WO2003029246A1 - Procede de production de derive d'acetamide pyrimidone et des cristaux de celui-ci - Google Patents
Procede de production de derive d'acetamide pyrimidone et des cristaux de celui-ci Download PDFInfo
- Publication number
- WO2003029246A1 WO2003029246A1 PCT/JP2002/009912 JP0209912W WO03029246A1 WO 2003029246 A1 WO2003029246 A1 WO 2003029246A1 JP 0209912 W JP0209912 W JP 0209912W WO 03029246 A1 WO03029246 A1 WO 03029246A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pyrimidone
- crystals
- producing
- acetamide derivative
- acetamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
L'invention concerne un procédé permettant de produire industriellement, rapidement et à haut rendement un dérivé d'acétamide pyrimidone ayant un effet inhibiteur de chymase, par exemple, 2-(5-formylamino-6-oxo-2-phényle-1,6-dihydropyrimidine-1-yl)-N-{[3,4-dioxo-1-phényle-7-(2-pyridyloxy)]-2-heptyle}acétamide. Le produit pouvant être obtenu sous la forme de cristaux selon le procédé précité, on peut donc réaliser aisément des opérations telles que la filtration. Il devient alors inutile d'utiliser la chromatographie sur gel de silice au niveau de l'isolation/de la purification du produit. Il devient également inutile d'utiliser du chlorure de méthylène. On peut donc établir un procédé de production respectueux de l'environnement.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001-302990 | 2001-09-28 | ||
JP2001302990A JP2003104984A (ja) | 2001-09-28 | 2001-09-28 | 置換アミノピリミジニルアセトアミド誘導体の製造法 |
JP2002-75686 | 2002-03-19 | ||
JP2002075686A JP2003277374A (ja) | 2002-03-19 | 2002-03-19 | ピリミドンアセタミド誘導体の新規製造法とその結晶 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003029246A1 true WO2003029246A1 (fr) | 2003-04-10 |
Family
ID=26623390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/009912 WO2003029246A1 (fr) | 2001-09-28 | 2002-09-26 | Procede de production de derive d'acetamide pyrimidone et des cristaux de celui-ci |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2003029246A1 (fr) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998009949A1 (fr) * | 1996-09-06 | 1998-03-12 | Nippon Kayaku Kabushiki Kaisha | Nouveaux derives d'acetamide et inhibiteurs de protease |
-
2002
- 2002-09-26 WO PCT/JP2002/009912 patent/WO2003029246A1/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998009949A1 (fr) * | 1996-09-06 | 1998-03-12 | Nippon Kayaku Kabushiki Kaisha | Nouveaux derives d'acetamide et inhibiteurs de protease |
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