WO2003059515A3 - Fluidfördervorrichtung und verfahren zum zu- und abführen von fluiden - Google Patents

Fluidfördervorrichtung und verfahren zum zu- und abführen von fluiden Download PDF

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Publication number
WO2003059515A3
WO2003059515A3 PCT/EP2003/000391 EP0300391W WO03059515A3 WO 2003059515 A3 WO2003059515 A3 WO 2003059515A3 EP 0300391 W EP0300391 W EP 0300391W WO 03059515 A3 WO03059515 A3 WO 03059515A3
Authority
WO
WIPO (PCT)
Prior art keywords
conveying device
withdrawal
introduction
fluid
fluids
Prior art date
Application number
PCT/EP2003/000391
Other languages
English (en)
French (fr)
Other versions
WO2003059515A2 (de
Inventor
Nico Michaelsen
Olaf Sollboehmer
Original Assignee
Evotec Ag
Nico Michaelsen
Olaf Sollboehmer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Ag, Nico Michaelsen, Olaf Sollboehmer filed Critical Evotec Ag
Priority to EP03729467A priority Critical patent/EP1465731A2/de
Priority to AU2003235723A priority patent/AU2003235723A1/en
Publication of WO2003059515A2 publication Critical patent/WO2003059515A2/de
Publication of WO2003059515A3 publication Critical patent/WO2003059515A3/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B65B3/06—Methods of, or means for, filling the material into the containers or receptacles by gravity flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B01L2200/022—Variable spacings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
    • G01N2035/1069—Multiple transfer devices for transfer to or from containers having different spacing by adjusting the spacing between multiple probes of a single transferring head

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Jet Pumps And Other Pumps (AREA)

Abstract

Eine Fluidfördervorrichtung zum Zu- und/oder Abführen von Fluiden in bzw. aus Vertiefungen (34) einer Mikrostruktur weist ein Fluidtransportmittel (28), wie eine Kapillare, auf. Mit dem Fluidtransportmittel (28) ist eine Fördereinrichtung, wie beispielsweise eine Pumpe, zum Zu- und/oder Abführen des Fluides zu bzw. aus den Vertiefungen (34) verbunden. Erfindungsgemäß weist die Fluidfördervorrichtung (10) eine Haltevorrichtung (12) auf, mit der das Fluidtransportmittel (28) gelenkig verbunden ist. Es ist somit möglich, die Fluidfördervorrichtung horizontal gegenüber der Mikrostruktur zu bewegen, wobei das Fluidtransportmittel (28) automatisch von einer in die nächste Vertiefung (34) gleitet.
PCT/EP2003/000391 2002-01-18 2003-01-16 Fluidfördervorrichtung und verfahren zum zu- und abführen von fluiden WO2003059515A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03729467A EP1465731A2 (de) 2002-01-18 2003-01-16 Fluidfördervorrichtung und verfahren zum zu- und abführen von fluiden
AU2003235723A AU2003235723A1 (en) 2002-01-18 2003-01-16 Fluid conveying device and method for the introduction and withdrawal of fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10201749.2 2002-01-18
DE2002101749 DE10201749A1 (de) 2002-01-18 2002-01-18 Fluidfördervorrichtung und Verfahren zum Zu-und Abführen von Fluiden

Publications (2)

Publication Number Publication Date
WO2003059515A2 WO2003059515A2 (de) 2003-07-24
WO2003059515A3 true WO2003059515A3 (de) 2004-01-15

Family

ID=7712445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000391 WO2003059515A2 (de) 2002-01-18 2003-01-16 Fluidfördervorrichtung und verfahren zum zu- und abführen von fluiden

Country Status (4)

