WO2003023034A3 - Regulation de tau-tubuline kinase humaine - Google Patents

Regulation de tau-tubuline kinase humaine Download PDF

Info

Publication number
WO2003023034A3
WO2003023034A3 PCT/EP2002/010102 EP0210102W WO03023034A3 WO 2003023034 A3 WO2003023034 A3 WO 2003023034A3 EP 0210102 W EP0210102 W EP 0210102W WO 03023034 A3 WO03023034 A3 WO 03023034A3
Authority
WO
WIPO (PCT)
Prior art keywords
human tau
tubulin kinase
regulation
reagents
tubulin
Prior art date
Application number
PCT/EP2002/010102
Other languages
English (en)
Other versions
WO2003023034A2 (fr
Inventor
Jiing-Ren Liou
Original Assignee
Bayer Ag
Jiing-Ren Liou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Jiing-Ren Liou filed Critical Bayer Ag
Publication of WO2003023034A2 publication Critical patent/WO2003023034A2/fr
Publication of WO2003023034A3 publication Critical patent/WO2003023034A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des réactifs qui régulent la tau-tubuline kinase ainsi que des réactifs qui se lient à des produits géniques de tau-tubuline kinase humaine pouvant jouer un rôle dans la prévention, le traitement ou la correction de dysfonctionnements ou de maladies incluant notamment, mais pas exclusivement, des affections des système nerveux périphérique et central, en particulier la maladie d'Alzheimer.
PCT/EP2002/010102 2001-09-12 2002-09-10 Regulation de tau-tubuline kinase humaine WO2003023034A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31836401P 2001-09-12 2001-09-12
US60/318,364 2001-09-12

Publications (2)

Publication Number Publication Date
WO2003023034A2 WO2003023034A2 (fr) 2003-03-20
WO2003023034A3 true WO2003023034A3 (fr) 2003-10-16

Family

ID=23237866

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/010102 WO2003023034A2 (fr) 2001-09-12 2002-09-10 Regulation de tau-tubuline kinase humaine

Country Status (1)

Country Link
WO (1) WO2003023034A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521230B2 (en) * 2002-10-16 2009-04-21 Board Of Regents Of The University Of Nebraska Nucleic acid encoding a Brain Derived Tau Kinase polypeptide and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248559B1 (en) * 1993-03-02 2001-06-19 Mitsubishi Chemical Corporation Gene encoding human tau-protein kinase I and use thereof
WO2001059063A2 (fr) * 2000-01-31 2001-08-16 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps
WO2002008399A2 (fr) * 2000-07-21 2002-01-31 Incyte Genomics, Inc. Kinases humaines
WO2002048333A2 (fr) * 2000-12-12 2002-06-20 Lexicon Genetics Incorporated Nouvelles kinases humaines et polynucleotides les codant
WO2002055681A2 (fr) * 2001-01-11 2002-07-18 Bayer Ag Regulation de la tau-tubuline kinase humaine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248559B1 (en) * 1993-03-02 2001-06-19 Mitsubishi Chemical Corporation Gene encoding human tau-protein kinase I and use thereof
WO2001059063A2 (fr) * 2000-01-31 2001-08-16 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps
WO2002008399A2 (fr) * 2000-07-21 2002-01-31 Incyte Genomics, Inc. Kinases humaines
WO2002048333A2 (fr) * 2000-12-12 2002-06-20 Lexicon Genetics Incorporated Nouvelles kinases humaines et polynucleotides les codant
WO2002055681A2 (fr) * 2001-01-11 2002-07-18 Bayer Ag Regulation de la tau-tubuline kinase humaine

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 29 August 2001 (2001-08-29), TOMIZAWA ET AL, XP002238313, retrieved from EBI Database accession no. AB046593 *
DATABASE EMBL [online] XP002238312, retrieved from EBI Database accession no. AB058758 *
DATABASE EMBL [online] XP002238314, retrieved from EBI Database accession no. ABA15297 *
DATABASE EMBL [online] XP002238315, retrieved from EBI Database accession no. ABA15597 *
DATABASE EMBL [online] XP002238316, retrieved from EBI Database accession no. ABA14775 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XX.THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 8, no. 2, AB058758, 2001, pages 85 - 95, XP001030942, ISSN: 1340-2838, Retrieved from the Internet <URL:EBI> *
TAKAHASHI MIHO ET AL: "A novel tau-tubulin kinase from bovine brain", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 372, no. 1, 1995, pages 59 - 64, XP002224022, ISSN: 0014-5793 *
TOMIZAWA^A K ET AL: "Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 492, no. 3, AB04659, 16 March 2001 (2001-03-16), pages 221 - 227, XP004257367, ISSN: 0014-5793, Retrieved from the Internet <URL:EBI> *

Also Published As

Publication number Publication date
WO2003023034A2 (fr) 2003-03-20

Similar Documents

Publication Publication Date Title
WO2002004610A3 (fr) Regulation d&#39;une enzyme humaine du type dipeptidyl-peptidase iv
WO2001077149A3 (fr) Regulation d&#39;une proteine gpcr type cyslt2 humaine
WO2003023034A3 (fr) Regulation de tau-tubuline kinase humaine
WO2002002755A3 (fr) Regulation d&#39;enzyme de type thimet oligopeptidase humaine
WO2004031375A3 (fr) Regulation de la pde1c humaine
WO2002010403A3 (fr) Regulation d&#39;une enzyme humaine de type phospholipase c a phosphatidylinositol specifique
WO2002055681A3 (fr) Regulation de la tau-tubuline kinase humaine
WO2002036613A3 (fr) Regulation de la proteine humaine de type &#39;patched&#39;
WO2002053749A3 (fr) Regulation de la proteine kinase serine/threonine humaine
WO2002046403A3 (fr) Regulation de la proteine humaine du type &#39;patched&#39;
WO2003025174A3 (fr) Regulation de la proteine humaine de type mrp1
WO2002062974A3 (fr) Regulation de la proteine humaine elongase hselo1
WO2003033708A3 (fr) Regulation de la proteine kinase humaine a serine/threonine
WO2002053716A3 (fr) Regulation de l&#39;ornithine decarboxylase humaine
WO2002046402A3 (fr) Regulation de la proteine humaine de type &#39;patched&#39;
WO2002062975A3 (fr) Regulation de la proteine humaine du type elongase hselo1
WO2002061057A3 (fr) Regulation de la serine/threonine proteine kinase humaine de type wee1
WO2002033080A3 (fr) Regulation du recepteur humain membranaire liant la netrine unc5h-1
WO2002036781A3 (fr) Regulation de la glutathione-s-transferase humaine
WO2001070967A3 (fr) Regulation du recepteur humain couple a la proteine g semblable a serotonine
WO2002033056A3 (fr) Regulation de serine-threonine kinase humaine
WO2001072833A3 (fr) Regulation de recepteur humain de type ephrine
WO2002018566A3 (fr) Regulation d&#39;enzyme de type l-asparaginase humaine
WO2002033095A3 (fr) Regulation de serine-threonine proteine kinase humaine
WO2002033096A3 (fr) Regulation de la serine-threonine proteine kinase humaine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP