JPH10194920A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic having low skin irritation and good use feeling and exhibiting excellent beautifying action or anti-inflammation action by combinedly using a substance having beautifying action or anti-inflammation action with a specific oil solution having a specific solubility parameter. SOLUTION: This cosmetic comprises (A) a substance having beautifying action or anti-inflammation action and (B) one or two or more kinds of oil solutions, especially two or more kinds of oil solutions selected from oil solutions having >=15.7 and <=21.0 solubility parameter (δ). The component B is preferably obtained by compounding substance (B1 ) having >=15.7 and <=17.2 solubility parameter (δ) (preferably isotridecyl isononanoate) with a substance (B2 ) having >=17.5 and <=21.0 solubility parameter (δ) (preferably monoisostearic acid-monomyristic acid diglyceryl) at (10/1) to (1/2) weight ratio. The component A includes L-ascorbic acid or hydroquinone derivative. It is preferable to further add a humectant (e.g. ethanol or glycerol) to the system.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a cosmetic having improved transdermal absorption of a substance having a whitening effect or an anti-inflammatory effect.

[0002]

2. Description of the Related Art Conventionally, various substances have been used in cosmetics and the like as components that exhibit a whitening effect, an anti-inflammatory effect and the like by transdermal absorption. However, since the stratum corneum, which is the outermost layer of the skin, originally has a physiological function as a barrier to prevent invasion of foreign substances from outside the body, it is not sufficient to simply mix such a substance in an external preparation. It does not have skin absorbability and cannot show its original function. In addition, many of the substances exhibiting excellent whitening effect and anti-inflammatory effect by being absorbed by the skin cannot exhibit their original effects due to low percutaneous absorption ability in the stratum corneum.

[0003] Therefore, in recent years, transdermal absorption enhancers such as dimethylsulfoxide, dimethylformamide, dimethylacetamide, and methyldecylsulfoxide have been used for the purpose of improving the transdermal absorbability of various substances. But,
These percutaneous absorption enhancers do not provide a satisfactory percutaneous absorption promotion effect, and may cause erythema on the skin due to strong skin irritation. Was not enough.

[0004]

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a cosmetic composition having a low skin irritation property and an improved percutaneous absorption of a substance having a whitening effect or an anti-inflammatory effect.

[0005]

Means for Solving the Problems In view of such circumstances, the present inventors have conducted intensive studies, and as a result, if a substance having a whitening action or an anti-inflammatory action is used in combination with an oil having a specific solubility parameter, skin irritation will be reduced. Completed the present invention by finding that a cosmetic material exhibiting excellent whitening and anti-inflammatory effects can be obtained because the percutaneous absorbability of a substance having a low, good feeling in use and having a whitening or anti-inflammatory effect is improved. did.

That is, the present invention relates to (A) a substance having a whitening or anti-inflammatory effect, and (B) a solubility parameter δ.
Contains one or more oils selected from oils in the range of 15.7 <δ ≦ 21.0.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present specification, a solubility parameter refers to a measure of compatibility between substances, and is obtained by calculating Hansen's three-dimensional solubility parameter using the following equation (i). . In the formula, each term on the right side is a calculation formula (ii) based on the molar attractive constant of Van Krevelen.
To (iv).

[0008]

Δ = (δd ² + δp ² + δh ² ) ^1/2 (i)

Δ; solubility parameter δd; term due to London's dispersive force (van der Waals force) (dispersion term) δp: term due to molecular polarity (polar term) δh: term due to hydrogen bond (hydrogen bond term)

[0010]

Δd = ΣF _di / ΣV _i (ii) δp = (ΣF _pi ² ) ^1/2 / ΣV _i (iii) δh = (ΣF _hi / ΣV _i ) ^1/2 (iv)

F _di , F _pi , F _hi ; molar attraction constant V _i ; molar volume

Note that δd, δp, and δh can be calculated from the above equations (ii) to (iv) based on the molar attraction constants (F _di , F _pi , F _hi ) of the atomic groups as described above. in the present specification, with respect to the molar attraction constants, using the Van Krevelen Rayori determined value, molar volume (V _i) was used the volume value of a defined group of atoms by Fedor.

