WO2003028673A1

WO2003028673A1 - Cosmetic preparation

Info

Publication number: WO2003028673A1
Application number: PCT/JP2002/009269
Authority: WO
Inventors: Atsushi Suzumatsu; Hikaru Sumida; Toshio Uesaka; Kimihiko Hori; Mami Nonomura
Original assignee: Kao Corporation
Priority date: 2001-09-11
Filing date: 2002-09-11
Publication date: 2003-04-10

Abstract

A cosmetic preparation which contains the following ingredients (A) and (B): cedrol and an oil having a total carbon number of 22 or larger and an SP value of 17 to 21. The cosmetic preparation has improved percutaneous cedrol absorbability and excellent antiallergic (IL4 production inhibitory) activity and is not irritative.

Description

Description Cosmetic Technical Field

The present invention relates to a cosmetic composition in which the transdermal absorbability of cedrol is improved and the antiallergic (IL4 production suppression) action is excellent. Background art

In general, the surface of the skin (epidermal) is covered with the stratum corneum, and has a structure that prevents the invasion of foreign substances from outside the body.Sufficient transdermal absorbability can be obtained simply by incorporating the active ingredient into cosmetics. hard. In order to improve this, various percutaneous absorption enhancers, for example, polar compounds such as dimethyl sulfoxide, N-methylpyrrolidone, and methyl sorbate have been proposed (Japanese Patent Application Laid-Open No. 61-331129). However, although these transdermal absorption enhancers are excellent in transdermal absorption, they are not sufficient in terms of irritation, stability, and feeling of use.

On the other hand, the present inventors have found that cedrol has an antiallergic action due to its excellent inhibitory action on IL4 production (Japanese Unexamined Patent Publication No. 2000-3099528). However, in many cases, transdermal absorption of cedrol into the stratum corneum was not sufficient.

An object of the present invention is to provide a cosmetic composition in which the transdermal absorbability of cedrol is improved, the effect of cedrol can be sufficiently exerted, and there is no irritation. Disclosure of the invention

The inventor of the present invention has found that, when an oil agent having a specific SP value range is used in combination with Cedokul, cedrol can be stably compounded, and at the same time, the antiallergic (IL4 production inhibitory) action of a cosmetic containing cedrol is further enhanced. Was found to be non-irritating. The present invention comprises the following components (A) and (B):

(A) Cedrol, (B) An oil agent with a total carbon number of 22 or more and an SP value of 17 to 21

And a cosmetic containing the same. BEST MODE FOR CARRYING OUT THE INVENTION

Cedrol of component (A) used in the cosmetic of the present invention is a kind of sesquiterpene alcohol, and has an optical isomer, but is generally a (d) isomer represented by the formula (1). Exists in. Cedrol as an active ingredient of the antiallergic effect of the present invention

The (d) isomer is preferred, but the optical isomer (1) or the (d) isomer

(1) There is no problem in effectiveness even in the form of mixed body.

Cedrol is generally known as a fragrance component contained in essential oils of plants such as Pinaceae, Cedars, Cypresses, Scorpiones, Prunus, etc. It can be obtained by purifying essential oils such as fern wood oil and hiba oil by distillation or the like, and can also be obtained by synthesis. As the cedrol used in the present invention, any of the above-mentioned essential oil products and synthetic products may be used, or a commercially available product may be used.

Cedrol of the component (A) is contained in the cosmetic of the present invention in an amount of 0.01 to 10% by weight, particularly 0.1 to 5% by weight. / ₀ is preferable because an antiallergic effect can be effectively exerted.

The oil agent of the component (B) used in the cosmetic of the present invention has a total carbon number of 22 or more.

7 to 21 things. Here, the SP value of the oil agent is the solubility parameter δ, which is a material constant given by δ = (E / V) ^1/2 from the molecular cohesion energy 液体 of the liquid and the molecular volume V. The SP value is obtained by the method for obtaining the dissolution parameters described on pages 78 to 78 of “Solutions and Solubility, 3rd Edition” by Kozo Shinoda (Maruzen Co., Ltd., 1991).

