WO2003041747A1 - Composition, method and apparatus for sterilisation of medical instruments - Google Patents
Composition, method and apparatus for sterilisation of medical instruments Download PDFInfo
- Publication number
- WO2003041747A1 WO2003041747A1 PCT/GB2002/005061 GB0205061W WO03041747A1 WO 2003041747 A1 WO2003041747 A1 WO 2003041747A1 GB 0205061 W GB0205061 W GB 0205061W WO 03041747 A1 WO03041747 A1 WO 03041747A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- solution
- instruments
- repellent
- container
- iodine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 31
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 6
- 239000000203 mixture Substances 0.000 title description 6
- 239000000243 solution Substances 0.000 claims abstract description 48
- 230000002940 repellent Effects 0.000 claims abstract description 17
- 239000005871 repellent Substances 0.000 claims abstract description 17
- 238000002791 soaking Methods 0.000 claims abstract description 15
- 239000012670 alkaline solution Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000001954 sterilising effect Effects 0.000 claims abstract description 9
- 239000002699 waste material Substances 0.000 claims abstract description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 45
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 15
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 14
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 11
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 11
- 229910052794 bromium Inorganic materials 0.000 claims description 11
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 11
- 239000003513 alkali Substances 0.000 claims description 8
- GOOXRYWLNNXLFL-UHFFFAOYSA-H azane oxygen(2-) ruthenium(3+) ruthenium(4+) hexachloride Chemical compound N.N.N.N.N.N.N.N.N.N.N.N.N.N.[O--].[O--].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+3].[Ru+3].[Ru+4] GOOXRYWLNNXLFL-UHFFFAOYSA-H 0.000 claims description 8
- 238000013019 agitation Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000000527 sonication Methods 0.000 claims description 5
- 239000008237 rinsing water Substances 0.000 claims description 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 15
- 229910052740 iodine Inorganic materials 0.000 description 15
- 239000011630 iodine Substances 0.000 description 15
- 235000011121 sodium hydroxide Nutrition 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 10
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 8
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 8
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 8
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 7
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 241000700605 Viruses Species 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000024777 Prion disease Diseases 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- -1 for example Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012487 rinsing solution Substances 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000001621 Mucoproteins Human genes 0.000 description 1
- 108010093825 Mucoproteins Proteins 0.000 description 1
- 208000035415 Reinfection Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 208000008864 scrapie Diseases 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/70—Cleaning devices specially adapted for surgical instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/14—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aliphatic hydrocarbons or mono-alcohols
- C11D1/146—Sulfuric acid esters
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/044—Hydroxides or bases
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/02—Inorganic compounds
- C11D7/04—Water-soluble compounds
- C11D7/06—Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/10—Objects to be cleaned
Definitions
- This invention relates to a composition, method and apparatus for sterilising (or pre-soaking) , for example, medical instruments such as surgical (including ophthalmic) , dental and/or veterinary instruments, and also instruments used in microbiology laboratories.
- medical instruments such as surgical (including ophthalmic) , dental and/or veterinary instruments, and also instruments used in microbiology laboratories.
- ⁇ sterilising' is used herein to refer to removal of disease causing agents, but because the rinsing step may use tap water, the term does not necessarily infer that the process results in instruments which are ⁇ sterile' according to common medical terminology.
- a method of sterilising medical instruments comprising the steps of:
- the heated alkaline solution ensures the inactivation of all known bacteria and viruses, except CJD and BSE, while the repellent properties of SDS ensures the removal of the CJD and/or BSE proteins from the instruments.
- the solution is preferably heated to a temperature of between 50°C and 85°C, more preferably to a temperature of around 70°C, typically for a period of up to 30 minutes.
- the solution can be used at room temperature.
- the method includes, for example, three rinses each of about 5 minutes in length.
- the alkali in the solution is preferably sodium hydroxide or potassium hydroxide, but may be any suitable alkali, for example, ammonium hydroxide, which is, however, less preferred.
- the alkali is preferably present in a concentration of between
- the amount of alkali in the solution should not be such as to cause substantial corrosion to the instruments being sterilised.
