WO2004016589A3 - Procede de production de donepezil hydrochlorure tres pur - Google Patents

Procede de production de donepezil hydrochlorure tres pur Download PDF

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Publication number
WO2004016589A3
WO2004016589A3 PCT/IL2003/000665 IL0300665W WO2004016589A3 WO 2004016589 A3 WO2004016589 A3 WO 2004016589A3 IL 0300665 W IL0300665 W IL 0300665W WO 2004016589 A3 WO2004016589 A3 WO 2004016589A3
Authority
WO
WIPO (PCT)
Prior art keywords
donepezil
hydrochloride
highly pure
solution
donepezil hydrochloride
Prior art date
Application number
PCT/IL2003/000665
Other languages
English (en)
Other versions
WO2004016589A2 (fr
Inventor
Boris Tishin
Alexander Vilensky
Pavel Potyabin
Original Assignee
Finetech Lab Ltd
Gutman Arie L
Boris Tishin
Alexander Vilensky
Pavel Potyabin
Nisnevich Gennady
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Finetech Lab Ltd, Gutman Arie L, Boris Tishin, Alexander Vilensky, Pavel Potyabin, Nisnevich Gennady filed Critical Finetech Lab Ltd
Priority to AU2003249565A priority Critical patent/AU2003249565A1/en
Publication of WO2004016589A2 publication Critical patent/WO2004016589A2/fr
Publication of WO2004016589A3 publication Critical patent/WO2004016589A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé de préparation de Donepezil hydrochlorure possédant une pureté obtenue par chromatographie liquide (méthode de mesure de surface relative) de plus de 97 %, la teneur en impuretés individuelles ne dépassant 0,02 % par superficie. Ledit procédé consiste à former une base Donepezil dans une solution et à traiter la solution à base Donezepil avec un HCl, sans isolement préalable de la base Donezepil ; et éventuellement à recristalliser l'hydrochlorure pour donner au Donezepil hydrochlorure la pureté voulue obtenue par chromatographie liquide. La base Donezepil en solution peut être obtenue par cyclisation intramoléculaire d'acide 2-(3,4-diméthoxybenzyl)-3-(N-benzyl-4-pipéridine)propionique ou d'un sel de celui-ci.
PCT/IL2003/000665 2002-08-14 2003-08-11 Procede de production de donepezil hydrochlorure tres pur WO2004016589A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003249565A AU2003249565A1 (en) 2002-08-14 2003-08-11 Process for production of highly pure donepezil hydrochloride

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL151253 2002-08-14
IL15125302A IL151253A0 (en) 2002-08-14 2002-08-14 Process for production of highly pure donepezil hydrochloride

Publications (2)

Publication Number Publication Date
WO2004016589A2 WO2004016589A2 (fr) 2004-02-26
WO2004016589A3 true WO2004016589A3 (fr) 2004-06-10

Family

ID=29596422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000665 WO2004016589A2 (fr) 2002-08-14 2003-08-11 Procede de production de donepezil hydrochlorure tres pur

Country Status (3)

Country Link
AU (1) AU2003249565A1 (fr)
IL (1) IL151253A0 (fr)
WO (1) WO2004016589A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006035433A2 (fr) 2004-09-29 2006-04-06 Chemagis Ltd. Utilisation de maleate de donepezil purifie pour preparer un hydrochlorure de donepezil amorphe pharmaceutiquement pur
GB0609835D0 (en) * 2006-05-18 2006-06-28 Pliva Istrazivanje I Razvoj D Impurities of a pharmaceutical product
KR20080092515A (ko) * 2007-04-12 2008-10-16 동화약품공업주식회사 도네페질 중간체의 제조방법
KR100953038B1 (ko) * 2007-12-12 2010-04-14 일동제약주식회사 염산 도네페질의 개량된 제조방법
WO2011051957A2 (fr) * 2009-10-30 2011-05-05 Neuland Laboratories Ltd. Procédé de préparation d'hydrochlorure de donépézil

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997022584A1 (fr) * 1995-12-15 1997-06-26 Pfizer Inc. Procedes de preparation de 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine et intermediaires utilises a cet effet
WO2000009483A2 (fr) * 1998-08-17 2000-02-24 Finetech Ltd. Nouveau procede et intermediaires pour la production de donepezil et de ses composes apparentes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997022584A1 (fr) * 1995-12-15 1997-06-26 Pfizer Inc. Procedes de preparation de 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine et intermediaires utilises a cet effet
WO2000009483A2 (fr) * 1998-08-17 2000-02-24 Finetech Ltd. Nouveau procede et intermediaires pour la production de donepezil et de ses composes apparentes

Also Published As

Publication number Publication date
AU2003249565A1 (en) 2004-03-03
IL151253A0 (en) 2003-04-10
AU2003249565A8 (en) 2004-03-03
WO2004016589A2 (fr) 2004-02-26

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