The substance having a whitening or anti-inflammatory effect of the component (A) used in the present invention is not particularly limited as long as it has a whitening or anti-inflammatory effect and is used in ordinary cosmetics. Can be used. Among them, those having a whitening effect include, for example, L-ascorbic acid and its derivatives, hydroquinone derivatives,
Kojic acid and its derivatives, placenta extracts, plant extracts having a whitening effect, spiroether compounds, and the like.

[0014] Specifically, ascorbic acid and its derivatives are not particularly limited.
L- which is a monovalent metal salt of ascorbic acid phosphate ester
Sodium ascorbic acid phosphate, potassium L-ascorbic acid phosphate, magnesium divalent metal salt L-ascorbic acid phosphate,
L-ascorbic acid phosphate calcium salt, trivalent metal salt L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate monovalent metal salt L-ascorbic acid sulfate sodium salt, L -Potassium ascorbic acid sulfate, 2
L-ascorbic acid sulfate potassium magnesium salt which is a valent metal salt; L-ascorbic acid sulfate calcium salt which is a trivalent metal salt; L-ascorbic acid sulfate aluminum salt which is a trivalent metal salt; and a monovalent metal salt of L-ascorbic acid. L-ascorbate sodium salt, L-ascorbate potassium salt, divalent metal salt L-ascorbate magnesium salt, L-ascorbate calcium salt, trivalent metal salt L-ascorbate aluminum salt and the like. Can be.

The hydroquinone derivative is not particularly limited, and examples thereof include a condensate of hydroquinone and a sugar, and a condensate of an alkylhydroquinone and a sugar obtained by introducing one alkyl group having 1 to 4 carbon atoms into hydroquinone. Among these, arbutin and the like are preferable.

The kojic acid and its derivatives are not particularly restricted but include, for example, kojic acid, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamoate, Examples thereof include monoesters such as kojic acid monobenzoate, diesters such as kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, and kojic acid dioleate.

As the placenta extract, those which are generally marketed as a water-soluble placenta extract and used as cosmetic raw materials can be used. For example, the placenta of mammals such as cows, pigs, and humans can be washed and blood removed. , Crushing, freezing, and the like, and after extracting the water-soluble component, further removing impurities to obtain the same.

Examples of plant extracts having a whitening effect include chamomile, tea, cuckoo, clove, licorice,
Loquat, spruce, ginseng, peonies, hawthorn, barley winter, ginger, suegasa, mulberry bark, magnolia, inchenbukaku, asenyaku,
Extracts such as yellow gon, aloe, altea, spiraea, Dutch mustard, kina, comfrey, rosemary, and funnel.

Among these, the chamomile extract is a chamomile [Matricaria chamomilla]
L. (Compositee)] can be obtained as an extract by extracting the flower with water or a hydrophilic organic solvent such as methanol, ethanol, propanol, propylene glycol, 1,3-butylene glycol or a mixture thereof. The extract can be dried and obtained in the form of a dry powder. Extraction with a hydrophilic organic solvent such as castor oil, persic oil, liquid paraffin, soybean oil, isopropyl myristate, lower fatty acid triglyceride, medium fatty acid triglyceride, sunflower oil, neopentyl glycol dicaprate, squalane, or a mixed solvent thereof. Can be obtained. In the present invention, one of the thus obtained chamomile extract
Species or a combination of two or more can be used.

Such an extract of chamomile generally contains azulene, camazulene, umbelliferone, 7-methoxycoumarin, matricin, maticalin, taraxasterol, lupeol, apiin, chroman, spiroether and the like. Here, a preferable method for extracting chamomile includes, for example, the following method.