The total carbon number of the oil agent of the component (Β) is 22 or more, and particularly preferably 22 to 40, Further, the SP value at 25 ° C is preferably from 17 to 21, particularly preferably from 17.0 to 19.0. Specific examples of the component (B) include d 1 -α-tocopherol (total carbon number 29: SP value (25 ° C) 19.4 (the same applies hereinafter)), glyceryl monoisostearate and glyceryl monomyristate (35: 18.4), diisostearyl malate (40:

18.2), neopentylanolecol dicaprate (25: 17.7), propylene glycol dicaprate (39: 17.5), propylene glycol dinonanoate (29: 17.6), tetraisostearin Acid diglyceryl (60: 17.4), decyltetradecanol (24: 17.9), daliseryl tri-prillate (24: 17.9), glyceryl triacetyl ricinoleate (63:

17.9), glyceryl triisostearate (57: 17.2), diglyceryl triisostearate (60: 18.0), trimethylpropane triisostearate (65: 17.2), glyceryl trioctanoate (57:17) 7), glyceryl tricaprate (33: 17.8), polyoxyethylene pyrostearate isostearate (25) glyceryl ether (175: 205), polyoxyethylene pionate (2) myristyl ether (23) : 17.3), polyoxyethylene myristate (3) myristyl ether (34: 17.5), dioctyldodecyl lauroylglutamate (57: 17.5), cetyl ricinolate (34: 18.0), ricinolein Acid tetrahydrofurfuryl (28:

19.3), linoleic acid d 1-hydroxytocopherol (47: 17.5), octyldodecyl lactate (23: 18.5), dithiobutyrate adipate (22: 18.5), butyl acetyl ricinoleate (24: 17.3), Batyl isostearate

(39: 18.0), polypropylene glycol isostearate (23:

18.6), polyoxypropylene (10) cetyl ether (106: 18.4), octyl oxastearate (26: 18.3), isotridecyl isononanoate

(22: 17.0), polyglyceryl disostearate (42-192:

19.4) and so on.

As component (B), glyceryl monomyristate monoisostearate, diisostearyl malate, neopentyl alcohol dicaprate, propylene glycol dicaprate, propylene glycol dinonanoate, decyltetradecaate are particularly preferred. 9 Nol, glyceryl tricaprylate, glyceryl tricaprate, polyoxyethylene propionate (2) myristyl ether, polyoxyethylene myristate (3) myristyl ether, cetyl ricinoleate, octyldodecyl lactate, dioctyl adipate, acetyl ricinoleate Butyl, polypropylene glycol isostearate, octyl oxastearate, and isotridecyl isononanoate are preferred.

Two or more types of oil agents of component (B) may be used in combination. Further, in the cosmetic of the present invention 0. 0 0 1-5 0 weight ^_0/0, especially 0. 0 1-2 0 weight ^_0/0 preferably contained. In the cosmetic of the present invention, disodium edetate, sodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, dalconic acid, etc. can be used to appropriately contain an oil agent other than the component (B). Caffeine, tannin, tranexamic acid and derivatives thereof; hibamata extract, botanical extract, carrot extract, eucalyptus extract, bodaiju extract, potato beetle extract, モ remoko ゥ extract, asuna mouth extract, zuzekis, peony extract, ノ ownoku extract, taiso ゥ extract, Citrus extract, Cheer extract, Touki extract, Ogongonkisu, Jokinin extract, Anoretea extract, No, Mameris extract, Suginaesu, Aloe extract, Dokudami extract, Malonie extract, Noceri extract, Yu Various extracts, such as nosita extract, honeysuckle extract, tenchia extract, nonola extract, beech extract, and mugwort extract; various crude drugs; essential oils such as eucalyptus oil, lavender oil, tea tree oil, orange oil, sage oil, and rosemary oil; acetic acid Whitening agents such as tocopherol, glycyrrhizic acid and its derivatives, vitamin C; sugars such as dalicose, fructose and trehalose; polysaccharides such as xanthan gum, hyaluronic acid, pullulan, hydroxycellulose, carrageenan and mannan; Polyethylene dalicol having a molecular weight of 1000 or more can be appropriately contained. In addition to the above-mentioned components, the cosmetics of the present invention also contain components commonly used in external preparations for skin such as cosmetics, for example, humectants, antioxidants, ultraviolet absorbers, surfactants, thickeners, alcohols, and organic compounds. Acids, alkalis, powder components, coloring agents, aqueous components, water, fragrances, various skin nutrients, and the like can be appropriately contained as necessary.

