WO2003050071A1 - Process for the preparation of methionine - Google Patents
Process for the preparation of methionine Download PDFInfo
- Publication number
- WO2003050071A1 WO2003050071A1 PCT/EP2002/008742 EP0208742W WO03050071A1 WO 2003050071 A1 WO2003050071 A1 WO 2003050071A1 EP 0208742 W EP0208742 W EP 0208742W WO 03050071 A1 WO03050071 A1 WO 03050071A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methionine
- process according
- employed
- compounds
- sodium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
Definitions
- the invention relates to a process for the preparation of methionine of high bulk density, in which a mixture which comprises a compound which has a foaming action and a compound which influences crystallization is added to the hydrolysis solution, and to the mixture itself.
- JP 09000241 thus describes that the addition of various additives from the family of nitrogen-containing polyoxyalkylenes in the fermentative production of amino acids leads to a reduction in foaming.
- JP 09000241 relates to the preparation of defoa er mixtures which are composed of fats or oils and the reaction products of fatty acids or derivatives thereof and polyalcohols with alkylene oxides . These mixtures are suitable for use in fermentations . It is known that the yield of lysine and tryptophan production can be increased if silicone are used as foam-destroying additives, instead of sunflower oil. The influence of various silicone oils is investigated by comparison in Khim.-Farm. Zh (1972), 6(5), 27-30.
- Methionine is in general precipitated out of these solutions in the form of very flat leaflets, separating off of which proceeds only very slowly and therefore uneconomically.
- the present invention is based on the object of minimizing the formation of foam in the methionine process and at the same time positively influencing the crystal habit of the methionine which has precipitated out after the recrystallization.
- n an integer from 9 to 19, preferably 15 to 17,
- n a distribution in the range from 1 to 10, wherein the maximum is preferably 5 to 8, in particular 6 to 7 ,
- modified celluloses in particular methylcellulose, methylhydroxycellulose, methylhydroxypropylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, sodium carboxymethylhydroxyethylcellulose and sodium carboxymethylhydroxypropylcellulose in a weight ratio of 1:10 to 10:1, preferably 1:3 to 3:1.
- the fatty acid contents in compounds according to formula (1) are preferably of natural origin, and are saturated or unsaturated, depending on the meaning of x.
- the mixture is advantageously employed in the form of an aqueous solution or emulsion with a total additive content of 1 to 5 wt.%, in particular 2 to 4 wt.%, based on the total amount.
- hydroxycelluloses dissolved in water can lead to highly viscous solutions, it is advantageous to use low molecular weight hydroxycelluloses with a viscosity of ⁇ 300 mPas (as a 2% solution in water) .
- the viscosity can furthermore also be adjusted via the degree of dilution.
- an aqueous solution or emulsion of the additives (1) and (2) with a viscosity of between 5 and 5000 mPas, based on a 2% solution of the additives in water, in particular 10 to 500 mPas, is prepared by dissolving or emulsifying the compounds according formula (1) and (2) in the desired amount.
- One important aspect of the invention is that the defoaming action and the crystallization can be controlled by changing the ratios of amounts of (1) to (2) in the mixture.
- Foaming depends greatly on the composition of the process solutions and the other process conditions, such as, for example, pressure and temperature.
- the mixtures according to the invention already display their defoaming and a crystal growth-promoting action when small amounts are added. Amounts of 10 to 500 ppm, based on the methionine, are already active.
- the invention also provides a process for the preparation of methionine, in particular with a purity of 80 to 100 wt.%, by reaction of the components 3- methylmercaptopropionaldehyde, hydrogen cyanide, ammonia and carbon dioxide or of those components from which the above-mentioned components can be prepared, optionally in the presence of water, to give 5- (2-methylmercaptoethyl) - hydantoin and conversion thereof into methionine, which is characterized in that, before carbon dioxide is passed in, an aqueous mixture which comprises compounds of the general formula
- n an integer from 9 to 19, preferably 15, 17 or 19
- n a distribution in the range from 1 to 10, wherein the maximum is preferably 5 to 8 , in particular 6 to 7 ,
- the methionine which has precipitated out is dissolved and, in particular using the mother liquor, which preferably comprises the additives (1) and (2) mentioned, is crystallized in the presence of crystalline methionine, optionally with the addition of further amounts of the aqueous mixture.
- the high stirring energy known from the prior art does not have to be introduced during the precipitation or the crystallization.
- the process claimed can be carried out continuously or discontinuously.
- the additive (1) has a defoaming action, while at the same time the presence of (2) has no adverse influence on the defoaming.