- the repellent is preferably sodium dodecyl sulphate (SDS) , but may be replaced by any other suitable anionic surfactant.
- the counter ion of the surfactant (sodium) may be varied, as well as the hydrophobic chain length (from 12 carbon atoms to, for example, 10 or 14 carbon atoms) .
- the amount of repellent in the soaking solution is preferably between 0.5 or 1 and 3 or 5% by weight, with an amount of 1% by weight being most preferred.
- a further optional component of the solution is iodine or bromine.
- iodine or bromine in the solution can give a more effective sterilisation.
- the addition of iodine or bromine to an alkaline solution results mainly in the formation of the oxoanions 10 " , I0 3 ⁇ , BrO " and Br0 3 " .
- These oxoanions act as oxidising agents so as to render proteins, protein fragments, DNA or DNA fragments substantially inert.
- the alkali for example, sodium hydroxide solubilizes (e.g. disintegrates) the agents to be sterilized.
- the repellent, for example, SDS also assists in the solubilization process.
- Suitable surfactants such as SDS, also tends to remove electric charge from the agents to be sterilized. This allows the disease causing agents, e.g. proteins or DNA or fragments thereof to be de- bonded from a surface of, e.g. a surgical instrument.
- the combined effect of the alkali (e.g. sodium hydroxide) and repellent (e.g. SDS) is to increase the surface area of agent on which the oxoanions produced by the iodine or bromine can have an effect.
- the iodine or bromine are preferably added in an amount of between 0.01% and 0.2% by weight, with 0.1% by weight being preferred.
- the iodine or bromine may be supplemented by, or wholly or partially replaced by Ruthenium red, a known staining composition.
- Ruthenium red is effective at concentrations as low as 1 part per million (ppm) , up to preferably 100 ppm, with 10 ppm being a more preferred maximum.
- Ruthenium red binds to acid mucopolysaccharides or acid mucoproteins (e.g. in protein/DNA complexes).
- the solution is aqueous.
- a particularly preferred solution is 1 molar sodium hydroxide, 3% SDS and 0.1% iodine (percentages expressed as weight percent per lOOg water) .
- concentrations of each component in this solution could, independently, be at least 0.5 molar sodium hydroxide,
- This composition is effective to combat BSE/CJD by sterilizing surfaces of surgical equipment or other surfaces or apparatus. However, it is also effective to combat other agents such as bacteria, typically those which cause hospital-borne infection.
- the soaking of the instruments in the alkaline solution according to the first aspect of the present invention may be accomplished in a number of ways.
- the instruments may be immersed in water first, and then a concentrate or powder added to produce the appropriate concentration of soaking solution.
- the strength of the concentrate will be determined by the solubility of the components used, but may be a lOx, 20x or 50x concentrate if possible.
- a suitable mixture of powdered components may also be provided.
- the method may also include the step of agitation, i.e. subjecting the solution in which the instruments are, or the instruments, to agitation. If the agitation is of the instruments, this may occur by agitation of a container in which the instruments are held.
- the method may also include the step of treating the instruments by sonication, i.e. subjecting the solution in which the instruments are to ultrasound, which preferably has a frequency of 20 kHz or higher, more preferably about 30 kHz. This step may be repeated at various stages of the method, as appropriate, for example, during the soaking stage and at the end of each rinsing stage.
- a further preferable method step to follow steps (i) and (ii) is to soak the instruments in an aqueous solution of iodine and or bromine.
- This further soaking step is carried out without any alkaline or repellent.
- iodine and bromine are thought to bind sites on the agent (e.g. protein or DNA, after solubilization) to render it substantially inert or ineffective. This makes the agent inactive for reinfection.
- the iodine or bromine are preferably present in the solution in an amount of between 0.01% and 0.2% by weight, with 0.1% by weight being preferred.
- they may be replaced by Ruthenium Red, present in an amount which may be as low as 1 part per million (ppm) , up to preferably 100 ppm, with 10 ppm being a more preferred maximum.
