WO2003068969A1 - Mouse spermatogenesis genes, human male sterility-associated genes and diagnostic system using the same - Google Patents

Mouse spermatogenesis genes, human male sterility-associated genes and diagnostic system using the same Download PDF

Info

Publication number
WO2003068969A1
WO2003068969A1 PCT/JP2003/001572 JP0301572W WO03068969A1 WO 2003068969 A1 WO2003068969 A1 WO 2003068969A1 JP 0301572 W JP0301572 W JP 0301572W WO 03068969 A1 WO03068969 A1 WO 03068969A1
Authority
WO
WIPO (PCT)
Prior art keywords
genes
male sterility
same
mass
mouse spermatogenesis
Prior art date
Application number
PCT/JP2003/001572
Other languages
English (en)
French (fr)
Inventor
Yoshitake Nishimune
Hiromitsu Tanaka
Masami Nozaki
Original Assignee
Japan Science And Technology Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science And Technology Agency filed Critical Japan Science And Technology Agency
Priority to JP2003568082A priority Critical patent/JP4146353B2/ja
Priority to US10/504,582 priority patent/US7842783B2/en
Priority to KR1020047012460A priority patent/KR100828506B1/ko
Priority to CA002476561A priority patent/CA2476561A1/en
Priority to EP03705175A priority patent/EP1484399A4/en
Priority to CN038061627A priority patent/CN1643148B/zh
Publication of WO2003068969A1 publication Critical patent/WO2003068969A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PCT/JP2003/001572 2002-02-14 2003-02-14 Mouse spermatogenesis genes, human male sterility-associated genes and diagnostic system using the same WO2003068969A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2003568082A JP4146353B2 (ja) 2002-02-14 2003-02-14 マウス精子形成遺伝子とヒト男性不妊関連遺伝子、ならびにこれらを用いた診断システム
US10/504,582 US7842783B2 (en) 2002-02-14 2003-02-14 Mouse spermatogenesis genes related to human male sterility
KR1020047012460A KR100828506B1 (ko) 2002-02-14 2003-02-14 마우스 정자 형성 유전자와 인간 남성 불임 관련 유전자,및 이들을 사용한 진단 시스템
CA002476561A CA2476561A1 (en) 2002-02-14 2003-02-14 Mouse spermatogenesis genes, human male sterility-associated genes and diagnostic system using the same
EP03705175A EP1484399A4 (en) 2002-02-14 2003-02-14 MOUSE-SPERMATOGENESIS, HUMAN MESES ASSOCIATED WITH MALE STERILITY, AND THIS DIAGNOSTIC SYSTEM USED
CN038061627A CN1643148B (zh) 2002-02-14 2003-02-14 小鼠精子形成基因、人男性不育关连基因、以及利用该基因的诊断系统

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2002036649 2002-02-14
JP2002-036649 2002-02-14
JP2002-381241 2002-12-27
JP2002381241 2002-12-27

Publications (1)

Publication Number Publication Date
WO2003068969A1 true WO2003068969A1 (en) 2003-08-21

Family

ID=27736494

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/001572 WO2003068969A1 (en) 2002-02-14 2003-02-14 Mouse spermatogenesis genes, human male sterility-associated genes and diagnostic system using the same

Country Status (7)