- the recrystallization is preferably carried out by a procedure in which, preferably, methionine suspended in the mother liquor is pumped in circulation at a temperature of 30 to 60 2 C, and a methionine solution which has a concentration of 70 to 150 g/1, in particular 90 to 130 g/1, and has been heated up to 60 to 110 S C, in particular 80 to 100 2 C, is admixed to this suspension.
- the methionine solution mentioned last optionally comprises a content of 5 to 20 vol.% of mother liquor from the preparation process.
- Methionine precipitates out in the desired purity by the cooling. Methionine with a purity of 80 to 100 wt.%, in particular 90 to 100 wt.%, which is not to be achieved in one-stage processes, is obtained with this step of recrystallization.
- the ration of amounts between the suspension pumped in circulation and the solution admixed is in general 1-10:1, in particular 2-6:1, preferably 3-5:1.
- constituents (1) and (2) can also be added individually. (2) in particular displays its properties in particular during the crystallization.
- the addition of carbon dioxide is continued at 30 a C until the pH is reduced to 8.0. Foam forms on the reaction mixture at a height of 1 centimeter, while at the same time methionine is precipitated.
- 60 g methionine are suspended at 40 S C in 300 ml water and 40 g filtrate of the mother liquor from the precipitation with carbon dioxide and the suspension is pumped in circulation.
- a heat exchanger is connected in series in order to keep the temperature constant.
- a hot solution at 90 a C of 180 g methionine in 1170 g water and 150 g filtrate of the mother liquor from the precipitation with carbon dioxide is added to this solution with a rate of 1 liter of solution per hour.
- the SEM photograph with the image number 173029 shows the coarsely crystalline structure of the end product obtained in this way.
- 0.6 liter of the hot solution is added, 500 ml of the circulating suspension are removed and a further 500 ml of hot solution are added.
- the suspension is filtered off, the solid is rinsed with 300 ml acetone and dried to constant weight at 60 a C in a vacuum drying cabinet and the bulk density is determined.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- Steroid Compounds (AREA)
- Degasification And Air Bubble Elimination (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/497,949 US7179938B2 (en) | 2001-12-08 | 2002-08-06 | Process for the preparation of methionine |
AU2002321293A AU2002321293A1 (en) | 2001-12-08 | 2002-08-06 | Process for the preparation of methionine |
DE60232268T DE60232268D1 (en) | 2001-12-08 | 2002-08-06 | PROCESS FOR THE PREPARATION OF METHIONIN |
MXPA04005443A MXPA04005443A (en) | 2001-12-08 | 2002-08-06 | Process for the preparation of methionine. |
KR1020047008821A KR100874836B1 (en) | 2001-12-08 | 2002-08-06 | Method for preparing methionine |
AT02754978T ATE430725T1 (en) | 2001-12-08 | 2002-08-06 | METHION FOR PRODUCING METHIONINE |
CA002469526A CA2469526A1 (en) | 2001-12-08 | 2002-08-06 | Process for the preparation of methionine |
EP02754978A EP1451139B1 (en) | 2001-12-08 | 2002-08-06 | Process for the preparation of methionine |
JP2003551098A JP4213038B2 (en) | 2001-12-08 | 2002-08-06 | Method for producing methionine |
BR0214781-5A BR0214781A (en) | 2001-12-08 | 2002-08-06 | Process for the preparation of methionine |
IL16238202A IL162382A0 (en) | 2001-12-08 | 2002-08-06 | Process for the preparation of methionine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10160358.4 | 2001-12-08 | ||
DE10160358A DE10160358A1 (en) | 2001-12-08 | 2001-12-08 | Process for the production of methionine |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003050071A1 true WO2003050071A1 (en) | 2003-06-19 |
WO2003050071A8 WO2003050071A8 (en) | 2004-04-22 |
Family
ID=7708513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/008742 WO2003050071A1 (en) | 2001-12-08 | 2002-08-06 | Process for the preparation of methionine |
Country Status (16)