That is, the chamomile flower is dried and cut into small pieces. After adding squalane thereto and immersing it from room temperature to 50 ° C. with occasional stirring, the extract is separated by pressing to obtain an extract.
This extract is filtered to obtain a chamomile extract.

Further, examples of the spiroether compound include those represented by the following general formula (1).

[0023]

Embedded image

[In the formula, a wavy line indicates that the bonding state may be either Z or E.]

The spiroether compound (1) is, for example, a chamomile of Matricaria spp.
Vol., Pp. 384-388 (1992), Chrysanthemum genus (Agric. Biol. Chem. 48, 13).
67-1369, 1984), the genus Tanacetam,
It has been reported that it can be obtained from several Asteraceae plants such as Artemisia and Leucansemum, and the components obtained by solvent extraction, steam distillation, etc. can be isolated by subjecting them to chromatography as usual. . The spiroether compound (1) suppresses the production of melanin in melanocytes, reduces or eliminates pigmentation based on external stimuli such as ultraviolet rays, has an excellent effect of preventing and improving pigmentation, and has a skin whitening effect. (JP-A-7-206657, etc.).

One of these substances having a whitening effect can be used alone or in combination of two or more. It is preferable to add 0.0001 to 15% by weight in the total composition, and particularly preferable to use 0.0001 to 10% by weight. % By weight, and 0.001 to 5% by weight
It is preferable to mix them because they are more excellent in usability and stability. In the case where a plant extract is used, it is 0.1% in terms of dry solid content in the whole composition from the viewpoint of whitening effect and stability.
It is preferable to mix 00001 to 5% by weight, especially 0.1% by weight.
It is preferable to add 0005 to 3% by weight, more preferably 0.001 to 2% by weight, since a sufficient whitening effect, moisturizing effect, effect of preventing and improving rough skin can be obtained, and excellent feeling in use and stability can be obtained.

Among the components (A), those having an anti-inflammatory effect include, for example, glycyrrhizic acid and salts thereof,
Glycyrrhetinic acid and its salts, isopropylaminocaproic acid and its salts, allantoin, lysozyme chloride, guaiazulene, methyl salicylate, γ-oryzanol, and the like, among which glycyrrhetinic acid, stearyl glycyrrhetinate, and epsilon aminocaproic acid are preferable.

These anti-inflammatory substances can be used singly or in combination of two or more. It is preferable to add 0.001 to 5% by weight in the total composition, and particularly preferable to use 0.1 to 5% by weight.
When 01 to 2% by weight and further 0.01 to 1% by weight are blended,
It is preferable in terms of usability and stability.