Country Link
US (1) US7842783B2 (ja)
EP (1) EP1484399A4 (ja)
JP (3) JP4146353B2 (ja)
KR (2) KR100828506B1 (ja)
CN (1) CN1643148B (ja)
CA (1) CA2476561A1 (ja)
WO (1) WO2003068969A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008067649A (ja) * 2006-09-14 2008-03-27 Osaka Univ 妊孕性診断キット、変異検出方法、ポリヌクレオチド、及びポリペプチド
JP2008237114A (ja) * 2007-03-27 2008-10-09 Osaka Univ 妊孕性診断キット、変異検出方法、ポリヌクレオチド、ポリペプチド、発現ベクター、及び発現キット
JP2013528283A (ja) * 2010-05-27 2013-07-08 建▲遠▼ 李 ヒト睾丸および副睾丸で発現される３０５種類の生殖関連精子局在タンパク質の検出方法
JP2017510250A (ja) * 2014-01-27 2017-04-13 セルマティックス， インコーポレイテッド 遺伝的領域が、不妊に関連するか評価するための方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5713351B2 (ja) 2009-03-17 2015-05-07 凸版印刷株式会社 妊孕性検査方法、妊孕性検査キット、ポリヌクレオチド、ポリペプチド、及び抗体
CN101775371B (zh) * 2009-12-02 2012-03-14 唐爱发 一种抗睾丸hTSC29蛋白的抗体或抗体片段及其应用
CN101775372B (zh) * 2009-12-02 2012-01-11 桂耀庭 一种抗睾丸hT279蛋白的抗体或抗体片段及其应用
US9177098B2 (en) 2012-10-17 2015-11-03 Celmatix Inc. Systems and methods for determining the probability of a pregnancy at a selected point in time
US10162800B2 (en) 2012-10-17 2018-12-25 Celmatix Inc. Systems and methods for determining the probability of a pregnancy at a selected point in time
US9836577B2 (en) 2012-12-14 2017-12-05 Celmatix, Inc. Methods and devices for assessing risk of female infertility
NZ758970A (en) 2013-11-07 2022-10-28 Ozgene Holdings Pty Ltd Compositions and methods for producing genetically modified animals
CN103743910B (zh) * 2013-12-27 2015-11-18 上海市计划生育科学研究所 Ctbs蛋白作为精卵结合受体的靶点在筛选精卵结合抑制剂中的应用
US10208350B2 (en) 2014-07-17 2019-02-19 Celmatix Inc. Methods and systems for assessing infertility and related pathologies
US10030241B2 (en) 2015-03-30 2018-07-24 General Electric Company Methods and kits for capturing sperm nucleic acids
US9957548B2 (en) 2015-03-30 2018-05-01 General Electric Company Methods of capturing sperm nucleic acids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090555A (en) * 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VIJAYARAGHAVAN S. ET AL.: "Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein", MOL. ENDROCRINOL., vol. 13, no. 5, 1999, pages 705 - 717, XP001029110 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008067649A (ja) * 2006-09-14 2008-03-27 Osaka Univ 妊孕性診断キット、変異検出方法、ポリヌクレオチド、及びポリペプチド
JP2008237114A (ja) * 2007-03-27 2008-10-09 Osaka Univ 妊孕性診断キット、変異検出方法、ポリヌクレオチド、ポリペプチド、発現ベクター、及び発現キット
JP2013528283A (ja) * 2010-05-27 2013-07-08 建▲遠▼ 李 ヒト睾丸および副睾丸で発現される３０５種類の生殖関連精子局在タンパク質の検出方法
JP2017510250A (ja) * 2014-01-27 2017-04-13 セルマティックス， インコーポレイテッド 遺伝的領域が、不妊に関連するか評価するための方法

Also Published As

Publication number Publication date
JP4146353B2 (ja) 2008-09-10
EP1484399A4 (en) 2006-04-05
CN1643148B (zh) 2011-04-20
CA2476561A1 (en) 2003-08-21
US7842783B2 (en) 2010-11-30
EP1484399A1 (en) 2004-12-08
KR100828506B1 (ko) 2008-05-13
JP4229973B2 (ja) 2009-02-25
JP2008173125A (ja) 2008-07-31
JPWO2003068969A1 (ja) 2005-06-02
CN1643148A (zh) 2005-07-20
JP4276691B2 (ja) 2009-06-10
KR20070061926A (ko) 2007-06-14
KR20040096564A (ko) 2004-11-16
US20050176943A1 (en) 2005-08-11
JP2008154592A (ja) 2008-07-10

Similar Documents

Publication Publication Date Title
WO2003068969A1 (en) Mouse spermatogenesis genes, human male sterility-associated genes and diagnostic system using the same
WO2006029184A3 (en) Genes useful for diagnosing and monitoring inflammation related disorders
WO2001047944A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
EP2014776A3 (en) Diagnosis of diseases associated with DNA transcription
NZ598724A (en) Soybean transgenic event mon 87708 and methods of use thereof
WO1999053040A3 (de) Menschliche nukleinsäuresequenzen aus ovartumorgewebe
NZ599670A (en) Diagnostic and therapeutic methods for rheumatic heart disease based upon group a streptococcus markers
WO2004035760A3 (en) Complete biosynthetic gene set for biosynthesis of albicidin, resistance genes, and uses thereof
WO2000029623A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001096527A3 (en) Peptides with physiological activity
WO1999046374A3 (de) Menschliche nukleinsäuresequenzen aus prostatatumorgewebe
EP2172214A3 (en) Chlamydia antigens and corresponding DNA fragments and uses thereof
WO1999046375A3 (de) Menschliche nukleinsäuresequenzen aus prostatagewebe
WO2001040521A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001048245A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
EP1536003A4 (en) METHOD FOR DETECTING A GENE POLYMORPHISM
WO2004027062A3 (de) Funktionelle korrektur der -786 c/t-varianz des humanen enos-gens
WO2003047532A3 (en) Compositions and methods for the therapeutic use of an atonal-associated sequence for a gastrointestinal condition
WO2004042066A3 (en) NtSM GENE
WO1997040134A3 (en) Human dnase ii
WO2001034818A3 (en) Sorghum dwarfing genes and methods of use
WO2001030991A3 (en) Human narcolepsy gene
WO2004046327A3 (en) Inhibitory oliogonucleotides targeted to bcl-2
WO2001051670A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
CN1952139A (zh) 蝎子电压门控钠通道基因、编码蛋白及其克隆方法

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA CN JP KR US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT SE SI SK TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2003568082

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 1020047012460

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2476561

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003705175

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 20038061627

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 10504582

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2003705175

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1020077011884

Country of ref document: KR

Ref document number: 1020077011875

Country of ref document: KR