WO2003024511A1 - Dispositif d'administration de fluide medical - Google Patents

Dispositif d'administration de fluide medical Download PDF

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Publication number
WO2003024511A1
WO2003024511A1 PCT/US2002/029189 US0229189W WO03024511A1 WO 2003024511 A1 WO2003024511 A1 WO 2003024511A1 US 0229189 W US0229189 W US 0229189W WO 03024511 A1 WO03024511 A1 WO 03024511A1
Authority
WO
WIPO (PCT)
Prior art keywords
delivery device
film
low density
density polyethylene
layer film
Prior art date
Application number
PCT/US2002/029189
Other languages
English (en)
Other versions
WO2003024511A8 (fr
Inventor
Kevin Hetzler
Chia-Hsi Chu
Original Assignee
Becton Dickinson And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson And Company filed Critical Becton Dickinson And Company
Priority to AU2002341662A priority Critical patent/AU2002341662A1/en
Publication of WO2003024511A1 publication Critical patent/WO2003024511A1/fr
Publication of WO2003024511A8 publication Critical patent/WO2003024511A8/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M2005/5006—Having means for destroying the syringe barrel, e.g. by cutting or piercing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels

Definitions

  • This invention relates to a medical fluid delivery device having a collapsible crushable enclosure wall containing the medical fluid or more particularly a single-use disposable delivery device, such as a syringe having a bulb-shaped compressible enclosure, formed of a laminate having an inner moisture barrier.
  • Single-use medical fluid delivery devices having a collapsible wall enclosure which delivers the medical fluid to a patient upon compression of the enclosure wall are known in the art.
  • the terms "medical fluid” and “medical liquid” are intended to include medicaments, vaccines, drugs and the like which may be delivered to a patient by the delivery device.
  • single-use disposable devices of this type include a bulb-shaped enclosure which contains the medical fluid or liquid. Thus, upon compression of the collapsible enclosure wall, the medical fluid or liquid is expelled from the enclosure through an outlet to the patient.
  • Such single-use delivery devices may also be utilized in conjunction with a syringe, for example, wherein a medical liquid is delivered to a needle cannula for injection to a patient upon compression of the collapsible enclosure wall by the patient or a medical worker. That is, during injection, the patient or medical worker compresses the collapsible enclosure wall which delivers a medical liquid through the needle cannula to the patient.
  • U.S. Patent No. 4,955,871 discloses a single-use disposable syringe which includes a reservoir for a medical liquid formed from two sheets of thermoplastic sealed together in face-to-face relation, wherein a bulb-shaped central portion is formed by either injecting air under pressure between the sheets into a die cavity or vacuum forming.
  • the disclosed single-use disposable syringe further includes a double ended needle cannula supported on a hub which is received within a tubular nozzle portion of the blow molded or vacuum formed delivery device to pierce a membrane within the tubular nozzle portion and provide fluid communication between the liquid reservoir in the bulb-shaped delivery device and the needle cannula.
  • the patient or healthcare worker drives the sharp end of the needle cannula through the membrane to establish fluid communication between the reservoir and the needle cannula. Then, during injection, the user compresses the bulb-shaped delivery device, thereby delivering the medical liquid through the needle cannula to the patient.
  • a cap having a radial rib is provided to protect against accidental needle sticks and to assist in driving the needle cannula through the membrane.
  • the single-use disposable syringe disclosed in this patent is not reusable because the bulb-shaped reservoir is substantially collapsed during use to expel medicament out of the reservoir, such that the bulb- shaped reservoir cannot be reformed.
  • the medical fluid delivery device of this invention is directed to the material selected for the delivery device, which in U.S.
  • Patent No. 4,955,871 is the bulb-shaped reservoir formed by bonding and blow or vacuum forming the sheets as described above.
  • the thermoformable sheets disclosed in U.S. Patent No. 4,955,871 are a laminate comprised of an outer film of polyethylene terephthalate, a bonding layer formed from an emulsion of polyvinylidene chloride, which is coated on the polyethylene terephthalate film and dried, and an inner layer of polyethylene film which is glued to the polyethylene terephthalate film using polyurethane as the adhesive.
  • the delivery device is then formed by bringing two laminated sheets together described above, heating the sheets to their thermoforming temperature and then either blow molding or vacuum forming the sheets in a die, forming the bulb- shaped delivery device and an integral tubular nozzle described above.