Examples of the oil agent having a solubility parameter δ of the component (B) used in the present invention in the range of 15.7 <δ ≦ 21.0 include, for example, ethyl arachidonic acid, ethyl linolenate, isononyl isononanoate, and isopalmitic acid. Octyl, isopropyl linoleate, octyl isoperargonate, oleyl linoleate, isotridecyl isononanoate, ethyl linoleate, isopropyl isostearate, isocetyl octanoate, oleyl eicosanoate, isostearyl octanoate, isodecyl pivalate, isodecyl isononanoate, eicosanoic acid Elsil, octyldodecyl oleate, isostearyl pivalate, isostearyl isostearate, isosetyl isostearate, isostearyl eicosanoate, octyldodecyl eicosanoate, oley Isopropyl acetate, octyldodecyl dimethyloctanoate, hexyldecyl dimethyloctanoate, oleyl myristate, stearyl eicosanoate, ethyl oleate, decyl oleate, isocetyl stearate, octyl stearate, octyl dodecyl stearate, isostearyl palmitate, Isocetyl palmitate, octyl palmitate, isostearyl myristate, isocetyl myristate, isotridecyl myristate, octyl dodecyl myristate,
Isostearyl laurate, hexyl isostearate, myristyl isostearate, lauryl isostearate, stearyl oleate, cetyl oleate, isobutyl stearate, isobutyl palmitate, isopropyl palmitate, octyl myristate, isodecyl laurate, butyl isostearate, pelargone Octyl acid, isopropyl myristate, isoamyl laurate, isohexyl laurate, myristyl neopentanoate, isobutyl pelargonate, lauryl palmitate, decyl myristate, ethyl stearate, ethyl palmitate, butyl myristate, ethyl laurate, methyl myristate , Methyl laurate, propylene glycol dinonanoate, diisopropyl sebacate,
Glyceryl trioctanoate, glyceryl tricaprate, diisobutyl adipate, neopentyl glycol dicaprate, propylene glycol dicaprate, dihexyl adipate, glyceryl triacetyl ricinoleate, diisopropyl adipate, glyceryl tricaprate, diglyceryl triisostearate, diethyl sebacate , Diglyceryl monoisostearate monomyristate, butyl adipate, dibutyl adipate,
Diisostearyl malate, octyl oxystearate, octyl methoxycinnamate, octyl dodecyl lactate, isostearyl lactate, oleyl lactate, methyl ricinoleate, octyl paradimethylaminobenzoate, myristyl lactate, dl-α-tocopherol, nicotinic acid dl−
Examples thereof include α-tocopherol, lauryl lactate, and diglyceryl monomyristate monoisostearate. Of these, those having a total carbon number of 10 to 90 are preferable, and those having a total carbon number of 20 to 80 are particularly preferable.

The oil component (B) can be used alone or in combination of two or more, but it is preferable to use two or more in combination, and (B-1) the solubility parameter δ is 15.7. One or more selected from oil agents in the range of <δ ≦ 17.2, and (B-2) selected from oil agents in which the solubility parameter δ is in the range of 17.5 ≦ δ ≦ 21.0. It is preferable to use one kind or a combination of two or more kinds.

Examples of the oil agent having a solubility parameter δ in the range of 15.7 <δ ≦ 17.2 used as the component (B-1) include, for example, ethyl arachidonic acid, ethyl linolenate, isononyl isononanoate, Octyl palmitate, isopropyl linoleate, octyl isoperargonate, oleyl linoleate, isotridecyl isononanoate, ethyl linoleate, isopropyl isostearate, isocetyl octanoate, oleyl eicosanoate, isostearyl octanoate, isodecyl pivalate, isodecyl isononanoate, Elsil eicosanoate,
Octyldodecyl oleate, Isostearyl pivalate, Isostearyl isostearate, Isocetyl isostearate, Isostearyl eicosanoate, Octyldodecyl eicosanate, Isopropyl oleate, Octyldodecyl dimethyloctanoate, Hexyldecyl dimethyloctanoate, Oleyl myristate, Eicosan Stearyl acid, Ethyl oleate, Decyl oleate, Isocetyl stearate, Octyl stearate, Octyl dodecyl stearate, Isostearyl palmitate, Isocetyl palmitate, Octyl palmitate,
Isostearyl myristate, isocetyl myristate, isotridecyl myristate, octyl dodecyl myristate, isostearyl laurate, hexyl isostearate, myristyl isostearate, lauryl isostearate, stearyl oleate, cetyl oleate, isobutyl stearate, isobutyl palmitate , Isopropyl palmitate, octyl myristate, isodecyl laurate, butyl isostearate,
Octyl pelargonate, isopropyl myristate, isoamyl laurate, isohexyl laurate, myristyl neopentanoate, isobutyl pelargonate, lauryl palmitate, decyl myristate, ethyl stearate, ethyl palmitate, butyl myristate, ethyl laurate, myristate Methyl, methyl laurate and the like are mentioned, and among these, isotridecyl isononanoate is particularly preferred.