- Such a further soaking step is followed by a further rinsing step, wherein the first rinsing solution is preferably an alkaline solution, for example of 0.05 to 0.2 M sodium hydroxide.
- the first rinsing solution is preferably an alkaline solution, for example of 0.05 to 0.2 M sodium hydroxide.
- the solution used in the first step of the method of the first aspect of the invention is another, independent aspect of the invention. Accordingly, in a second aspect of the present invention, there is provided a solution as described in the first aspect of the invention, ie. an alkaline solution containing a repellent. Preferred embodiments of this aspect are described above in relation to the first aspect of the invention.
- an apparatus suitable for carrying out the method of the first aspect comprises a container having a water inlet in the upper regions thereof, an outlet from the lower regions thereof for waste, support means for locating the instruments to be sterilised within an intermediate region of the container, and heating means for heating the solution within the container.
- the apparatus further comprises a fan within the container, activated, for example, to circulate the solution when the temperature thereof reaches the optimum value of, typically 70°C during the sterilisation process, and to circulate rinsing water during the rinsing stages.
- This fan can also be used for agitating either the soaking solution or the rinsing water.
- the support means may comprise a grid or mesh through which the solution and the rinsing water can readily pass.
- the apparatus may also further comprise an ultrasound generator for carrying out sonication (preferably at a frequency of at least 20kHz, more preferably at about 30kHz) , and means for dispensing a concentrate or powder precursor to the soaking solution.
- an ultrasound generator for carrying out sonication (preferably at a frequency of at least 20kHz, more preferably at about 30kHz)
- means for dispensing a concentrate or powder precursor to the soaking solution preferably at a frequency of at least 20kHz, more preferably at about 30kHz
- the apparatus may be combined with an autoclave.
- Fig. 1 is a schematic section through apparatus for carrying out the method of the invention, the apparatus including a container 2 having an inlet 4 to the upper regions thereof and an outlet 6 from the lower regions thereof.
- a grid or mesh 8 is provided above the level of the outlet 6 to support thereon surgical instruments 10 to be sterilised.
- a heating element 12 and a circulating fan 14 are provided in the lower regions of the container 2 below the grid 8.
- a sonicator (not shown) may also be provided in this region of the container 2.
- the container 2 is provided with a lid 16 and has a liquid level indicator 18 therein.
- the apparatus is used as follows:
- 3% sodium dodecyl sulphate (SDS) in powder form and one mole sodium hydroxide in pellet form are added to the water, the lid 16 is located on the container 2, and the apparatus is switched on.
- a short period (e.g. 3 to 5 minutes) of ultrasound treatment may be carried out, to dislodge particles from the instrument 10, and to break up any aggregated particles.
- the solution may contain 0.1% iodine and/or at least 1 ppm Ruthenium red.
- the heating element 12 heats the solution up to a temperature of, typically 70 °C and maintains this temperature .for around 30 minutes. As the temperature of the solution reaches the desired value, the fan 14 is automatically activated to circulate the solution within the container 2.
- the fan 14 may also be used to agitate the water, or the surgical instrument 10 may be directly agitated, eg. by agitation of a basket (not shown) containing them.
- the caustic soda destroys all known bacteria and viruses except CJD and BSE proteins, SDS within the solution acting as an electrical repellent whereby any CJD or BSE proteins are physically unbound from the instruments 10 into the solution.
- the iodine/Ruthenium red products inactivates these proteins by binding to them.
- the solution is drained from the container 2 through the outlet 6, the grid 8 allowing the liquid to pass therethrough whilst maintaining the instruments 10 within the container 2.
- Water is then fed into the container 2 through the inlet 4 to the level 18 and is circulated in the container 2 by the fan 14, typically for a period of about 5 minutes, after which it is drained from the container 2 through the outlet 6. Again, agitation or ultrasound treatment may be carried out during each rinsing stage.
- This rinsing procedure is repeated for, for example, two further periods of 5 minutes each such that all the NaOH/SDS/iodine solution is removed from the instruments 10 and from the container 2.