  • the laminate selected for the single-use disposable syringe disclosed in U.S. Patent No. 4,955,871 has several disadvantages as follows. First, following radiation sterilization, extractables are found in the medical liquid at least in trace amounts. Second, the bonded sheets are subject to delamination. Third, during incineration of the delivery device following use, the polyvinylidene chloride creates hydrochloric acid and the polyurethane produces further toxins. Finally, the manufacturing process is expensive, requiring either special equipment or manual operations. Therefore, there is a need to provide a safe disposable medical liquid delivery device which avoids the problems described. SUMMARY OF THE INVENTION
  • the medical fluid delivery device of this invention has a collapsible crushable enclosure wall formed of a thermoformable laminate and is therefore suitable for many applications, including but not limited to the single-use disposable syringe disclosed in the above-referenced U.S. Patent No. 4,955,871, the disclosure of which is incorporated herein by reference.
  • the medical fluid delivery device of this invention is not limited to the disposable syringe disclosed in this patent, but may be utilized with any medical fluid delivery device having a collapsible crushable enclosure wall, particularly including liquid fluid delivery devices subject to radiation sterilization and which may be formed by conventional thermoforming methods.
  • the collapsible crushable enclosure wall of the medical fluid delivery device of this invention preferably includes an inner layer film of low density polyethylene forming a moisture barrier as described in the above-referenced U.S. Patent.
  • the outer layer film is formed of a cyclic olefin or a cyclic olefin copolymer preferably having a melting temperature of between 1 to 10° C greater than the melting temperature of the inner layer of film of low density polyethylene and bonded directly to the inner layer film of low density polyethylene.
  • the inner layer film of low density polyethylene and the outer layer film of cyclic olefin or cyclic olefin copolymer are coextruded and bonded together in face-to-face relation during the coextrusion process.
  • the low density polyethylene film can be bonded to the cyclic olefin or cyclic olefin copolymer during extrusion of the low density polyethylene film, although not preferred.
  • the preferred process prevents delamination and results in a superior delivery device.
  • the films may then be bonded together and thermoformed by conventional methods as described, for example, in the above-referenced U.S. Patent.
  • the delivery device After filling the reservoir formed between the films with a medical fluid, the delivery device may be sterilized by radiation without extractables in the medical fluid or liquid in the reservoir. Further, the delivery device is transparent, having improved clarity over the prior art including the above-referenced U.S. Patent.
  • the outer layer film of cyclic olefin or cyclic olefin copolymer has a thickness of between 1 and 7 mils, preferably 3 to 6 mils and most preferably about 5 mils.
  • the inner layer film of low density polyethylene preferably has a thickness of between 1 and 4 mils or preferably about 3 mils, particularly where the inner layer of low density polyethylene is formed of a laminate as now described.
  • the first layer film in contact with the medical fluid is formed of a linear low density polyethylene, providing improved strength at ambient temperatures during filling, storage and use, and the second layer between the first layer and the outer layer of cyclic olefin or cyclic olefin copolymer is formed of a film of high pressure low density polyethylene providing strength at elevated temperatures during forming.
  • the crushable enclosure wall is formed of a laminate comprising at least three film layers including a first inner film layer formed of linear low density polyethylene, a second inner film layer formed of high pressure low density polyethylene and an outer film layer formed of a cyclic olefin or cyclic olefin copolymer, wherein the outer film layer has a melting temperature of between 1 and 10° C greater than the melting temperature of the inner film layers, preferably both the first and second inner film layers, to assure uniform heat softening of all three film layers during thermoforrning.
  • all three film layers are coextruded and bonded together during coextrusion, wherein the first inner film layer of linear low density polyethylene has a thickness of between 1 and 3 mils, preferably about two mils and the second inner film layer of high pressure low density polyethylene has a thickness of between 0.5 and 2 mils, preferably about 1 mil.
  • the outer film layer formed of a cyclic olefin or cyclic olefin copolymer preferably has a melting temperature of 1 to 10° C greater than the inner layer film or films of low density polyethylene or more preferably between 3 and 7° C or about 4 to 5° C.