Oils having a solubility parameter δ in the range of 17.5 ≦ δ ≦ 21.0 used as the component (B-2) include, for example, propylene glycol dinonanoate, diisopropyl sebacate, glyceryl trioctanoate, and tricaprin. Glyceryl acid, diisobutyl adipate, neopentyl glycol dicaprate, propylene glycol dicaprate, dihexyl adipate,
Glyceryl triacetyl ricinoleate, diisopropyl adipate, glyceryl tricaprate, diglyceryl triisostearate, diethyl sebacate, diglyceryl monoisostearate diglyceryl, dibutyl adipate, and the like. Of these, monomyristine monoisostearate Diglyceryl acid is particularly preferred.

When component (B-1) and component (B-2) are used in combination as component (B), isotridecyl isononanoate is used as component (B-1) and component (B-2)
It is particularly preferred to use diglyceryl monomyristate monoisostearate. In this case, another oil agent used as the component (B) may be used in combination.

The amount of the component (B) is not particularly limited, but from the viewpoint of the effect of promoting the percutaneous absorption of the component (A) and the feeling upon use, the total amount of the component (A) is 0.001 to 40% by weight, preferably 0.1 to 40% by weight. It is preferable that the content is 0.01 to 30% by weight, more preferably 0.01 to 10% by weight. In addition, as the component (B), the component (B
When using a mixture of component (B-1) and component (B-2), the weight ratio (B-1) / (B-2) of component (B-1) to component (B-2) in component (B) is 10%. / 1-2, especially 1
It is particularly preferred that it be in the range of 0/1 to 2/1.

The cosmetic of the present invention may further comprise a humectant as the component (C). The humectant is not particularly limited as long as it is used for ordinary cosmetics. For example, ethanol, glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, ethylene glycol, 1,4-butylene glycol , Diglycerin, polyglycerin such as triglycerin, glucose, maltose, maltitol, sucrose, fructose, threitol, erythritol, starch-degrading sugar and the like. Among these, ethanol,
1,3-butylene glycol and glycerin are particularly preferred from the viewpoint of feeling of use.

The amount of component (C) is not particularly limited, but is preferably 0.001 to 40% by weight, more preferably 0.01 to 30% by weight, and more preferably 0.01 to 1% by weight, based on the total composition.
It is preferable to add 0% by weight, because it is more excellent in use feeling.

In the cosmetic of the present invention, in addition to the above-mentioned components, oils, organic acids, alkalis, surfactants, ultraviolet absorbers, powders, pigments and the like other than those described above as long as the effects of the present invention are not impaired. Dyes, preservatives / fungicides, antioxidants, chelating agents,
Components commonly used in pharmaceuticals such as thickeners, fragrances and water, quasi-drugs, cosmetics and the like can be appropriately compounded.

Specific examples of oils include liquid paraffin, squalane, higher fatty acids, higher alcohols and the like; examples of organic acids include citric acid and lactic acid; examples of alkalis include caustic soda and triethanol Amines and the like.

Among the surfactants, hydrophilic surfactants include nonionic surfactants such as polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil,
Polyoxyethylene castor oil or hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil laurate, polyoxyethylene hydrogenated castor oil isostearate, polyoxyethylene hydrogenated castor oil pyroglutamate isostearic acid diester; polyoxyethylene sorbitan monolaurate; Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monoisostearate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene glyceryl monostearate, poly Polyoxyethylene glycos such as oxyethylene glyceryl monoisostearate and polyoxyethylene glyceryl triisostearate Fatty acid esters of polyoxyethylene lauryl ether, polyoxyethylene hexyl decyl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene octyl dodecyl ether, polyoxyethylene behenyl ether, polyoxyethylene nonyl phenyl ether, Polyoxyethylene alkyl ethers such as polyoxyethylene polyoxypropylene decyl tetradecyl ether; polyoxyethylene addition surfactants such as polyoxyethylene fatty acid esters such as polyoxyethylene monooleate; polyglycerin alkyl ether; Glycerin fatty acid esters, sucrose fatty acid esters and the like can be mentioned.