Country | Link |
---|---|
US (1) | US7179938B2 (en) |
EP (1) | EP1451139B1 (en) |
JP (1) | JP4213038B2 (en) |
KR (1) | KR100874836B1 (en) |
CN (1) | CN1332926C (en) |
AT (1) | ATE430725T1 (en) |
AU (1) | AU2002321293A1 (en) |
BR (1) | BR0214781A (en) |
CA (1) | CA2469526A1 (en) |
DE (2) | DE10160358A1 (en) |
ES (1) | ES2325574T3 (en) |
IL (1) | IL162382A0 (en) |
MX (1) | MXPA04005443A (en) |
RU (1) | RU2294922C2 (en) |
WO (1) | WO2003050071A1 (en) |
ZA (1) | ZA200404479B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2641898A1 (en) * | 2012-03-20 | 2013-09-25 | Evonik Industries AG | Method for manufacturing methionine |
EP2848607A1 (en) | 2013-09-17 | 2015-03-18 | Evonik Industries AG | Method for extracting methionine |
CN104744326A (en) * | 2015-02-12 | 2015-07-01 | 山东新和成氨基酸有限公司 | Method for continuously preparing high-bulk density methionine crystals |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2928910B1 (en) * | 2008-03-20 | 2010-03-12 | Arkema France | IMPROVED PROCESS FOR THE PRODUCTION OF CYANHYDRIC ACID |
FR2938535B1 (en) * | 2008-11-20 | 2012-08-17 | Arkema France | PROCESS FOR PRODUCING METHYLMERCAPTOPROPIONALDEHYDE AND METHIONINE FROM RENEWABLE MATERIALS |
JP5930329B2 (en) | 2011-02-23 | 2016-06-08 | エボニック デグサ ゲーエムベーハーEvonik Degussa GmbH | Preparation of 2-hydroxy-4- (methylthio) butyronitrile from 3- (methylthio) propanal and hydrogen cyanide |
DE102011081828A1 (en) | 2011-08-30 | 2013-02-28 | Evonik Degussa Gmbh | Process for the reaction of methylmercaptopropionaldehyde from crude acrolein and crude methylmercaptan |
MX2014002250A (en) | 2011-08-30 | 2014-04-25 | Evonik Degussa Gmbh | Method for producing a methionine salt. |
EP3625211B1 (en) * | 2017-05-15 | 2021-03-17 | Evonik Operations GmbH | Process for preparing methionine |
US20220001304A1 (en) * | 2018-09-28 | 2022-01-06 | Doe Global Technologies Llc | Hydroxyethyl cellulose derivative foam control agents and methods of processing foodstuffs |
EP3986861B1 (en) | 2019-06-18 | 2023-08-02 | Evonik Operations GmbH | Process for the preparation of d,l-methionine |
CN111100051B (en) | 2019-12-31 | 2022-01-28 | 山东新和成氨基酸有限公司 | Additive used in methionine preparation process and methionine preparation method |
CN114058094B (en) * | 2020-07-31 | 2023-04-11 | 中国石油化工股份有限公司 | Foaming material composition, foaming material and preparation method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1080220A (en) * | 1963-12-20 | 1967-08-23 | Exxon Standard Sa | Coating composition |
US3917683A (en) * | 1970-05-08 | 1975-11-04 | Degussa | Process for the preparation of DL-methionine |
JPH01288267A (en) * | 1988-05-16 | 1989-11-20 | Tokuyama Soda Co Ltd | Filth treating agent |
JPH03266979A (en) * | 1990-03-15 | 1991-11-27 | Teijin Ltd | Culture of cell |
JPH04244056A (en) * | 1991-01-31 | 1992-09-01 | Sumitomo Chem Co Ltd | Production of methionine |
US5681692A (en) * | 1996-02-02 | 1997-10-28 | Eastman Kodak Company | Nonagglomerating antifoamants |
US5990349A (en) * | 1995-12-18 | 1999-11-23 | Degussa Aktiengesellschaft | Process for the preparation of D,L-methionine or the salt thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR910004482B1 (en) * | 1989-02-15 | 1991-06-29 | 선종건 | Oral pharmaceutical compositions |
JP4482973B2 (en) * | 1998-09-11 | 2010-06-16 | 住友化学株式会社 | Method for producing methionine |
DE19846825A1 (en) * | 1998-10-10 | 2000-04-13 | Degussa | Free-flowing moldings containing methionine and process for their production |
JP2001072656A (en) * | 1999-07-02 | 2001-03-21 | Nippon Soda Co Ltd | Control over physical property of methionine crystal powder |
-
2001
- 2001-12-08 DE DE10160358A patent/DE10160358A1/en not_active Withdrawn
-
2002
- 2002-08-06 AT AT02754978T patent/ATE430725T1/en not_active IP Right Cessation
- 2002-08-06 JP JP2003551098A patent/JP4213038B2/en not_active Expired - Fee Related
- 2002-08-06 EP EP02754978A patent/EP1451139B1/en not_active Expired - Lifetime
- 2002-08-06 IL IL16238202A patent/IL162382A0/en unknown