  • the outer film layer is formed of a blend of cyclic olefins or cyclic olefin copolymers to achieve the desired properties, including melting temperature.
  • Figure 1 is an exploded view of a single-use disposable syringe which includes the medical fluid delivery device of this invention
  • Figure 2 is an assembled view of the single-use disposable syringe shown in Figure 1;
  • Figure 3 illustrates the single-use disposable syringe of Figures 1 and 2 during injection after collapse of the delivery device
  • Figure 4 is a cross-sectional view of the delivery device shown in Figure 1 in the direction of view arrows 4-4; and Figure 5 is a cross-sectional view similar to Figure 4 illustrating a second preferred embodiment of the drug delivery device of this invention.
  • the medical fluid delivery device of this invention having a collapsible crushable enclosure wall reservoir may contain any fluid medicament, drug or vaccine and is particularly useful for liquid medicaments, drugs and vaccines, referred to herein as medical fluids or medical liquids, and is therefore not limited to any specific delivery device.
  • the delivery device of this invention will now be described in the context of the single-use disposable syringe described in the above- referenced U.S. Patent No. 4,955,871 for ease of description only and without limitation of the embodiment of the delivery device except as specifically set forth hereinbelow.
  • a medical liquid delivery device 20 is disclosed in combination with a disposable syringe as disclosed in the above-referenced U.S. Patent.
  • the delivery device 20 includes a bulb-shaped reservoir 22 having a tubular outlet or nozzle portion 24 in fluid communication with the bulb-shaped reservoir 22 including a pierceable membrane 26 and an outlet 28.
  • the tubular outlet portion 24 includes an internal annular rib 30 spaced from the pierceable membrane 26 and an external annular rib 31.
  • the delivery device 20 may be formed by conventional thermoforming techniques.
  • the syringe assembly includes a double ended needle cannula 32, which is secured by conventional means to a needle hub 34, wherein the double ended needle cannula 32 includes a first sharp end 36, which is received within the outlet 28 of the tubular outlet portion 24, and an opposed second sharp end 38 used for aspiration or injection.
  • the second sharp end 38 is received in a cap 20 having a closed end 42 and an open end 44 which receives the second sharp end 38 of the needle cannula 32.
  • the needle hub 34 includes a smaller diameter portion 46 having an external diameter for receipt in the open end 44 of the cap 40 and a larger diameter portion 48, having an external diameter for receipt in the outlet 28 of the tubular outlet portion 24.
  • the cap 44 further includes an external rib 50 to assist in manipulation of the cap during use as now briefly described.
  • the bulb-shaped reservoir is filled with a single dose of a medical liquid prior to use.
  • the reservoir 22 is sealed by the pierceable membrane 26.
  • the reservoir 22 may be filled with a filler tube (not shown) in fluid communication with the reservoir and then sealed.
  • the first end 36 of the double ended needle cannula is received in the outlet 28 of the tubular outlet portion 24 of the delivery device 20 and then driven through the pierceable membrane 26 providing fluid communication between the bulb-shaped reservoir 22 and the double ended needle cannula 32.
  • the delivery device of this invention may be conventional and is not limited to the embodiment shown in Figures 1 to 3.
  • Figure 4 is a crosssection of one preferred embodiment of the medical liquid delivery device 20 of this invention, wherein the bulb-shaped reservoir 22 is a laminate comprised of an inner layer film 52 of low density polyethylene and an outer layer film 54 of a cyclic olefin or cyclic olefin copolymer.
  • the inner layer film 52 and the outer layer film 54 are preferably coextruded and then thermoformed, wherein the melting temperature of the outer layer film 54 has a melting temperature of between 1 and 10° C greater than the melting temperature of the inner layer film 52 or more preferably at least 4° C greater than the melting temperature of the inner film layer 52 as described above.
  • One preferred method of forming the bulb- shaped reservoir 22 is to coextrude the inner layer film 52 with the outer layer film 54 as sheets or films, wherein the films 52 and 54 are brought together during the coextrusion process, intimately bonding the inner layer 52 to the outer layer 54. Then, during the thermoforming process, the film laminates are again heated to their melting temperature and thermoformed in a die (not shown), forming a peripheral portion 56 as described, for example, in the above-referenced patent.
  • the outer layer film 54 is a blend of cyclic olefins or cyclic olefin copolymers having a thickness of between 1 and 7 mils, more preferably between 3 and 6 mils, or preferably about 5 mils.
  • the inner layer film has a thickness of 2 to 5 mils, preferably 2 to 4 mils, or more preferably about 3 mils.
  • Figure 5 illustrates a more preferred embodiment of the medical liquid delivery device 20, wherein the inner film layer is comprised of a first inner film layer 58 of linear low density polyethylene and a second inner film layer 60 of high pressure low density polyethylene.
  • the first inner film layer 58 of linear low density polyethylene provides improved strength at ambient temperature during filling, storage and use
  • the second inner layer 60 of high pressure low density polyethylene provides improved strength during thermoforming, wherein the laminate is heated to its melting temperature.
  • the first inner film layer 58 has a thickness of between 1 to 3 mils or about 2 mils and the second inner film layer 60 has a thickness of between 0.5 and 2 mils or about 1 mil.
  • a preferred embodiment of the medical fluid delivery device has a thickness of between 1 to 3 mils or about 2 mils and the second inner film layer 60 has a thickness of between 0.5 and 2 mils or about 1 mil.
  • the 20 of this invention includes an outer layer film 54 having a melting temperature slightly greater than the melting temperature of the inner film layer 52 as shown in Figure 4 or film layers 58 and 60 shown in Figure 5, such that during thermoforming, the laminate is uniformly heated to its melting temperature.
  • the outer film layer 54 is preferably a blend of cyclic olefins or cyclic olefin copolymers to achieve the desired melting temperature.
  • the outer film layer 54 may, for example, be a blend of Topas® 6015 or 6017 available from Ticona GmbH or "BD Crystal Clear Polymer” available from Zeon Chemicals of Japan and Topas® 8007 available from Ticona GmbH or Zeonor 750R available from Zeon Corporation.
  • the desired melting temperature compatible with the inner layer of low density polyethylene can be achieved.
  • Low density polyethylene including linear low density polyethylene and high pressure low density polyethylene are commercially available from numerous sources.
  • the medical fluid delivery device of this invention includes a laminate comprised of three layers as shown in Figure 5, the first and second inner film layers 58 and 60 are coextruded with the outer film layer 54 and bonded during the coextrusion process.
  • the delivery device 20 shown in Figure 5 may then be thermoformed as described above with reference to Figure 4, wherein the laminate is heated to its melting or thermoforming temperature and formed in a die by conventional thermoforming techniques.
  • the resultant medical fluid delivery devices 20 shown in Figures 4 and 5 have several important advantages over the known prior art, particularly including but not limited to the disclosure of U.S. Patent No. 4,955,871.
  • the laminate of this invention may be formed by coextrusion, wherein the melting temperatures of the lamina are very similar, the laminate is not subject to delamination and conventional coextrusion apparatus may be used. The manufacturing cost is also significantly reduced. Further, the clarity is improved. Finally, the laminate has improved safety, including very low extractables after radiation sterilization and toxic fumes are not generated during incineration or disposal. Finally, the laminate can be easily and permanently crushed during use, wherein the bulb-shaped liquid reservoir 22 is squeezed by the user, thereby preventing reuse.
  • the medical fluid delivery device includes a collapsible crushable enclosure wall formed of a laminate as described above.
  • the medical fluid delivery device of this invention is not limited to a syringe and the bulb-shaped enclosure may be of any suitable form provided the enclosure wall is collapsible and crushable to prevent reuse.
  • the medical fluid delivery device of this invention may also be used as a respiratory delivery device.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif d'administration de fluide médical qui comprend une paroi d'enveloppe pliante et écrasable formée d'un stratifié comprenant une couche intérieure de polyéthylène basse densité liée à une couche extérieure d'une oléfine cyclique ou d'un copolymère d'oléfine cyclique possédant une température de fusion supérieure de 1 à 10 °C à la température de fusion de la couche intérieure. La couche extérieure peut être un mélange d'oléfines cycliques ou de copolymères d'oléfines cycliques et la couche intérieure peut comprendre une première couche intérieure de polyéthylène linéaire basse densité et une couche intermédiaire de polyéthylène basse densité haute pression.
PCT/US2002/029189 2001-09-17 2002-09-13 Dispositif d'administration de fluide medical WO2003024511A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002341662A AU2002341662A1 (en) 2001-09-17 2002-09-13 Single-use disposable syringe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32299701P 2001-09-17 2001-09-17
US60/322,997 2001-09-17