As anionic surfactants, polyoxyethylene alkyl sulfate surfactants such as polyoxyethylene lauryl ether triethanolamine sulfate; N-acyl amino acid salts such as sodium lauroyl sarcosine and sodium lauroyl methylalanine; Surfactants: sodium polyoxyethylene lauryl ether phosphate, sodium polyoxyethylene cetyl ether phosphate, dipolyoxyethylene alkyl ether phosphoric acid, tripolyoxyethylene alkyl ether phosphoric acid,
Dipolyoxyethylene nonyl phenyl ether phosphoric acid,
And polyoxyethylene alkyl ether phosphate surfactants such as sodium polyoxyethylene lauryl ether phosphate and sodium dipolyoxyethylene lauryl ether phosphate. Examples of amphoteric surfactants include alkyl betaines, alkyl amido betaines, and alkyl amido betaines, and cationic surfactants include di-long chain alkyl quaternary ammonium salts, mono-long chain alkyl quaternary ammonium salts, and di long chain alkyls. Examples include polyoxyethylene quaternary ammonium salts, bis (hydroxyalkyl) quaternary ammonium salts, and quaternary ammonium salts having an amide / ester bond.

Of these, polyoxyethylene-added nonionic surfactants are preferable, and those having an ethylene oxide addition mole number of 20 to 60 are particularly preferable.

Examples of the ultraviolet absorber include benzophenone, 4-t-butyl-4'-methoxy-dibenzoylmethane, glyceryl ethylhexanoate dimethoxycinnamate, 2-ethylhexyl-4-methoxycinnamic acid, p-
Examples include aminobenzoic acid esters and phenyl salicylate.

The cosmetic of the present invention can be produced according to a usual method, and may be in any form such as a liquid, a water-in-oil type or an oil-in-water type emulsion, a gel, a paste, and a solid. be able to. In particular, it is suitable as a skin cosmetic such as a lotion, a milky lotion, a cream, and a serum.

[0044]

EFFECT OF THE INVENTION The cosmetic of the present invention has a low irritancy to the skin, a good feeling upon use, and an improved percutaneous absorption of a substance having a whitening or anti-inflammatory effect as an active ingredient, An excellent whitening effect or anti-inflammatory effect can be obtained at a low dose.

[0045]

EXAMPLES The present invention will be described below in detail with reference to examples, but the present invention is not limited to these examples. The spiroether compounds used in the following examples are represented by the spiroether compound Z in the case where the bond state of the wavy line in the general formula (1) is Z, and the spiroether compound E in the case where the bond state is E.

Examples 1 to 10 and Comparative Examples 1 and 2 Cosmetics having the compositions shown in Tables 1 and 2 were produced by a conventional method.
The skin penetration of a spiro ether compound, a substance having a whitening effect, was tested by the following method. The results are shown in Tables 1 and 2.

(Test Method) A fixed amount of cosmetic is applied to the skin surface of the washed Yucatan micropig and left in a constant temperature room (temperature: 37 ° C., humidity: saturation). After a certain period of time, the unpermeated components remaining on the skin surface were removed, and the permeated components were extracted and collected, and the percutaneous absorption of the spiroether compound was measured by HPLC. The percutaneous absorption was shown as a value per unit area (μg / cm ² ).

[0048]

[Table 1]

[0049]

[Table 2]

As is clear from Tables 1 and 2, the cosmetic of the present invention has superior skin permeability compared to the cosmetic of Comparative Example.
It was excellent in whitening effect. In addition, high security,
The feeling of use was also good.

Examples 11 to 12 and Comparative Example 3 Whitening cosmetics having the compositions shown in Table 4 were produced by a conventional method. For these whitening cosmetics, the skin penetration of the spiroether compound was tested in the same manner as in Examples 1 to 10, and the whitening effect was tested by the following method. Table 4 shows the results.

