WO2003025181A3 - Dna sequences that encode variable regions of antibodies that bind to the prion protein (prp), and prp-binding polypeptides - Google Patents

Dna sequences that encode variable regions of antibodies that bind to the prion protein (prp), and prp-binding polypeptides Download PDF

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Publication number
WO2003025181A3
WO2003025181A3 PCT/EP2002/009370 EP0209370W WO03025181A3 WO 2003025181 A3 WO2003025181 A3 WO 2003025181A3 EP 0209370 W EP0209370 W EP 0209370W WO 03025181 A3 WO03025181 A3 WO 03025181A3
Authority
WO
WIPO (PCT)
Prior art keywords
prp
antibodies
bind
variable regions
dna sequences
Prior art date
Application number
PCT/EP2002/009370
Other languages
German (de)
French (fr)
Other versions
WO2003025181A2 (en
Inventor
Markus Moser
Bruno Oesch
Original Assignee
Prionics Ag
Markus Moser
Bruno Oesch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prionics Ag, Markus Moser, Bruno Oesch filed Critical Prionics Ag
Priority to EP02772185A priority Critical patent/EP1423520A2/en
Publication of WO2003025181A2 publication Critical patent/WO2003025181A2/en
Publication of WO2003025181A3 publication Critical patent/WO2003025181A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a DNA sequence that encodes variable regions of antibodies that bind to PrP. Said DNA sequence contains at least one sequence indicated under SEQ1 to SEQ4 or at least a part of said sequence, and encodes polypeptides that bind PrP. The invention further relates to a polypeptide derived from the DNA sequence, which comprises at least one PrP-binding region, except for the polypeptides that are identical to a chain of the antibodies 6H4 or 15B3, and to the use of the polypeptides in the therapy, diagnosis and prevention of prion-related diseases.
PCT/EP2002/009370 2001-09-05 2002-08-22 Dna sequences that encode variable regions of antibodies that bind to the prion protein (prp), and prp-binding polypeptides WO2003025181A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02772185A EP1423520A2 (en) 2001-09-05 2002-08-22 Dna sequences that encode variable regions of antibodies that bind to the prion protein (prp), and prp-binding polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2001143647 DE10143647A1 (en) 2001-09-05 2001-09-05 New DNA sequences encoding antibody variable regions, useful for preparation of polypeptides for treatment, prevention and diagnosis of prion diseases
DE10143647.5 2001-09-05

Publications (2)

Publication Number Publication Date
WO2003025181A2 WO2003025181A2 (en) 2003-03-27
WO2003025181A3 true WO2003025181A3 (en) 2003-09-25

Family

ID=7697895

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/009370 WO2003025181A2 (en) 2001-09-05 2002-08-22 Dna sequences that encode variable regions of antibodies that bind to the prion protein (prp), and prp-binding polypeptides

Country Status (3)

Country Link
EP (1) EP1423520A2 (en)
DE (1) DE10143647A1 (en)
WO (1) WO2003025181A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0227886D0 (en) 2002-11-29 2003-01-08 Medical Res Council Prion inhibition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037210A1 (en) * 1997-02-21 1998-08-27 KANTON ZÜRICH vertreten durch DIE ERZIEHUNGSDIREKTION Immunological detection of prions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037210A1 (en) * 1997-02-21 1998-08-27 KANTON ZÜRICH vertreten durch DIE ERZIEHUNGSDIREKTION Immunological detection of prions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HEPPNER F L ET AL: "PREVENTION OF SCRAPIE PATHOGENESIS BY TRANSGENIC EXPRESSION OF ANTI-PRION PROTEIN ANTIBODIES", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 294, 2001, pages 178 - 182, XP001094132, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
DE10143647A1 (en) 2003-03-27
EP1423520A2 (en) 2004-06-02
WO2003025181A2 (en) 2003-03-27

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