Publications (2)

Publication Number Publication Date
WO2003024511A1 true WO2003024511A1 (fr) 2003-03-27
WO2003024511A8 WO2003024511A8 (fr) 2004-02-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/029189 WO2003024511A1 (fr) 2001-09-17 2002-09-13 Dispositif d'administration de fluide medical

Country Status (2)

Country Link
AU (1) AU2002341662A1 (fr)
WO (1) WO2003024511A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1523954A1 (fr) * 2003-10-16 2005-04-20 Straumann Holding AG Capsule en un copolymére cyclique d'oléfines pour la conservation d'un objet médical
WO2011006922A1 (fr) 2009-07-14 2011-01-20 Sanofi-Aventis Deutschland Gmbh Récipient pour médicament à couche interne souple et à couche externe rigide
US10155088B2 (en) 2014-03-04 2018-12-18 Merck Sharp & Dohme Corp. Prefilled disposable injection device
US10182969B2 (en) 2015-03-10 2019-01-22 Regeneron Pharmaceuticals, Inc. Aseptic piercing system and method
US11547801B2 (en) 2017-05-05 2023-01-10 Regeneron Pharmaceuticals, Inc. Auto-injector
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876771A (en) * 1951-09-28 1959-03-10 Dunmire Russell Paul Hypodermic syringes
US4261482A (en) * 1978-07-12 1981-04-14 Toyo Seikan Kaisha Limited Squeeze vessel
US4548601A (en) * 1984-04-09 1985-10-22 Lary Banning G Prepackaged, injectable pharmaceutical and hypodermic needle combination
US4955871A (en) * 1987-04-29 1990-09-11 Path Single-use disposable syringe

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876771A (en) * 1951-09-28 1959-03-10 Dunmire Russell Paul Hypodermic syringes
US4261482A (en) * 1978-07-12 1981-04-14 Toyo Seikan Kaisha Limited Squeeze vessel
US4548601A (en) * 1984-04-09 1985-10-22 Lary Banning G Prepackaged, injectable pharmaceutical and hypodermic needle combination
US4955871A (en) * 1987-04-29 1990-09-11 Path Single-use disposable syringe

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8637128B2 (en) 2003-10-16 2014-01-28 Straumann Holding Ag Cyclic olefin copolymer external capsule for preserving medical device
WO2005039435A1 (fr) * 2003-10-16 2005-05-06 Straumann Holding Ag Capsule externe a copolymere d'olefine cyclique pour proteger un dispositif medical
EP1523954A1 (fr) * 2003-10-16 2005-04-20 Straumann Holding AG Capsule en un copolymére cyclique d'oléfines pour la conservation d'un objet médical
US8679395B2 (en) 2009-07-14 2014-03-25 Sanofi-Aventis Deutschland Gmbh Medicament container
JP2012532718A (ja) * 2009-07-14 2012-12-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 可撓性内層及び剛性外層を備えた薬剤容器
CN102470209A (zh) * 2009-07-14 2012-05-23 赛诺菲-安万特德国有限公司 具有柔性内层和刚性外层的药物容器
WO2011006922A1 (fr) 2009-07-14 2011-01-20 Sanofi-Aventis Deutschland Gmbh Récipient pour médicament à couche interne souple et à couche externe rigide
AU2010272597B2 (en) * 2009-07-14 2014-09-11 Sanofi-Aventis Deutschland Gmbh Medicament container with a flexible inner layer and a rigid outer layer
US10155088B2 (en) 2014-03-04 2018-12-18 Merck Sharp & Dohme Corp. Prefilled disposable injection device
US10182969B2 (en) 2015-03-10 2019-01-22 Regeneron Pharmaceuticals, Inc. Aseptic piercing system and method
US11406565B2 (en) 2015-03-10 2022-08-09 Regeneran Pharmaceuticals, Inc. Aseptic piercing system and method
US11547801B2 (en) 2017-05-05 2023-01-10 Regeneron Pharmaceuticals, Inc. Auto-injector
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

Also Published As

Publication number Publication date
WO2003024511A8 (fr) 2004-02-19
AU2002341662A1 (en) 2003-04-01

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