WO2003033447A1 - Composes lumineux et reactifs de marquage l'utilisant - Google Patents

Composes lumineux et reactifs de marquage l'utilisant Download PDF

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Publication number
WO2003033447A1
WO2003033447A1 PCT/JP2002/010511 JP0210511W WO03033447A1 WO 2003033447 A1 WO2003033447 A1 WO 2003033447A1 JP 0210511 W JP0210511 W JP 0210511W WO 03033447 A1 WO03033447 A1 WO 03033447A1
Authority
WO
WIPO (PCT)
Prior art keywords
labeling reagents
compounds
luminous
same
labeling
Prior art date
Application number
PCT/JP2002/010511
Other languages
English (en)
French (fr)
Inventor
Michihiro Saito
Ernoe Pretsch
Original Assignee
Hitachi High-Technologies Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi High-Technologies Corporation filed Critical Hitachi High-Technologies Corporation
Priority to US10/491,788 priority Critical patent/US7154007B2/en
Priority to DE60233742T priority patent/DE60233742D1/de
Priority to EP02772986A priority patent/EP1437338B1/en
Priority to JP2003536189A priority patent/JP4117248B2/ja
Publication of WO2003033447A1 publication Critical patent/WO2003033447A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PCT/JP2002/010511 2001-10-10 2002-10-10 Composes lumineux et reactifs de marquage l'utilisant WO2003033447A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/491,788 US7154007B2 (en) 2001-10-10 2002-10-10 Luminous compounds and labeling reagents using the same
DE60233742T DE60233742D1 (de) 2001-10-10 2002-10-10 Leuchtverbindungen und markierungsreagentien für die diese verwendet werden
EP02772986A EP1437338B1 (en) 2001-10-10 2002-10-10 Luminous compounds and labeling reagents using the same
JP2003536189A JP4117248B2 (ja) 2001-10-10 2002-10-10 発光性化合物及びそれを用いた標識試薬

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-312562 2001-10-10
JP2001312562 2001-10-10

Publications (1)

Publication Number Publication Date
WO2003033447A1 true WO2003033447A1 (fr) 2003-04-24

Family

ID=19131198

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/010511 WO2003033447A1 (fr) 2001-10-10 2002-10-10 Composes lumineux et reactifs de marquage l'utilisant

Country Status (6)

Country Link
US (1) US7154007B2 (ja)
EP (1) EP1437338B1 (ja)
JP (1) JP4117248B2 (ja)
CN (1) CN100378056C (ja)
DE (1) DE60233742D1 (ja)
WO (1) WO2003033447A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7211440B2 (en) * 2002-03-08 2007-05-01 Wallac Oy Dissociative fluorescence enhancement assay
JP2008303196A (ja) * 2007-06-11 2008-12-18 Orient Chem Ind Ltd β−ジケトン希土類金属錯体、その製造方法および製造中間体、ならびにβ−ジケトン希土類金属錯体を含むインキ組成物
US7736620B2 (en) 2004-08-10 2010-06-15 National University Corporation Kyushu Institute Of Technology Europium-diketone chelate compound and fluorescent material using the same
CN102391162A (zh) * 2011-09-28 2012-03-28 大连理工大学 三种基于铕(III)与氯磺酰化四齿β-二酮配位体形成的荧光配合物及其应用
JP2013528185A (ja) * 2010-05-27 2013-07-08 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ タンパク質の標識法及びキット
CN104926698A (zh) * 2014-03-18 2015-09-23 中国科学院大连化学物理研究所 一种四齿β二酮配体-铕荧光配合物及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0794174A2 (en) * 1996-03-08 1997-09-10 Suzuki Motor Corporation Labeled reagents for use in immunoassays and fluorescent compounds and complexes used therein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA714221B (en) * 1970-07-10 1972-03-29 Astra Ab Insecticides
SE425439B (sv) * 1981-04-30 1982-09-27 Wallac Oy Immunologisk analys med lantanidkelatkomplex som markor
KR19990064310A (ko) * 1995-10-17 1999-07-26 윌리암스 로저 에이 시클로옥시게나제-2의 검출방법
JP2000019171A (ja) * 1998-04-28 2000-01-21 Kazuko Matsumoto 標識プローブによる分析方法
GB9927844D0 (en) * 1999-11-26 2000-01-26 Glaxo Group Ltd Chemical compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0794174A2 (en) * 1996-03-08 1997-09-10 Suzuki Motor Corporation Labeled reagents for use in immunoassays and fluorescent compounds and complexes used therein

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BAXTER A.J.G. ET AL.: "Azoalkene route to methyl 2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylate (FPL 64176) and analogs: synthesis of 1-(BOC-amino)pyrrole-3-carboxylates and their conversion to 1H-pyrroles via 1-aminopyrroles", SYNTHESIS, no. 2, 1994, pages 207 - 211, XP002028877 *
DAS M. & HAWORTH D.T.: "Dipole moments of some beta-diketones and monothio-beta-diketones", SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, vol. 25, no. 5, 1995, pages 845 - 857, XP002961725 *
PASHKEVICH K.I. ET AL.: "Synthesis and structure of fluorine-containing beta-chlorovinyl ketones", IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA, no. 9, 1986, pages 2125 - 2127, XP002961726 *
See also references of EP1437338A4 *
UHLEMANN E. ET AL.: "Liquid-liquid extraction of gallium with bidentate ligands", ANALYTICA CHIMICA ACTA, vol. 130, no. 1, 1981, pages 177 - 182, XP002961727 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7211440B2 (en) * 2002-03-08 2007-05-01 Wallac Oy Dissociative fluorescence enhancement assay
US7381567B2 (en) 2002-03-08 2008-06-03 Wallac Oy Dissociative fluorescence enhancement assay
US7736620B2 (en) 2004-08-10 2010-06-15 National University Corporation Kyushu Institute Of Technology Europium-diketone chelate compound and fluorescent material using the same
CN1956942B (zh) * 2004-08-10 2010-12-22 国立大学法人九州工业大学 二酮铕螯合化合物及使用其的荧光材料
JP2008303196A (ja) * 2007-06-11 2008-12-18 Orient Chem Ind Ltd β−ジケトン希土類金属錯体、その製造方法および製造中間体、ならびにβ−ジケトン希土類金属錯体を含むインキ組成物
JP2013528185A (ja) * 2010-05-27 2013-07-08 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ タンパク質の標識法及びキット
CN102391162A (zh) * 2011-09-28 2012-03-28 大连理工大学 三种基于铕(III)与氯磺酰化四齿β-二酮配位体形成的荧光配合物及其应用
CN104926698A (zh) * 2014-03-18 2015-09-23 中国科学院大连化学物理研究所 一种四齿β二酮配体-铕荧光配合物及应用

Also Published As

Publication number Publication date
JPWO2003033447A1 (ja) 2005-07-28
US20050033039A1 (en) 2005-02-10
US7154007B2 (en) 2006-12-26
EP1437338A4 (en) 2006-02-08
CN1568298A (zh) 2005-01-19
DE60233742D1 (de) 2009-10-29
EP1437338B1 (en) 2009-09-16
CN100378056C (zh) 2008-04-02
EP1437338A1 (en) 2004-07-14
JP4117248B2 (ja) 2008-07-16

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