Country Link
EP (1) EP1465731A2 (de)
AU (1) AU2003235723A1 (de)
DE (1) DE10201749A1 (de)
WO (1) WO2003059515A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2855612B1 (fr) 2003-05-28 2006-02-24 Biomerieux Sa Procede de mise en place d'un recipient contenant un liquide dans un dispositif de prelevement du liquide et dispositif de prelevement pour la mise en oeuvre du procede
DE102006030068A1 (de) 2006-06-28 2008-01-03 M2P-Labs Gmbh Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635345A (en) * 1969-03-13 1972-01-18 Jerome A Rodder Chromatography
US3738493A (en) * 1971-09-24 1973-06-12 Analytical Instr Spec Apparatus for simultaneous application of samples to thin layer chromatography plates
US3754654A (en) * 1970-04-13 1973-08-28 Instrumenta Ab Device for applying a liquid along a line on a support
FR2630216A1 (fr) * 1988-04-14 1989-10-20 Ibal Installation robotisee d'analyses, notamment medicales
US6063339A (en) * 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
WO2001019678A1 (en) * 1999-09-14 2001-03-22 Pharmacopeia, Inc. Article comprising a multi-channel dispensing head
DE19962689A1 (de) * 1999-12-23 2001-07-05 Tecconsult & Trading Gmbh Vorrichtung zum Auftragen von flüssigen Proben mittels Pipetten auf Platten, Folie o. dgl.
CA2400432A1 (en) * 2000-02-15 2001-08-23 Unitec Co., Ltd. Apparatus for positioning substances for detection and film for positioning substances for detection and manufacturing method of carrier for substances for detection
US20010036425A1 (en) * 1995-10-12 2001-11-01 Michel Gazeau Device for transferring samples of micro-amounts of liquids
US20010051714A1 (en) * 2000-01-10 2001-12-13 Shiping Chen Linear probe carrier

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59191637U (ja) * 1983-06-04 1984-12-19 株式会社　堀場製作所 試料吸引機構
AT392362B (de) * 1987-07-02 1991-03-25 Avl Verbrennungskraft Messtech Eingabevorrichtung zum einbringen fluessiger oder gasfoermiger medien
AT392363B (de) * 1987-07-06 1991-03-25 Avl Verbrennungskraft Messtech Eingabevorrichtung zum einbringen fluessiger oder gasfoermiger medien
GB9208386D0 (en) * 1992-04-16 1992-06-03 Amersham Int Plc Storage and dispensing device for liquids
JP3307816B2 (ja) * 1995-12-19 2002-07-24 シスメックス株式会社 試料吸引装置
AU7180898A (en) * 1996-11-15 1998-06-03 Biochem Immunosystems Inc. A blood cell analyzer with tube holder and cap piercer
DE29806459U1 (de) * 1998-04-08 1998-07-02 Wetzler, Gabriel, 56579 Rengsdorf Haltevorrichtung für eine Mehrzahl von gleichartigen Arbeitsmitteln, deren gegenseitiger Abstand veränderbar ist
DE19946525A1 (de) * 1999-09-28 2001-05-03 Fraunhofer Ges Forschung Vorrichtung zur Aufnahme und Abgabe kleinster Flüssigkeitsmengen

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635345A (en) * 1969-03-13 1972-01-18 Jerome A Rodder Chromatography
US3754654A (en) * 1970-04-13 1973-08-28 Instrumenta Ab Device for applying a liquid along a line on a support
US3738493A (en) * 1971-09-24 1973-06-12 Analytical Instr Spec Apparatus for simultaneous application of samples to thin layer chromatography plates
FR2630216A1 (fr) * 1988-04-14 1989-10-20 Ibal Installation robotisee d'analyses, notamment medicales
US20010036425A1 (en) * 1995-10-12 2001-11-01 Michel Gazeau Device for transferring samples of micro-amounts of liquids
US6063339A (en) * 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
WO2001019678A1 (en) * 1999-09-14 2001-03-22 Pharmacopeia, Inc. Article comprising a multi-channel dispensing head
DE19962689A1 (de) * 1999-12-23 2001-07-05 Tecconsult & Trading Gmbh Vorrichtung zum Auftragen von flüssigen Proben mittels Pipetten auf Platten, Folie o. dgl.
US20010051714A1 (en) * 2000-01-10 2001-12-13 Shiping Chen Linear probe carrier
CA2400432A1 (en) * 2000-02-15 2001-08-23 Unitec Co., Ltd. Apparatus for positioning substances for detection and film for positioning substances for detection and manufacturing method of carrier for substances for detection

Also Published As

Publication number Publication date
AU2003235723A8 (en) 2003-07-30
DE10201749A1 (de) 2003-08-07
WO2003059515A2 (de) 2003-07-24
AU2003235723A1 (en) 2003-07-30
EP1465731A2 (de) 2004-10-13

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