WO2001019856A3 - Secreted human proteins, polynucleotides encoding them and methods of using the same - Google Patents

Secreted human proteins, polynucleotides encoding them and methods of using the same Download PDF

Info

Publication number
WO2001019856A3
WO2001019856A3 PCT/US2000/025106 US0025106W WO0119856A3 WO 2001019856 A3 WO2001019856 A3 WO 2001019856A3 US 0025106 W US0025106 W US 0025106W WO 0119856 A3 WO0119856 A3 WO 0119856A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides encoding
methods
polyx
same
human proteins
Prior art date
Application number
PCT/US2000/025106
Other languages
French (fr)
Other versions
WO2001019856A2 (en
Inventor
Richard A Shimkets
Elma Fernandes
John L Herrmann
Xiaohong Liu
Meijia Yang
Ferenc L Boldog
Original Assignee
Curagen Corp
Richard A Shimkets
Elma Fernandes
John L Herrmann
Xiaohong Liu
Meijia Yang
Ferenc L Boldog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, Richard A Shimkets, Elma Fernandes, John L Herrmann, Xiaohong Liu, Meijia Yang, Ferenc L Boldog filed Critical Curagen Corp
Priority to CA002384749A priority Critical patent/CA2384749A1/en
Priority to EP00961880A priority patent/EP1250425A2/en
Priority to AU73773/00A priority patent/AU7377300A/en
Priority to JP2001523633A priority patent/JP2003531571A/en
Publication of WO2001019856A2 publication Critical patent/WO2001019856A2/en
Publication of WO2001019856A3 publication Critical patent/WO2001019856A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides polypeptides, designated herein as POLYX polypeptides, as well as polynucleotides encoding POLYX polypeptides, and antibodies that immunospecifically-bind to POLYX polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the POLYX polypeptide, polynucleotide, and antibody are used in the detection, prevention, and treatment of a broad range of pathological states.
PCT/US2000/025106 1999-09-13 2000-09-13 Secreted human proteins, polynucleotides encoding them and methods of using the same WO2001019856A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002384749A CA2384749A1 (en) 1999-09-13 2000-09-13 Novel human proteins, polynucleotides encoding them and methods of using the same
EP00961880A EP1250425A2 (en) 1999-09-13 2000-09-13 Secreted human proteins, polynucleotides encoding them and methods of using the same
AU73773/00A AU7377300A (en) 1999-09-13 2000-09-13 Novel human proteins, polynucleotides encoding them and methods of using the same
JP2001523633A JP2003531571A (en) 1999-09-13 2000-09-13 Novel human proteins, polynucleotides encoding them, and methods of using them

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US15362999P 1999-09-13 1999-09-13
US60/153,629 1999-09-13
US15452099P 1999-09-16 1999-09-16
US60/154,520 1999-09-16
US15476299P 1999-09-20 1999-09-20
US60/154,762 1999-09-20
US15923199P 1999-10-13 1999-10-13
US60/159,231 1999-10-13
US65963400A 2000-09-12 2000-09-12
US09/659,634 2000-09-12

Publications (2)

Publication Number Publication Date
WO2001019856A2 WO2001019856A2 (en) 2001-03-22
WO2001019856A3 true WO2001019856A3 (en) 2002-08-15

Family

ID=27538456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/025106 WO2001019856A2 (en) 1999-09-13 2000-09-13 Secreted human proteins, polynucleotides encoding them and methods of using the same

Country Status (5)

Country Link
EP (1) EP1250425A2 (en)
JP (1) JP2003531571A (en)
AU (1) AU7377300A (en)
CA (1) CA2384749A1 (en)
WO (1) WO2001019856A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2386925A1 (en) * 1999-10-13 2001-04-19 Curagen Corporation Proteins and polynucleotides encoded thereby
EP1790725A2 (en) * 2000-03-03 2007-05-30 Curagen Corporation Proteins named after FCTRX and nucleic acids encoding same
US20030235821A1 (en) * 2001-06-04 2003-12-25 Zerhusen Bryan D. Novel Human proteins, polynucleotides encoding them and methods of using the same