(Whitening Effect Test for UV-B-Induced Pigment Spots) The inner arm of 20 healthy male subjects was irradiated with ultraviolet rays in the UV-B region twice the minimum erythema dose once a day for 2 days. The whitening effect by continuously applying the sample to the test site twice a day on the induced pigment spots for one month was examined. The evaluation was performed using a color difference meter (manufactured by Minolta, CR-300), the L ^* value was calculated from the obtained Munsell value, and the ΔΔL ^* value representing the recovery was used. Note that ΔΔL ^*
The values were defined as follows: The sample application test site and the sample uncoated test site of the sample application immediately before the L ^* value, respectively L _0, L _{0 ',} each of the sites in the L ^* values after each successive coating 1 month L _1, L _1', ΔΔL ^* was expressed by the following equation.

[0053]

ΔL ^* = (L ₁ −L ₀ ) − (L _{1 ′} −L _{0 ′} )

The evaluation was shown by the average value of the evaluation points of 20 subjects. Table 3 shows the relationship between the evaluation points and the criteria.

[0055]

[Table 3]

[0056]

[Table 4]

Examples 13 to 15 and Comparative Examples 4 to 5 Cosmetics having the compositions shown in Table 5 were produced by a conventional method.
The whitening effect was evaluated in the same manner as in Nos. 1 to 12. Table 5 shows the results.

[0058]

[Table 5]

Examples 16 to 18 and Comparative Examples 6 to 8 Cosmetics having the compositions shown in Table 6 were produced by a conventional method, and their anti-inflammatory effects were evaluated. Table 6 shows the results.

(Evaluation method) UV-B was applied to the inside of the upper arm of 20 healthy male subjects using a Toshiba FS-20SE lamp.
The region was irradiated once with twice the amount of minimal erythema (2 MED). Immediately after that, 15 μl of each cosmetic was applied and 24
After the time, redness (a ^* value) and skin temperature were measured. Redness was measured using a color difference meter (manufactured by Minolta, CR-300), and the a ^* value was calculated from the obtained Munsell value. UV-
The Δa ^* value was defined as how much a ^* after 24 hours of B irradiation increased from the a ^* value before UV-B irradiation. The skin temperature was measured using a radiation thermometer (Tasco Japan, THI-5).
00). The results were shown as average values.

[0061]

[Table 6]

Examples 19 to 23 Whitening cosmetics having the following compositions were produced by a conventional method.

Example 19 (Emulsion)

Table 7 (Components) (% by weight) (1) Palmitic acid 1.0 (2) Stearic acid 1.0 (3) Cetanol 1.0 (4) Monohexadecyl phosphate sodium salt 2.0 (5) Sorbitan monostearate 0.5 (6) Glycerin 10.0 (7) Ethanol 5.0 (8) Spiroether compound Z 0.5 (9) Isotridecyl isononanoate (δ = 16.56) 3.0 (10) Monoisostearin Diglyceryl monomyristate (δ = 18.43) 1.0 (11) Lactic acid 2.0 (12) Arbutin 3.0 (13) Purified water balance

Example 20 (Emulsion)

(Components) (% by weight) (1) 1,3-butylene glycol 3.0 (2) glycerin 5.0 (3) Sodium hyaluronate 0.2 (4) Polyacrylic acid (Carbopol; Good) 0.2 (5) Potassium hydroxide 0.06 (6) Polyoxyethylene hydrogenated castor oil (40E.O. ^{* 1} ) 1.0 (7) α-monoisostearyl glyceryl ether 0.2 ( 8) Sorbitan monostearate 0.2 (9) Spiroether compound Z 0.01 (10) Isotridecyl isononanoate (δ = 16.56) 5.0 (11) Diglyceryl monomyristate monoisostearate (δ = 18.43) 1 1.0 (12) Succinic acid 1.5 (13) Urea 2.0 (14) ε-Aminocaproic acid 1.0 (15) Chamomile (chamomile liquid; manufactured by Ichimaru Falcos) 5.0 (16) Bovine placenta extraction (Biofaruko CP-20; manufactured by Ichimaru Pharcos Co., Ltd.) 1.0 (17) Purified water Balance * 1: ethylene oxide addition molar number