- a further soaking step is carried out with a 0.1 % by weight solution of iodine, for 30 minutes (optionally including sonication) , followed by a first 5 minute rinse with a 0.1 M sodium hydroxide solution and second and third rinses of five minutes with water.
- the instruments 10 can then be removed from the container 2 knowing that they are sterile - i.e. all known bacteria and viruses have been inactivated, and any CJD and/or BSE proteins have been removed due to the repellent properties of SDS, and rendered inert by the iodine.
- the sodium hydroxide may be replaced by, for example, potassium hydroxide.
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
Claims
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0127059.4 | 2001-11-10 | ||
GB0127059A GB0127059D0 (en) | 2001-11-10 | 2001-11-10 | Method and apparatus for sterilising medical instruments |
GB0210376A GB0210376D0 (en) | 2001-11-10 | 2002-05-07 | Composition method and apparatus for sterilisation |
GB0210376.0 | 2002-05-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003041747A1 true WO2003041747A1 (en) | 2003-05-22 |
Family
ID=26246756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2002/005061 WO2003041747A1 (en) | 2001-11-10 | 2002-11-08 | Composition, method and apparatus for sterilisation of medical instruments |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2003041747A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1974687A1 (en) * | 2007-03-30 | 2008-10-01 | Tyco Healthcare Group, LP | Surgical instrument debris collection system |
CN107115152A (en) * | 2017-04-28 | 2017-09-01 | 中国人民解放军第三军医大学第三附属医院 | Operating theater instruments preprocessor |
CN113458066A (en) * | 2021-07-09 | 2021-10-01 | 河南省农业科学院畜牧兽医研究所 | Cattle embryo transfer rifle subassembly cleaning and sterilizing device |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994022305A1 (en) * | 1993-04-01 | 1994-10-13 | Unilever N.V. | Disinfectant compositions |
WO1999015012A1 (en) * | 1997-09-25 | 1999-04-01 | Henkel-Ecolab Gmbh & Co. Ohg | Method for cleaning and disinfecting medical instruments |
US6015529A (en) * | 1997-12-17 | 2000-01-18 | Johnson & Johnson Medical, Inc. | Tray/container system for cleaning/sterilization processes |
-
2002
- 2002-11-08 WO PCT/GB2002/005061 patent/WO2003041747A1/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994022305A1 (en) * | 1993-04-01 | 1994-10-13 | Unilever N.V. | Disinfectant compositions |
WO1999015012A1 (en) * | 1997-09-25 | 1999-04-01 | Henkel-Ecolab Gmbh & Co. Ohg | Method for cleaning and disinfecting medical instruments |
US6015529A (en) * | 1997-12-17 | 2000-01-18 | Johnson & Johnson Medical, Inc. | Tray/container system for cleaning/sterilization processes |
Non-Patent Citations (1)
Title |
---|
TATEISHI J ET AL: "PRACTICAL METHODS FOR CHEMICAL INACTIVATION OF CREUTZFELDT-JAKOB DISEASE PATHOGEN", MICROBIOLOGY AND IMMUNOLOGY, TOKYO, JP, vol. 35, no. 2, 1991, pages 163 - 166, XP000865567, ISSN: 0385-5600 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1974687A1 (en) * | 2007-03-30 | 2008-10-01 | Tyco Healthcare Group, LP | Surgical instrument debris collection system |
US8734730B2 (en) | 2007-03-30 | 2014-05-27 | Covidien Lp | Surgical instrument debris collection system |
CN107115152A (en) * | 2017-04-28 | 2017-09-01 | 中国人民解放军第三军医大学第三附属医院 | Operating theater instruments preprocessor |
CN113458066A (en) * | 2021-07-09 | 2021-10-01 | 河南省农业科学院畜牧兽医研究所 | Cattle embryo transfer rifle subassembly cleaning and sterilizing device |
CN113458066B (en) * | 2021-07-09 | 2024-03-15 | 河南省农业科学院畜牧兽医研究所 | Cleaning and sterilizing device for bovine embryo transplanting gun assembly |
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