- 2002-08-06 CA CA002469526A patent/CA2469526A1/en not_active Abandoned
- 2002-08-06 US US10/497,949 patent/US7179938B2/en not_active Expired - Fee Related
- 2002-08-06 MX MXPA04005443A patent/MXPA04005443A/en active IP Right Grant
- 2002-08-06 DE DE60232268T patent/DE60232268D1/en not_active Expired - Lifetime
- 2002-08-06 WO PCT/EP2002/008742 patent/WO2003050071A1/en active Application Filing
- 2002-08-06 BR BR0214781-5A patent/BR0214781A/en not_active IP Right Cessation
- 2002-08-06 RU RU2004121138/04A patent/RU2294922C2/en not_active IP Right Cessation
- 2002-08-06 KR KR1020047008821A patent/KR100874836B1/en not_active IP Right Cessation
- 2002-08-06 ES ES02754978T patent/ES2325574T3/en not_active Expired - Lifetime
- 2002-08-06 CN CNB028243897A patent/CN1332926C/en not_active Expired - Fee Related
- 2002-08-06 AU AU2002321293A patent/AU2002321293A1/en not_active Abandoned
-
2004
- 2004-06-07 ZA ZA200404479A patent/ZA200404479B/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1080220A (en) * | 1963-12-20 | 1967-08-23 | Exxon Standard Sa | Coating composition |
US3917683A (en) * | 1970-05-08 | 1975-11-04 | Degussa | Process for the preparation of DL-methionine |
JPH01288267A (en) * | 1988-05-16 | 1989-11-20 | Tokuyama Soda Co Ltd | Filth treating agent |
JPH03266979A (en) * | 1990-03-15 | 1991-11-27 | Teijin Ltd | Culture of cell |
JPH04244056A (en) * | 1991-01-31 | 1992-09-01 | Sumitomo Chem Co Ltd | Production of methionine |
US5990349A (en) * | 1995-12-18 | 1999-11-23 | Degussa Aktiengesellschaft | Process for the preparation of D,L-methionine or the salt thereof |
US5681692A (en) * | 1996-02-02 | 1997-10-28 | Eastman Kodak Company | Nonagglomerating antifoamants |
Non-Patent Citations (3)
Title |
---|
DATABASE WPI Derwent World Patents Index; AN 1990-004588, XP002223484 * |
DATABASE WPI Derwent World Patents Index; AN 1992-019318 [03], XP002223482 * |
DATABASE WPI Derwent World Patents Index; AN 1992-337741 [41], XP002223483 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2641898A1 (en) * | 2012-03-20 | 2013-09-25 | Evonik Industries AG | Method for manufacturing methionine |
WO2013139562A1 (en) * | 2012-03-20 | 2013-09-26 | Evonik Industries Ag | Process for the preparation of methionine |
US9156782B2 (en) | 2012-03-20 | 2015-10-13 | Evonik Industries Ag | Process for the preparation of methionine |
US9464045B2 (en) | 2012-03-20 | 2016-10-11 | Evonik Degussa Gmbh | Process for the preparation of methionine |
EP3187489A1 (en) * | 2012-03-20 | 2017-07-05 | Evonik Degussa GmbH | Process for the preparation of methionine |
RU2640656C2 (en) * | 2012-03-20 | 2018-01-11 | Эвоник Дегусса Гмбх | Method of producing methionine |
EP2848607A1 (en) | 2013-09-17 | 2015-03-18 | Evonik Industries AG | Method for extracting methionine |
WO2015039935A1 (en) * | 2013-09-17 | 2015-03-26 | Evonik Industries Ag | Process for obtaining methionine |
US9617209B2 (en) | 2013-09-17 | 2017-04-11 | Evonik Degussa Gmbh | Process for obtaining methionine |
CN104744326A (en) * | 2015-02-12 | 2015-07-01 | 山东新和成氨基酸有限公司 | Method for continuously preparing high-bulk density methionine crystals |
Also Published As
Publication number | Publication date |
---|---|
ES2325574T3 (en) | 2009-09-09 |
CA2469526A1 (en) | 2003-06-19 |
JP4213038B2 (en) | 2009-01-21 |
JP2005511733A (en) | 2005-04-28 |
RU2004121138A (en) | 2006-01-10 |
ZA200404479B (en) | 2006-02-22 |
WO2003050071A8 (en) | 2004-04-22 |
AU2002321293A1 (en) | 2003-06-23 |
US7179938B2 (en) | 2007-02-20 |
IL162382A0 (en) | 2005-11-20 |
BR0214781A (en) | 2004-11-09 |
DE10160358A1 (en) | 2003-06-18 |
KR20040061024A (en) | 2004-07-06 |
DE60232268D1 (en) | 2009-06-18 |
US20050131111A1 (en) | 2005-06-16 |
EP1451139B1 (en) | 2009-05-06 |
CN1332926C (en) | 2007-08-22 |
RU2294922C2 (en) | 2007-03-10 |
EP1451139A1 (en) | 2004-09-01 |
CN1599712A (en) | 2005-03-23 |
ATE430725T1 (en) | 2009-05-15 |
MXPA04005443A (en) | 2006-02-24 |
KR100874836B1 (en) | 2008-12-19 |
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