WO2003048113A1 - Tramadol analogs and uses thereof - Google Patents

Tramadol analogs and uses thereof Download PDF

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Publication number
WO2003048113A1
WO2003048113A1 PCT/US2002/038390 US0238390W WO03048113A1 WO 2003048113 A1 WO2003048113 A1 WO 2003048113A1 US 0238390 W US0238390 W US 0238390W WO 03048113 A1 WO03048113 A1 WO 03048113A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound according
compound
methyl
formula
tramadol
Prior art date
Application number
PCT/US2002/038390
Other languages
English (en)
French (fr)
Inventor
Chris Hugh Senanayake
Thomas P. Jerussi
Paul T. Grover
Qun Kevin Fang
Mark Currie
Original Assignee
Sepracor Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc. filed Critical Sepracor Inc.
Priority to AU2002364517A priority Critical patent/AU2002364517A1/en
Publication of WO2003048113A1 publication Critical patent/WO2003048113A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
PCT/US2002/038390 2001-11-30 2002-12-02 Tramadol analogs and uses thereof WO2003048113A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002364517A AU2002364517A1 (en) 2001-11-30 2002-12-02 Tramadol analogs and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33527501P 2001-11-30 2001-11-30
US60/335,275 2001-11-30

Publications (1)

Publication Number Publication Date
WO2003048113A1 true WO2003048113A1 (en) 2003-06-12

Family

ID=23311050

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038390 WO2003048113A1 (en) 2001-11-30 2002-12-02 Tramadol analogs and uses thereof

Country Status (3)

Country Link
US (1) US6780891B2 (US20030171440A1-20030911-C00010.png)
AU (1) AU2002364517A1 (US20030171440A1-20030911-C00010.png)
WO (1) WO2003048113A1 (US20030171440A1-20030911-C00010.png)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097051A2 (en) * 2002-05-17 2003-11-27 Merck Patent Gmbh Use of compounds that are effective as selective opiate receptor modulators
WO2005113486A1 (en) * 2004-05-14 2005-12-01 Janssen Pharmaceutica N.V. Carboxamido opioid compounds
US7385065B2 (en) 2002-12-17 2008-06-10 Tioga Pharmaceuticals, Inc. Derivatives of asimadoline with covalently bonded acids
US7960429B2 (en) 2007-03-30 2011-06-14 Tioga Pharmaceuticals, Inc Kappa-opiate agonists for the treatment of diarrhea-predominant irritable bowel syndrome
WO2012102875A3 (en) * 2011-01-27 2012-10-18 Eli Lilly And Company Analgesic compounds, methods, and formulations
CN103497145A (zh) * 2013-10-10 2014-01-08 南昌大学 一种光学纯多奈哌齐的制备工艺
DE102013009114A1 (de) * 2013-05-29 2014-12-04 Franz Gerstheimer Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen
WO2019053494A1 (en) * 2017-09-18 2019-03-21 R L Fine Chem Private Limited PROCESS FOR THE PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF

Families Citing this family (26)

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DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
US8128957B1 (en) 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
DE10356362A1 (de) * 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen
NZ548212A (en) * 2003-12-29 2010-07-30 Sepracor Inc Pyrrole and pyrazole DAAO inhibitors
CN101031322A (zh) * 2004-10-01 2007-09-05 日本脏器制药株式会社 固体药物制剂
EP1904066B1 (en) 2005-07-06 2018-05-23 Sunovion Pharmaceuticals Inc. COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS
US7884247B2 (en) * 2005-07-22 2011-02-08 Gruenenthal Gmbh Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof
EP2336103A3 (de) * 2005-07-22 2011-07-20 Grünenthal GmbH HCL-Polymorphe von 3-[2-(Dimethylamino)methyl-(cyclohex-1-yl)]phenol
JP5432526B2 (ja) 2006-01-06 2014-03-05 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害剤としてのシクロアルキルアミン
KR101381768B1 (ko) * 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
TWI449542B (zh) * 2006-03-30 2014-08-21 Nippon Zoki Pharmaceutical Co 固形醫藥製劑
AU2007233041B2 (en) 2006-03-31 2013-05-02 Sepracor Inc. Preparation of chiral amides and amines
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP2010516697A (ja) * 2007-01-18 2010-05-20 セプラコール インク． Ｄ−アミノ酸オキシダーゼ阻害剤
NZ580429A (en) 2007-05-31 2012-04-27 Sepracor Inc Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2011110595A1 (de) 2010-03-10 2011-09-15 Grünenthal GmbH Kristalline salze und/oder cokristalle von o-desmethyltramadol
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
US11000488B2 (en) 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol
CN113861048A (zh) * 2020-06-30 2021-12-31 南京诺瑞特医药科技有限公司 去甲曲马多的盐及其用途
GB2606011A (en) * 2021-04-22 2022-10-26 Mexichem Fluor Sa De Cv Composition

Citations (2)

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GB997399A (en) * 1963-04-02 1965-07-07 Gruenenthal Chemie Phenol ethers that contain basic groups
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols

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MX9205106A (es) 1991-09-06 1993-05-01 Johnson & Johnson Composiciones que comprenden un material de tramadol y cualquiera de codeina, oxicodona o hidrocodona y su uso
US5223541A (en) 1991-09-13 1993-06-29 Mcneilab, Inc. Tramadol n-oxide material, enantiomers and compositions thereof, and their use
IL103096A (en) 1992-09-08 1996-12-05 Chemagis Ltd Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.
US6017963A (en) 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
IL116281A (en) 1995-12-07 1999-06-20 Chemagis Ltd Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
DE19601745C1 (de) 1996-01-19 1997-10-09 Gruenenthal Gmbh Verfahren zur Racematspaltung von Tramadol
DE19601744C2 (de) 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
WO1998040053A1 (en) 1997-03-11 1998-09-17 Darwin Discovery Limited Dosage forms comprising separate portions of r- and s-enantiomers
GB9826540D0 (en) 1998-12-02 1999-01-27 Darwin Discovery Ltd Process
CN1329590A (zh) 1998-12-02 2002-01-02 达尔文发现有限公司 治疗产品及其应用
CN1349423A (zh) 1999-03-01 2002-05-15 奥索-麦克尼尔药品公司 包含曲马多物质和选择性cox－2抑制剂药物的组合物
EP1313460A2 (en) 1999-11-09 2003-05-28 Darwin Discovery Limited Therapeutic use and formulation of (-)-tramadol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB997399A (en) * 1963-04-02 1965-07-07 Gruenenthal Chemie Phenol ethers that contain basic groups
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097051A3 (en) * 2002-05-17 2004-12-09 Merck Patent Gmbh Use of compounds that are effective as selective opiate receptor modulators
WO2003097051A2 (en) * 2002-05-17 2003-11-27 Merck Patent Gmbh Use of compounds that are effective as selective opiate receptor modulators
EP2074997A1 (en) * 2002-05-17 2009-07-01 Tioga Pharmaceuticals, Inc. Use of Asimadoline for the treatment of digestive disorders
US7385065B2 (en) 2002-12-17 2008-06-10 Tioga Pharmaceuticals, Inc. Derivatives of asimadoline with covalently bonded acids
US7915228B2 (en) 2002-12-17 2011-03-29 Tioga Pharmaceuticals, Inc. Derivatives of asimadoline with covalently bonded acids
KR101204751B1 (ko) 2004-05-14 2012-11-27 얀센 파마슈티카 엔.브이. 카복사미도 아편유사약물 화합물
WO2005113486A1 (en) * 2004-05-14 2005-12-01 Janssen Pharmaceutica N.V. Carboxamido opioid compounds
EA013261B1 (ru) * 2004-05-14 2010-04-30 Янссен Фармацевтика, Н.В. Опиоидные соединения, замещенные карбоксамидогруппой
US7745492B2 (en) 2004-05-14 2010-06-29 Janssen Pharmaceutical Carboxamido opioid compounds
US7244866B2 (en) 2004-05-14 2007-07-17 Janssen Pharmaceutical N.V. Carboxamido opioid compounds
JP2007537278A (ja) * 2004-05-14 2007-12-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ カルボキサミド系オピオイド化合物
TWI418345B (zh) * 2004-05-14 2013-12-11 Janssen Pharmaceutica Nv 羰醯胺基類鴉片化合物
US7960429B2 (en) 2007-03-30 2011-06-14 Tioga Pharmaceuticals, Inc Kappa-opiate agonists for the treatment of diarrhea-predominant irritable bowel syndrome
US8877800B2 (en) 2007-03-30 2014-11-04 Tioga Pharmaceuticals, Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant irritable bowel syndrome
CN103328433A (zh) * 2011-01-27 2013-09-25 伊莱利利公司 镇痛化合物、方法和制剂
WO2012102875A3 (en) * 2011-01-27 2012-10-18 Eli Lilly And Company Analgesic compounds, methods, and formulations
US8802728B2 (en) 2011-01-27 2014-08-12 Eli Lilly And Company Analgesic compounds, methods, and formulations
KR101612168B1 (ko) 2011-01-27 2016-04-12 일라이 릴리 앤드 캄파니 진통제 화합물, 방법, 및 제제
EA024101B1 (ru) * 2011-01-27 2016-08-31 Эли Лилли Энд Компани Соединения, обладающие анальгезирующими свойствами, содержащие их составы и их применение в терапии
DE102013009114A1 (de) * 2013-05-29 2014-12-04 Franz Gerstheimer Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen
CN103497145A (zh) * 2013-10-10 2014-01-08 南昌大学 一种光学纯多奈哌齐的制备工艺
CN103497145B (zh) * 2013-10-10 2016-01-27 南昌大学 一种光学纯多奈哌齐的制备工艺
WO2019053494A1 (en) * 2017-09-18 2019-03-21 R L Fine Chem Private Limited PROCESS FOR THE PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF
US10781163B2 (en) 2017-09-18 2020-09-22 R L Finechem Private Limited Process for preparation of O-Desmethyltramadol and salts thereof

Also Published As

Publication number Publication date
AU2002364517A1 (en) 2003-06-17
US20030171440A1 (en) 2003-09-11
US6780891B2 (en) 2004-08-24

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