The cosmetic of the present invention can be produced according to a usual method, for example, cream, 9 Can be used as cosmetics such as emulsions, lotions, packs, and jewels. Example

Examples 1 to 5

A cosmetic having the following composition was prepared by a conventional method, and its transdermal absorption and irritation were evaluated. (Composition):. Cedrol 0 1 (wt ^_0/0) oil (Table 1) 2

Polyoxyethylene (60) hydrogenated castor oil 2

Ethanano 1 5

Purified water balance

(Evaluation method)

(1) Percutaneous absorption:

A patch test patch with a hole diameter of 16 mm was applied to the upper arm of panelists (10 persons), and 200 L of the sample was applied. After the application, the pansoil was peeled off for 6 hours, and then the applied portion was tape-striped 10 times with a cellophane tape, and the amount of cedrol in the stratum corneum adhered to the cellophane tape was measured.

The quantification of cedrol was measured by gas chromatography of an ethanol extract from 10 cellophane tapes. The percutaneous absorption rate was determined by the following formula, and was determined according to the criteria.

Cedrol content in the stratum corneum in close contact with the cellophane tape (average value of 10 people) Transdermal absorption rate (%) = X100 Amount of cedrol applied Percutaneous absorption criteria: 1;

2; Percutaneous absorption rate 1% or more and less than 2%

3: Percutaneous absorption 2% or more and less than 3%

4; Percutaneous absorption rate '3% or more

(2) Irritation:

Sensitive skin panelists (10 people) applied their cosmetics after washing their face with stone stone, and the skin condition 1 minute later was evaluated according to the following criteria. A: 0 people who felt any irritation

B: 1-2 people who felt a little irritation

C: 3-5 people who felt any irritation

D: 6 or more people who felt slight irritation Table 1 shows the results. All of the cosmetics of the present invention had excellent transdermal absorbability and were not irritating.

Example 6 (Emulsion) Cedrol 0 Polyglyceryl diisostearate 25 Glyceryl monoisostearate 25 Glyceryl monomyristate 25 Polyoxyethylene (20) hydrogenated castor oil 2 Methyl polysiloxane (6 cs) 0 5 Cholesterol 0 2 Cholesteryl disostearate 0 1 Cetinoreanoconore 0 3 Stearyl alcohol 0 2 Glycerin 0 Carboxyvinyl polymer

(Carbopol 981, manufactured by B.F. GOODRICH) 0.2 Hydroxy hydroxide 0.1 Co / Pearic acid 0.01 Vegetable extract

(Fanorecorex buttonpi, one 0.5 yurikuri extract

(Eucalyptus extract BGF, manufactured by Maruzen Pharmaceutical Co.) 2.0 Paraoxybenzoic acid ester 0.2 Purified water

Example 7 (Giel) Cedrol 0.1 Diisostearyl malate 4 Polyoxyethylene (40) hydrogenated castor oil 0.2

Glycerin 6 Echinoreanorenocore 5 Power lipoxyvinyl polymer

(Carbopol 980, manufactured by BF GOODRICH) 0.7 Adipic acid 0.02 Potassium hydroxide 0.3 Altea extract

(Fuarco Rex Altea, manufactured by Ichimaru Fuarcos) 1.0 Remoco Extract

(Ju Extract, Maruzen Pharmaceutical Co., Ltd.) 0.1 Power Mitsuru Extract (Power Mitsuru Liquid, Ichimaru Fuarcos Co., Ltd.) 0.5 Paraoxybenzoic acid ester 0.3 Example 8 (Lotion) Cedrol 0.1 Isotridecyl isononanoate 1.5 Polyoxyethylene (60) Hydrogenated castor oil 2 Glycerin 0 Tris (ethoxyxetixethyl) phosphate 2 Ataryl acid / alkyl methacrylate copolymer