Example 21 (cream)

(Ingredient) (% by weight) (1) Stearic acid 2.0 (2) Isotridecyl isononanoate (δ = 16.56) 7.0 (3) Diglyceryl monomyristate monoisostearate (δ = 18.43) 4 0.0 (4) Cholesterol 3.0 (5) Cetanol 2.0 (6) Arginine 2-hexadecylphosphate 2.0 (7) Polyoxyethylene hydrogenated castor oil (40E.O. ^{* 1} ) 0.5 (8) α-monoisostearyl glyceryl ether 0.2 (9) Spiro ether compound Z 0.01 (10) Spiro ether compound E 0.01 (11) Succinic acid 1.0 (12) Kojic acid 1.0 ( 13) Glycerin 5.0 (14) Sodium hyaluronate 0.05 (15) Polyacrylic acid (Carbopol; manufactured by Goodrich) 0.5 (16) Sodium hydroxide 0.15 (17) Purified water balance * 1 : Number of moles of ethylene oxide added

Example 22 (Cream foundation)

(Table 10) (Components) (% by weight) (1) Titanium oxide 6.0 (2) Sericite 8.0 (3) Iron oxide (red, yellow, black) 1.2 (4) Sorbitan fatty acid ester (Reodol) MO-6; manufactured by Kao Corporation) 5.0 (5) Isotridecyl isononanoate (δ = 16.56) 12.0 (6) Diglyceryl monoisostearate monomyristate (δ = 18.43) 3.0 (7) Dimethylpolysiloxane (KF96A 6cs; manufactured by Shin-Etsu Chemical Co., Ltd.) 30.0 (8) Spiroether compound Z 0.01 (9) Glycerin 2.0 (10) Purified water balance

Example 23 (Powder Foundation)

(Table 11) (Components) (% by weight) (1) Titanium oxide 10.0 (2) Sericite 30.0 (3) Talc balance (4) Kaolin 5.0 (5) Bengala 2.0 (6) Yellow Iron oxide 2.5 (7) Black iron oxide 0.1 (8) Polyethylene powder 4.0 (9) Isotridecyl isononanoate (δ = 16.56) 1.5 (10) Diglyceryl monomyristate monoisostearate (δ = 18.43) 0.6 (11) Dimethylpolysiloxane (KF96A 6cs; manufactured by Shin-Etsu Chemical Co., Ltd.) 12.0 (12) Spiroether compound Z 0.01

Each of the whitening cosmetics obtained in Examples 19 to 23 had good transdermal absorbability of the active ingredient, excellent whitening effect, high safety, and good usability. .

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Yumiko Sato 2-1-3 Bunka, Sumida-ku, Tokyo Inside Kao Research Institute

Claims (5)

[Claims] 1. A substance having (A) a whitening or anti-inflammatory effect, and (B) a solubility parameter δ of 15.7 <δ ≦.
A cosmetic comprising one or more oils selected from oils in the range of 21.0. 2. The cosmetic according to claim 1, wherein the component (B) is a combination of two or more oil agents having a solubility parameter δ in the range of 15.7 <δ ≦ 21.0. . 3. Component (B) comprises (B-1) one or more oil agents selected from oil agents having a solubility parameter δ in the range of 15.7 <δ ≦ 17.2, and (B-2) The cosmetic according to claim 1 or 2, wherein the cosmetic parameter is one or a combination of two or more selected from oil agents having a solubility parameter δ in the range of 17.5 ≦ δ ≦ 21.0. 4. Component (B) comprises (B-1) and (B-
2) by weight ratio (B-1) / (B-2) = 10/1 to 1
The cosmetic according to claim 3, wherein the cosmetic is combined at a ratio of / 2. 5. The method according to claim 1, further comprising (C) a humectant.
The cosmetic according to any one of claims 4 to 4.