-03 | Centre National de la Recherche Scientifique | Complexes de nadp avec la protéine maba de mycobacterium tuberculosis ou avec des mutants de ce dernier, et leurs applications dans la conception et le criblage d'antibiotiques |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994026765A1 (fr) * | 1993-05-13 | 1994-11-24 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Utilisation des genes de m. tuberculosis, m. bovis et m. smegmatis conferant une resistance a l'isoniazide |
WO1994026312A1 (fr) * | 1993-05-13 | 1994-11-24 | Jacobs William R Jr | PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT DES INFECTIONS MYCOBACTERIENNES AU MOYEN D'UN GENE inhA |
-
2002
- 2002-03-29 FR FR0204018A patent/FR2837836B1/fr not_active Expired - Fee Related
-
2003
- 2003-03-28 EP EP03740540A patent/EP1490491B1/fr not_active Expired - Lifetime
- 2003-03-28 WO PCT/FR2003/000990 patent/WO2003082911A2/fr active IP Right Grant
- 2003-03-28 ES ES03740540T patent/ES2283790T3/es not_active Expired - Lifetime
- 2003-03-28 DE DE60312497T patent/DE60312497T2/de not_active Expired - Lifetime
- 2003-03-28 US US10/503,939 patent/US20060035294A1/en not_active Abandoned
- 2003-03-28 AU AU2003258723A patent/AU2003258723A1/en not_active Abandoned
- 2003-03-28 AT AT03740540T patent/ATE356872T1/de not_active IP Right Cessation
-
2009
- 2009-04-14 US US12/423,586 patent/US20100240084A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994026765A1 (fr) * | 1993-05-13 | 1994-11-24 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Utilisation des genes de m. tuberculosis, m. bovis et m. smegmatis conferant une resistance a l'isoniazide |
WO1994026312A1 (fr) * | 1993-05-13 | 1994-11-24 | Jacobs William R Jr | PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT DES INFECTIONS MYCOBACTERIENNES AU MOYEN D'UN GENE inhA |
Non-Patent Citations (7)
Title |
---|
A BANERJEE ET AL.: "The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance", MICROBIOLOGY, vol. 144, no. 10, October 1998 (1998-10-01), CONSULTANTS BUREAU, NEW YORK, NY, US, pages 2697 - 2704, XP002229443, ISSN: 0026-2617 * |
A C PRICE ET AL.: "Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis", BIOCHEMISTRY., vol. 40, no. 43, 2001, AMERICAN CHEMICAL SOCIETY. EASTON, PA., US, pages 12772 - 12781, XP002229444, ISSN: 0006-2960 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2000, P KIEPIELA ET AL: "Genomic mutations in the katG, inhA and aphC are useful for the prediction of isoniazid resistance in Mycobacterium tuberculosis isolates from Kwazulu Natal, South Africa", XP002229447, Database accession no. PREV200000182099 * |
H MARRAKCHI ET AL.: "MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II", MICROBIOLOGY, vol. 148, no. 4, April 2002 (2002-04-01), CONSULTANTS BUREAU, NEW YORK, NY, US, pages 951 - 960, XP002229445, ISSN: 0026-2617 * |
M COHEN-GONSAUD ET AL.: "Crystal structure and fluorescence spectroscopy of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis", BIOPHYSICAL JOURNAL, vol. 82, no. 1 part 2, January 2002 (2002-01-01), NEW YORK, US, US, pages 453A, XP002229792, ISSN: 0006-3495 * |
M COHEN-GONSAUD ET AL.: "Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis", JOURNAL OF MOLECULAR BIOLOGY, vol. 320, no. 2, 5 July 2002 (2002-07-05), LONDON, GB, pages 249 - 261, XP002229446, ISSN: 0022-2836 * |
TUBERCLE AND LUNG DISEASE, vol. 80, no. 1, 2000, pages 47 - 56 * |
Also Published As
Publication number | Publication date |
---|---|
ES2283790T3 (es) | 2007-11-01 |
AU2003258723A1 (en) | 2003-10-13 |
EP1490491B1 (fr) | 2007-03-14 |
DE60312497T2 (de) | 2007-09-20 |
EP1490491A2 (fr) | 2004-12-29 |
ATE356872T1 (de) | 2007-04-15 |
FR2837836A1 (fr) | 2003-10-03 |
AU2003258723A8 (en) | 2003-10-13 |
DE60312497D1 (de) | 2007-04-26 |
WO2003082911A2 (fr) | 2003-10-09 |
US20100240084A1 (en) | 2010-09-23 |
US20060035294A1 (en) | 2006-02-16 |
FR2837836B1 (fr) | 2005-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007004876A3 (fr) | Peptides inhibant l'enzyme de conversion d'angiotensine | |
EP1801206A4 (fr) | Methode de synthese de la l-arginine, de la l-ornithine, ou de la l-citrulline | |
HUP0105331A2 (hu) | Új karbonil-reduktáz, ennek génje és alkalmazásának módszere | |
AU2002354696A1 (en) | Method for purifying an enzyme, a purified enzyme produced thereby, and use of this enzyme | |
WO2007058267A8 (fr) | Proteine innovante et gene codant pour la proteine | |
WO2003082911A3 (fr) | Utilisation de la proteine maba (fabg1) de mycobacterium tuberculosis pour la conception et le criblage d'antibiotiques | |
WO2008146259A3 (fr) | Clivage spécifique de malt1 dans un procédé de dosage et de criblage | |
WO2002093177A3 (fr) | Analyses, methodes et dispositifs | |
WO2003070229A3 (fr) | Utilisation d'inhibiteurs de proteinases pour le traitement de maladies auto-immunes | |
AU4871993A (en) | Dictyostelium dipeptidylaminopeptidase | |
WO2004024765A8 (fr) | Structure de cristal d'une enzyme de conversion de l'angiotensine (ace) et ses utilisations | |
WO2007014951A3 (fr) | Procedes de criblage de substances antibacteriennes | |
MY150639A (en) | T cell adhesion molecule and antibody thereto | |
SG170757A1 (en) | Polypeptide having esterase activity and recombinant esterase and use thereof | |
DK0828004T3 (da) | Proteindisulfidisomerase-gen afledt af stamme af methylotrof gær | |
DE60121225D1 (de) | Tetrapeptidische tryptase substrate und ihre verwendung zur tryptase aktivitätbestimmung | |
WO2003054194A3 (fr) | Tridegines modifiees, leur production et leur utilisation comme inhibiteurs de transglutaminase | |
WO2006136982A3 (fr) | Polypeptide isole de la proteine de controle du complement du virus vaccinal de recombinaison (hrvcp) | |
WO2002083729A3 (fr) | Polypeptides, leurs derives et leurs utilisations | |
EP1536010A4 (fr) | Medicaments destines a la prevention et au traitement du cancer | |
WO2005003289A3 (fr) | Variants de l'amine oxydase ap1 | |
WO2004042043A3 (fr) | Structures cristallines de 3-epimerases bacteriennes de ribulose-phosphate | |
WO2003070769A3 (fr) | Composes organiques | |
WO2002061074A1 (fr) | Nouvelle proteine et adn la comprenant | |
WO2006067406B1 (fr) | Fragments de peptides immunomodulateurs de cd23 et utilisations correspondantes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003740540 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2003740540 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2006035294 Country of ref document: US Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10503939 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 10503939 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |
|
WWG | Wipo information: grant in national office |
Ref document number: 2003740540 Country of ref document: EP |