(PEMULEN TR-1, BF GOODRICH) 0. Potassium hydroxide 0,2 Adipic acid 0,1 Edetic acid 2 sodium 2,0 Peony extract (Peony extract, Maruzen Pharmaceutical) 0 2 Carrot extract (Carrot extract K , Maruzen Pharmaceutical Co., Ltd.) 0 05 Paraoxybenzoic acid ester 0 5 Purified water

Example 9 (Cream) Cedrol 0.1 Neopentyl alkazolate dicaprate 3 Polyglyceryl stearate 53.5 Cetinorea noreco 1.5 Stearyl alcohol

Ν— (3-hexadecyl oxy-2-hydroxypropyl)

1-—2-hydroxyethylhexadenicamide 4 cholesterol monophosphate 0.8 cholesteryl disostearate 0.5 glycerin 20 citrate 0.02 Sodium Hydroxide 0.002 Touki Extract (Touki Extract BG, manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.1 Zuzu Extract (Zuzu Extract, manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.5 Paraoxybenzoic acid ester 0.2 0.2 Phenylethoxyethanol . 5 Example 10 (Lotion)

(% By weight) Cedrol 0.01 Monomer monoistearate glyceryl ristate 0.5 Polyoxyethylene (60) hydrogenated castor oil 2 glycerin 5 polyglyceryl diisostearate

Ataryl acid '' alkyl methacrylate copolymer

(PEMULEN TR-1, manufactured by F. F. GOODRICH) 0.1 Potassium hydroxide 0.2 Lactic acid 0.1 Ethedic acid 2 sodium 0.20 Equinin extract

(Yokuinin liquid B, manufactured by Ichimaru Buarcos) 0.5 Asuna mouth extract

(Asunaro Liquid, manufactured by Ichimaru Fuarcos) 2.0 Paraoxybenzoic acid ester 0.5 Purified water

Example 1 1 (water-in-oil cream) Cedrol 0.5 0.5 glyceryl tricaprylate 1.5 kN. Dextrin noremitate 1 N-lauroyl mono-L-glutamic acid

Di (cholesteryl. Otatildodecyl) 2

Cholesteryl isostearate 5

Olive oil 1 0

Cetyl-1,3-dimethylbutyl ether

-π Fuchsolic acid: 1 0

Dimethyl siloxane xan methyl (p-decylglyceryl ether)

Siloxane copolymer 1 5 Polyoxyethylene tristearyl phosphate (15) Hardened castor oil 1

Sodium hyanoleronate 1 glycerin

Etildanorecoside

1,2,1-pentanedione

Lavender oil

Dokudami extract

(Falco Rex Dokudami Ichimaru manufactured by Farucos) 0.2 Chiyo extract

(Fuarcolex Chiyoji, manufactured by Ichimaru Fuarcos Co., Ltd.) 0 Paraoxybenzoic acid ester 03 The cosmetics of the present invention of Examples 6 to 11 are all excellent in transdermal absorption of cedrol and have no irritation. Industrial applicability

INDUSTRIAL APPLICABILITY The cosmetic composition of the present invention has improved percutaneous absorption of cedrol, has excellent antiallergic (IL 4 production inhibition) action, and has no irritation.

Claims

The scope of the claims

1. The following components (A) and (B):

(A) Sedronore,

(B) Oil agent with total carbon number of 22 or more and SP value of 17 to 21

Cosmetics containing.

2. The cosmetic according to claim 1, wherein the cosmetic is an oil agent having a total carbon number of 22 to 40.

3. The cosmetic according to claim 1, wherein the component (B) is an oil having an SP value of 17.0 to 19.0.

4. The cosmetic according to any one of claims 1 to 3, comprising 0.001 to 10% by weight of the component (A) and 0.001 to 50% by weight of the component (B).