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007198A2 (en) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Dna sequences and secreted proteins encoded thereby
WO1998045712A2 (en) * 1997-04-08 1998-10-15 Human Genome Sciences, Inc. 20 human secreted proteins
WO1998057983A2 (en) * 1997-06-18 1998-12-23 Zymogenetics, Inc. Mammalian neuro-growth factor like protein
WO1999005256A2 (en) * 1997-07-24 1999-02-04 President And Fellows Of Harvard College Method for cloning secreted proteins
WO1999006550A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN PROSTATE
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
WO1999063088A2 (en) * 1998-06-02 1999-12-09 Genentech, Inc. Membrane-bound proteins and nucleic acids encoding the same
WO2000018904A2 (en) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Secreted proteins and nucleic acids encoding them
WO2001010902A2 (en) * 1999-08-11 2001-02-15 Curagen Corporation Nucleoc acids and secreted polypeptides encoded thereby

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007198A2 (en) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Dna sequences and secreted proteins encoded thereby
WO1998045712A2 (en) * 1997-04-08 1998-10-15 Human Genome Sciences, Inc. 20 human secreted proteins
WO1998057983A2 (en) * 1997-06-18 1998-12-23 Zymogenetics, Inc. Mammalian neuro-growth factor like protein
WO1999005256A2 (en) * 1997-07-24 1999-02-04 President And Fellows Of Harvard College Method for cloning secreted proteins
WO1999006550A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN PROSTATE
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
WO1999063088A2 (en) * 1998-06-02 1999-12-09 Genentech, Inc. Membrane-bound proteins and nucleic acids encoding the same
WO2000018904A2 (en) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Secreted proteins and nucleic acids encoding them
WO2001010902A2 (en) * 1999-08-11 2001-02-15 Curagen Corporation Nucleoc acids and secreted polypeptides encoded thereby

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 1 February 1999 (1999-02-01), WATERSTON R.H. ETAL.: "Homo sapiens BAC clone RP11-284E5 from 2, complete sequence.", XP002181755, retrieved from EBI Database accession no. AC006460 *
DATABASE EMBL [online] 9 March 1999 (1999-03-09), STONE,N.E. ET AL.: "Homo sapiens chromosome 4 clone C0026P05 map 4P16, complete sequence", XP002181950, retrieved from NCBI Database accession no. AC005599 *

Also Published As

Publication number Publication date
EP1250425A2 (en) 2002-10-23
JP2003531571A (en) 2003-10-28
WO2001019856A2 (en) 2001-03-22
AU7377300A (en) 2001-04-17
CA2384749A1 (en) 2001-03-22

Similar Documents

Publication Publication Date Title
WO2001092523A3 (en) Human polynucleotides and polypeptides encoded thereby
WO2000058473A3 (en) Nucleic acids including open reading frames encoding polypeptides; 'orfx'
WO2002057453A3 (en) Polypetides and nucleic acids encoding same
WO2001010902A3 (en) Nucleoc acids and secreted polypeptides encoded thereby
WO2000053742A3 (en) Polynucleotides and proteins encoded thereby
WO2002029058A3 (en) Human proteins, polynucleotides encoding them and methods of using the same
WO2002066647A3 (en) Type 2 ctokine receptor and nucleic acids encoding same
WO2002016599A3 (en) Proteins and nucleic acids encoding same
WO2000078802A3 (en) Secreted polypeptides and corresponding polynucleotides
WO2002029038A3 (en) Novel proteins and nucleic acids encoding same and antibodies directed against these proteins
WO2001085767A3 (en) Human proteins polynucleotides encoding them and methods of using the same
WO2001074856A3 (en) Wnt-7b-like polypeptides and nucleic acids encoding same
WO2002055702A3 (en) Human proteins, polynucleotides encoding them and methods of using the same
WO2002002625A3 (en) Novel fibroblast growth factors and nucleic acids encoding same
WO2001066747A8 (en) Proteins named fctrx and nucleic acids encoding same
WO2002066643A3 (en) Proteins, polynucleotides encoding them and methods of using the same
WO2001005971A3 (en) Secreted polypeptides and corresponding polynucleotides
WO2000061754A3 (en) Human proteins and polynucleotides encoding them
WO2001019856A3 (en) Secreted human proteins, polynucleotides encoding them and methods of using the same
WO2003025147A3 (en) Novel polynucleotides and proteins encoded thereby
WO2001079294A3 (en) Human proteins, polynucleotides encoding them and methods of using the same
WO2001074851A3 (en) Novel proteins and nucleic acids encoding same
WO2002057452A3 (en) Human proteins, polynucleotides encoding them and methods of using the same
WO2000070046A3 (en) Secreted polypeptides and corresponding polynucleotides
WO2001042471A8 (en) Polypeptides and polynucleotides encoding same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2384749

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 73773/00

Country of ref document: AU

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 523633

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000961880

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2000961880

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2000961880

Country of ref document: EP